Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IKF4_LEIDO

TriTrypDb:

LdBPK_332820.1 , LdCL_330035300 , LDHU3_33.3960

Length:

833

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IKF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IKF4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.636
CLV_C14_Caspase3-7	454	458	PF00656	0.585
CLV_C14_Caspase3-7	536	540	PF00656	0.595
CLV_C14_Caspase3-7	607	611	PF00656	0.695
CLV_NRD_NRD_1	233	235	PF00675	0.700
CLV_NRD_NRD_1	240	242	PF00675	0.721
CLV_NRD_NRD_1	282	284	PF00675	0.745
CLV_NRD_NRD_1	305	307	PF00675	0.762
CLV_NRD_NRD_1	430	432	PF00675	0.559
CLV_NRD_NRD_1	444	446	PF00675	0.646
CLV_NRD_NRD_1	486	488	PF00675	0.772
CLV_NRD_NRD_1	489	491	PF00675	0.760
CLV_NRD_NRD_1	50	52	PF00675	0.820
CLV_NRD_NRD_1	566	568	PF00675	0.585
CLV_NRD_NRD_1	628	630	PF00675	0.806
CLV_NRD_NRD_1	708	710	PF00675	0.812
CLV_NRD_NRD_1	723	725	PF00675	0.615
CLV_NRD_NRD_1	765	767	PF00675	0.728
CLV_NRD_NRD_1	768	770	PF00675	0.723
CLV_NRD_NRD_1	97	99	PF00675	0.694
CLV_PCSK_FUR_1	303	307	PF00082	0.625
CLV_PCSK_FUR_1	487	491	PF00082	0.758
CLV_PCSK_FUR_1	766	770	PF00082	0.819
CLV_PCSK_FUR_1	93	97	PF00082	0.717
CLV_PCSK_KEX2_1	233	235	PF00082	0.700
CLV_PCSK_KEX2_1	240	242	PF00082	0.721
CLV_PCSK_KEX2_1	282	284	PF00082	0.745
CLV_PCSK_KEX2_1	305	307	PF00082	0.762
CLV_PCSK_KEX2_1	430	432	PF00082	0.560
CLV_PCSK_KEX2_1	444	446	PF00082	0.644
CLV_PCSK_KEX2_1	486	488	PF00082	0.785
CLV_PCSK_KEX2_1	489	491	PF00082	0.774
CLV_PCSK_KEX2_1	50	52	PF00082	0.820
CLV_PCSK_KEX2_1	628	630	PF00082	0.806
CLV_PCSK_KEX2_1	708	710	PF00082	0.798
CLV_PCSK_KEX2_1	722	724	PF00082	0.641
CLV_PCSK_KEX2_1	768	770	PF00082	0.732
CLV_PCSK_KEX2_1	95	97	PF00082	0.770
CLV_PCSK_PC1ET2_1	768	770	PF00082	0.723
CLV_PCSK_PC7_1	236	242	PF00082	0.688
CLV_PCSK_PC7_1	764	770	PF00082	0.725
CLV_PCSK_PC7_1	93	99	PF00082	0.781
CLV_PCSK_SKI1_1	136	140	PF00082	0.626
CLV_PCSK_SKI1_1	146	150	PF00082	0.701
CLV_PCSK_SKI1_1	19	23	PF00082	0.648
CLV_PCSK_SKI1_1	346	350	PF00082	0.661
CLV_PCSK_SKI1_1	375	379	PF00082	0.668
CLV_PCSK_SKI1_1	391	395	PF00082	0.765
CLV_PCSK_SKI1_1	434	438	PF00082	0.552
DEG_APCC_DBOX_1	390	398	PF00400	0.721
DEG_SPOP_SBC_1	124	128	PF00917	0.625
DEG_SPOP_SBC_1	505	509	PF00917	0.744
DEG_SPOP_SBC_1	745	749	PF00917	0.669
DOC_ANK_TNKS_1	109	116	PF00023	0.647
DOC_CYCLIN_RxL_1	429	440	PF00134	0.561
DOC_CYCLIN_yCln2_LP_2	596	602	PF00134	0.706
DOC_MAPK_gen_1	131	139	PF00069	0.621
DOC_MAPK_gen_1	430	437	PF00069	0.536
DOC_MAPK_gen_1	486	496	PF00069	0.639
DOC_PIKK_1	730	738	PF02985	0.807
DOC_PP1_RVXF_1	17	23	PF00149	0.644
DOC_PP4_FxxP_1	658	661	PF00568	0.639
DOC_USP7_MATH_1	120	124	PF00917	0.727
DOC_USP7_MATH_1	151	155	PF00917	0.745
DOC_USP7_MATH_1	161	165	PF00917	0.808
DOC_USP7_MATH_1	254	258	PF00917	0.735
DOC_USP7_MATH_1	281	285	PF00917	0.799
DOC_USP7_MATH_1	451	455	PF00917	0.704
DOC_USP7_MATH_1	469	473	PF00917	0.692
DOC_USP7_MATH_1	505	509	PF00917	0.817
DOC_USP7_MATH_1	635	639	PF00917	0.642
DOC_USP7_MATH_1	648	652	PF00917	0.800
DOC_USP7_MATH_1	653	657	PF00917	0.694
DOC_USP7_MATH_1	667	671	PF00917	0.520
DOC_USP7_MATH_1	718	722	PF00917	0.809
DOC_USP7_MATH_1	746	750	PF00917	0.738
DOC_USP7_MATH_1	758	762	PF00917	0.620
DOC_USP7_MATH_1	775	779	PF00917	0.786
DOC_USP7_MATH_1	793	797	PF00917	0.514
DOC_USP7_UBL2_3	434	438	PF12436	0.654
DOC_WW_Pin1_4	157	162	PF00397	0.707
DOC_WW_Pin1_4	191	196	PF00397	0.675
DOC_WW_Pin1_4	277	282	PF00397	0.731
DOC_WW_Pin1_4	59	64	PF00397	0.722
DOC_WW_Pin1_4	591	596	PF00397	0.671
DOC_WW_Pin1_4	613	618	PF00397	0.789
DOC_WW_Pin1_4	657	662	PF00397	0.672
DOC_WW_Pin1_4	711	716	PF00397	0.716
DOC_WW_Pin1_4	9	14	PF00397	0.620
LIG_14-3-3_CanoR_1	146	151	PF00244	0.722
LIG_14-3-3_CanoR_1	155	161	PF00244	0.620
LIG_14-3-3_CanoR_1	197	206	PF00244	0.724
LIG_14-3-3_CanoR_1	240	250	PF00244	0.726
LIG_14-3-3_CanoR_1	282	287	PF00244	0.772
LIG_14-3-3_CanoR_1	341	345	PF00244	0.629
LIG_14-3-3_CanoR_1	346	356	PF00244	0.620
LIG_14-3-3_CanoR_1	37	47	PF00244	0.835
LIG_14-3-3_CanoR_1	405	411	PF00244	0.727
LIG_14-3-3_CanoR_1	56	63	PF00244	0.501
LIG_14-3-3_CanoR_1	708	715	PF00244	0.802
LIG_14-3-3_CanoR_1	774	780	PF00244	0.804
LIG_BIR_II_1	1	5	PF00653	0.668
LIG_BRCT_BRCA1_1	206	210	PF00533	0.664
LIG_BRCT_BRCA1_1	537	541	PF00533	0.610
LIG_BRCT_BRCA1_1	654	658	PF00533	0.667
LIG_CtBP_PxDLS_1	407	411	PF00389	0.687
LIG_CtBP_PxDLS_1	620	624	PF00389	0.716
LIG_deltaCOP1_diTrp_1	440	449	PF00928	0.540
LIG_EH1_1	818	826	PF00400	0.615
LIG_FHA_1	15	21	PF00498	0.635
LIG_FHA_1	320	326	PF00498	0.795
LIG_FHA_1	523	529	PF00498	0.781
LIG_FHA_1	614	620	PF00498	0.685
LIG_FHA_1	749	755	PF00498	0.625
LIG_FHA_2	274	280	PF00498	0.699
LIG_FHA_2	374	380	PF00498	0.716
LIG_FHA_2	511	517	PF00498	0.702
LIG_FHA_2	534	540	PF00498	0.551
LIG_FHA_2	675	681	PF00498	0.694
LIG_Integrin_RGD_1	629	631	PF01839	0.709
LIG_Integrin_RGD_1	771	773	PF01839	0.705
LIG_LIR_Apic_2	655	661	PF02991	0.650
LIG_LIR_Gen_1	2	8	PF02991	0.654
LIG_LIR_Gen_1	23	30	PF02991	0.655
LIG_LIR_Gen_1	677	687	PF02991	0.790
LIG_LIR_Nem_3	2	7	PF02991	0.657
LIG_LIR_Nem_3	23	27	PF02991	0.649
LIG_LIR_Nem_3	328	334	PF02991	0.617
LIG_LIR_Nem_3	355	359	PF02991	0.669
LIG_LIR_Nem_3	677	682	PF02991	0.778
LIG_LIR_Nem_3	827	833	PF02991	0.616
LIG_MLH1_MIPbox_1	654	658	PF16413	0.667
LIG_MYND_1	360	364	PF01753	0.661
LIG_MYND_1	617	621	PF01753	0.678
LIG_SH2_STAP1	4	8	PF00017	0.651
LIG_SH2_STAP1	734	738	PF00017	0.725
LIG_SH2_STAT3	45	48	PF00017	0.829
LIG_SH2_STAT5	125	128	PF00017	0.636
LIG_SH2_STAT5	332	335	PF00017	0.576
LIG_SH3_3	354	360	PF00018	0.672
LIG_SH3_3	614	620	PF00018	0.812
LIG_SH3_3	789	795	PF00018	0.719
LIG_SUMO_SIM_par_1	363	368	PF11976	0.714
LIG_TRAF2_1	412	415	PF00917	0.753
LIG_TRAF2_1	425	428	PF00917	0.382
LIG_TRAF2_1	572	575	PF00917	0.568
LIG_WRC_WIRS_1	654	659	PF05994	0.763
LIG_WRC_WIRS_1	816	821	PF05994	0.629
MOD_CDC14_SPxK_1	194	197	PF00782	0.612
MOD_CDK_SPK_2	277	282	PF00069	0.633
MOD_CDK_SPxK_1	191	197	PF00069	0.612
MOD_CDK_SPxK_1	277	283	PF00069	0.597
MOD_CK1_1	123	129	PF00069	0.642
MOD_CK1_1	154	160	PF00069	0.677
MOD_CK1_1	190	196	PF00069	0.753
MOD_CK1_1	285	291	PF00069	0.710
MOD_CK1_1	38	44	PF00069	0.740
MOD_CK1_1	461	467	PF00069	0.611
MOD_CK1_1	481	487	PF00069	0.760
MOD_CK1_1	507	513	PF00069	0.741
MOD_CK1_1	522	528	PF00069	0.633
MOD_CK1_1	535	541	PF00069	0.619
MOD_CK1_1	558	564	PF00069	0.665
MOD_CK1_1	59	65	PF00069	0.673
MOD_CK1_1	598	604	PF00069	0.774
MOD_CK1_1	622	628	PF00069	0.749
MOD_CK1_1	694	700	PF00069	0.695
MOD_CK1_1	710	716	PF00069	0.756
MOD_CK1_1	748	754	PF00069	0.714
MOD_CK1_1	82	88	PF00069	0.720
MOD_CK1_1	89	95	PF00069	0.736
MOD_CK2_1	373	379	PF00069	0.724
MOD_CK2_1	526	532	PF00069	0.674
MOD_CK2_1	558	564	PF00069	0.665
MOD_CK2_1	674	680	PF00069	0.687
MOD_Cter_Amidation	231	234	PF01082	0.591
MOD_Cter_Amidation	484	487	PF01082	0.646
MOD_GlcNHglycan	104	107	PF01048	0.675
MOD_GlcNHglycan	122	125	PF01048	0.664
MOD_GlcNHglycan	162	166	PF01048	0.739
MOD_GlcNHglycan	169	172	PF01048	0.728
MOD_GlcNHglycan	179	183	PF01048	0.619
MOD_GlcNHglycan	211	214	PF01048	0.734
MOD_GlcNHglycan	227	230	PF01048	0.523
MOD_GlcNHglycan	256	259	PF01048	0.755
MOD_GlcNHglycan	454	457	PF01048	0.745
MOD_GlcNHglycan	480	483	PF01048	0.749
MOD_GlcNHglycan	549	552	PF01048	0.492
MOD_GlcNHglycan	59	62	PF01048	0.772
MOD_GlcNHglycan	607	610	PF01048	0.811
MOD_GlcNHglycan	63	66	PF01048	0.772
MOD_GlcNHglycan	633	636	PF01048	0.655
MOD_GlcNHglycan	644	647	PF01048	0.719
MOD_GlcNHglycan	650	653	PF01048	0.703
MOD_GlcNHglycan	669	672	PF01048	0.526
MOD_GlcNHglycan	710	713	PF01048	0.817
MOD_GlcNHglycan	748	751	PF01048	0.679
MOD_GlcNHglycan	760	763	PF01048	0.740
MOD_GSK3_1	109	116	PF00069	0.829
MOD_GSK3_1	120	127	PF00069	0.629
MOD_GSK3_1	151	158	PF00069	0.734
MOD_GSK3_1	163	170	PF00069	0.751
MOD_GSK3_1	185	192	PF00069	0.737
MOD_GSK3_1	205	212	PF00069	0.775
MOD_GSK3_1	236	243	PF00069	0.645
MOD_GSK3_1	273	280	PF00069	0.767
MOD_GSK3_1	281	288	PF00069	0.827
MOD_GSK3_1	289	296	PF00069	0.563
MOD_GSK3_1	340	347	PF00069	0.636
MOD_GSK3_1	35	42	PF00069	0.623
MOD_GSK3_1	406	413	PF00069	0.762
MOD_GSK3_1	452	459	PF00069	0.705
MOD_GSK3_1	504	511	PF00069	0.724
MOD_GSK3_1	519	526	PF00069	0.666
MOD_GSK3_1	57	64	PF00069	0.644
MOD_GSK3_1	591	598	PF00069	0.715
MOD_GSK3_1	631	638	PF00069	0.589
MOD_GSK3_1	648	655	PF00069	0.752
MOD_GSK3_1	667	674	PF00069	0.482
MOD_GSK3_1	689	696	PF00069	0.790
MOD_GSK3_1	707	714	PF00069	0.568
MOD_GSK3_1	74	81	PF00069	0.726
MOD_GSK3_1	744	751	PF00069	0.704
MOD_GSK3_1	800	807	PF00069	0.500
MOD_GSK3_1	82	89	PF00069	0.792
MOD_N-GLC_1	38	43	PF02516	0.792
MOD_N-GLC_1	689	694	PF02516	0.826
MOD_N-GLC_2	224	226	PF02516	0.606
MOD_N-GLC_2	235	237	PF02516	0.622
MOD_NEK2_1	102	107	PF00069	0.653
MOD_NEK2_1	172	177	PF00069	0.677
MOD_NEK2_1	196	201	PF00069	0.797
MOD_NEK2_1	209	214	PF00069	0.577
MOD_NEK2_1	40	45	PF00069	0.656
MOD_NEK2_1	552	557	PF00069	0.443
MOD_NEK2_1	815	820	PF00069	0.584
MOD_NEK2_1	83	88	PF00069	0.726
MOD_NEK2_2	163	168	PF00069	0.586
MOD_NEK2_2	458	463	PF00069	0.550
MOD_NEK2_2	635	640	PF00069	0.611
MOD_NEK2_2	653	658	PF00069	0.588
MOD_PIKK_1	400	406	PF00454	0.661
MOD_PIKK_1	410	416	PF00454	0.586
MOD_PK_1	282	288	PF00069	0.728
MOD_PK_1	586	592	PF00069	0.527
MOD_PKA_1	240	246	PF00069	0.697
MOD_PKA_1	282	288	PF00069	0.612
MOD_PKA_1	708	714	PF00069	0.833
MOD_PKA_2	109	115	PF00069	0.731
MOD_PKA_2	154	160	PF00069	0.683
MOD_PKA_2	196	202	PF00069	0.735
MOD_PKA_2	235	241	PF00069	0.795
MOD_PKA_2	281	287	PF00069	0.804
MOD_PKA_2	340	346	PF00069	0.660
MOD_PKA_2	505	511	PF00069	0.808
MOD_PKA_2	707	713	PF00069	0.808
MOD_PKA_2	775	781	PF00069	0.725
MOD_PKA_2	83	89	PF00069	0.721
MOD_PKB_1	234	242	PF00069	0.701
MOD_PKB_1	54	62	PF00069	0.820
MOD_PKB_1	722	730	PF00069	0.726
MOD_Plk_1	523	529	PF00069	0.692
MOD_Plk_4	109	115	PF00069	0.669
MOD_Plk_4	163	169	PF00069	0.720
MOD_Plk_4	205	211	PF00069	0.649
MOD_Plk_4	282	288	PF00069	0.660
MOD_Plk_4	327	333	PF00069	0.703
MOD_Plk_4	622	628	PF00069	0.593
MOD_Plk_4	653	659	PF00069	0.664
MOD_Plk_4	775	781	PF00069	0.803
MOD_Plk_4	815	821	PF00069	0.584
MOD_ProDKin_1	157	163	PF00069	0.706
MOD_ProDKin_1	191	197	PF00069	0.677
MOD_ProDKin_1	277	283	PF00069	0.733
MOD_ProDKin_1	59	65	PF00069	0.719
MOD_ProDKin_1	591	597	PF00069	0.673
MOD_ProDKin_1	613	619	PF00069	0.791
MOD_ProDKin_1	657	663	PF00069	0.669
MOD_ProDKin_1	711	717	PF00069	0.716
MOD_ProDKin_1	9	15	PF00069	0.618
MOD_SUMO_for_1	437	440	PF00179	0.656
MOD_SUMO_rev_2	395	403	PF00179	0.681
MOD_SUMO_rev_2	561	570	PF00179	0.674
MOD_SUMO_rev_2	731	741	PF00179	0.724
TRG_DiLeu_BaEn_4	78	84	PF01217	0.600
TRG_ENDOCYTIC_2	134	137	PF00928	0.606
TRG_ENDOCYTIC_2	331	334	PF00928	0.685
TRG_ENDOCYTIC_2	4	7	PF00928	0.654
TRG_ENDOCYTIC_2	432	435	PF00928	0.554
TRG_ER_diArg_1	130	133	PF00400	0.615
TRG_ER_diArg_1	233	236	PF00400	0.701
TRG_ER_diArg_1	281	283	PF00400	0.739
TRG_ER_diArg_1	303	306	PF00400	0.747
TRG_ER_diArg_1	430	432	PF00400	0.563
TRG_ER_diArg_1	443	445	PF00400	0.630
TRG_ER_diArg_1	486	489	PF00400	0.770
TRG_ER_diArg_1	496	499	PF00400	0.695
TRG_ER_diArg_1	627	629	PF00400	0.812
TRG_ER_diArg_1	722	724	PF00400	0.739
TRG_ER_diArg_1	93	96	PF00400	0.717
TRG_NES_CRM1_1	810	822	PF08389	0.723
TRG_NLS_MonoCore_2	765	770	PF00514	0.820
TRG_NLS_MonoExtC_3	765	770	PF00514	0.718
TRG_NLS_MonoExtN_4	764	771	PF00514	0.720
TRG_Pf-PMV_PEXEL_1	375	379	PF00026	0.668
TRG_Pf-PMV_PEXEL_1	474	478	PF00026	0.777
TRG_Pf-PMV_PEXEL_1	544	549	PF00026	0.666

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I487	Leptomonas seymouri	38%	95%
A4HLX9	Leishmania braziliensis	63%	99%
A4I9A8	Leishmania infantum	99%	100%
E9B4A8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q3R8	Leishmania major	86%	100%