LeishMANIAdb
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Peptidase S24-like family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Peptidase S24-like family protein
Gene product:
mitochondrial inner membrane signal peptidase, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IK39_LEIDO
TriTrypDb:
LdBPK_360220.1 , LdCL_360007200 , LDHU3_36.0320
Length:
225

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0005743 mitochondrial inner membrane 5 1
GO:0016020 membrane 2 8
GO:0019866 organelle inner membrane 4 1
GO:0031090 organelle membrane 3 1
GO:0031966 mitochondrial membrane 4 1
GO:0032991 protein-containing complex 1 1
GO:0042720 mitochondrial inner membrane peptidase complex 3 1
GO:0098796 membrane protein complex 2 1
GO:0098798 mitochondrial protein-containing complex 2 1
GO:0098800 inner mitochondrial membrane protein complex 3 1
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Expansion

Sequence features

A0A3Q8IK39
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IK39

Function

Biological processes
TermNameLevelCount
GO:0006465 signal peptide processing 5 12
GO:0006508 proteolysis 4 12
GO:0006518 peptide metabolic process 4 12
GO:0006627 protein processing involved in protein targeting to mitochondrion 7 1
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0016485 protein processing 5 12
GO:0019538 protein metabolic process 3 12
GO:0034982 mitochondrial protein processing 6 1
GO:0043170 macromolecule metabolic process 3 12
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 12
GO:0004175 endopeptidase activity 4 12
GO:0004252 serine-type endopeptidase activity 5 12
GO:0008233 peptidase activity 3 12
GO:0008236 serine-type peptidase activity 4 12
GO:0016787 hydrolase activity 2 12
GO:0017171 serine hydrolase activity 3 12
GO:0140096 catalytic activity, acting on a protein 2 12
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 133 137 PF00656 0.352
CLV_NRD_NRD_1 187 189 PF00675 0.426
CLV_NRD_NRD_1 63 65 PF00675 0.426
CLV_PCSK_KEX2_1 187 189 PF00082 0.426
CLV_PCSK_KEX2_1 63 65 PF00082 0.426
CLV_PCSK_KEX2_1 89 91 PF00082 0.286
CLV_PCSK_PC1ET2_1 89 91 PF00082 0.286
CLV_PCSK_SKI1_1 90 94 PF00082 0.331
DEG_Nend_UBRbox_1 1 4 PF02207 0.418
DOC_CYCLIN_RxL_1 195 204 PF00134 0.380
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I5U2 Leptomonas seymouri 69% 100%
A0A0S4KL01 Bodo saltans 33% 100%
A0A1X0P9C8 Trypanosomatidae 44% 100%
A0A3R7N3L4 Trypanosoma rangeli 40% 100%
A4HNM8 Leishmania braziliensis 83% 100%
A4ICW7 Leishmania infantum 99% 100%
D0A2I2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E9ASD7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q258 Leishmania major 92% 100%
V5BA41 Trypanosoma cruzi 44% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS