LeishMANIAdb
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Phosphatidic acid phosphatase protein-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphatidic acid phosphatase protein-like protein
Gene product:
phosphatidic acid phosphatase protein-like protein
Species:
Leishmania donovani
UniProt:
A0A3Q8IK66_LEIDO
TriTrypDb:
LdBPK_191380.1 * , LdCL_190019500 , LDHU3_19.1670
Length:
400

Annotations

LeishMANIAdb annotations

Distinctively related to eukaryotic PLPP enzymes.. This family of protens expanded considerably in Kinetoplastids (might be due to metabolic dependence on host lipids)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 23
NetGPI no yes: 0, no: 23
Cellular components
Term Name Level Count
GO:0016020 membrane 2 24
GO:0110165 cellular anatomical entity 1 24

Expansion

Sequence features

A0A3Q8IK66
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IK66

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 24
GO:0006644 phospholipid metabolic process 4 24
GO:0006793 phosphorus metabolic process 3 24
GO:0006796 phosphate-containing compound metabolic process 4 24
GO:0008152 metabolic process 1 24
GO:0009987 cellular process 1 24
GO:0019637 organophosphate metabolic process 3 24
GO:0044237 cellular metabolic process 2 24
GO:0044238 primary metabolic process 2 24
GO:0044255 cellular lipid metabolic process 3 24
GO:0071704 organic substance metabolic process 2 24
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0008195 phosphatidate phosphatase activity 6 3
GO:0016787 hydrolase activity 2 3
GO:0016788 hydrolase activity, acting on ester bonds 3 3
GO:0016791 phosphatase activity 5 3
GO:0042578 phosphoric ester hydrolase activity 4 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 374 378 PF00656 0.405
CLV_NRD_NRD_1 380 382 PF00675 0.762
CLV_NRD_NRD_1 388 390 PF00675 0.684
CLV_PCSK_KEX2_1 352 354 PF00082 0.771
CLV_PCSK_KEX2_1 380 382 PF00082 0.762
CLV_PCSK_KEX2_1 388 390 PF00082 0.684
CLV_PCSK_PC1ET2_1 352 354 PF00082 0.632
DEG_APCC_DBOX_1 143 151 PF00400 0.503
DOC_MAPK_DCC_7 248 258 PF00069 0.291
DOC_PP1_RVXF_1 209 215 PF00149 0.422
DOC_USP7_MATH_1 106 110 PF00917 0.652
DOC_USP7_MATH_1 340 344 PF00917 0.447
DOC_USP7_MATH_1 53 57 PF00917 0.354
DOC_WW_Pin1_4 360 365 PF00397 0.540
LIG_14-3-3_CanoR_1 211 215 PF00244 0.412
LIG_14-3-3_CanoR_1 242 247 PF00244 0.235
LIG_14-3-3_CanoR_1 358 365 PF00244 0.543
LIG_14-3-3_CanoR_1 43 48 PF00244 0.236
LIG_BIR_III_2 202 206 PF00653 0.400
LIG_BRCT_BRCA1_1 219 223 PF00533 0.282
LIG_BRCT_BRCA1_1 72 76 PF00533 0.315
LIG_DLG_GKlike_1 242 249 PF00625 0.279
LIG_FHA_1 155 161 PF00498 0.503
LIG_FHA_1 23 29 PF00498 0.214
LIG_FHA_1 245 251 PF00498 0.402
LIG_FHA_2 106 112 PF00498 0.650
LIG_FHA_2 190 196 PF00498 0.493
LIG_FHA_2 308 314 PF00498 0.437
LIG_FHA_2 372 378 PF00498 0.406
LIG_FHA_2 58 64 PF00498 0.383
LIG_IRF3_LxIS_1 24 31 PF10401 0.390
LIG_IRF3_LxIS_1 250 257 PF10401 0.258
LIG_LIR_Gen_1 195 205 PF02991 0.448
LIG_LIR_Gen_1 20 29 PF02991 0.332
LIG_LIR_Gen_1 245 254 PF02991 0.345
LIG_LIR_Gen_1 287 296 PF02991 0.400
LIG_LIR_Gen_1 313 321 PF02991 0.458
LIG_LIR_Gen_1 44 55 PF02991 0.213
LIG_LIR_Nem_3 195 200 PF02991 0.437
LIG_LIR_Nem_3 20 24 PF02991 0.332
LIG_LIR_Nem_3 245 249 PF02991 0.254
LIG_LIR_Nem_3 287 292 PF02991 0.353
LIG_LIR_Nem_3 295 299 PF02991 0.443
LIG_LIR_Nem_3 313 319 PF02991 0.399
LIG_LIR_Nem_3 44 50 PF02991 0.244
LIG_LIR_Nem_3 59 64 PF02991 0.297
LIG_LIR_Nem_3 73 79 PF02991 0.240
LIG_LIR_Nem_3 97 101 PF02991 0.602
LIG_LYPXL_S_1 139 143 PF13949 0.367
LIG_LYPXL_yS_3 140 143 PF13949 0.566
LIG_NRBOX 23 29 PF00104 0.403
LIG_PDZ_Wminus1_1 398 400 PF00595 0.533
LIG_Pex14_2 292 296 PF04695 0.307
LIG_Pex14_2 72 76 PF04695 0.357
LIG_Pex14_2 9 13 PF04695 0.580
LIG_PTB_Apo_2 190 197 PF02174 0.557
LIG_PTB_Phospho_1 190 196 PF10480 0.557
LIG_SH2_CRK 197 201 PF00017 0.462
LIG_SH2_STAP1 180 184 PF00017 0.528
LIG_SH2_STAP1 64 68 PF00017 0.369
LIG_SH2_STAT5 171 174 PF00017 0.460
LIG_SH2_STAT5 180 183 PF00017 0.466
LIG_SH2_STAT5 197 200 PF00017 0.479
LIG_SH2_STAT5 306 309 PF00017 0.403
LIG_SH2_STAT5 77 80 PF00017 0.276
LIG_SH2_STAT5 83 86 PF00017 0.379
LIG_SH3_3 332 338 PF00018 0.540
LIG_SH3_3 376 382 PF00018 0.414
LIG_SH3_3 89 95 PF00018 0.590
LIG_SUMO_SIM_anti_2 25 31 PF11976 0.351
LIG_SUMO_SIM_anti_2 257 262 PF11976 0.442
LIG_SUMO_SIM_anti_2 65 70 PF11976 0.294
LIG_SUMO_SIM_par_1 25 31 PF11976 0.299
LIG_SUMO_SIM_par_1 254 259 PF11976 0.407
LIG_SUMO_SIM_par_1 32 37 PF11976 0.300
LIG_TRAF2_1 87 90 PF00917 0.450
LIG_TYR_ITIM 138 143 PF00017 0.601
LIG_TYR_ITIM 314 319 PF00017 0.456
LIG_UBA3_1 32 39 PF00899 0.163
LIG_WRC_WIRS_1 289 294 PF05994 0.351
LIG_WRC_WIRS_1 372 377 PF05994 0.401
MOD_CDK_SPxxK_3 360 367 PF00069 0.537
MOD_CK1_1 154 160 PF00069 0.400
MOD_CK1_1 182 188 PF00069 0.506
MOD_CK1_1 213 219 PF00069 0.420
MOD_CK2_1 105 111 PF00069 0.693
MOD_CK2_1 2 8 PF00069 0.494
MOD_DYRK1A_RPxSP_1 360 364 PF00069 0.381
MOD_GlcNHglycan 108 111 PF01048 0.508
MOD_GlcNHglycan 215 218 PF01048 0.223
MOD_GlcNHglycan 286 289 PF01048 0.315
MOD_GlcNHglycan 323 326 PF01048 0.568
MOD_GlcNHglycan 329 333 PF01048 0.688
MOD_GlcNHglycan 343 346 PF01048 0.718
MOD_GlcNHglycan 360 363 PF01048 0.733
MOD_GSK3_1 117 124 PF00069 0.705
MOD_GSK3_1 178 185 PF00069 0.494
MOD_GSK3_1 213 220 PF00069 0.444
MOD_GSK3_1 28 35 PF00069 0.334
MOD_GSK3_1 284 291 PF00069 0.342
MOD_GSK3_1 336 343 PF00069 0.520
MOD_GSK3_1 371 378 PF00069 0.461
MOD_GSK3_1 53 60 PF00069 0.304
MOD_LATS_1 41 47 PF00433 0.287
MOD_N-GLC_1 375 380 PF02516 0.662
MOD_NEK2_1 28 33 PF00069 0.257
MOD_NEK2_1 292 297 PF00069 0.318
MOD_NEK2_1 307 312 PF00069 0.306
MOD_NEK2_1 375 380 PF00069 0.565
MOD_NEK2_1 70 75 PF00069 0.323
MOD_NEK2_2 288 293 PF00069 0.349
MOD_PKA_1 380 386 PF00069 0.412
MOD_PKA_2 210 216 PF00069 0.412
MOD_PKA_2 380 386 PF00069 0.562
MOD_Plk_1 375 381 PF00069 0.463
MOD_Plk_1 48 54 PF00069 0.277
MOD_Plk_1 62 68 PF00069 0.221
MOD_Plk_4 117 123 PF00069 0.665
MOD_Plk_4 22 28 PF00069 0.309
MOD_Plk_4 224 230 PF00069 0.253
MOD_Plk_4 256 262 PF00069 0.322
MOD_Plk_4 278 284 PF00069 0.269
MOD_Plk_4 288 294 PF00069 0.291
MOD_ProDKin_1 360 366 PF00069 0.537
MOD_SUMO_rev_2 315 325 PF00179 0.374
TRG_DiLeu_BaLyEn_6 245 250 PF01217 0.304
TRG_ENDOCYTIC_2 115 118 PF00928 0.687
TRG_ENDOCYTIC_2 140 143 PF00928 0.492
TRG_ENDOCYTIC_2 16 19 PF00928 0.294
TRG_ENDOCYTIC_2 197 200 PF00928 0.473
TRG_ENDOCYTIC_2 293 296 PF00928 0.299
TRG_ENDOCYTIC_2 316 319 PF00928 0.460
TRG_ENDOCYTIC_2 77 80 PF00928 0.242
TRG_ER_diArg_1 127 130 PF00400 0.598
TRG_ER_diArg_1 166 169 PF00400 0.417
TRG_ER_diArg_1 379 381 PF00400 0.561
TRG_ER_diArg_1 388 390 PF00400 0.477
TRG_Pf-PMV_PEXEL_1 388 392 PF00026 0.730
TRG_Pf-PMV_PEXEL_1 86 90 PF00026 0.281

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P344 Leptomonas seymouri 58% 100%
A0A0N1I1J3 Leptomonas seymouri 30% 100%
A0A0S4JH63 Bodo saltans 32% 100%
A0A1X0P677 Trypanosomatidae 39% 100%
A0A1X0P6S8 Trypanosomatidae 32% 100%
A0A1X0P729 Trypanosomatidae 32% 100%
A0A3Q8ID01 Leishmania donovani 29% 100%
A0A3S5IRX0 Trypanosoma rangeli 39% 100%
A0A422MQK2 Trypanosoma rangeli 33% 100%
A4H9I2 Leishmania braziliensis 29% 100%
A4HA84 Leishmania braziliensis 71% 100%
A4HXR8 Leishmania infantum 29% 100%
A4HYG7 Leishmania infantum 100% 100%
C9ZUG5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
C9ZZW0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
D0A051 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
E9AS87 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
E9AS88 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
O08564 Rattus norvegicus 26% 100%
O88956 Cavia porcellus 27% 100%
P60588 Sus scrofa 26% 100%
Q4QD76 Leishmania major 92% 100%
Q61469 Mus musculus 28% 100%
Q8K593 Rattus norvegicus 24% 100%
Q8LFD1 Arabidopsis thaliana 25% 100%
Q9UUA6 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 24% 100%
V5B5J9 Trypanosoma cruzi 39% 100%
V5BM01 Trypanosoma cruzi 32% 100%
V5BWA7 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS