Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IKB1_LEIDO

TriTrypDb:

LdBPK_362680.1 , LdCL_360032800 , LDHU3_36.3650

Length:

373

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IKB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IKB1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	174	176	PF00675	0.649
CLV_NRD_NRD_1	218	220	PF00675	0.639
CLV_NRD_NRD_1	258	260	PF00675	0.557
CLV_NRD_NRD_1	311	313	PF00675	0.548
CLV_NRD_NRD_1	348	350	PF00675	0.575
CLV_NRD_NRD_1	42	44	PF00675	0.528
CLV_NRD_NRD_1	79	81	PF00675	0.675
CLV_PCSK_KEX2_1	174	176	PF00082	0.649
CLV_PCSK_KEX2_1	258	260	PF00082	0.557
CLV_PCSK_KEX2_1	311	313	PF00082	0.548
CLV_PCSK_KEX2_1	321	323	PF00082	0.572
CLV_PCSK_KEX2_1	348	350	PF00082	0.575
CLV_PCSK_KEX2_1	42	44	PF00082	0.528
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.590
CLV_PCSK_SKI1_1	175	179	PF00082	0.594
CLV_PCSK_SKI1_1	20	24	PF00082	0.672
CLV_PCSK_SKI1_1	259	263	PF00082	0.477
CLV_PCSK_SKI1_1	312	316	PF00082	0.614
DEG_APCC_DBOX_1	300	308	PF00400	0.641
DEG_SPOP_SBC_1	10	14	PF00917	0.522
DEG_SPOP_SBC_1	34	38	PF00917	0.588
DOC_CKS1_1	270	275	PF01111	0.605
DOC_CYCLIN_RxL_1	257	266	PF00134	0.532
DOC_MAPK_gen_1	112	120	PF00069	0.565
DOC_MAPK_gen_1	308	317	PF00069	0.643
DOC_MAPK_gen_1	40	49	PF00069	0.535
DOC_MAPK_MEF2A_6	190	197	PF00069	0.495
DOC_MAPK_MEF2A_6	40	49	PF00069	0.638
DOC_PP1_RVXF_1	257	264	PF00149	0.689
DOC_PP4_FxxP_1	146	149	PF00568	0.670
DOC_USP7_MATH_1	205	209	PF00917	0.653
DOC_USP7_MATH_1	283	287	PF00917	0.628
DOC_USP7_MATH_1	320	324	PF00917	0.621
DOC_USP7_MATH_1	34	38	PF00917	0.589
DOC_WW_Pin1_4	145	150	PF00397	0.580
DOC_WW_Pin1_4	269	274	PF00397	0.562
DOC_WW_Pin1_4	279	284	PF00397	0.462
DOC_WW_Pin1_4	4	9	PF00397	0.618
LIG_14-3-3_CanoR_1	154	158	PF00244	0.525
LIG_14-3-3_CanoR_1	232	237	PF00244	0.584
LIG_14-3-3_CanoR_1	284	288	PF00244	0.661
LIG_14-3-3_CanoR_1	306	311	PF00244	0.611
LIG_14-3-3_CanoR_1	80	86	PF00244	0.652
LIG_Actin_WH2_2	300	318	PF00022	0.504
LIG_BIR_II_1	1	5	PF00653	0.679
LIG_BRCT_BRCA1_1	147	151	PF00533	0.570
LIG_FHA_1	201	207	PF00498	0.662
LIG_FHA_1	332	338	PF00498	0.675
LIG_FHA_2	184	190	PF00498	0.484
LIG_FHA_2	21	27	PF00498	0.668
LIG_FHA_2	225	231	PF00498	0.641
LIG_FHA_2	236	242	PF00498	0.593
LIG_IRF3_LxIS_1	240	246	PF10401	0.438
LIG_LIR_Apic_2	144	149	PF02991	0.670
LIG_LIR_Gen_1	355	365	PF02991	0.523
LIG_LIR_Gen_1	70	79	PF02991	0.675
LIG_LIR_Nem_3	230	234	PF02991	0.508
LIG_LIR_Nem_3	246	252	PF02991	0.568
LIG_LIR_Nem_3	355	360	PF02991	0.521
LIG_LIR_Nem_3	50	55	PF02991	0.544
LIG_LIR_Nem_3	70	74	PF02991	0.687
LIG_LYPXL_yS_3	52	55	PF13949	0.596
LIG_PDZ_Class_3	368	373	PF00595	0.620
LIG_SH2_CRK	231	235	PF00017	0.504
LIG_SH2_PTP2	357	360	PF00017	0.512
LIG_SH2_SRC	247	250	PF00017	0.670
LIG_SH2_STAP1	247	251	PF00017	0.623
LIG_SH2_STAT5	161	164	PF00017	0.544
LIG_SH2_STAT5	201	204	PF00017	0.604
LIG_SH2_STAT5	357	360	PF00017	0.517
LIG_SH3_3	2	8	PF00018	0.641
LIG_SH3_3	334	340	PF00018	0.652
LIG_TRAF2_1	300	303	PF00917	0.581
LIG_UBA3_1	21	25	PF00899	0.558
MOD_CDK_SPK_2	279	284	PF00069	0.516
MOD_CK1_1	133	139	PF00069	0.563
MOD_CK1_1	235	241	PF00069	0.525
MOD_CK1_1	250	256	PF00069	0.448
MOD_CK1_1	291	297	PF00069	0.598
MOD_CK2_1	147	153	PF00069	0.651
MOD_CK2_1	183	189	PF00069	0.496
MOD_CK2_1	20	26	PF00069	0.674
MOD_CK2_1	235	241	PF00069	0.622
MOD_CK2_1	272	278	PF00069	0.685
MOD_CK2_1	283	289	PF00069	0.529
MOD_CK2_1	296	302	PF00069	0.514
MOD_CK2_1	320	326	PF00069	0.607
MOD_CK2_1	89	95	PF00069	0.717
MOD_GlcNHglycan	249	252	PF01048	0.560
MOD_GlcNHglycan	298	301	PF01048	0.674
MOD_GlcNHglycan	317	320	PF01048	0.416
MOD_GlcNHglycan	322	325	PF01048	0.612
MOD_GlcNHglycan	344	347	PF01048	0.655
MOD_GSK3_1	141	148	PF00069	0.623
MOD_GSK3_1	200	207	PF00069	0.532
MOD_GSK3_1	243	250	PF00069	0.528
MOD_GSK3_1	279	286	PF00069	0.516
MOD_GSK3_1	320	327	PF00069	0.564
MOD_GSK3_1	87	94	PF00069	0.695
MOD_N-GLC_1	353	358	PF02516	0.600
MOD_N-GLC_1	87	92	PF02516	0.684
MOD_N-GLC_2	107	109	PF02516	0.529
MOD_NEK2_1	103	108	PF00069	0.597
MOD_NEK2_1	169	174	PF00069	0.680
MOD_NEK2_1	243	248	PF00069	0.521
MOD_NEK2_1	263	268	PF00069	0.646
MOD_NEK2_1	277	282	PF00069	0.427
MOD_NEK2_1	288	293	PF00069	0.582
MOD_NEK2_1	315	320	PF00069	0.596
MOD_PIKK_1	224	230	PF00454	0.607
MOD_PKA_2	111	117	PF00069	0.641
MOD_PKA_2	153	159	PF00069	0.528
MOD_PKA_2	283	289	PF00069	0.533
MOD_PKA_2	315	321	PF00069	0.533
MOD_Plk_1	152	158	PF00069	0.559
MOD_Plk_1	193	199	PF00069	0.610
MOD_Plk_1	263	269	PF00069	0.602
MOD_Plk_1	277	283	PF00069	0.432
MOD_Plk_1	288	294	PF00069	0.517
MOD_Plk_1	353	359	PF00069	0.576
MOD_Plk_1	69	75	PF00069	0.704
MOD_Plk_2-3	183	189	PF00069	0.616
MOD_Plk_2-3	70	76	PF00069	0.679
MOD_Plk_4	213	219	PF00069	0.593
MOD_Plk_4	272	278	PF00069	0.620
MOD_Plk_4	283	289	PF00069	0.579
MOD_Plk_4	333	339	PF00069	0.564
MOD_Plk_4	353	359	PF00069	0.603
MOD_ProDKin_1	145	151	PF00069	0.578
MOD_ProDKin_1	269	275	PF00069	0.560
MOD_ProDKin_1	279	285	PF00069	0.467
MOD_ProDKin_1	4	10	PF00069	0.617
MOD_SUMO_rev_2	183	191	PF00179	0.593
MOD_SUMO_rev_2	326	334	PF00179	0.540
TRG_DiLeu_BaEn_4	302	308	PF01217	0.545
TRG_ENDOCYTIC_2	201	204	PF00928	0.527
TRG_ENDOCYTIC_2	231	234	PF00928	0.504
TRG_ENDOCYTIC_2	357	360	PF00928	0.512
TRG_ENDOCYTIC_2	367	370	PF00928	0.527
TRG_ENDOCYTIC_2	52	55	PF00928	0.599
TRG_ER_diArg_1	142	145	PF00400	0.545
TRG_ER_diArg_1	173	175	PF00400	0.551
TRG_ER_diArg_1	257	259	PF00400	0.554
TRG_ER_diArg_1	310	312	PF00400	0.546
TRG_ER_diArg_1	347	349	PF00400	0.606
TRG_ER_diArg_1	42	44	PF00400	0.532
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYX6	Leptomonas seymouri	61%	97%
A0A1X0P7K9	Trypanosomatidae	39%	100%
A0A3R7K7R7	Trypanosoma rangeli	42%	100%
A4HPC3	Leishmania braziliensis	81%	100%
A4ICG1	Leishmania infantum	100%	100%
D0A3D6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AT32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q1G6	Leishmania major	98%	100%
V5BH32	Trypanosoma cruzi	38%	100%