LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania donovani
UniProt:
A0A3Q8IKC7_LEIDO
TriTrypDb:
LdBPK_312730.1 , LdCL_310035300 , LDHU3_31.4840
Length:
577

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 4
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IKC7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IKC7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 266 270 PF00656 0.794
CLV_C14_Caspase3-7 435 439 PF00656 0.641
CLV_C14_Caspase3-7 538 542 PF00656 0.505
CLV_NRD_NRD_1 427 429 PF00675 0.816
CLV_NRD_NRD_1 432 434 PF00675 0.739
CLV_NRD_NRD_1 444 446 PF00675 0.551
CLV_NRD_NRD_1 482 484 PF00675 0.749
CLV_PCSK_KEX2_1 427 429 PF00082 0.686
CLV_PCSK_KEX2_1 431 433 PF00082 0.711
CLV_PCSK_KEX2_1 444 446 PF00082 0.593
CLV_PCSK_KEX2_1 482 484 PF00082 0.749
CLV_PCSK_PC7_1 427 433 PF00082 0.822
CLV_PCSK_SKI1_1 391 395 PF00082 0.791
CLV_PCSK_SKI1_1 534 538 PF00082 0.712
DEG_SCF_TRCP1_1 553 559 PF00400 0.733
DEG_SPOP_SBC_1 557 561 PF00917 0.677
DEG_SPOP_SBC_1 8 12 PF00917 0.716
DOC_CKS1_1 407 412 PF01111 0.711
DOC_MAPK_gen_1 153 162 PF00069 0.772
DOC_MAPK_gen_1 444 452 PF00069 0.755
DOC_MAPK_gen_1 482 488 PF00069 0.739
DOC_MAPK_gen_1 517 527 PF00069 0.568
DOC_MAPK_JIP1_4 156 162 PF00069 0.731
DOC_MAPK_MEF2A_6 520 529 PF00069 0.571
DOC_PP1_SILK_1 189 194 PF00149 0.757
DOC_PP2B_LxvP_1 530 533 PF13499 0.668
DOC_PP4_FxxP_1 311 314 PF00568 0.731
DOC_USP7_MATH_1 113 117 PF00917 0.759
DOC_USP7_MATH_1 138 142 PF00917 0.834
DOC_USP7_MATH_1 271 275 PF00917 0.864
DOC_USP7_MATH_1 31 35 PF00917 0.795
DOC_USP7_MATH_1 319 323 PF00917 0.837
DOC_USP7_MATH_1 328 332 PF00917 0.702
DOC_USP7_MATH_1 399 403 PF00917 0.743
DOC_USP7_MATH_1 456 460 PF00917 0.849
DOC_USP7_UBL2_3 306 310 PF12436 0.846
DOC_WW_Pin1_4 103 108 PF00397 0.779
DOC_WW_Pin1_4 142 147 PF00397 0.834
DOC_WW_Pin1_4 200 205 PF00397 0.742
DOC_WW_Pin1_4 274 279 PF00397 0.792
DOC_WW_Pin1_4 299 304 PF00397 0.778
DOC_WW_Pin1_4 310 315 PF00397 0.663
DOC_WW_Pin1_4 322 327 PF00397 0.702
DOC_WW_Pin1_4 335 340 PF00397 0.647
DOC_WW_Pin1_4 386 391 PF00397 0.714
DOC_WW_Pin1_4 406 411 PF00397 0.553
DOC_WW_Pin1_4 56 61 PF00397 0.828
LIG_14-3-3_CanoR_1 108 113 PF00244 0.694
LIG_14-3-3_CanoR_1 202 211 PF00244 0.706
LIG_14-3-3_CanoR_1 272 278 PF00244 0.695
LIG_14-3-3_CanoR_1 286 292 PF00244 0.707
LIG_14-3-3_CanoR_1 385 393 PF00244 0.655
LIG_14-3-3_CanoR_1 431 441 PF00244 0.784
LIG_14-3-3_CanoR_1 482 486 PF00244 0.728
LIG_14-3-3_CanoR_1 487 497 PF00244 0.703
LIG_14-3-3_CanoR_1 508 514 PF00244 0.763
LIG_14-3-3_CanoR_1 517 527 PF00244 0.668
LIG_14-3-3_CanoR_1 69 74 PF00244 0.745
LIG_BRCT_BRCA1_1 233 237 PF00533 0.834
LIG_BRCT_BRCA1_1 360 364 PF00533 0.713
LIG_CSL_BTD_1 407 410 PF09270 0.630
LIG_CtBP_PxDLS_1 146 150 PF00389 0.738
LIG_DLG_GKlike_1 444 452 PF00625 0.755
LIG_DLG_GKlike_1 69 77 PF00625 0.742
LIG_FHA_1 107 113 PF00498 0.762
LIG_FHA_1 142 148 PF00498 0.769
LIG_FHA_1 174 180 PF00498 0.727
LIG_FHA_1 224 230 PF00498 0.769
LIG_FHA_1 9 15 PF00498 0.745
LIG_FHA_2 536 542 PF00498 0.655
LIG_FHA_2 75 81 PF00498 0.737
LIG_Integrin_isoDGR_2 67 69 PF01839 0.766
LIG_LIR_Apic_2 308 314 PF02991 0.728
LIG_LIR_Nem_3 327 332 PF02991 0.860
LIG_LIR_Nem_3 348 354 PF02991 0.735
LIG_Pex14_2 118 122 PF04695 0.745
LIG_SH2_STAT5 351 354 PF00017 0.678
LIG_SH3_3 329 335 PF00018 0.785
LIG_SH3_3 33 39 PF00018 0.813
LIG_SH3_3 372 378 PF00018 0.729
LIG_SH3_3 407 413 PF00018 0.732
LIG_SH3_3 447 453 PF00018 0.822
LIG_SH3_3 49 55 PF00018 0.578
LIG_SH3_3 567 573 PF00018 0.720
LIG_SUMO_SIM_par_1 144 152 PF11976 0.641
LIG_SUMO_SIM_par_1 38 43 PF11976 0.751
MOD_CDC14_SPxK_1 302 305 PF00782 0.773
MOD_CDK_SPK_2 103 108 PF00069 0.779
MOD_CDK_SPK_2 299 304 PF00069 0.701
MOD_CDK_SPK_2 386 391 PF00069 0.714
MOD_CDK_SPxK_1 299 305 PF00069 0.779
MOD_CDK_SPxxK_3 103 110 PF00069 0.643
MOD_CDK_SPxxK_3 299 306 PF00069 0.740
MOD_CK1_1 106 112 PF00069 0.786
MOD_CK1_1 141 147 PF00069 0.832
MOD_CK1_1 196 202 PF00069 0.797
MOD_CK1_1 203 209 PF00069 0.745
MOD_CK1_1 218 224 PF00069 0.741
MOD_CK1_1 231 237 PF00069 0.622
MOD_CK1_1 274 280 PF00069 0.754
MOD_CK1_1 322 328 PF00069 0.824
MOD_CK1_1 337 343 PF00069 0.604
MOD_CK1_1 355 361 PF00069 0.474
MOD_CK1_1 384 390 PF00069 0.783
MOD_CK1_1 398 404 PF00069 0.580
MOD_CK1_1 421 427 PF00069 0.713
MOD_CK1_1 496 502 PF00069 0.813
MOD_CK1_1 542 548 PF00069 0.793
MOD_CK1_1 549 555 PF00069 0.756
MOD_CK1_1 556 562 PF00069 0.648
MOD_CK1_1 71 77 PF00069 0.739
MOD_CK2_1 74 80 PF00069 0.737
MOD_GlcNHglycan 136 139 PF01048 0.832
MOD_GlcNHglycan 179 182 PF01048 0.681
MOD_GlcNHglycan 195 198 PF01048 0.642
MOD_GlcNHglycan 221 224 PF01048 0.814
MOD_GlcNHglycan 273 276 PF01048 0.696
MOD_GlcNHglycan 31 34 PF01048 0.817
MOD_GlcNHglycan 359 363 PF01048 0.748
MOD_GlcNHglycan 369 372 PF01048 0.636
MOD_GlcNHglycan 397 400 PF01048 0.816
MOD_GlcNHglycan 401 404 PF01048 0.738
MOD_GlcNHglycan 423 426 PF01048 0.713
MOD_GlcNHglycan 458 461 PF01048 0.842
MOD_GlcNHglycan 463 466 PF01048 0.776
MOD_GlcNHglycan 467 472 PF01048 0.678
MOD_GlcNHglycan 510 513 PF01048 0.718
MOD_GlcNHglycan 548 551 PF01048 0.824
MOD_GlcNHglycan 553 556 PF01048 0.788
MOD_GlcNHglycan 560 563 PF01048 0.682
MOD_GlcNHglycan 98 102 PF01048 0.777
MOD_GSK3_1 102 109 PF00069 0.679
MOD_GSK3_1 113 120 PF00069 0.710
MOD_GSK3_1 123 130 PF00069 0.703
MOD_GSK3_1 134 141 PF00069 0.658
MOD_GSK3_1 145 152 PF00069 0.675
MOD_GSK3_1 156 163 PF00069 0.688
MOD_GSK3_1 173 180 PF00069 0.569
MOD_GSK3_1 192 199 PF00069 0.621
MOD_GSK3_1 210 217 PF00069 0.629
MOD_GSK3_1 219 226 PF00069 0.725
MOD_GSK3_1 249 256 PF00069 0.843
MOD_GSK3_1 270 277 PF00069 0.851
MOD_GSK3_1 310 317 PF00069 0.784
MOD_GSK3_1 324 331 PF00069 0.667
MOD_GSK3_1 380 387 PF00069 0.805
MOD_GSK3_1 395 402 PF00069 0.562
MOD_GSK3_1 477 484 PF00069 0.722
MOD_GSK3_1 496 503 PF00069 0.601
MOD_GSK3_1 535 542 PF00069 0.713
MOD_GSK3_1 544 551 PF00069 0.707
MOD_GSK3_1 553 560 PF00069 0.631
MOD_GSK3_1 69 76 PF00069 0.800
MOD_LATS_1 175 181 PF00433 0.675
MOD_LATS_1 7 13 PF00433 0.718
MOD_N-GLC_1 142 147 PF02516 0.767
MOD_N-GLC_1 173 178 PF02516 0.678
MOD_N-GLC_1 399 404 PF02516 0.810
MOD_NEK2_1 118 123 PF00069 0.765
MOD_NEK2_1 149 154 PF00069 0.682
MOD_NEK2_1 186 191 PF00069 0.727
MOD_NEK2_1 380 385 PF00069 0.739
MOD_NEK2_1 461 466 PF00069 0.747
MOD_NEK2_1 546 551 PF00069 0.838
MOD_NEK2_1 73 78 PF00069 0.807
MOD_NEK2_2 113 118 PF00069 0.756
MOD_PIKK_1 203 209 PF00454 0.695
MOD_PIKK_1 216 222 PF00454 0.711
MOD_PIKK_1 384 390 PF00454 0.783
MOD_PKA_1 304 310 PF00069 0.657
MOD_PKA_1 427 433 PF00069 0.822
MOD_PKA_1 444 450 PF00069 0.551
MOD_PKA_1 571 577 PF00069 0.635
MOD_PKA_2 102 108 PF00069 0.679
MOD_PKA_2 123 129 PF00069 0.652
MOD_PKA_2 149 155 PF00069 0.743
MOD_PKA_2 192 198 PF00069 0.762
MOD_PKA_2 231 237 PF00069 0.806
MOD_PKA_2 271 277 PF00069 0.658
MOD_PKA_2 384 390 PF00069 0.648
MOD_PKA_2 395 401 PF00069 0.609
MOD_PKA_2 427 433 PF00069 0.822
MOD_PKA_2 444 450 PF00069 0.551
MOD_PKA_2 454 460 PF00069 0.684
MOD_PKA_2 481 487 PF00069 0.638
MOD_PKA_2 507 513 PF00069 0.746
MOD_PKA_2 523 529 PF00069 0.587
MOD_PKA_2 68 74 PF00069 0.746
MOD_Plk_1 118 124 PF00069 0.748
MOD_Plk_4 113 119 PF00069 0.753
MOD_Plk_4 187 193 PF00069 0.758
MOD_Plk_4 224 230 PF00069 0.847
MOD_Plk_4 389 395 PF00069 0.633
MOD_Plk_4 535 541 PF00069 0.579
MOD_Plk_4 74 80 PF00069 0.737
MOD_ProDKin_1 103 109 PF00069 0.777
MOD_ProDKin_1 142 148 PF00069 0.835
MOD_ProDKin_1 200 206 PF00069 0.743
MOD_ProDKin_1 274 280 PF00069 0.791
MOD_ProDKin_1 299 305 PF00069 0.779
MOD_ProDKin_1 310 316 PF00069 0.662
MOD_ProDKin_1 322 328 PF00069 0.703
MOD_ProDKin_1 335 341 PF00069 0.644
MOD_ProDKin_1 386 392 PF00069 0.716
MOD_ProDKin_1 406 412 PF00069 0.552
MOD_ProDKin_1 56 62 PF00069 0.828
MOD_SUMO_rev_2 240 245 PF00179 0.839
MOD_SUMO_rev_2 302 311 PF00179 0.733
MOD_SUMO_rev_2 43 50 PF00179 0.714
TRG_DiLeu_BaEn_1 436 441 PF01217 0.749
TRG_DiLeu_BaLyEn_6 36 41 PF01217 0.757
TRG_DiLeu_BaLyEn_6 375 380 PF01217 0.750
TRG_ENDOCYTIC_2 351 354 PF00928 0.678
TRG_ER_diArg_1 107 110 PF00400 0.638
TRG_ER_diArg_1 284 287 PF00400 0.751
TRG_ER_diArg_1 426 428 PF00400 0.817
TRG_ER_diArg_1 431 433 PF00400 0.749
TRG_ER_diArg_1 444 446 PF00400 0.534
TRG_ER_diArg_1 481 483 PF00400 0.742
TRG_Pf-PMV_PEXEL_1 110 115 PF00026 0.634

Homologs

Protein Taxonomy Sequence identity Coverage
A4HJQ4 Leishmania braziliensis 53% 100%
A4I770 Leishmania infantum 99% 100%
E9B265 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
Q4Q5Z5 Leishmania major 89% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS