LeishMANIAdb
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Small GTP-binding protein domain protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Small GTP-binding protein domain protein
Gene product:
developmentally regulated GTP-binding protein 1, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IK74_LEIDO
TriTrypDb:
LdBPK_362380.1 , LdCL_360029500 , LDHU3_36.3170
Length:
368

Annotations

Annotations by Jardim et al.

Membrane associated proteins, developmentally regulated GTP-binding 1

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

A0A3Q8IK74
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IK74

Function

Biological processes
Term Name Level Count
GO:0002181 cytoplasmic translation 5 1
GO:0006412 translation 4 1
GO:0006518 peptide metabolic process 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009058 biosynthetic process 2 1
GO:0009059 macromolecule biosynthetic process 4 1
GO:0009987 cellular process 1 1
GO:0019538 protein metabolic process 3 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 1
GO:0043043 peptide biosynthetic process 5 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043603 amide metabolic process 3 1
GO:0043604 amide biosynthetic process 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044271 cellular nitrogen compound biosynthetic process 4 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901566 organonitrogen compound biosynthetic process 4 1
GO:1901576 organic substance biosynthetic process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0003924 GTPase activity 7 12
GO:0005488 binding 1 12
GO:0005525 GTP binding 5 12
GO:0016462 pyrophosphatase activity 5 12
GO:0016787 hydrolase activity 2 12
GO:0016817 hydrolase activity, acting on acid anhydrides 3 12
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 12
GO:0017076 purine nucleotide binding 4 12
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 12
GO:0019001 guanyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032561 guanyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 228 232 PF00656 0.597
CLV_NRD_NRD_1 180 182 PF00675 0.534
CLV_PCSK_KEX2_1 38 40 PF00082 0.511
CLV_PCSK_PC1ET2_1 38 40 PF00082 0.511
CLV_PCSK_SKI1_1 108 112 PF00082 0.337
CLV_PCSK_SKI1_1 205 209 PF00082 0.337
DOC_MAPK_DCC_7 170 180 PF00069 0.455
DOC_MAPK_DCC_7 237 245 PF00069 0.537
DOC_MAPK_gen_1 108 117 PF00069 0.537
DOC_MAPK_gen_1 128 137 PF00069 0.406
DOC_MAPK_gen_1 170 180 PF00069 0.496
DOC_MAPK_gen_1 181 190 PF00069 0.359
DOC_MAPK_MEF2A_6 139 148 PF00069 0.537
DOC_MAPK_MEF2A_6 173 180 PF00069 0.524
DOC_MAPK_MEF2A_6 237 245 PF00069 0.537
DOC_MAPK_RevD_3 167 182 PF00069 0.480
DOC_PP1_RVXF_1 63 69 PF00149 0.389
DOC_PP2B_LxvP_1 115 118 PF13499 0.537
DOC_PP2B_PxIxI_1 175 181 PF00149 0.505
DOC_PP2B_PxIxI_1 240 246 PF00149 0.577
DOC_USP7_MATH_1 314 318 PF00917 0.623
DOC_USP7_MATH_1 43 47 PF00917 0.608
DOC_USP7_UBL2_3 48 52 PF12436 0.663
DOC_WW_Pin1_4 171 176 PF00397 0.592
DOC_WW_Pin1_4 310 315 PF00397 0.585
LIG_14-3-3_CanoR_1 139 144 PF00244 0.537
LIG_Actin_WH2_2 157 174 PF00022 0.613
LIG_BIR_II_1 1 5 PF00653 0.555
LIG_Clathr_ClatBox_1 145 149 PF01394 0.537
LIG_deltaCOP1_diTrp_1 282 290 PF00928 0.537
LIG_FHA_1 138 144 PF00498 0.537
LIG_FHA_1 191 197 PF00498 0.537
LIG_FHA_1 201 207 PF00498 0.537
LIG_FHA_2 195 201 PF00498 0.537
LIG_FHA_2 223 229 PF00498 0.623
LIG_FHA_2 84 90 PF00498 0.537
LIG_Integrin_RGD_1 221 223 PF01839 0.348
LIG_LIR_Apic_2 303 307 PF02991 0.537
LIG_LIR_Gen_1 282 293 PF02991 0.537
LIG_LIR_Gen_1 94 102 PF02991 0.542
LIG_LIR_Nem_3 282 288 PF02991 0.537
LIG_LIR_Nem_3 94 98 PF02991 0.542
LIG_LYPXL_SIV_4 238 246 PF13949 0.623
LIG_NRBOX 276 282 PF00104 0.548
LIG_PTB_Apo_2 329 336 PF02174 0.623
LIG_PTB_Phospho_1 329 335 PF10480 0.623
LIG_RPA_C_Fungi 134 146 PF08784 0.389
LIG_SH2_CRK 294 298 PF00017 0.389
LIG_SH2_CRK 304 308 PF00017 0.389
LIG_SH2_SRC 239 242 PF00017 0.474
LIG_SH2_STAP1 335 339 PF00017 0.446
LIG_SH2_STAT5 224 227 PF00017 0.467
LIG_SH2_STAT5 239 242 PF00017 0.289
LIG_SH2_STAT5 244 247 PF00017 0.206
LIG_SH2_STAT5 294 297 PF00017 0.389
LIG_SH3_4 296 303 PF00018 0.389
LIG_SUMO_SIM_anti_2 142 149 PF11976 0.389
LIG_SUMO_SIM_anti_2 255 261 PF11976 0.389
LIG_SUMO_SIM_par_1 142 149 PF11976 0.389
LIG_TRAF2_1 253 256 PF00917 0.389
LIG_UBA3_1 144 152 PF00899 0.389
LIG_WRC_WIRS_1 318 323 PF05994 0.437
MOD_CK1_1 189 195 PF00069 0.405
MOD_CK1_1 317 323 PF00069 0.505
MOD_CK1_1 81 87 PF00069 0.408
MOD_CK2_1 222 228 PF00069 0.446
MOD_CK2_1 250 256 PF00069 0.389
MOD_CK2_1 5 11 PF00069 0.475
MOD_CK2_1 83 89 PF00069 0.379
MOD_GlcNHglycan 269 272 PF01048 0.389
MOD_GSK3_1 186 193 PF00069 0.392
MOD_GSK3_1 310 317 PF00069 0.456
MOD_GSK3_1 70 77 PF00069 0.389
MOD_GSK3_1 78 85 PF00069 0.389
MOD_N-GLC_1 171 176 PF02516 0.604
MOD_NEK2_1 14 19 PF00069 0.623
MOD_NEK2_1 83 88 PF00069 0.389
MOD_NEK2_2 216 221 PF00069 0.509
MOD_NEK2_2 339 344 PF00069 0.389
MOD_PIKK_1 14 20 PF00454 0.524
MOD_Plk_1 216 222 PF00069 0.526
MOD_Plk_1 93 99 PF00069 0.388
MOD_Plk_2-3 250 256 PF00069 0.389
MOD_Plk_4 139 145 PF00069 0.389
MOD_Plk_4 75 81 PF00069 0.389
MOD_ProDKin_1 171 177 PF00069 0.594
MOD_ProDKin_1 310 316 PF00069 0.456
MOD_SUMO_for_1 37 40 PF00179 0.554
TRG_ENDOCYTIC_2 335 338 PF00928 0.446
TRG_NES_CRM1_1 149 163 PF08389 0.401

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7B2 Leptomonas seymouri 93% 100%
A0A0N1I7A1 Leptomonas seymouri 48% 98%
A0A0S4JLR9 Bodo saltans 50% 98%
A0A0S4JSR7 Bodo saltans 84% 100%
A0A1X0P4R4 Trypanosomatidae 51% 98%
A0A1X0P8M9 Trypanosomatidae 87% 100%
A0A3S7XAC8 Leishmania donovani 50% 98%
A0A422N5U7 Trypanosoma rangeli 50% 98%
A0A422NIT8 Trypanosoma rangeli 86% 100%
A4HNJ2 Leishmania braziliensis 49% 100%
A4HP94 Leishmania braziliensis 96% 100%
A4IC49 Leishmania infantum 50% 100%
A4IDJ9 Leishmania infantum 100% 100%
C9ZYC5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 98%
D0A397 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 89% 100%
E9AG04 Leishmania major 49% 100%
E9AT02 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
E9B757 Leishmania mexicana (strain MHOM/GT/2001/U1103) 50% 100%
P17103 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 39% 99%
P32233 Mus musculus 69% 100%
P32234 Drosophila melanogaster 65% 100%
P32235 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 53% 100%
P34280 Caenorhabditis elegans 56% 100%
P39729 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 61% 100%
P43690 Xenopus laevis 69% 100%
P53295 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 49% 100%
P55039 Homo sapiens 56% 100%
Q3MHP5 Bos taurus 69% 100%
Q4Q1J6 Leishmania major 99% 100%
Q54HP3 Dictyostelium discoideum 66% 99%
Q54WT4 Dictyostelium discoideum 53% 100%
Q58722 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 49% 94%
Q58D56 Bos taurus 55% 100%
Q9CAI1 Arabidopsis thaliana 54% 92%
Q9LQK0 Arabidopsis thaliana 54% 92%
Q9QXB9 Mus musculus 55% 100%
Q9SVA6 Arabidopsis thaliana 64% 100%
Q9UT21 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 61% 100%
Q9Y295 Homo sapiens 69% 100%
V5BKY5 Trypanosoma cruzi 88% 75%
V5DQF8 Trypanosoma cruzi 49% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS