Small_GTP-binding_protein_Rab18_putative/GeneDB:L mjF.33.1840

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

small GTP-binding protein Rab18, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IK84_LEIDO

TriTrypDb:

LdBPK_331940.1 , LdCL_330026200 , LDHU3_33.2850

Length:

217

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, small GTP-binding Rab18

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3Q8IK84

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IK84

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006904	vesicle docking involved in exocytosis	3	1
GO:0008104	protein localization	4	1
GO:0009306	protein secretion	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0017157	regulation of exocytosis	5	1
GO:0022406	membrane docking	2	1
GO:0032879	regulation of localization	3	1
GO:0032940	secretion by cell	3	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0003924	GTPase activity	7	11
GO:0005488	binding	1	11
GO:0005525	GTP binding	5	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0017076	purine nucleotide binding	4	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	53	57	PF00656	0.428
CLV_NRD_NRD_1	119	121	PF00675	0.554
CLV_NRD_NRD_1	199	201	PF00675	0.704
CLV_PCSK_KEX2_1	119	121	PF00082	0.554
CLV_PCSK_KEX2_1	198	200	PF00082	0.668
CLV_PCSK_SKI1_1	199	203	PF00082	0.680
CLV_PCSK_SKI1_1	79	83	PF00082	0.426
CLV_PCSK_SKI1_1	9	13	PF00082	0.476
DEG_SCF_TRCP1_1	18	24	PF00400	0.428
DEG_SPOP_SBC_1	123	127	PF00917	0.476

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Z9	Leptomonas seymouri	34%	92%
A0A0N0P3A0	Leptomonas seymouri	38%	80%
A0A0N0P3G2	Leptomonas seymouri	28%	100%
A0A0N0P3Q3	Leptomonas seymouri	30%	100%
A0A0N0P6K4	Leptomonas seymouri	27%	100%
A0A0N0P6P8	Leptomonas seymouri	42%	100%
A0A0N0P8G7	Leptomonas seymouri	81%	100%
A0A0N0P8I1	Leptomonas seymouri	36%	98%
A0A0N0P971	Leptomonas seymouri	31%	100%
A0A0N1HU31	Leptomonas seymouri	28%	88%

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