EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IKE9_LEIDO

TriTrypDb:

LdBPK_361510.1 , LdCL_360020600 , LDHU3_36.1940

Length:

155

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IKE9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IKE9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005509	calcium ion binding	5	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	57	59	PF00675	0.549
CLV_PCSK_KEX2_1	57	59	PF00082	0.554
CLV_PCSK_SKI1_1	141	145	PF00082	0.414
CLV_PCSK_SKI1_1	49	53	PF00082	0.447
CLV_PCSK_SKI1_1	87	91	PF00082	0.438
DOC_USP7_MATH_1	102	106	PF00917	0.678
DOC_USP7_MATH_1	3	7	PF00917	0.730
LIG_14-3-3_CanoR_1	134	138	PF00244	0.530
LIG_14-3-3_CanoR_1	87	92	PF00244	0.439
LIG_14-3-3_CanoR_1	95	101	PF00244	0.433
LIG_BIR_II_1	1	5	PF00653	0.690
LIG_BIR_III_4	130	134	PF00653	0.548
LIG_BRCT_BRCA1_1	65	69	PF00533	0.606
LIG_FHA_1	78	84	PF00498	0.432
LIG_FHA_2	68	74	PF00498	0.500
LIG_LIR_Gen_1	75	85	PF02991	0.454
LIG_LIR_Nem_3	138	143	PF02991	0.419
LIG_LIR_Nem_3	31	36	PF02991	0.438
LIG_LIR_Nem_3	75	81	PF02991	0.425
LIG_NRBOX	143	149	PF00104	0.556
LIG_SH2_STAT5	23	26	PF00017	0.470
LIG_SH3_1	42	48	PF00018	0.438
LIG_SH3_3	10	16	PF00018	0.666
LIG_SH3_3	42	48	PF00018	0.438
LIG_SUMO_SIM_par_1	79	84	PF11976	0.402
LIG_TRAF2_1	119	122	PF00917	0.548
MOD_CK1_1	106	112	PF00069	0.704
MOD_CK1_1	6	12	PF00069	0.635
MOD_CK1_1	67	73	PF00069	0.593
MOD_CK2_1	73	79	PF00069	0.541
MOD_GlcNHglycan	1	4	PF01048	0.724
MOD_GlcNHglycan	105	108	PF01048	0.679
MOD_GlcNHglycan	7	11	PF01048	0.693
MOD_GSK3_1	102	109	PF00069	0.603
MOD_GSK3_1	143	150	PF00069	0.522
MOD_GSK3_1	63	70	PF00069	0.504
MOD_GSK3_1	73	80	PF00069	0.402
MOD_N-GLC_2	96	98	PF02516	0.416
MOD_NEK2_1	147	152	PF00069	0.542
MOD_NEK2_1	94	99	PF00069	0.420
MOD_PKA_2	133	139	PF00069	0.532
MOD_PKA_2	94	100	PF00069	0.443
MOD_Plk_2-3	73	79	PF00069	0.440
MOD_Plk_4	143	149	PF00069	0.495
MOD_Plk_4	64	70	PF00069	0.604
MOD_Plk_4	73	79	PF00069	0.420
MOD_SUMO_rev_2	55	65	PF00179	0.536
TRG_ER_diArg_1	56	58	PF00400	0.566
TRG_ER_diLys_1	151	155	PF00400	0.598
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX85	Leptomonas seymouri	66%	93%
A0A0S4JG18	Bodo saltans	53%	100%
A0A1X0P8S8	Trypanosomatidae	50%	97%
A0A422NI72	Trypanosoma rangeli	54%	100%
A4HP05	Leishmania braziliensis	83%	100%
A4IDB4	Leishmania infantum	99%	100%
D0A2Y1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9ASR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4Q1T1	Leishmania major	92%	100%
V5BJX8	Trypanosoma cruzi	56%	100%