MutS domain V family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA mismatch repair protein MSH6, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IK49_LEIDO

TriTrypDb:

LdBPK_362050.1 , LdCL_360026000 , LDHU3_36.2670

Length:

1014

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IK49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IK49

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006259	DNA metabolic process	4	11
GO:0006281	DNA repair	5	11
GO:0006298	mismatch repair	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0006950	response to stress	2	11
GO:0006974	DNA damage response	4	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0033554	cellular response to stress	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0046483	heterocycle metabolic process	3	11
GO:0050896	response to stimulus	1	11
GO:0051716	cellular response to stimulus	2	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0032042	mitochondrial DNA metabolic process	5	1
GO:0043504	mitochondrial DNA repair	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0003690	double-stranded DNA binding	5	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0008094	ATP-dependent activity, acting on DNA	2	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0030983	mismatched DNA binding	6	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140097	catalytic activity, acting on DNA	3	11
GO:0140299	small molecule sensor activity	1	11
GO:0140612	DNA damage sensor activity	2	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:0140657	ATP-dependent activity	1	11
GO:0140664	ATP-dependent DNA damage sensor activity	3	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	229	233	PF00656	0.434
CLV_NRD_NRD_1	192	194	PF00675	0.386
CLV_NRD_NRD_1	264	266	PF00675	0.466
CLV_NRD_NRD_1	411	413	PF00675	0.328
CLV_NRD_NRD_1	608	610	PF00675	0.330
CLV_PCSK_KEX2_1	192	194	PF00082	0.399
CLV_PCSK_KEX2_1	221	223	PF00082	0.629
CLV_PCSK_KEX2_1	264	266	PF00082	0.479
CLV_PCSK_KEX2_1	411	413	PF00082	0.240
CLV_PCSK_KEX2_1	459	461	PF00082	0.240
CLV_PCSK_KEX2_1	563	565	PF00082	0.330
CLV_PCSK_KEX2_1	608	610	PF00082	0.330
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.629
CLV_PCSK_PC1ET2_1	459	461	PF00082	0.240
CLV_PCSK_PC1ET2_1	563	565	PF00082	0.330
CLV_PCSK_SKI1_1	165	169	PF00082	0.461
CLV_PCSK_SKI1_1	205	209	PF00082	0.656
CLV_PCSK_SKI1_1	265	269	PF00082	0.475
CLV_PCSK_SKI1_1	411	415	PF00082	0.278
CLV_PCSK_SKI1_1	527	531	PF00082	0.337
CLV_PCSK_SKI1_1	628	632	PF00082	0.321
CLV_PCSK_SKI1_1	653	657	PF00082	0.272
CLV_PCSK_SKI1_1	673	677	PF00082	0.128
CLV_PCSK_SKI1_1	771	775	PF00082	0.406
CLV_PCSK_SKI1_1	815	819	PF00082	0.244
CLV_PCSK_SKI1_1	86	90	PF00082	0.295
CLV_PCSK_SKI1_1	903	907	PF00082	0.330
DEG_ODPH_VHL_1	172	183	PF01847	0.494
DEG_SCF_TRCP1_1	342	348	PF00400	0.652
DEG_SPOP_SBC_1	584	588	PF00917	0.528
DOC_ANK_TNKS_1	943	950	PF00023	0.459
DOC_CKS1_1	149	154	PF01111	0.440
DOC_CYCLIN_yClb5_NLxxxL_5	438	447	PF00134	0.530
DOC_CYCLIN_yClb5_NLxxxL_5	506	513	PF00134	0.528
DOC_CYCLIN_yCln2_LP_2	799	805	PF00134	0.530
DOC_MAPK_FxFP_2	15	18	PF00069	0.551
DOC_MAPK_gen_1	459	469	PF00069	0.530
DOC_MAPK_gen_1	506	513	PF00069	0.469
DOC_MAPK_gen_1	53	62	PF00069	0.454
DOC_MAPK_MEF2A_6	506	513	PF00069	0.491
DOC_MAPK_MEF2A_6	55	63	PF00069	0.472
DOC_MAPK_MEF2A_6	628	637	PF00069	0.455
DOC_MAPK_MEF2A_6	788	796	PF00069	0.454
DOC_MAPK_MEF2A_6	828	837	PF00069	0.440
DOC_MAPK_MEF2A_6	968	976	PF00069	0.454
DOC_PP2B_LxvP_1	579	582	PF13499	0.530
DOC_PP4_FxxP_1	15	18	PF00568	0.551
DOC_USP7_MATH_1	103	107	PF00917	0.454
DOC_USP7_MATH_1	174	178	PF00917	0.439
DOC_USP7_MATH_1	213	217	PF00917	0.507
DOC_USP7_MATH_1	293	297	PF00917	0.530
DOC_USP7_MATH_1	378	382	PF00917	0.475
DOC_USP7_MATH_1	421	425	PF00917	0.496
DOC_USP7_MATH_1	558	562	PF00917	0.446
DOC_USP7_MATH_1	574	578	PF00917	0.420
DOC_USP7_MATH_1	584	588	PF00917	0.429
DOC_USP7_MATH_1	781	785	PF00917	0.440
DOC_WW_Pin1_4	148	153	PF00397	0.466
DOC_WW_Pin1_4	580	585	PF00397	0.501
DOC_WW_Pin1_4	641	646	PF00397	0.530
DOC_WW_Pin1_4	808	813	PF00397	0.528
DOC_WW_Pin1_4	905	910	PF00397	0.522
LIG_14-3-3_CanoR_1	236	245	PF00244	0.474
LIG_14-3-3_CanoR_1	412	418	PF00244	0.445
LIG_14-3-3_CanoR_1	420	428	PF00244	0.432
LIG_14-3-3_CanoR_1	653	659	PF00244	0.443
LIG_14-3-3_CanoR_1	700	708	PF00244	0.492
LIG_14-3-3_CanoR_1	731	740	PF00244	0.486
LIG_14-3-3_CanoR_1	860	870	PF00244	0.450
LIG_14-3-3_CanoR_1	903	909	PF00244	0.475
LIG_14-3-3_CanoR_1	942	947	PF00244	0.399
LIG_BRCT_BRCA1_1	11	15	PF00533	0.512
LIG_BRCT_BRCA1_1	280	284	PF00533	0.505
LIG_BRCT_BRCA1_1	471	475	PF00533	0.480
LIG_BRCT_BRCA1_1	942	946	PF00533	0.529
LIG_Clathr_ClatBox_1	630	634	PF01394	0.495
LIG_CtBP_PxDLS_1	777	783	PF00389	0.440
LIG_deltaCOP1_diTrp_1	109	114	PF00928	0.440
LIG_FHA_1	29	35	PF00498	0.476
LIG_FHA_1	330	336	PF00498	0.378
LIG_FHA_1	592	598	PF00498	0.458
LIG_FHA_1	787	793	PF00498	0.440
LIG_FHA_1	830	836	PF00498	0.440
LIG_FHA_1	838	844	PF00498	0.440
LIG_FHA_2	128	134	PF00498	0.399
LIG_FHA_2	152	158	PF00498	0.440
LIG_FHA_2	277	283	PF00498	0.441
LIG_FHA_2	325	331	PF00498	0.432
LIG_FHA_2	554	560	PF00498	0.530
LIG_FHA_2	669	675	PF00498	0.524
LIG_FHA_2	732	738	PF00498	0.567
LIG_FHA_2	804	810	PF00498	0.528
LIG_LIR_Apic_2	12	18	PF02991	0.552
LIG_LIR_Gen_1	1009	1014	PF02991	0.555
LIG_LIR_Gen_1	109	116	PF02991	0.442
LIG_LIR_Gen_1	311	319	PF02991	0.412
LIG_LIR_Gen_1	468	478	PF02991	0.461
LIG_LIR_Gen_1	54	63	PF02991	0.472
LIG_LIR_Gen_1	73	79	PF02991	0.472
LIG_LIR_Gen_1	814	825	PF02991	0.440
LIG_LIR_Gen_1	831	841	PF02991	0.440
LIG_LIR_Gen_1	891	902	PF02991	0.440
LIG_LIR_Nem_3	1009	1014	PF02991	0.555
LIG_LIR_Nem_3	109	113	PF02991	0.442
LIG_LIR_Nem_3	14	20	PF02991	0.415
LIG_LIR_Nem_3	311	316	PF02991	0.402
LIG_LIR_Nem_3	46	52	PF02991	0.440
LIG_LIR_Nem_3	468	473	PF02991	0.447
LIG_LIR_Nem_3	477	481	PF02991	0.454
LIG_LIR_Nem_3	54	60	PF02991	0.440
LIG_LIR_Nem_3	696	701	PF02991	0.483
LIG_LIR_Nem_3	726	732	PF02991	0.424
LIG_LIR_Nem_3	73	77	PF02991	0.472
LIG_LIR_Nem_3	814	820	PF02991	0.441
LIG_LIR_Nem_3	831	837	PF02991	0.440
LIG_LIR_Nem_3	891	897	PF02991	0.440
LIG_LRP6_Inhibitor_1	1007	1013	PF00058	0.393
LIG_LYPXL_SIV_4	589	597	PF13949	0.475
LIG_LYPXL_yS_3	17	20	PF13949	0.498
LIG_LYPXL_yS_3	729	732	PF13949	0.429
LIG_NRBOX	237	243	PF00104	0.424
LIG_NRBOX	547	553	PF00104	0.528
LIG_PDZ_Class_2	1009	1014	PF00595	0.588
LIG_Pex14_1	110	114	PF04695	0.440
LIG_Pex14_1	525	529	PF04695	0.528
LIG_Pex14_2	15	19	PF04695	0.496
LIG_Pex14_2	698	702	PF04695	0.528
LIG_Pex14_2	924	928	PF04695	0.399
LIG_PTAP_UEV_1	24	29	PF05743	0.552
LIG_PTB_Apo_2	77	84	PF02174	0.519
LIG_PTB_Apo_2	951	958	PF02174	0.483
LIG_Rb_pABgroove_1	563	571	PF01858	0.495
LIG_REV1ctd_RIR_1	60	69	PF16727	0.454
LIG_SH2_CRK	227	231	PF00017	0.408
LIG_SH2_CRK	441	445	PF00017	0.530
LIG_SH2_CRK	57	61	PF00017	0.491
LIG_SH2_CRK	74	78	PF00017	0.408
LIG_SH2_CRK	894	898	PF00017	0.440
LIG_SH2_CRK	959	963	PF00017	0.454
LIG_SH2_NCK_1	590	594	PF00017	0.394
LIG_SH2_PTP2	498	501	PF00017	0.528
LIG_SH2_PTP2	834	837	PF00017	0.454
LIG_SH2_SRC	38	41	PF00017	0.520
LIG_SH2_SRC	498	501	PF00017	0.528
LIG_SH2_STAP1	331	335	PF00017	0.424
LIG_SH2_STAP1	365	369	PF00017	0.530
LIG_SH2_STAP1	72	76	PF00017	0.451
LIG_SH2_STAT5	312	315	PF00017	0.326
LIG_SH2_STAT5	331	334	PF00017	0.420
LIG_SH2_STAT5	38	41	PF00017	0.570
LIG_SH2_STAT5	498	501	PF00017	0.528
LIG_SH2_STAT5	660	663	PF00017	0.472
LIG_SH2_STAT5	710	713	PF00017	0.471
LIG_SH2_STAT5	834	837	PF00017	0.454
LIG_SH3_3	146	152	PF00018	0.455
LIG_SH3_3	22	28	PF00018	0.440
LIG_SH3_3	724	730	PF00018	0.476
LIG_SH3_3	880	886	PF00018	0.472
LIG_SUMO_SIM_anti_2	145	151	PF11976	0.454
LIG_SUMO_SIM_anti_2	381	387	PF11976	0.440
LIG_SUMO_SIM_anti_2	739	744	PF11976	0.411
LIG_SUMO_SIM_anti_2	973	978	PF11976	0.454
LIG_SUMO_SIM_par_1	145	151	PF11976	0.454
LIG_SUMO_SIM_par_1	771	776	PF11976	0.350
LIG_SUMO_SIM_par_1	885	892	PF11976	0.440
LIG_TRAF2_1	430	433	PF00917	0.407
LIG_TRAF2_1	573	576	PF00917	0.528
LIG_TRAF2_1	935	938	PF00917	0.459
LIG_TYR_ITIM	727	732	PF00017	0.469
LIG_UBA3_1	241	248	PF00899	0.421
LIG_UBA3_1	748	756	PF00899	0.516
LIG_WRC_WIRS_1	312	317	PF05994	0.454
MOD_CDK_SPxxK_3	808	815	PF00069	0.528
MOD_CK1_1	159	165	PF00069	0.555
MOD_CK1_1	216	222	PF00069	0.673
MOD_CK1_1	30	36	PF00069	0.478
MOD_CK1_1	311	317	PF00069	0.481
MOD_CK1_1	326	332	PF00069	0.519
MOD_CK1_1	357	363	PF00069	0.460
MOD_CK1_1	422	428	PF00069	0.483
MOD_CK1_1	468	474	PF00069	0.469
MOD_CK1_1	483	489	PF00069	0.435
MOD_CK1_1	583	589	PF00069	0.494
MOD_CK1_1	689	695	PF00069	0.569
MOD_CK1_1	848	854	PF00069	0.551
MOD_CK1_1	950	956	PF00069	0.500
MOD_CK1_1	996	1002	PF00069	0.580
MOD_CK2_1	103	109	PF00069	0.440
MOD_CK2_1	127	133	PF00069	0.483
MOD_CK2_1	174	180	PF00069	0.335
MOD_CK2_1	276	282	PF00069	0.513
MOD_CK2_1	324	330	PF00069	0.404
MOD_CK2_1	378	384	PF00069	0.454
MOD_CK2_1	394	400	PF00069	0.454
MOD_CK2_1	553	559	PF00069	0.530
MOD_CK2_1	660	666	PF00069	0.493
MOD_CK2_1	668	674	PF00069	0.499
MOD_CK2_1	731	737	PF00069	0.556
MOD_CK2_1	803	809	PF00069	0.503
MOD_Cter_Amidation	409	412	PF01082	0.240
MOD_GlcNHglycan	201	204	PF01048	0.535
MOD_GlcNHglycan	238	241	PF01048	0.474
MOD_GlcNHglycan	299	302	PF01048	0.638
MOD_GlcNHglycan	335	338	PF01048	0.542
MOD_GlcNHglycan	342	345	PF01048	0.601
MOD_GlcNHglycan	356	359	PF01048	0.600
MOD_GlcNHglycan	421	424	PF01048	0.274
MOD_GlcNHglycan	519	522	PF01048	0.317
MOD_GlcNHglycan	575	579	PF01048	0.247
MOD_GlcNHglycan	587	590	PF01048	0.232
MOD_GlcNHglycan	702	705	PF01048	0.334
MOD_GlcNHglycan	845	848	PF01048	0.328
MOD_GSK3_1	212	219	PF00069	0.678
MOD_GSK3_1	226	233	PF00069	0.404
MOD_GSK3_1	23	30	PF00069	0.551
MOD_GSK3_1	252	259	PF00069	0.495
MOD_GSK3_1	278	285	PF00069	0.487
MOD_GSK3_1	289	296	PF00069	0.450
MOD_GSK3_1	297	304	PF00069	0.515
MOD_GSK3_1	329	336	PF00069	0.430
MOD_GSK3_1	354	361	PF00069	0.558
MOD_GSK3_1	390	397	PF00069	0.475
MOD_GSK3_1	465	472	PF00069	0.528
MOD_GSK3_1	554	561	PF00069	0.504
MOD_GSK3_1	580	587	PF00069	0.449
MOD_GSK3_1	682	689	PF00069	0.521
MOD_GSK3_1	702	709	PF00069	0.333
MOD_GSK3_1	782	789	PF00069	0.440
MOD_GSK3_1	885	892	PF00069	0.519
MOD_GSK3_1	9	16	PF00069	0.579
MOD_GSK3_1	901	908	PF00069	0.399
MOD_GSK3_1	989	996	PF00069	0.509
MOD_N-GLC_1	490	495	PF02516	0.276
MOD_N-GLC_1	761	766	PF02516	0.322
MOD_N-GLC_2	399	401	PF02516	0.254
MOD_N-GLC_2	403	405	PF02516	0.226
MOD_NEK2_1	168	173	PF00069	0.383
MOD_NEK2_1	226	231	PF00069	0.538
MOD_NEK2_1	297	302	PF00069	0.613
MOD_NEK2_1	413	418	PF00069	0.462
MOD_NEK2_1	443	448	PF00069	0.506
MOD_NEK2_1	469	474	PF00069	0.517
MOD_NEK2_1	668	673	PF00069	0.574
MOD_NEK2_1	702	707	PF00069	0.525
MOD_NEK2_1	773	778	PF00069	0.305
MOD_NEK2_1	786	791	PF00069	0.421
MOD_NEK2_1	89	94	PF00069	0.498
MOD_NEK2_2	829	834	PF00069	0.454
MOD_NEK2_2	871	876	PF00069	0.495
MOD_PIKK_1	490	496	PF00454	0.484
MOD_PKA_2	403	409	PF00069	0.506
MOD_PKA_2	419	425	PF00069	0.328
MOD_PKA_2	483	489	PF00069	0.510
MOD_PKA_2	859	865	PF00069	0.440
MOD_PKA_2	996	1002	PF00069	0.580
MOD_Plk_1	103	109	PF00069	0.440
MOD_Plk_1	216	222	PF00069	0.660
MOD_Plk_1	231	237	PF00069	0.374
MOD_Plk_1	673	679	PF00069	0.530
MOD_Plk_1	761	767	PF00069	0.425
MOD_Plk_2-3	282	288	PF00069	0.455
MOD_Plk_2-3	394	400	PF00069	0.528
MOD_Plk_4	156	162	PF00069	0.603
MOD_Plk_4	308	314	PF00069	0.439
MOD_Plk_4	347	353	PF00069	0.601
MOD_Plk_4	358	364	PF00069	0.422
MOD_Plk_4	465	471	PF00069	0.501
MOD_Plk_4	682	688	PF00069	0.514
MOD_Plk_4	706	712	PF00069	0.454
MOD_Plk_4	782	788	PF00069	0.440
MOD_Plk_4	829	835	PF00069	0.440
MOD_Plk_4	885	891	PF00069	0.517
MOD_Plk_4	980	986	PF00069	0.500
MOD_ProDKin_1	148	154	PF00069	0.466
MOD_ProDKin_1	580	586	PF00069	0.501
MOD_ProDKin_1	641	647	PF00069	0.530
MOD_ProDKin_1	808	814	PF00069	0.528
MOD_ProDKin_1	905	911	PF00069	0.522
MOD_SUMO_for_1	220	223	PF00179	0.650
MOD_SUMO_for_1	926	929	PF00179	0.528
MOD_SUMO_for_1	990	993	PF00179	0.530
MOD_SUMO_rev_2	202	209	PF00179	0.538
MOD_SUMO_rev_2	46	54	PF00179	0.454
TRG_DiLeu_BaEn_1	575	580	PF01217	0.530
TRG_DiLeu_BaEn_1	769	774	PF01217	0.465
TRG_DiLeu_BaEn_2	432	438	PF01217	0.409
TRG_DiLeu_BaLyEn_6	748	753	PF01217	0.471
TRG_ENDOCYTIC_2	17	20	PF00928	0.374
TRG_ENDOCYTIC_2	227	230	PF00928	0.413
TRG_ENDOCYTIC_2	312	315	PF00928	0.418
TRG_ENDOCYTIC_2	441	444	PF00928	0.530
TRG_ENDOCYTIC_2	49	52	PF00928	0.454
TRG_ENDOCYTIC_2	57	60	PF00928	0.454
TRG_ENDOCYTIC_2	729	732	PF00928	0.429
TRG_ENDOCYTIC_2	74	77	PF00928	0.404
TRG_ENDOCYTIC_2	834	837	PF00928	0.454
TRG_ENDOCYTIC_2	894	897	PF00928	0.440
TRG_ENDOCYTIC_2	921	924	PF00928	0.440
TRG_ENDOCYTIC_2	959	962	PF00928	0.454
TRG_ER_diArg_1	192	194	PF00400	0.410
TRG_ER_diArg_1	411	413	PF00400	0.528
TRG_ER_diArg_1	607	609	PF00400	0.530
TRG_NES_CRM1_1	307	321	PF08389	0.475
TRG_NES_CRM1_1	465	479	PF08389	0.530
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.240
TRG_Pf-PMV_PEXEL_1	609	613	PF00026	0.306

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6K5	Leptomonas seymouri	66%	98%
A0A0S4IMQ7	Bodo saltans	40%	100%
A0A0S4J224	Bodo saltans	26%	100%
A0A3R7LRN7	Trypanosoma rangeli	47%	100%
A0L7L5	Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1)	28%	100%
A0LG76	Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)	26%	100%
A0Q809	Francisella tularensis subsp. novicida (strain U112)	22%	100%
A1DCB2	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	26%	91%
A1K764	Azoarcus sp. (strain BH72)	25%	100%
A1R0M2	Borrelia turicatae (strain 91E135)	25%	100%
A1U2E8	Marinobacter nauticus (strain ATCC 700491 / DSM 11845 / VT8)	25%	100%
A1UU95	Bartonella bacilliformis (strain ATCC 35685 / NCTC 12138 / KC583)	25%	100%
A3PNR5	Cereibacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)	26%	100%
A4HL76	Leishmania braziliensis	26%	100%
A4HP61	Leishmania braziliensis	85%	100%
A4IDG7	Leishmania infantum	100%	100%
A4IXL2	Francisella tularensis subsp. tularensis (strain WY96-3418)	22%	100%
A4SFT1	Chlorobium phaeovibrioides (strain DSM 265 / 1930)	26%	100%
A5CDU2	Orientia tsutsugamushi (strain Boryong)	25%	100%
A5VN83	Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512)	25%	100%
A6LLR1	Thermosipho melanesiensis (strain DSM 12029 / CIP 104789 / BI429)	26%	100%
A6ZTR3	Saccharomyces cerevisiae (strain YJM789)	23%	100%
A7N9Y6	Francisella tularensis subsp. holarctica (strain FTNF002-00 / FTA)	22%	100%
A8F753	Pseudothermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / NBRC 107922 / TMO)	25%	100%
A8I275	Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / LMG 6465 / NBRC 14845 / NCIMB 13405 / ORS 571)	27%	100%
A8ZXH5	Desulfococcus oleovorans (strain DSM 6200 / JCM 39069 / Hxd3)	25%	100%
A9ILT1	Bartonella tribocorum (strain CIP 105476 / IBS 506)	25%	100%
A9KG24	Coxiella burnetii (strain Dugway 5J108-111)	24%	100%
A9KL10	Lachnoclostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg)	24%	100%
A9M792	Brucella canis (strain ATCC 23365 / NCTC 10854)	25%	100%
A9NCN3	Coxiella burnetii (strain RSA 331 / Henzerling II)	24%	100%
B0BRS8	Actinobacillus pleuropneumoniae serotype 3 (strain JL03)	25%	100%
B0CIQ5	Brucella suis (strain ATCC 23445 / NCTC 10510)	25%	100%
B0TX99	Francisella philomiragia subsp. philomiragia (strain ATCC 25017 / FSC 153 / O#319-036)	21%	100%
B0YCF6	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	26%	90%
B1N025	Leuconostoc citreum (strain KM20)	26%	100%
B2SEQ6	Francisella tularensis subsp. mediasiatica (strain FSC147)	22%	100%
B2V1M2	Clostridium botulinum (strain Alaska E43 / Type E3)	23%	100%
B3EEE1	Chlorobium limicola (strain DSM 245 / NBRC 103803 / 6330)	26%	100%
B3EP11	Chlorobium phaeobacteroides (strain BS1)	26%	100%
B3H2J9	Actinobacillus pleuropneumoniae serotype 7 (strain AP76)	25%	100%
B3QPY5	Chlorobaculum parvum (strain DSM 263 / NCIMB 8327)	27%	100%
B5EA63	Citrifermentans bemidjiense (strain ATCC BAA-1014 / DSM 16622 / JCM 12645 / Bem)	25%	100%
B7VK59	Vibrio atlanticus (strain LGP32)	26%	100%
B9K800	Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NBRC 107923 / NS-E)	25%	100%
C0R5H4	Wolbachia sp. subsp. Drosophila simulans (strain wRi)	24%	100%
C4K6P7	Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)	25%	100%
C6DZZ3	Geobacter sp. (strain M21)	26%	100%
D0A350	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E1BYJ2	Gallus gallus	27%	76%
E9ASW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O04716	Arabidopsis thaliana	29%	77%
O65607	Arabidopsis thaliana	29%	94%
O74502	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	81%
P13705	Mus musculus	26%	93%
P20585	Homo sapiens	25%	89%
P25336	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P26359	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
P43246	Homo sapiens	23%	100%
P43247	Mus musculus	23%	100%
P52701	Homo sapiens	28%	75%
P61669	Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)	25%	100%
P61670	Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)	27%	100%
P61672	Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)	26%	100%
P61673	Wolbachia pipientis wMel	23%	100%
Q03834	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	82%
Q0BNM7	Francisella tularensis subsp. holarctica (strain OSU18)	22%	100%
Q0BV38	Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)	27%	100%
Q0STR4	Clostridium perfringens (strain SM101 / Type A)	24%	100%
Q0TRD6	Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)	24%	100%
Q14GB1	Francisella tularensis subsp. tularensis (strain FSC 198)	22%	100%
Q1QE46	Psychrobacter cryohalolentis (strain ATCC BAA-1226 / DSM 17306 / VKM B-2378 / K5)	28%	98%
Q28VY6	Jannaschia sp. (strain CCS1)	27%	100%
Q2A5B5	Francisella tularensis subsp. holarctica (strain LVS)	22%	100%
Q2GG13	Ehrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas)	24%	100%
Q2JIA6	Synechococcus sp. (strain JA-2-3B'a(2-13))	26%	100%
Q2KD76	Rhizobium etli (strain CFN 42 / ATCC 51251)	25%	100%
Q2RNG0	Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1)	30%	100%
Q2YB94	Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71)	26%	100%
Q2YNZ0	Brucella abortus (strain 2308)	26%	100%
Q3IDC8	Pseudoalteromonas translucida (strain TAC 125)	25%	100%
Q3IYI5	Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.)	26%	100%
Q3M892	Trichormus variabilis (strain ATCC 29413 / PCC 7937)	25%	100%
Q3MHE4	Bos taurus	23%	100%
Q3YSJ8	Ehrlichia canis (strain Jake)	24%	100%
Q46CE2	Methanosarcina barkeri (strain Fusaro / DSM 804)	25%	100%
Q4Q1M8	Leishmania major	93%	100%
Q4Q4J6	Leishmania major	26%	100%
Q4WGB7	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	26%	90%
Q57FM9	Brucella abortus biovar 1 (strain 9-941)	26%	100%
Q5L7B7	Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow)	24%	100%
Q5NEV8	Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)	22%	100%
Q5QUB6	Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)	24%	100%
Q60BA1	Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)	26%	100%
Q64MG7	Bacteroides fragilis (strain YCH46)	24%	100%
Q6G542	Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1)	25%	100%
Q7MXR7	Porphyromonas gingivalis (strain ATCC BAA-308 / W83)	25%	100%
Q7NRW7	Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)	25%	100%
Q7W880	Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)	25%	100%
Q7WLT5	Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)	25%	100%
Q83CQ2	Coxiella burnetii (strain RSA 493 / Nine Mile phase I)	24%	100%
Q89VX1	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	26%	100%
Q8A334	Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50)	24%	100%
Q8F496	Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)	25%	100%
Q8G310	Brucella suis biovar 1 (strain 1330)	25%	100%
Q8KCC0	Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS)	27%	100%
Q8UIF2	Agrobacterium fabrum (strain C58 / ATCC 33970)	26%	100%
Q8XL87	Clostridium perfringens (strain 13 / Type A)	24%	100%
Q8YES6	Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)	25%	100%
Q98C21	Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)	25%	100%
V5DCH4	Trypanosoma cruzi	49%	100%