AP complex subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

beta adaptin, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IK57_LEIDO

TriTrypDb:

LdBPK_367080.1 , LdCL_360083400 , LDHU3_36.9450

Length:

746

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0030117	membrane coat	3	10
GO:0032991	protein-containing complex	1	12
GO:0098796	membrane protein complex	2	12
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0030119	AP-type membrane coat adaptor complex	3	2
GO:0030131	clathrin adaptor complex	4	2

Expansion

Sequence features

A0A3Q8IK57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IK57

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0016192	vesicle-mediated transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0005515	protein binding	2	8
GO:0030276	clathrin binding	3	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	334	338	PF00656	0.361
CLV_C14_Caspase3-7	569	573	PF00656	0.491
CLV_C14_Caspase3-7	634	638	PF00656	0.712
CLV_NRD_NRD_1	13	15	PF00675	0.522
CLV_NRD_NRD_1	146	148	PF00675	0.319
CLV_NRD_NRD_1	156	158	PF00675	0.286
CLV_NRD_NRD_1	30	32	PF00675	0.369
CLV_NRD_NRD_1	416	418	PF00675	0.370
CLV_NRD_NRD_1	432	434	PF00675	0.202
CLV_NRD_NRD_1	47	49	PF00675	0.343
CLV_NRD_NRD_1	5	7	PF00675	0.504
CLV_PCSK_KEX2_1	146	148	PF00082	0.343
CLV_PCSK_KEX2_1	30	32	PF00082	0.574
CLV_PCSK_KEX2_1	308	310	PF00082	0.400
CLV_PCSK_KEX2_1	416	418	PF00082	0.299
CLV_PCSK_KEX2_1	54	56	PF00082	0.307
CLV_PCSK_PC1ET2_1	308	310	PF00082	0.416
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.307
CLV_PCSK_SKI1_1	102	106	PF00082	0.429
CLV_PCSK_SKI1_1	355	359	PF00082	0.294
CLV_PCSK_SKI1_1	504	508	PF00082	0.308
CLV_PCSK_SKI1_1	546	550	PF00082	0.577
CLV_Separin_Metazoa	143	147	PF03568	0.324
CLV_Separin_Metazoa	387	391	PF03568	0.385
DEG_APCC_DBOX_1	492	500	PF00400	0.429
DEG_Nend_UBRbox_2	1	3	PF02207	0.545
DOC_CKS1_1	360	365	PF01111	0.324
DOC_CKS1_1	622	627	PF01111	0.732
DOC_CYCLIN_RxL_1	350	362	PF00134	0.324
DOC_CYCLIN_RxL_1	97	109	PF00134	0.454
DOC_MAPK_DCC_7	342	351	PF00069	0.308
DOC_MAPK_gen_1	157	164	PF00069	0.337
DOC_MAPK_gen_1	181	187	PF00069	0.429
DOC_MAPK_gen_1	350	360	PF00069	0.308
DOC_MAPK_gen_1	433	441	PF00069	0.308
DOC_MAPK_gen_1	85	92	PF00069	0.308
DOC_MAPK_HePTP_8	316	328	PF00069	0.308
DOC_MAPK_MEF2A_6	127	134	PF00069	0.308
DOC_MAPK_MEF2A_6	319	328	PF00069	0.308
DOC_MAPK_MEF2A_6	342	351	PF00069	0.308
DOC_MAPK_MEF2A_6	353	360	PF00069	0.308
DOC_MAPK_MEF2A_6	390	399	PF00069	0.312
DOC_MAPK_MEF2A_6	433	440	PF00069	0.343
DOC_MAPK_MEF2A_6	64	73	PF00069	0.393
DOC_MAPK_MEF2A_6	85	92	PF00069	0.351
DOC_MAPK_NFAT4_5	353	361	PF00069	0.308
DOC_MAPK_RevD_3	71	86	PF00069	0.308
DOC_PP4_FxxP_1	590	593	PF00568	0.432
DOC_PP4_FxxP_1	597	600	PF00568	0.456
DOC_USP7_MATH_1	361	365	PF00917	0.372
DOC_USP7_MATH_1	391	395	PF00917	0.416
DOC_USP7_MATH_1	458	462	PF00917	0.308
DOC_USP7_MATH_1	593	597	PF00917	0.430
DOC_USP7_MATH_1	623	627	PF00917	0.727
DOC_USP7_MATH_1	658	662	PF00917	0.677
DOC_USP7_MATH_1	678	682	PF00917	0.413
DOC_USP7_MATH_1	693	697	PF00917	0.596
DOC_USP7_UBL2_3	20	24	PF12436	0.610
DOC_USP7_UBL2_3	50	54	PF12436	0.311
DOC_WW_Pin1_4	115	120	PF00397	0.308
DOC_WW_Pin1_4	359	364	PF00397	0.324
DOC_WW_Pin1_4	621	626	PF00397	0.671
DOC_WW_Pin1_4	676	681	PF00397	0.648
DOC_WW_Pin1_4	684	689	PF00397	0.705
DOC_WW_Pin1_4	698	703	PF00397	0.699
LIG_14-3-3_CanoR_1	133	138	PF00244	0.446
LIG_14-3-3_CanoR_1	157	164	PF00244	0.329
LIG_14-3-3_CanoR_1	286	292	PF00244	0.352
LIG_14-3-3_CanoR_1	294	298	PF00244	0.321
LIG_14-3-3_CanoR_1	342	346	PF00244	0.316
LIG_14-3-3_CanoR_1	390	396	PF00244	0.361
LIG_14-3-3_CanoR_1	592	598	PF00244	0.508
LIG_Actin_WH2_2	130	148	PF00022	0.324
LIG_Actin_WH2_2	344	361	PF00022	0.454
LIG_Actin_WH2_2	567	582	PF00022	0.471
LIG_AP2alpha_1	672	676	PF02296	0.665
LIG_AP2alpha_2	670	672	PF02296	0.638
LIG_BRCT_BRCA1_1	22	26	PF00533	0.489
LIG_BRCT_BRCA1_1	66	70	PF00533	0.324
LIG_BRCT_BRCA1_1	686	690	PF00533	0.777
LIG_Clathr_ClatBox_1	438	442	PF01394	0.393
LIG_FHA_1	257	263	PF00498	0.393
LIG_FHA_1	294	300	PF00498	0.381
LIG_FHA_1	311	317	PF00498	0.204
LIG_FHA_1	360	366	PF00498	0.461
LIG_FHA_1	583	589	PF00498	0.413
LIG_FHA_1	93	99	PF00498	0.429
LIG_FHA_2	332	338	PF00498	0.423
LIG_FHA_2	484	490	PF00498	0.415
LIG_FHA_2	524	530	PF00498	0.345
LIG_FHA_2	567	573	PF00498	0.506
LIG_FHA_2	611	617	PF00498	0.728
LIG_FHA_2	78	84	PF00498	0.393
LIG_LIR_Apic_2	596	600	PF02991	0.469
LIG_LIR_Gen_1	345	356	PF02991	0.343
LIG_LIR_Gen_1	468	473	PF02991	0.308
LIG_LIR_Gen_1	644	651	PF02991	0.731
LIG_LIR_Gen_1	65	76	PF02991	0.297
LIG_LIR_Nem_3	337	343	PF02991	0.309
LIG_LIR_Nem_3	345	351	PF02991	0.310
LIG_LIR_Nem_3	468	472	PF02991	0.308
LIG_LIR_Nem_3	644	649	PF02991	0.682
LIG_LIR_Nem_3	65	71	PF02991	0.314
LIG_LIR_Nem_3	670	675	PF02991	0.667
LIG_LYPXL_SIV_4	600	608	PF13949	0.629
LIG_LYPXL_yS_3	435	438	PF13949	0.311
LIG_MAD2	555	563	PF02301	0.567
LIG_MLH1_MIPbox_1	22	26	PF16413	0.498
LIG_MYND_1	418	422	PF01753	0.324
LIG_NRBOX	183	189	PF00104	0.324
LIG_NRBOX	353	359	PF00104	0.324
LIG_NRBOX	516	522	PF00104	0.374
LIG_Pex14_1	234	238	PF04695	0.365
LIG_Pex14_2	672	676	PF04695	0.665
LIG_RPA_C_Fungi	26	38	PF08784	0.398
LIG_SH2_NCK_1	343	347	PF00017	0.454
LIG_SH2_SRC	89	92	PF00017	0.299
LIG_SH2_STAT3	25	28	PF00017	0.623
LIG_SH2_STAT5	140	143	PF00017	0.308
LIG_SH2_STAT5	155	158	PF00017	0.308
LIG_SH2_STAT5	238	241	PF00017	0.421
LIG_SH2_STAT5	25	28	PF00017	0.606
LIG_SH2_STAT5	315	318	PF00017	0.308
LIG_SH2_STAT5	340	343	PF00017	0.309
LIG_SH2_STAT5	469	472	PF00017	0.400
LIG_SH2_STAT5	68	71	PF00017	0.365
LIG_SH2_STAT5	89	92	PF00017	0.308
LIG_SH3_3	146	152	PF00018	0.365
LIG_SH3_3	323	329	PF00018	0.308
LIG_SH3_3	616	622	PF00018	0.692
LIG_SH3_3	696	702	PF00018	0.759
LIG_SH3_3	721	727	PF00018	0.604
LIG_SUMO_SIM_anti_2	183	190	PF11976	0.397
LIG_SUMO_SIM_par_1	103	109	PF11976	0.427
LIG_SUMO_SIM_par_1	437	442	PF11976	0.316
LIG_TRFH_1	140	144	PF08558	0.324
LIG_TYR_ITIM	66	71	PF00017	0.429
LIG_TYR_ITIM	87	92	PF00017	0.308
LIG_UBA3_1	303	308	PF00899	0.374
LIG_WRC_WIRS_1	107	112	PF05994	0.308
LIG_WRC_WIRS_1	594	599	PF05994	0.431
MOD_CDK_SPxxK_3	115	122	PF00069	0.308
MOD_CK1_1	253	259	PF00069	0.366
MOD_CK1_1	285	291	PF00069	0.361
MOD_CK1_1	582	588	PF00069	0.456
MOD_CK1_1	626	632	PF00069	0.674
MOD_CK1_1	679	685	PF00069	0.689
MOD_CK1_1	701	707	PF00069	0.694
MOD_CK2_1	133	139	PF00069	0.343
MOD_CK2_1	213	219	PF00069	0.429
MOD_CK2_1	246	252	PF00069	0.378
MOD_CK2_1	483	489	PF00069	0.397
MOD_CK2_1	704	710	PF00069	0.777
MOD_CK2_1	77	83	PF00069	0.393
MOD_GlcNHglycan	252	255	PF01048	0.365
MOD_GlcNHglycan	377	380	PF01048	0.403
MOD_GlcNHglycan	499	502	PF01048	0.308
MOD_GlcNHglycan	633	636	PF01048	0.722
MOD_GlcNHglycan	660	663	PF01048	0.697
MOD_GlcNHglycan	676	679	PF01048	0.565
MOD_GlcNHglycan	693	696	PF01048	0.676
MOD_GlcNHglycan	706	709	PF01048	0.607
MOD_GlcNHglycan	718	721	PF01048	0.613
MOD_GlcNHglycan	728	731	PF01048	0.750
MOD_GlcNHglycan	733	736	PF01048	0.697
MOD_GSK3_1	111	118	PF00069	0.324
MOD_GSK3_1	16	23	PF00069	0.538
MOD_GSK3_1	246	253	PF00069	0.402
MOD_GSK3_1	298	305	PF00069	0.315
MOD_GSK3_1	542	549	PF00069	0.398
MOD_GSK3_1	568	575	PF00069	0.497
MOD_GSK3_1	674	681	PF00069	0.652
MOD_GSK3_1	716	723	PF00069	0.730
MOD_N-GLC_1	115	120	PF02516	0.331
MOD_N-GLC_1	41	46	PF02516	0.393
MOD_N-GLC_1	58	63	PF02516	0.393
MOD_NEK2_1	111	116	PF00069	0.324
MOD_NEK2_1	16	21	PF00069	0.551
MOD_NEK2_1	26	31	PF00069	0.484
MOD_NEK2_1	331	336	PF00069	0.385
MOD_NEK2_1	483	488	PF00069	0.433
MOD_NEK2_1	520	525	PF00069	0.190
MOD_NEK2_1	579	584	PF00069	0.402
MOD_PIKK_1	285	291	PF00454	0.416
MOD_PIKK_1	310	316	PF00454	0.343
MOD_PIKK_1	626	632	PF00454	0.767
MOD_PIKK_1	693	699	PF00454	0.778
MOD_PIKK_1	718	724	PF00454	0.733
MOD_PIKK_1	736	742	PF00454	0.769
MOD_PK_1	133	139	PF00069	0.343
MOD_PKA_2	132	138	PF00069	0.372
MOD_PKA_2	156	162	PF00069	0.324
MOD_PKA_2	246	252	PF00069	0.398
MOD_PKA_2	285	291	PF00069	0.386
MOD_PKA_2	293	299	PF00069	0.403
MOD_PKA_2	341	347	PF00069	0.322
MOD_PKA_2	736	742	PF00069	0.769
MOD_Plk_1	138	144	PF00069	0.308
MOD_Plk_1	566	572	PF00069	0.501
MOD_Plk_1	58	64	PF00069	0.341
MOD_Plk_2-3	509	515	PF00069	0.385
MOD_Plk_2-3	572	578	PF00069	0.458
MOD_Plk_2-3	610	616	PF00069	0.651
MOD_Plk_4	106	112	PF00069	0.301
MOD_Plk_4	133	139	PF00069	0.423
MOD_Plk_4	253	259	PF00069	0.373
MOD_Plk_4	458	464	PF00069	0.345
MOD_Plk_4	483	489	PF00069	0.392
MOD_Plk_4	593	599	PF00069	0.440
MOD_Plk_4	64	70	PF00069	0.365
MOD_ProDKin_1	115	121	PF00069	0.308
MOD_ProDKin_1	359	365	PF00069	0.324
MOD_ProDKin_1	621	627	PF00069	0.672
MOD_ProDKin_1	676	682	PF00069	0.650
MOD_ProDKin_1	684	690	PF00069	0.709
MOD_ProDKin_1	698	704	PF00069	0.701
MOD_SUMO_for_1	349	352	PF00179	0.308
MOD_SUMO_rev_2	17	21	PF00179	0.652
MOD_SUMO_rev_2	451	461	PF00179	0.309
MOD_SUMO_rev_2	572	582	PF00179	0.469
MOD_SUMO_rev_2	79	87	PF00179	0.429
TRG_AP2beta_CARGO_1	345	355	PF09066	0.454
TRG_DiLeu_BaEn_1	352	357	PF01217	0.308
TRG_DiLeu_BaEn_1	83	88	PF01217	0.308
TRG_DiLeu_BaEn_2	467	473	PF01217	0.308
TRG_DiLeu_BaLyEn_6	516	521	PF01217	0.283
TRG_DiLeu_BaLyEn_6	539	544	PF01217	0.308
TRG_DiLeu_LyEn_5	352	357	PF01217	0.324
TRG_ENDOCYTIC_2	435	438	PF00928	0.299
TRG_ENDOCYTIC_2	469	472	PF00928	0.429
TRG_ENDOCYTIC_2	540	543	PF00928	0.298
TRG_ENDOCYTIC_2	594	597	PF00928	0.433
TRG_ENDOCYTIC_2	643	646	PF00928	0.754
TRG_ENDOCYTIC_2	68	71	PF00928	0.365
TRG_ENDOCYTIC_2	89	92	PF00928	0.303
TRG_ER_diArg_1	145	147	PF00400	0.343
TRG_ER_diArg_1	416	418	PF00400	0.374
TRG_ER_diArg_1	640	643	PF00400	0.517
TRG_NES_CRM1_1	495	509	PF08389	0.404
TRG_NLS_Bipartite_1	30	52	PF00514	0.429
TRG_Pf-PMV_PEXEL_1	14	18	PF00026	0.606
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	371	375	PF00026	0.244

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7B0	Leptomonas seymouri	82%	100%
A0A0N1IC81	Leptomonas seymouri	27%	96%
A0A0S4IS43	Bodo saltans	32%	79%
A0A0S4J8G3	Bodo saltans	27%	100%
A0A0S4JSJ9	Bodo saltans	56%	76%
A0A0S4KGY6	Bodo saltans	25%	87%
A0A1X0NL72	Trypanosomatidae	60%	77%
A0A1X0NUY1	Trypanosomatidae	31%	81%
A0A1X0P0E5	Trypanosomatidae	27%	95%
A0A3Q8I939	Leishmania donovani	30%	75%
A0A3R7L5L0	Trypanosoma rangeli	30%	82%
A0A3S5IS14	Trypanosoma rangeli	59%	78%
A0A422NKG4	Trypanosoma rangeli	27%	96%
A4HQJ9	Leishmania braziliensis	87%	100%
A4HV08	Leishmania infantum	30%	75%
A4ICB7	Leishmania infantum	100%	100%
D0A3P8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
D0A442	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	97%
E9ANP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	75%
E9AUB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O00203	Homo sapiens	25%	68%
O13939	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
O35643	Mus musculus	38%	79%
O43005	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
O43079	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
O81742	Arabidopsis thaliana	37%	84%
P27351	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
P36000	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
P46682	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	92%
P52303	Rattus norvegicus	38%	79%
P62944	Rattus norvegicus	36%	80%
P63009	Bos taurus	36%	80%
P63010	Homo sapiens	36%	80%
Q08DS7	Bos taurus	36%	78%
Q10567	Homo sapiens	35%	79%
Q13367	Homo sapiens	27%	69%
Q22498	Caenorhabditis elegans	20%	86%
Q32PG1	Bos taurus	25%	69%
Q4Q078	Leishmania major	96%	100%
Q4QGY0	Leishmania major	30%	75%
Q54R84	Dictyostelium discoideum	27%	89%
Q54X82	Dictyostelium discoideum	37%	79%
Q759E2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	24%	96%
Q7YRF1	Canis lupus familiaris	25%	68%
Q9DBG3	Mus musculus	36%	80%
Q9JME5	Mus musculus	26%	69%
Q9LDK9	Arabidopsis thaliana	28%	89%
Q9SUS3	Arabidopsis thaliana	38%	83%
Q9WV76	Mus musculus	29%	100%
Q9Y6B7	Homo sapiens	29%	100%
Q9Z1T1	Mus musculus	25%	68%
V5BRU9	Trypanosoma cruzi	31%	82%
V5BTB0	Trypanosoma cruzi	26%	96%
V5DDV1	Trypanosoma cruzi	63%	78%