Wd40 repeat domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

wd40 repeat domain-containing protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IKB9_LEIDO

TriTrypDb:

LdBPK_200180.1 , LdCL_200006600 , LDHU3_20.0190

Length:

805

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IKB9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IKB9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	448	452	PF00656	0.675
CLV_C14_Caspase3-7	479	483	PF00656	0.715
CLV_C14_Caspase3-7	504	508	PF00656	0.653
CLV_C14_Caspase3-7	579	583	PF00656	0.782
CLV_C14_Caspase3-7	601	605	PF00656	0.609
CLV_NRD_NRD_1	122	124	PF00675	0.518
CLV_NRD_NRD_1	492	494	PF00675	0.623
CLV_NRD_NRD_1	499	501	PF00675	0.716
CLV_NRD_NRD_1	580	582	PF00675	0.702
CLV_NRD_NRD_1	784	786	PF00675	0.434
CLV_PCSK_KEX2_1	122	124	PF00082	0.518
CLV_PCSK_KEX2_1	492	494	PF00082	0.598
CLV_PCSK_KEX2_1	499	501	PF00082	0.569
CLV_PCSK_KEX2_1	580	582	PF00082	0.702
CLV_PCSK_KEX2_1	655	657	PF00082	0.583
CLV_PCSK_KEX2_1	662	664	PF00082	0.626
CLV_PCSK_KEX2_1	754	756	PF00082	0.511
CLV_PCSK_KEX2_1	784	786	PF00082	0.648
CLV_PCSK_PC1ET2_1	655	657	PF00082	0.576
CLV_PCSK_PC1ET2_1	662	664	PF00082	0.636
CLV_PCSK_PC1ET2_1	754	756	PF00082	0.511
CLV_PCSK_PC7_1	495	501	PF00082	0.527
CLV_PCSK_PC7_1	576	582	PF00082	0.651
CLV_PCSK_SKI1_1	259	263	PF00082	0.500
CLV_PCSK_SKI1_1	381	385	PF00082	0.514
CLV_PCSK_SKI1_1	442	446	PF00082	0.629
CLV_PCSK_SKI1_1	478	482	PF00082	0.640
CLV_PCSK_SKI1_1	628	632	PF00082	0.581
CLV_PCSK_SKI1_1	656	660	PF00082	0.575
CLV_PCSK_SKI1_1	721	725	PF00082	0.588
DEG_APCC_DBOX_1	121	129	PF00400	0.532
DEG_APCC_DBOX_1	130	138	PF00400	0.403
DEG_APCC_DBOX_1	380	388	PF00400	0.509
DEG_APCC_DBOX_1	477	485	PF00400	0.633
DEG_Nend_Nbox_1	1	3	PF02207	0.675
DEG_SPOP_SBC_1	75	79	PF00917	0.637
DOC_ANK_TNKS_1	499	506	PF00023	0.665
DOC_CYCLIN_RxL_1	439	448	PF00134	0.628
DOC_MAPK_FxFP_2	363	366	PF00069	0.524
DOC_MAPK_gen_1	564	572	PF00069	0.723
DOC_MAPK_gen_1	784	793	PF00069	0.523
DOC_MAPK_MEF2A_6	285	292	PF00069	0.456
DOC_MAPK_MEF2A_6	326	335	PF00069	0.460
DOC_MAPK_MEF2A_6	566	574	PF00069	0.690
DOC_PP4_FxxP_1	363	366	PF00568	0.491
DOC_USP7_MATH_1	17	21	PF00917	0.568
DOC_USP7_MATH_1	343	347	PF00917	0.517
DOC_USP7_MATH_1	503	507	PF00917	0.710
DOC_USP7_MATH_1	542	546	PF00917	0.662
DOC_USP7_MATH_1	706	710	PF00917	0.583
DOC_WW_Pin1_4	117	122	PF00397	0.644
DOC_WW_Pin1_4	307	312	PF00397	0.747
DOC_WW_Pin1_4	77	82	PF00397	0.625
LIG_14-3-3_CanoR_1	104	109	PF00244	0.597
LIG_14-3-3_CanoR_1	321	330	PF00244	0.493
LIG_14-3-3_CanoR_1	707	711	PF00244	0.680
LIG_14-3-3_CanoR_1	726	734	PF00244	0.358
LIG_Actin_WH2_2	480	497	PF00022	0.589
LIG_Actin_WH2_2	685	703	PF00022	0.471
LIG_BIR_III_4	218	222	PF00653	0.632
LIG_BIR_III_4	470	474	PF00653	0.620
LIG_BRCT_BRCA1_1	361	365	PF00533	0.502
LIG_BRCT_BRCA1_1	672	676	PF00533	0.608
LIG_Clathr_ClatBox_1	222	226	PF01394	0.609
LIG_EH1_1	530	538	PF00400	0.516
LIG_FAT_LD_1	533	541	PF03623	0.724
LIG_FHA_1	187	193	PF00498	0.415
LIG_FHA_1	245	251	PF00498	0.572
LIG_FHA_1	277	283	PF00498	0.436
LIG_FHA_1	292	298	PF00498	0.318
LIG_FHA_1	322	328	PF00498	0.488
LIG_FHA_1	354	360	PF00498	0.432
LIG_FHA_1	398	404	PF00498	0.693
LIG_FHA_1	421	427	PF00498	0.493
LIG_FHA_1	638	644	PF00498	0.520
LIG_FHA_2	185	191	PF00498	0.513
LIG_FHA_2	211	217	PF00498	0.579
LIG_FHA_2	241	247	PF00498	0.393
LIG_FHA_2	411	417	PF00498	0.788
LIG_FHA_2	519	525	PF00498	0.643
LIG_FHA_2	549	555	PF00498	0.719
LIG_FHA_2	728	734	PF00498	0.672
LIG_FHA_2	738	744	PF00498	0.506
LIG_FHA_2	98	104	PF00498	0.661
LIG_LIR_Apic_2	273	278	PF02991	0.537
LIG_LIR_Apic_2	362	366	PF02991	0.523
LIG_LIR_Apic_2	42	48	PF02991	0.586
LIG_LIR_Gen_1	133	141	PF02991	0.473
LIG_LIR_Gen_1	185	196	PF02991	0.475
LIG_LIR_Gen_1	246	256	PF02991	0.546
LIG_LIR_Gen_1	80	91	PF02991	0.528
LIG_LIR_Nem_3	103	109	PF02991	0.545
LIG_LIR_Nem_3	185	191	PF02991	0.434
LIG_LIR_Nem_3	246	252	PF02991	0.565
LIG_LIR_Nem_3	262	268	PF02991	0.347
LIG_LIR_Nem_3	28	33	PF02991	0.521
LIG_LIR_Nem_3	286	292	PF02991	0.360
LIG_LIR_Nem_3	80	86	PF02991	0.522
LIG_NRBOX	440	446	PF00104	0.685
LIG_PALB2_WD40_1	788	796	PF16756	0.517
LIG_PDZ_Class_1	800	805	PF00595	0.389
LIG_Pex14_2	30	34	PF04695	0.604
LIG_SH2_CRK	265	269	PF00017	0.599
LIG_SH2_CRK	275	279	PF00017	0.396
LIG_SH2_CRK	83	87	PF00017	0.488
LIG_SH2_NCK_1	83	87	PF00017	0.510
LIG_SH2_PTP2	249	252	PF00017	0.534
LIG_SH2_SRC	157	160	PF00017	0.628
LIG_SH2_SRC	249	252	PF00017	0.534
LIG_SH2_STAP1	26	30	PF00017	0.528
LIG_SH2_STAP1	83	87	PF00017	0.510
LIG_SH2_STAT3	523	526	PF00017	0.644
LIG_SH2_STAT5	249	252	PF00017	0.534
LIG_SH3_3	11	17	PF00018	0.507
LIG_SH3_3	134	140	PF00018	0.527
LIG_SUMO_SIM_anti_2	235	243	PF11976	0.404
LIG_SUMO_SIM_anti_2	557	564	PF11976	0.720
LIG_SUMO_SIM_par_1	239	247	PF11976	0.458
LIG_SUMO_SIM_par_1	328	334	PF11976	0.455
LIG_TRAF2_1	156	159	PF00917	0.536
LIG_TRAF2_1	413	416	PF00917	0.794
LIG_TRAF2_1	712	715	PF00917	0.589
LIG_TYR_ITSM	245	252	PF00017	0.531
LIG_UBA3_1	2	11	PF00899	0.572
LIG_WRC_WIRS_1	749	754	PF05994	0.693
MOD_CDC14_SPxK_1	120	123	PF00782	0.481
MOD_CDK_SPK_2	117	122	PF00069	0.519
MOD_CDK_SPxK_1	117	123	PF00069	0.509
MOD_CK1_1	107	113	PF00069	0.465
MOD_CK1_1	325	331	PF00069	0.419
MOD_CK1_1	334	340	PF00069	0.422
MOD_CK1_1	545	551	PF00069	0.686
MOD_CK1_1	632	638	PF00069	0.683
MOD_CK1_1	670	676	PF00069	0.688
MOD_CK1_1	77	83	PF00069	0.554
MOD_CK2_1	109	115	PF00069	0.567
MOD_CK2_1	184	190	PF00069	0.522
MOD_CK2_1	210	216	PF00069	0.598
MOD_CK2_1	410	416	PF00069	0.801
MOD_CK2_1	511	517	PF00069	0.697
MOD_CK2_1	518	524	PF00069	0.604
MOD_CK2_1	540	546	PF00069	0.699
MOD_CK2_1	548	554	PF00069	0.608
MOD_CK2_1	671	677	PF00069	0.634
MOD_CK2_1	756	762	PF00069	0.661
MOD_GlcNHglycan	198	201	PF01048	0.649
MOD_GlcNHglycan	207	210	PF01048	0.728
MOD_GlcNHglycan	256	259	PF01048	0.634
MOD_GlcNHglycan	315	318	PF01048	0.590
MOD_GlcNHglycan	345	348	PF01048	0.566
MOD_GlcNHglycan	367	370	PF01048	0.579
MOD_GlcNHglycan	470	474	PF01048	0.620
MOD_GlcNHglycan	51	54	PF01048	0.458
MOD_GlcNHglycan	691	695	PF01048	0.563
MOD_GlcNHglycan	743	748	PF01048	0.587
MOD_GSK3_1	126	133	PF00069	0.469
MOD_GSK3_1	2	9	PF00069	0.648
MOD_GSK3_1	240	247	PF00069	0.431
MOD_GSK3_1	321	328	PF00069	0.466
MOD_GSK3_1	334	341	PF00069	0.363
MOD_GSK3_1	388	395	PF00069	0.622
MOD_GSK3_1	406	413	PF00069	0.557
MOD_GSK3_1	433	440	PF00069	0.638
MOD_GSK3_1	541	548	PF00069	0.672
MOD_GSK3_1	628	635	PF00069	0.626
MOD_GSK3_1	64	71	PF00069	0.658
MOD_GSK3_1	667	674	PF00069	0.619
MOD_N-GLC_1	406	411	PF02516	0.706
MOD_N-GLC_1	540	545	PF02516	0.687
MOD_N-GLC_1	92	97	PF02516	0.541
MOD_NEK2_1	2	7	PF00069	0.661
MOD_NEK2_1	233	238	PF00069	0.469
MOD_NEK2_1	264	269	PF00069	0.606
MOD_NEK2_1	313	318	PF00069	0.583
MOD_NEK2_1	359	364	PF00069	0.515
MOD_NEK2_1	397	402	PF00069	0.633
MOD_NEK2_1	433	438	PF00069	0.569
MOD_NEK2_1	487	492	PF00069	0.572
MOD_NEK2_1	540	545	PF00069	0.627
MOD_NEK2_1	654	659	PF00069	0.691
MOD_NEK2_1	682	687	PF00069	0.572
MOD_NEK2_1	76	81	PF00069	0.669
MOD_NEK2_1	800	805	PF00069	0.405
MOD_NEK2_2	706	711	PF00069	0.600
MOD_NEK2_2	748	753	PF00069	0.681
MOD_PIKK_1	397	403	PF00454	0.672
MOD_PIKK_1	406	412	PF00454	0.652
MOD_PIKK_1	6	12	PF00454	0.636
MOD_PIKK_1	632	638	PF00454	0.705
MOD_PIKK_1	682	688	PF00454	0.571
MOD_PIKK_1	727	733	PF00454	0.672
MOD_PKA_1	580	586	PF00069	0.712
MOD_PKA_2	130	136	PF00069	0.503
MOD_PKA_2	325	331	PF00069	0.573
MOD_PKA_2	359	365	PF00069	0.501
MOD_PKA_2	580	586	PF00069	0.790
MOD_PKA_2	706	712	PF00069	0.674
MOD_PKB_1	412	420	PF00069	0.780
MOD_Plk_1	259	265	PF00069	0.602
MOD_Plk_1	545	551	PF00069	0.741
MOD_Plk_1	628	634	PF00069	0.576
MOD_Plk_1	670	676	PF00069	0.611
MOD_Plk_1	778	784	PF00069	0.566
MOD_Plk_2-3	511	517	PF00069	0.718
MOD_Plk_2-3	671	677	PF00069	0.607
MOD_Plk_2-3	737	743	PF00069	0.669
MOD_Plk_4	104	110	PF00069	0.491
MOD_Plk_4	233	239	PF00069	0.483
MOD_Plk_4	359	365	PF00069	0.511
MOD_Plk_4	392	398	PF00069	0.609
MOD_Plk_4	511	517	PF00069	0.718
MOD_Plk_4	518	524	PF00069	0.650
MOD_Plk_4	671	677	PF00069	0.607
MOD_Plk_4	695	701	PF00069	0.653
MOD_Plk_4	737	743	PF00069	0.640
MOD_ProDKin_1	117	123	PF00069	0.634
MOD_ProDKin_1	307	313	PF00069	0.748
MOD_ProDKin_1	77	83	PF00069	0.616
MOD_SUMO_for_1	694	697	PF00179	0.527
TRG_DiLeu_BaEn_1	532	537	PF01217	0.727
TRG_DiLeu_BaEn_1	558	563	PF01217	0.722
TRG_DiLeu_BaEn_4	558	564	PF01217	0.723
TRG_DiLeu_BaEn_4	614	620	PF01217	0.616
TRG_DiLeu_BaLyEn_6	309	314	PF01217	0.675
TRG_ENDOCYTIC_2	157	160	PF00928	0.628
TRG_ENDOCYTIC_2	249	252	PF00928	0.541
TRG_ENDOCYTIC_2	265	268	PF00928	0.364
TRG_ENDOCYTIC_2	430	433	PF00928	0.592
TRG_ENDOCYTIC_2	83	86	PF00928	0.494
TRG_ER_diArg_1	121	123	PF00400	0.514
TRG_ER_diArg_1	13	16	PF00400	0.546
TRG_ER_diArg_1	491	493	PF00400	0.611
TRG_ER_diArg_1	563	566	PF00400	0.728
TRG_ER_diArg_1	784	787	PF00400	0.435
TRG_Pf-PMV_PEXEL_1	617	622	PF00026	0.693
TRG_Pf-PMV_PEXEL_1	726	731	PF00026	0.672
TRG_Pf-PMV_PEXEL_1	784	788	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVC8	Leptomonas seymouri	40%	99%
A4HBI4	Leishmania braziliensis	74%	100%
A4HYK7	Leishmania infantum	99%	100%
E9AUF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QD28	Leishmania major	92%	100%