LeishMANIAdb
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PWWP domain/TFIIS helical bundle-like domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
PWWP domain/TFIIS helical bundle-like domain containing protein, putative
Gene product:
PWWP domain/TFIIS helical bundle-like domain containing protein, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IKG6_LEIDO
TriTrypDb:
LdBPK_332960.1 , LdCL_330036700 , LDHU3_33.4110
Length:
593

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 9
GO:0043226 organelle 2 9
GO:0043227 membrane-bounded organelle 3 9
GO:0043229 intracellular organelle 3 9
GO:0043231 intracellular membrane-bounded organelle 4 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A0A3Q8IKG6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IKG6

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 3
GO:0006351 DNA-templated transcription 7 3
GO:0006725 cellular aromatic compound metabolic process 3 3
GO:0006807 nitrogen compound metabolic process 2 3
GO:0008152 metabolic process 1 3
GO:0009058 biosynthetic process 2 3
GO:0009059 macromolecule biosynthetic process 4 3
GO:0009987 cellular process 1 3
GO:0016070 RNA metabolic process 5 3
GO:0018130 heterocycle biosynthetic process 4 3
GO:0019438 aromatic compound biosynthetic process 4 3
GO:0032774 RNA biosynthetic process 5 3
GO:0034641 cellular nitrogen compound metabolic process 3 3
GO:0034654 nucleobase-containing compound biosynthetic process 4 3
GO:0043170 macromolecule metabolic process 3 3
GO:0044237 cellular metabolic process 2 3
GO:0044238 primary metabolic process 2 3
GO:0044249 cellular biosynthetic process 3 3
GO:0044271 cellular nitrogen compound biosynthetic process 4 3
GO:0046483 heterocycle metabolic process 3 3
GO:0071704 organic substance metabolic process 2 3
GO:0090304 nucleic acid metabolic process 4 3
GO:0097659 nucleic acid-templated transcription 6 3
GO:1901360 organic cyclic compound metabolic process 3 3
GO:1901362 organic cyclic compound biosynthetic process 4 3
GO:1901576 organic substance biosynthetic process 3 3
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 2
GO:0005488 binding 1 2
GO:0008270 zinc ion binding 6 2
GO:0043167 ion binding 2 2
GO:0043169 cation binding 3 2
GO:0046872 metal ion binding 4 2
GO:0046914 transition metal ion binding 5 2
GO:0097159 organic cyclic compound binding 2 2
GO:1901363 heterocyclic compound binding 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 394 398 PF00656 0.739
CLV_C14_Caspase3-7 515 519 PF00656 0.724
CLV_C14_Caspase3-7 61 65 PF00656 0.515
CLV_NRD_NRD_1 158 160 PF00675 0.677
CLV_NRD_NRD_1 161 163 PF00675 0.689
CLV_NRD_NRD_1 167 169 PF00675 0.744
CLV_NRD_NRD_1 170 172 PF00675 0.752
CLV_NRD_NRD_1 188 190 PF00675 0.707
CLV_NRD_NRD_1 191 193 PF00675 0.720
CLV_NRD_NRD_1 201 203 PF00675 0.651
CLV_NRD_NRD_1 234 236 PF00675 0.666
CLV_NRD_NRD_1 278 280 PF00675 0.609
CLV_NRD_NRD_1 285 287 PF00675 0.572
CLV_NRD_NRD_1 443 445 PF00675 0.534
CLV_NRD_NRD_1 468 470 PF00675 0.448
CLV_NRD_NRD_1 497 499 PF00675 0.651
CLV_PCSK_FUR_1 159 163 PF00082 0.729
CLV_PCSK_FUR_1 168 172 PF00082 0.627
CLV_PCSK_FUR_1 495 499 PF00082 0.628
CLV_PCSK_KEX2_1 161 163 PF00082 0.676
CLV_PCSK_KEX2_1 167 169 PF00082 0.666
CLV_PCSK_KEX2_1 170 172 PF00082 0.671
CLV_PCSK_KEX2_1 201 203 PF00082 0.710
CLV_PCSK_KEX2_1 234 236 PF00082 0.715
CLV_PCSK_KEX2_1 285 287 PF00082 0.593
CLV_PCSK_KEX2_1 443 445 PF00082 0.534
CLV_PCSK_KEX2_1 468 470 PF00082 0.448
CLV_PCSK_KEX2_1 497 499 PF00082 0.650
CLV_PCSK_PC1ET2_1 161 163 PF00082 0.684
CLV_PCSK_PC1ET2_1 167 169 PF00082 0.653
CLV_PCSK_PC1ET2_1 170 172 PF00082 0.656
CLV_PCSK_PC7_1 168 174 PF00082 0.595
CLV_PCSK_PC7_1 493 499 PF00082 0.626
CLV_PCSK_SKI1_1 242 246 PF00082 0.709
CLV_PCSK_SKI1_1 326 330 PF00082 0.398
CLV_PCSK_SKI1_1 352 356 PF00082 0.360
CLV_PCSK_SKI1_1 468 472 PF00082 0.504
DEG_SCF_FBW7_1 113 120 PF00400 0.834
DOC_CKS1_1 114 119 PF01111 0.699
DOC_CKS1_1 353 358 PF01111 0.550
DOC_CYCLIN_RxL_1 465 473 PF00134 0.491
DOC_MAPK_DCC_7 352 361 PF00069 0.542
DOC_MAPK_gen_1 326 335 PF00069 0.575
DOC_MAPK_gen_1 495 504 PF00069 0.698
DOC_MAPK_MEF2A_6 326 335 PF00069 0.575
DOC_MAPK_MEF2A_6 352 361 PF00069 0.575
DOC_PP4_FxxP_1 353 356 PF00568 0.561
DOC_PP4_FxxP_1 506 509 PF00568 0.698
DOC_PP4_FxxP_1 540 543 PF00568 0.732
DOC_USP7_MATH_1 10 14 PF00917 0.533
DOC_USP7_MATH_1 100 104 PF00917 0.558
DOC_USP7_MATH_1 117 121 PF00917 0.642
DOC_USP7_MATH_1 214 218 PF00917 0.742
DOC_USP7_MATH_1 238 242 PF00917 0.775
DOC_USP7_MATH_1 346 350 PF00917 0.542
DOC_USP7_MATH_1 40 44 PF00917 0.550
DOC_USP7_MATH_1 51 55 PF00917 0.510
DOC_USP7_MATH_1 83 87 PF00917 0.598
DOC_USP7_UBL2_3 163 167 PF12436 0.678
DOC_WW_Pin1_4 113 118 PF00397 0.784
DOC_WW_Pin1_4 266 271 PF00397 0.713
DOC_WW_Pin1_4 352 357 PF00397 0.550
DOC_WW_Pin1_4 516 521 PF00397 0.671
DOC_WW_Pin1_4 525 530 PF00397 0.558
DOC_WW_Pin1_4 534 539 PF00397 0.574
LIG_14-3-3_CanoR_1 285 293 PF00244 0.529
LIG_14-3-3_CanoR_1 326 332 PF00244 0.445
LIG_14-3-3_CanoR_1 546 555 PF00244 0.647
LIG_14-3-3_CanoR_1 565 570 PF00244 0.409
LIG_Actin_WH2_2 314 331 PF00022 0.575
LIG_BIR_II_1 1 5 PF00653 0.710
LIG_BIR_III_2 105 109 PF00653 0.792
LIG_BRCT_BRCA1_1 536 540 PF00533 0.754
LIG_CSL_BTD_1 23 26 PF09270 0.501
LIG_FHA_1 295 301 PF00498 0.533
LIG_FHA_1 353 359 PF00498 0.560
LIG_FHA_1 483 489 PF00498 0.542
LIG_FHA_1 546 552 PF00498 0.612
LIG_FHA_1 585 591 PF00498 0.481
LIG_FHA_2 147 153 PF00498 0.560
LIG_FHA_2 189 195 PF00498 0.732
LIG_FHA_2 262 268 PF00498 0.734
LIG_FHA_2 3 9 PF00498 0.678
LIG_FHA_2 311 317 PF00498 0.529
LIG_FHA_2 392 398 PF00498 0.676
LIG_FHA_2 415 421 PF00498 0.465
LIG_LIR_Apic_2 505 509 PF02991 0.698
LIG_LIR_Apic_2 537 543 PF02991 0.704
LIG_LIR_Apic_2 549 555 PF02991 0.437
LIG_LIR_Gen_1 13 22 PF02991 0.560
LIG_LIR_Gen_1 136 146 PF02991 0.712
LIG_LIR_Nem_3 13 17 PF02991 0.560
LIG_LIR_Nem_3 136 142 PF02991 0.716
LIG_LIR_Nem_3 521 527 PF02991 0.799
LIG_NRBOX 466 472 PF00104 0.572
LIG_PALB2_WD40_1 365 373 PF16756 0.501
LIG_PTB_Apo_2 364 371 PF02174 0.560
LIG_SH2_CRK 278 282 PF00017 0.662
LIG_SH2_CRK 552 556 PF00017 0.525
LIG_SH2_STAP1 567 571 PF00017 0.598
LIG_SH2_STAT3 249 252 PF00017 0.687
LIG_SH2_STAT3 567 570 PF00017 0.602
LIG_SH2_STAT5 477 480 PF00017 0.594
LIG_SH3_3 20 26 PF00018 0.515
LIG_SH3_3 517 523 PF00018 0.668
LIG_SUMO_SIM_anti_2 43 49 PF11976 0.561
LIG_SUMO_SIM_par_1 450 455 PF11976 0.510
LIG_SUMO_SIM_par_1 488 494 PF11976 0.555
LIG_TRAF2_1 107 110 PF00917 0.713
LIG_TRAF2_1 417 420 PF00917 0.480
LIG_TRAF2_1 93 96 PF00917 0.525
LIG_TRFH_1 258 262 PF08558 0.759
LIG_UBA3_1 321 329 PF00899 0.492
MOD_CDK_SPK_2 266 271 PF00069 0.680
MOD_CDK_SPxxK_3 539 546 PF00069 0.772
MOD_CK1_1 2 8 PF00069 0.707
MOD_CK1_1 240 246 PF00069 0.665
MOD_CK1_1 266 272 PF00069 0.711
MOD_CK1_1 391 397 PF00069 0.629
MOD_CK1_1 414 420 PF00069 0.562
MOD_CK1_1 519 525 PF00069 0.712
MOD_CK1_1 534 540 PF00069 0.751
MOD_CK1_1 86 92 PF00069 0.598
MOD_CK2_1 146 152 PF00069 0.556
MOD_CK2_1 207 213 PF00069 0.762
MOD_CK2_1 250 256 PF00069 0.665
MOD_CK2_1 286 292 PF00069 0.666
MOD_CK2_1 414 420 PF00069 0.499
MOD_GlcNHglycan 117 120 PF01048 0.773
MOD_GlcNHglycan 131 134 PF01048 0.806
MOD_GlcNHglycan 176 179 PF01048 0.757
MOD_GlcNHglycan 19 22 PF01048 0.286
MOD_GlcNHglycan 204 207 PF01048 0.691
MOD_GlcNHglycan 209 212 PF01048 0.718
MOD_GlcNHglycan 217 220 PF01048 0.678
MOD_GlcNHglycan 242 245 PF01048 0.652
MOD_GlcNHglycan 282 285 PF01048 0.660
MOD_GlcNHglycan 308 311 PF01048 0.602
MOD_GlcNHglycan 381 384 PF01048 0.626
MOD_GlcNHglycan 454 457 PF01048 0.501
MOD_GlcNHglycan 5 8 PF01048 0.616
MOD_GlcNHglycan 51 54 PF01048 0.353
MOD_GlcNHglycan 61 64 PF01048 0.362
MOD_GSK3_1 113 120 PF00069 0.805
MOD_GSK3_1 236 243 PF00069 0.698
MOD_GSK3_1 280 287 PF00069 0.663
MOD_GSK3_1 288 295 PF00069 0.651
MOD_GSK3_1 302 309 PF00069 0.442
MOD_GSK3_1 327 334 PF00069 0.528
MOD_GSK3_1 49 56 PF00069 0.501
MOD_GSK3_1 508 515 PF00069 0.756
MOD_GSK3_1 532 539 PF00069 0.667
MOD_GSK3_1 546 553 PF00069 0.537
MOD_LATS_1 200 206 PF00433 0.594
MOD_N-GLC_1 173 178 PF02516 0.749
MOD_N-GLC_1 482 487 PF02516 0.499
MOD_NEK2_1 1 6 PF00069 0.729
MOD_NEK2_1 338 343 PF00069 0.525
MOD_NEK2_1 452 457 PF00069 0.541
MOD_NEK2_1 491 496 PF00069 0.566
MOD_NEK2_1 502 507 PF00069 0.735
MOD_OFUCOSY 390 395 PF10250 0.728
MOD_PIKK_1 294 300 PF00454 0.609
MOD_PIKK_1 374 380 PF00454 0.501
MOD_PIKK_1 508 514 PF00454 0.709
MOD_PK_1 565 571 PF00069 0.508
MOD_PKA_2 188 194 PF00069 0.769
MOD_PKA_2 250 256 PF00069 0.664
MOD_PKA_2 284 290 PF00069 0.552
MOD_PKA_2 388 394 PF00069 0.640
MOD_PKA_2 545 551 PF00069 0.677
MOD_PKB_1 171 179 PF00069 0.600
MOD_Plk_1 146 152 PF00069 0.591
MOD_Plk_1 331 337 PF00069 0.525
MOD_Plk_2-3 222 228 PF00069 0.681
MOD_Plk_2-3 388 394 PF00069 0.668
MOD_Plk_4 10 16 PF00069 0.366
MOD_Plk_4 346 352 PF00069 0.608
MOD_Plk_4 53 59 PF00069 0.598
MOD_ProDKin_1 113 119 PF00069 0.785
MOD_ProDKin_1 266 272 PF00069 0.713
MOD_ProDKin_1 352 358 PF00069 0.550
MOD_ProDKin_1 516 522 PF00069 0.671
MOD_ProDKin_1 525 531 PF00069 0.600
MOD_ProDKin_1 534 540 PF00069 0.644
MOD_SUMO_for_1 247 250 PF00179 0.640
TRG_DiLeu_BaEn_2 298 304 PF01217 0.607
TRG_DiLeu_BaLyEn_6 466 471 PF01217 0.575
TRG_DiLeu_BaLyEn_6 486 491 PF01217 0.302
TRG_ENDOCYTIC_2 278 281 PF00928 0.662
TRG_ENDOCYTIC_2 524 527 PF00928 0.736
TRG_ER_diArg_1 201 204 PF00400 0.772
TRG_ER_diArg_1 467 469 PF00400 0.448
TRG_ER_diArg_1 492 495 PF00400 0.563
TRG_ER_diArg_1 497 499 PF00400 0.634
TRG_NLS_Bipartite_1 159 175 PF00514 0.699
TRG_NLS_Bipartite_1 234 249 PF00514 0.695
TRG_NLS_MonoCore_2 158 163 PF00514 0.656
TRG_NLS_MonoCore_2 166 171 PF00514 0.653
TRG_NLS_MonoExtC_3 158 163 PF00514 0.706
TRG_NLS_MonoExtC_3 166 171 PF00514 0.646
TRG_NLS_MonoExtC_3 188 193 PF00514 0.719
TRG_NLS_MonoExtC_3 244 250 PF00514 0.703
TRG_NLS_MonoExtN_4 159 164 PF00514 0.761
TRG_NLS_MonoExtN_4 166 173 PF00514 0.752
TRG_NLS_MonoExtN_4 188 193 PF00514 0.734
TRG_NLS_MonoExtN_4 242 249 PF00514 0.639
TRG_Pf-PMV_PEXEL_1 468 473 PF00026 0.446

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I5Y6 Leptomonas seymouri 53% 100%
A0A1X0NRB1 Trypanosomatidae 31% 100%
A0A422NKE1 Trypanosoma rangeli 33% 100%
A4HLZ3 Leishmania braziliensis 78% 99%
A4I9C3 Leishmania infantum 100% 100%
E9B4C2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q3Q3 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS