CRAL-TRIO domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IKB2_LEIDO

TriTrypDb:

LdBPK_332360.1 , LdCL_330030600 , LDHU3_33.3400

Length:

648

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IKB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IKB2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.568
CLV_C14_Caspase3-7	179	183	PF00656	0.538
CLV_C14_Caspase3-7	268	272	PF00656	0.532
CLV_C14_Caspase3-7	382	386	PF00656	0.537
CLV_C14_Caspase3-7	400	404	PF00656	0.623
CLV_C14_Caspase3-7	49	53	PF00656	0.526
CLV_C14_Caspase3-7	515	519	PF00656	0.360
CLV_NRD_NRD_1	343	345	PF00675	0.633
CLV_NRD_NRD_1	55	57	PF00675	0.557
CLV_NRD_NRD_1	638	640	PF00675	0.464
CLV_PCSK_FUR_1	340	344	PF00082	0.640
CLV_PCSK_KEX2_1	342	344	PF00082	0.621
CLV_PCSK_KEX2_1	55	57	PF00082	0.557
CLV_PCSK_KEX2_1	638	640	PF00082	0.468
CLV_PCSK_SKI1_1	154	158	PF00082	0.549
CLV_PCSK_SKI1_1	229	233	PF00082	0.620
DEG_SCF_FBW7_1	98	105	PF00400	0.585
DEG_SCF_FBW7_2	612	619	PF00400	0.491
DEG_SPOP_SBC_1	223	227	PF00917	0.602
DEG_SPOP_SBC_1	231	235	PF00917	0.534
DEG_SPOP_SBC_1	237	241	PF00917	0.493
DEG_SPOP_SBC_1	604	608	PF00917	0.328
DOC_ANK_TNKS_1	266	273	PF00023	0.534
DOC_ANK_TNKS_1	558	565	PF00023	0.319
DOC_CYCLIN_RxL_1	151	161	PF00134	0.567
DOC_MAPK_gen_1	307	316	PF00069	0.583
DOC_MAPK_gen_1	483	492	PF00069	0.312
DOC_MAPK_gen_1	596	604	PF00069	0.295
DOC_PP1_RVXF_1	175	181	PF00149	0.580
DOC_USP7_MATH_1	102	106	PF00917	0.580
DOC_USP7_MATH_1	148	152	PF00917	0.634
DOC_USP7_MATH_1	222	226	PF00917	0.606
DOC_USP7_MATH_1	231	235	PF00917	0.532
DOC_USP7_MATH_1	324	328	PF00917	0.772
DOC_USP7_MATH_1	39	43	PF00917	0.582
DOC_USP7_MATH_1	397	401	PF00917	0.617
DOC_USP7_MATH_1	62	66	PF00917	0.567
DOC_WW_Pin1_4	328	333	PF00397	0.608
DOC_WW_Pin1_4	528	533	PF00397	0.317
DOC_WW_Pin1_4	540	545	PF00397	0.333
DOC_WW_Pin1_4	612	617	PF00397	0.493
DOC_WW_Pin1_4	96	101	PF00397	0.637
LIG_14-3-3_CanoR_1	103	111	PF00244	0.552
LIG_14-3-3_CanoR_1	154	164	PF00244	0.569
LIG_14-3-3_CanoR_1	177	186	PF00244	0.585
LIG_14-3-3_CanoR_1	218	222	PF00244	0.700
LIG_14-3-3_CanoR_1	229	237	PF00244	0.543
LIG_14-3-3_CanoR_1	264	274	PF00244	0.583
LIG_14-3-3_CanoR_1	299	305	PF00244	0.540
LIG_14-3-3_CanoR_1	30	34	PF00244	0.525
LIG_14-3-3_CanoR_1	599	605	PF00244	0.298
LIG_14-3-3_CterR_2	644	648	PF00244	0.533
LIG_APCC_ABBA_1	537	542	PF00400	0.319
LIG_BIR_II_1	1	5	PF00653	0.547
LIG_BIR_III_2	403	407	PF00653	0.528
LIG_BIR_III_2	518	522	PF00653	0.294
LIG_BRCT_BRCA1_1	390	394	PF00533	0.492
LIG_BRCT_BRCA1_1	566	570	PF00533	0.280
LIG_deltaCOP1_diTrp_1	592	598	PF00928	0.285
LIG_eIF4E_1	452	458	PF01652	0.316
LIG_FHA_1	151	157	PF00498	0.582
LIG_FHA_1	173	179	PF00498	0.542
LIG_FHA_1	231	237	PF00498	0.540
LIG_FHA_1	283	289	PF00498	0.545
LIG_FHA_1	497	503	PF00498	0.355
LIG_FHA_1	99	105	PF00498	0.582
LIG_FHA_2	177	183	PF00498	0.538
LIG_FHA_2	185	191	PF00498	0.493
LIG_FHA_2	266	272	PF00498	0.580
LIG_FHA_2	299	305	PF00498	0.769
LIG_FHA_2	47	53	PF00498	0.531
LIG_FHA_2	506	512	PF00498	0.331
LIG_LIR_Gen_1	377	387	PF02991	0.520
LIG_LIR_Nem_3	456	461	PF02991	0.321
LIG_LIR_Nem_3	482	487	PF02991	0.399
LIG_LIR_Nem_3	534	540	PF02991	0.346
LIG_LIR_Nem_3	567	573	PF02991	0.307
LIG_LIR_Nem_3	595	601	PF02991	0.290
LIG_MYND_3	538	542	PF01753	0.355
LIG_Pex14_1	594	598	PF04695	0.278
LIG_Pex14_2	5	9	PF04695	0.558
LIG_Pex14_2	566	570	PF04695	0.280
LIG_Rb_LxCxE_1	543	563	PF01857	0.359
LIG_REV1ctd_RIR_1	482	490	PF16727	0.300
LIG_SH2_NCK_1	122	126	PF00017	0.672
LIG_SH2_NCK_1	571	575	PF00017	0.382
LIG_SH2_SRC	122	125	PF00017	0.554
LIG_SH2_STAP1	196	200	PF00017	0.524
LIG_SH2_STAP1	35	39	PF00017	0.589
LIG_SH2_STAT5	251	254	PF00017	0.722
LIG_SH2_STAT5	442	445	PF00017	0.454
LIG_SH2_STAT5	461	464	PF00017	0.282
LIG_SH3_3	115	121	PF00018	0.525
LIG_SH3_3	403	409	PF00018	0.576
LIG_SH3_3	94	100	PF00018	0.638
LIG_SUMO_SIM_anti_2	511	518	PF11976	0.391
LIG_SUMO_SIM_anti_2	580	585	PF11976	0.287
LIG_SUMO_SIM_par_1	505	512	PF11976	0.325
LIG_SUMO_SIM_par_1	600	608	PF11976	0.314
LIG_TRAF2_1	301	304	PF00917	0.570
LIG_TRAF2_1	331	334	PF00917	0.611
LIG_TYR_ITIM	459	464	PF00017	0.287
MOD_CDK_SPK_2	540	545	PF00069	0.360
MOD_CDK_SPK_2	98	103	PF00069	0.590
MOD_CDK_SPxxK_3	328	335	PF00069	0.612
MOD_CDK_SPxxK_3	96	103	PF00069	0.567
MOD_CK1_1	14	20	PF00069	0.548
MOD_CK1_1	160	166	PF00069	0.580
MOD_CK1_1	203	209	PF00069	0.573
MOD_CK1_1	328	334	PF00069	0.765
MOD_CK1_1	364	370	PF00069	0.612
MOD_CK1_1	543	549	PF00069	0.324
MOD_CK1_1	603	609	PF00069	0.336
MOD_CK1_1	61	67	PF00069	0.568
MOD_CK2_1	184	190	PF00069	0.525
MOD_CK2_1	298	304	PF00069	0.781
MOD_CK2_1	328	334	PF00069	0.622
MOD_CK2_1	390	396	PF00069	0.681
MOD_CK2_1	505	511	PF00069	0.376
MOD_Cter_Amidation	53	56	PF01082	0.513
MOD_GlcNHglycan	141	144	PF01048	0.596
MOD_GlcNHglycan	150	153	PF01048	0.571
MOD_GlcNHglycan	16	19	PF01048	0.577
MOD_GlcNHglycan	160	163	PF01048	0.559
MOD_GlcNHglycan	182	185	PF01048	0.568
MOD_GlcNHglycan	202	205	PF01048	0.562
MOD_GlcNHglycan	240	243	PF01048	0.589
MOD_GlcNHglycan	355	358	PF01048	0.688
MOD_GlcNHglycan	37	40	PF01048	0.571
MOD_GlcNHglycan	399	402	PF01048	0.603
MOD_GlcNHglycan	41	44	PF01048	0.540
MOD_GlcNHglycan	474	477	PF01048	0.357
MOD_GlcNHglycan	511	514	PF01048	0.496
MOD_GlcNHglycan	52	55	PF01048	0.515
MOD_GlcNHglycan	60	63	PF01048	0.465
MOD_GlcNHglycan	75	78	PF01048	0.490
MOD_GSK3_1	10	17	PF00069	0.541
MOD_GSK3_1	156	163	PF00069	0.657
MOD_GSK3_1	172	179	PF00069	0.548
MOD_GSK3_1	180	187	PF00069	0.638
MOD_GSK3_1	232	239	PF00069	0.604
MOD_GSK3_1	322	329	PF00069	0.681
MOD_GSK3_1	35	42	PF00069	0.564
MOD_GSK3_1	46	53	PF00069	0.561
MOD_GSK3_1	505	512	PF00069	0.386
MOD_GSK3_1	58	65	PF00069	0.527
MOD_GSK3_1	600	607	PF00069	0.303
MOD_GSK3_1	69	76	PF00069	0.527
MOD_GSK3_1	98	105	PF00069	0.545
MOD_N-GLC_1	11	16	PF02516	0.542
MOD_N-GLC_1	364	369	PF02516	0.606
MOD_N-GLC_1	50	55	PF02516	0.638
MOD_N-GLC_1	604	609	PF02516	0.339
MOD_N-GLC_1	66	71	PF02516	0.511
MOD_N-GLC_1	72	77	PF02516	0.550
MOD_NEK2_1	1	6	PF00069	0.572
MOD_NEK2_1	11	16	PF00069	0.506
MOD_NEK2_1	156	161	PF00069	0.674
MOD_NEK2_1	232	237	PF00069	0.611
MOD_NEK2_1	244	249	PF00069	0.507
MOD_NEK2_1	28	33	PF00069	0.550
MOD_NEK2_1	288	293	PF00069	0.627
MOD_NEK2_1	505	510	PF00069	0.307
MOD_NEK2_2	594	599	PF00069	0.288
MOD_PIKK_1	335	341	PF00454	0.736
MOD_PK_1	577	583	PF00069	0.340
MOD_PKA_2	102	108	PF00069	0.553
MOD_PKA_2	14	20	PF00069	0.548
MOD_PKA_2	176	182	PF00069	0.615
MOD_PKA_2	217	223	PF00069	0.684
MOD_PKA_2	266	272	PF00069	0.582
MOD_PKA_2	29	35	PF00069	0.553
MOD_PKA_2	298	304	PF00069	0.547
MOD_PKA_2	348	354	PF00069	0.580
MOD_PKA_2	39	45	PF00069	0.551
MOD_Plk_1	325	331	PF00069	0.593
MOD_Plk_1	388	394	PF00069	0.567
MOD_Plk_1	604	610	PF00069	0.355
MOD_Plk_1	66	72	PF00069	0.543
MOD_Plk_2-3	298	304	PF00069	0.630
MOD_Plk_2-3	379	385	PF00069	0.540
MOD_Plk_2-3	390	396	PF00069	0.685
MOD_Plk_4	1	7	PF00069	0.547
MOD_Plk_4	195	201	PF00069	0.521
MOD_Plk_4	232	238	PF00069	0.557
MOD_Plk_4	543	549	PF00069	0.324
MOD_Plk_4	605	611	PF00069	0.386
MOD_Plk_4	66	72	PF00069	0.570
MOD_ProDKin_1	328	334	PF00069	0.610
MOD_ProDKin_1	528	534	PF00069	0.315
MOD_ProDKin_1	540	546	PF00069	0.330
MOD_ProDKin_1	612	618	PF00069	0.489
MOD_ProDKin_1	96	102	PF00069	0.635
MOD_SUMO_rev_2	582	591	PF00179	0.337
TRG_DiLeu_BaEn_2	466	472	PF01217	0.298
TRG_ENDOCYTIC_2	446	449	PF00928	0.420
TRG_ENDOCYTIC_2	461	464	PF00928	0.414
TRG_ENDOCYTIC_2	57	60	PF00928	0.534
TRG_ER_diArg_1	294	297	PF00400	0.738
TRG_ER_diArg_1	340	343	PF00400	0.634
TRG_ER_diArg_1	485	488	PF00400	0.288
TRG_ER_diArg_1	55	57	PF00400	0.557
TRG_ER_diArg_1	557	560	PF00400	0.343
TRG_ER_diArg_1	642	645	PF00400	0.468
TRG_Pf-PMV_PEXEL_1	414	418	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	447	451	PF00026	0.342

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILQ5	Leptomonas seymouri	49%	100%
E9AHP2	Leishmania infantum	99%	100%