A small protein consisting of 2+2 helical bundles, very conserved in Eukaryota. Might have an N-terminal transit signal.. Localization: Mitochondrial (by feature)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 16 |
| NetGPI | no | yes: 0, no: 16 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 17 |
| GO:0110165 | cellular anatomical entity | 1 | 17 |
| GO:0005794 | Golgi apparatus | 5 | 2 |
| GO:0043226 | organelle | 2 | 2 |
| GO:0043227 | membrane-bounded organelle | 3 | 2 |
| GO:0043229 | intracellular organelle | 3 | 2 |
| GO:0043231 | intracellular membrane-bounded organelle | 4 | 2 |
| GO:0005737 | cytoplasm | 2 | 1 |
Related structures:
AlphaFold database: A0A3Q8IK58
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_C14_Caspase3-7 | 85 | 89 | PF00656 | 0.436 |
| CLV_NRD_NRD_1 | 140 | 142 | PF00675 | 0.274 |
| CLV_NRD_NRD_1 | 186 | 188 | PF00675 | 0.334 |
| CLV_NRD_NRD_1 | 192 | 194 | PF00675 | 0.309 |
| CLV_NRD_NRD_1 | 22 | 24 | PF00675 | 0.241 |
| CLV_PCSK_KEX2_1 | 186 | 188 | PF00082 | 0.334 |
| CLV_PCSK_KEX2_1 | 194 | 196 | PF00082 | 0.293 |
| CLV_PCSK_PC1ET2_1 | 194 | 196 | PF00082 | 0.326 |
| CLV_PCSK_SKI1_1 | 121 | 125 | PF00082 | 0.225 |
| CLV_PCSK_SKI1_1 | 23 | 27 | PF00082 | 0.349 |
| CLV_Separin_Metazoa | 20 | 24 | PF03568 | 0.419 |
| DEG_APCC_DBOX_1 | 120 | 128 | PF00400 | 0.225 |
| DEG_Nend_Nbox_1 | 1 | 3 | PF02207 | 0.573 |
| DOC_MAPK_gen_1 | 98 | 107 | PF00069 | 0.567 |
| DOC_MAPK_MEF2A_6 | 121 | 128 | PF00069 | 0.326 |
| DOC_PP1_RVXF_1 | 119 | 126 | PF00149 | 0.236 |
| DOC_PP1_RVXF_1 | 24 | 31 | PF00149 | 0.419 |
| DOC_PP2B_LxvP_1 | 34 | 37 | PF13499 | 0.472 |
| DOC_USP7_MATH_1 | 182 | 186 | PF00917 | 0.508 |
| DOC_USP7_UBL2_3 | 153 | 157 | PF12436 | 0.550 |
| DOC_WW_Pin1_4 | 57 | 62 | PF00397 | 0.241 |
| LIG_Actin_RPEL_3 | 93 | 112 | PF02755 | 0.419 |
| LIG_FHA_1 | 49 | 55 | PF00498 | 0.307 |
| LIG_FHA_2 | 142 | 148 | PF00498 | 0.552 |
| LIG_LIR_Gen_1 | 11 | 21 | PF02991 | 0.592 |
| LIG_LIR_Gen_1 | 122 | 133 | PF02991 | 0.357 |
| LIG_LIR_Gen_1 | 40 | 50 | PF02991 | 0.504 |
| LIG_LIR_Gen_1 | 66 | 73 | PF02991 | 0.402 |
| LIG_LIR_Nem_3 | 11 | 16 | PF02991 | 0.502 |
| LIG_LIR_Nem_3 | 122 | 128 | PF02991 | 0.363 |
| LIG_LIR_Nem_3 | 40 | 46 | PF02991 | 0.501 |
| LIG_LIR_Nem_3 | 60 | 65 | PF02991 | 0.264 |
| LIG_LIR_Nem_3 | 66 | 70 | PF02991 | 0.354 |
| LIG_NRBOX | 101 | 107 | PF00104 | 0.408 |
| LIG_NRBOX | 119 | 125 | PF00104 | 0.194 |
| LIG_NRP_CendR_1 | 202 | 203 | PF00754 | 0.346 |
| LIG_Pex14_1 | 9 | 13 | PF04695 | 0.457 |
| LIG_Pex14_2 | 63 | 67 | PF04695 | 0.314 |
| LIG_PTB_Apo_2 | 56 | 63 | PF02174 | 0.366 |
| LIG_SH2_CRK | 99 | 103 | PF00017 | 0.456 |
| LIG_SH2_PTP2 | 43 | 46 | PF00017 | 0.309 |
| LIG_SH2_SRC | 172 | 175 | PF00017 | 0.603 |
| LIG_SH2_SRC | 43 | 46 | PF00017 | 0.265 |
| LIG_SH2_STAP1 | 161 | 165 | PF00017 | 0.507 |
| LIG_SH2_STAP1 | 39 | 43 | PF00017 | 0.495 |
| LIG_SH2_STAT5 | 145 | 148 | PF00017 | 0.579 |
| LIG_SH2_STAT5 | 172 | 175 | PF00017 | 0.579 |
| LIG_SH2_STAT5 | 43 | 46 | PF00017 | 0.312 |
| LIG_SH2_STAT5 | 48 | 51 | PF00017 | 0.316 |
| LIG_SH3_3 | 47 | 53 | PF00018 | 0.343 |
| LIG_SUMO_SIM_anti_2 | 66 | 72 | PF11976 | 0.381 |
| LIG_SUMO_SIM_anti_2 | 88 | 94 | PF11976 | 0.512 |
| LIG_SUMO_SIM_par_1 | 69 | 75 | PF11976 | 0.389 |
| LIG_TYR_ITIM | 97 | 102 | PF00017 | 0.455 |
| LIG_UBA3_1 | 72 | 81 | PF00899 | 0.304 |
| LIG_WRC_WIRS_1 | 64 | 69 | PF05994 | 0.251 |
| MOD_N-GLC_2 | 130 | 132 | PF02516 | 0.322 |
| MOD_NEK2_1 | 63 | 68 | PF00069 | 0.285 |
| MOD_PKA_1 | 141 | 147 | PF00069 | 0.521 |
| MOD_PKA_1 | 80 | 86 | PF00069 | 0.554 |
| MOD_Plk_4 | 141 | 147 | PF00069 | 0.577 |
| MOD_Plk_4 | 63 | 69 | PF00069 | 0.369 |
| MOD_Plk_4 | 86 | 92 | PF00069 | 0.553 |
| MOD_ProDKin_1 | 57 | 63 | PF00069 | 0.241 |
| MOD_SUMO_rev_2 | 190 | 196 | PF00179 | 0.528 |
| TRG_DiLeu_BaLyEn_6 | 50 | 55 | PF01217 | 0.265 |
| TRG_ENDOCYTIC_2 | 43 | 46 | PF00928 | 0.304 |
| TRG_ENDOCYTIC_2 | 99 | 102 | PF00928 | 0.472 |
| TRG_ER_diArg_1 | 193 | 196 | PF00400 | 0.530 |
| TRG_NLS_MonoExtC_3 | 79 | 85 | PF00514 | 0.419 |
| TRG_NLS_MonoExtN_4 | 77 | 84 | PF00514 | 0.511 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0S4JEM7 | Bodo saltans | 25% | 97% |
| A0A1X0P0Z7 | Trypanosomatidae | 27% | 96% |
| A0A1X0P100 | Trypanosomatidae | 45% | 76% |
| A0A3R7ML24 | Trypanosoma rangeli | 27% | 99% |
| A0A3S7X6T0 | Leishmania donovani | 26% | 100% |
| A0A422NG43 | Trypanosoma rangeli | 44% | 68% |
| A4HLL2 | Leishmania braziliensis | 82% | 100% |
| A4HLL3 | Leishmania braziliensis | 26% | 89% |
| A4I924 | Leishmania infantum | 26% | 100% |
| D0A526 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 33% | 89% |
| E9AHN5 | Leishmania infantum | 100% | 100% |
| E9B3Y8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 95% | 100% |
| E9B3Y9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 26% | 100% |
| Q4Q435 | Leishmania major | 26% | 100% |
| Q4Q436 | Leishmania major | 91% | 100% |