S1/P1 Nuclease family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3'-nucleotidase/nuclease precursor, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IK90_LEIDO

TriTrypDb:

LdBPK_312380.1 , LdCL_310031800 , LDHU3_31.4230

Length:

348

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 23, no: 6
NetGPI	no	yes: 0, no: 29

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0009986	cell surface	2	1

Expansion

Sequence features

A0A3Q8IK90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IK90

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	30
GO:0006259	DNA metabolic process	4	30
GO:0006308	DNA catabolic process	5	30
GO:0006725	cellular aromatic compound metabolic process	3	30
GO:0006807	nitrogen compound metabolic process	2	30
GO:0008152	metabolic process	1	30
GO:0009056	catabolic process	2	30
GO:0009057	macromolecule catabolic process	4	30
GO:0009987	cellular process	1	30
GO:0019439	aromatic compound catabolic process	4	30
GO:0034641	cellular nitrogen compound metabolic process	3	30
GO:0034655	nucleobase-containing compound catabolic process	4	30
GO:0043170	macromolecule metabolic process	3	30
GO:0044237	cellular metabolic process	2	30
GO:0044238	primary metabolic process	2	30
GO:0044248	cellular catabolic process	3	30
GO:0044260	obsolete cellular macromolecule metabolic process	3	30
GO:0044265	obsolete cellular macromolecule catabolic process	4	30
GO:0044270	cellular nitrogen compound catabolic process	4	30
GO:0046483	heterocycle metabolic process	3	30
GO:0046700	heterocycle catabolic process	4	30
GO:0071704	organic substance metabolic process	2	30
GO:0090304	nucleic acid metabolic process	4	30
GO:1901360	organic cyclic compound metabolic process	3	30
GO:1901361	organic cyclic compound catabolic process	4	30
GO:1901575	organic substance catabolic process	3	30
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006195	purine nucleotide catabolic process	6	1
GO:0006196	AMP catabolic process	7	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009123	nucleoside monophosphate metabolic process	5	1
GO:0009125	nucleoside monophosphate catabolic process	6	1
GO:0009126	purine nucleoside monophosphate metabolic process	6	1
GO:0009128	purine nucleoside monophosphate catabolic process	7	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009154	purine ribonucleotide catabolic process	6	1
GO:0009158	ribonucleoside monophosphate catabolic process	7	1
GO:0009161	ribonucleoside monophosphate metabolic process	6	1
GO:0009166	nucleotide catabolic process	6	1
GO:0009167	purine ribonucleoside monophosphate metabolic process	7	1
GO:0009169	purine ribonucleoside monophosphate catabolic process	8	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009261	ribonucleotide catabolic process	5	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046033	AMP metabolic process	7	1
GO:0046434	organophosphate catabolic process	4	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:0072523	purine-containing compound catabolic process	5	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901136	carbohydrate derivative catabolic process	4	1
GO:1901292	nucleoside phosphate catabolic process	5	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	30
GO:0003824	catalytic activity	1	30
GO:0004518	nuclease activity	4	30
GO:0004519	endonuclease activity	5	30
GO:0005488	binding	1	30
GO:0016787	hydrolase activity	2	30
GO:0016788	hydrolase activity, acting on ester bonds	3	30
GO:0043167	ion binding	2	30
GO:0043169	cation binding	3	30
GO:0046872	metal ion binding	4	30
GO:0097159	organic cyclic compound binding	2	30
GO:1901363	heterocyclic compound binding	2	30
GO:0008252	nucleotidase activity	6	1
GO:0008254	3'-nucleotidase activity	7	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	95	97	PF00675	0.423
CLV_PCSK_SKI1_1	14	18	PF00082	0.529
CLV_PCSK_SKI1_1	153	157	PF00082	0.543
CLV_PCSK_SKI1_1	222	226	PF00082	0.375
CLV_PCSK_SKI1_1	248	252	PF00082	0.426
CLV_PCSK_SKI1_1	256	260	PF00082	0.444
DOC_MAPK_MEF2A_6	340	348	PF00069	0.503
DOC_USP7_MATH_1	226	230	PF00917	0.270
DOC_USP7_UBL2_3	14	18	PF12436	0.199
DOC_USP7_UBL2_3	239	243	PF12436	0.288
DOC_WW_Pin1_4	32	37	PF00397	0.317
DOC_WW_Pin1_4	74	79	PF00397	0.255
LIG_14-3-3_CanoR_1	96	105	PF00244	0.186
LIG_Actin_WH2_2	253	268	PF00022	0.231
LIG_APCC_ABBA_1	113	118	PF00400	0.193
LIG_BIR_II_1	1	5	PF00653	0.153
LIG_BIR_III_3	1	5	PF00653	0.153
LIG_FHA_1	207	213	PF00498	0.280
LIG_FHA_1	288	294	PF00498	0.443
LIG_FHA_1	304	310	PF00498	0.337
LIG_FHA_1	320	326	PF00498	0.326
LIG_FHA_1	71	77	PF00498	0.328
LIG_FHA_1	99	105	PF00498	0.295
LIG_FHA_2	198	204	PF00498	0.361
LIG_FHA_2	293	299	PF00498	0.413
LIG_GBD_Chelix_1	257	265	PF00786	0.491
LIG_GBD_Chelix_1	311	319	PF00786	0.165
LIG_LIR_Apic_2	169	175	PF02991	0.246
LIG_LIR_Gen_1	179	188	PF02991	0.290
LIG_LIR_Nem_3	179	184	PF02991	0.287
LIG_PDZ_Class_2	343	348	PF00595	0.566
LIG_Pex14_2	57	61	PF04695	0.293
LIG_PTB_Apo_2	211	218	PF02174	0.295
LIG_PTB_Phospho_1	211	217	PF10480	0.295
LIG_SH2_CRK	223	227	PF00017	0.246
LIG_SH2_SRC	190	193	PF00017	0.359
LIG_SH2_STAP1	217	221	PF00017	0.252
LIG_SH2_STAT5	190	193	PF00017	0.272
LIG_SH3_3	167	173	PF00018	0.233
LIG_SH3_3	30	36	PF00018	0.256
LIG_SH3_3	62	68	PF00018	0.268
LIG_SH3_5	134	138	PF00018	0.171
LIG_SUMO_SIM_anti_2	321	327	PF11976	0.219
LIG_SUMO_SIM_par_1	143	149	PF11976	0.249
LIG_SUMO_SIM_par_1	342	347	PF11976	0.517
LIG_SUMO_SIM_par_1	71	77	PF11976	0.357
LIG_TRAF2_1	295	298	PF00917	0.337
LIG_WRC_WIRS_1	293	298	PF05994	0.329
MOD_CK1_1	269	275	PF00069	0.334
MOD_CK2_1	159	165	PF00069	0.349
MOD_CK2_1	197	203	PF00069	0.318
MOD_CK2_1	292	298	PF00069	0.483
MOD_GlcNHglycan	50	53	PF01048	0.426
MOD_GlcNHglycan	92	95	PF01048	0.526
MOD_GSK3_1	226	233	PF00069	0.309
MOD_GSK3_1	260	267	PF00069	0.286
MOD_GSK3_1	288	295	PF00069	0.446
MOD_GSK3_1	299	306	PF00069	0.430
MOD_GSK3_1	48	55	PF00069	0.329
MOD_GSK3_1	70	77	PF00069	0.249
MOD_GSK3_1	95	102	PF00069	0.323
MOD_N-GLC_1	197	202	PF02516	0.463
MOD_N-GLC_1	207	212	PF02516	0.451
MOD_N-GLC_1	261	266	PF02516	0.555
MOD_N-GLC_1	288	293	PF02516	0.703
MOD_NEK2_1	191	196	PF00069	0.281
MOD_NEK2_1	206	211	PF00069	0.345
MOD_NEK2_1	260	265	PF00069	0.311
MOD_NEK2_1	287	292	PF00069	0.392
MOD_NEK2_1	319	324	PF00069	0.267
MOD_NEK2_1	48	53	PF00069	0.283
MOD_NEK2_1	90	95	PF00069	0.331
MOD_PIKK_1	103	109	PF00454	0.171
MOD_PKA_1	243	249	PF00069	0.293
MOD_PKA_1	96	102	PF00069	0.153
MOD_PKA_2	95	101	PF00069	0.262
MOD_Plk_1	191	197	PF00069	0.280
MOD_Plk_1	207	213	PF00069	0.272
MOD_Plk_1	261	267	PF00069	0.323
MOD_Plk_1	287	293	PF00069	0.335
MOD_Plk_1	70	76	PF00069	0.260
MOD_Plk_4	269	275	PF00069	0.336
MOD_Plk_4	288	294	PF00069	0.375
MOD_Plk_4	319	325	PF00069	0.242
MOD_Plk_4	83	89	PF00069	0.258
MOD_ProDKin_1	32	38	PF00069	0.317
MOD_ProDKin_1	74	80	PF00069	0.255
MOD_SUMO_rev_2	177	187	PF00179	0.240
MOD_SUMO_rev_2	235	240	PF00179	0.210
TRG_DiLeu_BaEn_1	247	252	PF01217	0.231
TRG_ENDOCYTIC_2	181	184	PF00928	0.275
TRG_ER_diArg_1	330	333	PF00400	0.517
TRG_NES_CRM1_1	103	118	PF08389	0.337

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8Q7	Leptomonas seymouri	37%	96%
A0A0S4JAL3	Bodo saltans	40%	100%
A0A0S4JML7	Bodo saltans	28%	96%
A0A1X0P2K7	Trypanosomatidae	44%	100%
A0A3Q8IBF6	Leishmania donovani	47%	100%
A0A3Q8IEW3	Leishmania donovani	39%	100%
A0A3Q8IFH4	Leishmania donovani	63%	100%
A0A3S7X3A6	Leishmania donovani	39%	100%
A0A422N7B0	Trypanosoma rangeli	41%	100%
A4H6V5	Leishmania braziliensis	46%	100%
A4HI96	Leishmania braziliensis	33%	100%
A4HJL3	Leishmania braziliensis	64%	100%
A4I5I0	Leishmania infantum	39%	100%
A4I736	Leishmania infantum	63%	100%
C9ZQH5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZQH6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZQW0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AGC7	Leishmania infantum	47%	100%
E9ANW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9B0S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9B0S5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9B231	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
F4JJL0	Arabidopsis thaliana	27%	100%
Q4Q630	Leishmania major	62%	100%
Q4Q7F3	Leishmania major	37%	100%
Q4Q7F4	Leishmania major	37%	100%
Q4QGQ3	Leishmania major	45%	100%
Q66VY6	Leishmania major	90%	100%
Q8LDW6	Arabidopsis thaliana	27%	100%
Q9C9G4	Arabidopsis thaliana	26%	100%
V5B8Z9	Trypanosoma cruzi	39%	90%