Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IK37_LEIDO

TriTrypDb:

LdBPK_366190.1 , LdCL_360069300 , LDHU3_36.8200

Length:

292

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IK37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IK37

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	5
GO:0005488	binding	1	5
GO:0005515	protein binding	2	5
GO:0019905	syntaxin binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	279	283	PF00656	0.657
CLV_NRD_NRD_1	112	114	PF00675	0.574
CLV_NRD_NRD_1	158	160	PF00675	0.408
CLV_NRD_NRD_1	163	165	PF00675	0.427
CLV_NRD_NRD_1	235	237	PF00675	0.518
CLV_NRD_NRD_1	39	41	PF00675	0.559
CLV_NRD_NRD_1	81	83	PF00675	0.489
CLV_PCSK_KEX2_1	141	143	PF00082	0.490
CLV_PCSK_KEX2_1	158	160	PF00082	0.364
CLV_PCSK_KEX2_1	206	208	PF00082	0.505
CLV_PCSK_KEX2_1	234	236	PF00082	0.513
CLV_PCSK_KEX2_1	91	93	PF00082	0.588
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.490
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.531
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.588
CLV_PCSK_SKI1_1	114	118	PF00082	0.483
CLV_PCSK_SKI1_1	221	225	PF00082	0.564
CLV_PCSK_SKI1_1	236	240	PF00082	0.403
CLV_PCSK_SKI1_1	273	277	PF00082	0.660
CLV_PCSK_SKI1_1	49	53	PF00082	0.500
CLV_PCSK_SKI1_1	72	76	PF00082	0.612
CLV_Separin_Metazoa	231	235	PF03568	0.532
DOC_CYCLIN_RxL_1	14	24	PF00134	0.520
DOC_MAPK_gen_1	14	22	PF00069	0.568
DOC_SPAK_OSR1_1	194	198	PF12202	0.469
DOC_USP7_MATH_1	225	229	PF00917	0.551
DOC_USP7_MATH_1	237	241	PF00917	0.466
DOC_USP7_MATH_1	260	264	PF00917	0.573
DOC_USP7_UBL2_3	246	250	PF12436	0.428
DOC_WW_Pin1_4	157	162	PF00397	0.404
LIG_14-3-3_CanoR_1	142	149	PF00244	0.454
LIG_BIR_II_1	1	5	PF00653	0.516
LIG_FHA_1	158	164	PF00498	0.577
LIG_FHA_1	169	175	PF00498	0.464
LIG_FHA_1	218	224	PF00498	0.601
LIG_FHA_1	270	276	PF00498	0.514
LIG_FHA_2	167	173	PF00498	0.606
LIG_FHA_2	212	218	PF00498	0.498
LIG_FHA_2	274	280	PF00498	0.563
LIG_LIR_Gen_1	133	143	PF02991	0.469
LIG_LIR_Gen_1	267	275	PF02991	0.557
LIG_LIR_Nem_3	133	138	PF02991	0.500
LIG_LIR_Nem_3	267	271	PF02991	0.545
LIG_LIR_Nem_3	68	74	PF02991	0.558
LIG_PCNA_PIPBox_1	185	194	PF02747	0.421
LIG_PCNA_yPIPBox_3	178	192	PF02747	0.465
LIG_Pex14_2	191	195	PF04695	0.600
LIG_SH2_CRK	71	75	PF00017	0.554
LIG_SH2_NCK_1	209	213	PF00017	0.559
LIG_TRAF2_1	55	58	PF00917	0.531
LIG_WRC_WIRS_1	265	270	PF05994	0.452
MOD_CDK_SPxxK_3	157	164	PF00069	0.404
MOD_CK1_1	2	8	PF00069	0.581
MOD_CK1_1	211	217	PF00069	0.492
MOD_CK2_1	109	115	PF00069	0.480
MOD_CK2_1	127	133	PF00069	0.578
MOD_CK2_1	141	147	PF00069	0.479
MOD_CK2_1	166	172	PF00069	0.605
MOD_CK2_1	225	231	PF00069	0.475
MOD_CK2_1	237	243	PF00069	0.423
MOD_CK2_1	52	58	PF00069	0.524
MOD_GlcNHglycan	1	4	PF01048	0.510
MOD_GlcNHglycan	129	132	PF01048	0.635
MOD_GlcNHglycan	210	213	PF01048	0.491
MOD_GSK3_1	168	175	PF00069	0.574
MOD_GSK3_1	193	200	PF00069	0.467
MOD_GSK3_1	260	267	PF00069	0.618
MOD_GSK3_1	269	276	PF00069	0.574
MOD_GSK3_1	52	59	PF00069	0.521
MOD_N-GLC_1	269	274	PF02516	0.410
MOD_PIKK_1	197	203	PF00454	0.523
MOD_PIKK_1	260	266	PF00454	0.486
MOD_PIKK_1	285	291	PF00454	0.500
MOD_PK_1	52	58	PF00069	0.485
MOD_PKA_1	141	147	PF00069	0.581
MOD_PKA_2	141	147	PF00069	0.506
MOD_PKA_2	193	199	PF00069	0.502
MOD_PKA_2	217	223	PF00069	0.545
MOD_PKB_1	234	242	PF00069	0.557
MOD_ProDKin_1	157	163	PF00069	0.403
MOD_SUMO_rev_2	200	208	PF00179	0.440
MOD_SUMO_rev_2	28	33	PF00179	0.522
TRG_AP2beta_CARGO_1	133	142	PF09066	0.582
TRG_ENDOCYTIC_2	71	74	PF00928	0.556
TRG_ER_diArg_1	13	16	PF00400	0.495
TRG_ER_diArg_1	157	159	PF00400	0.504
TRG_ER_diArg_1	233	236	PF00400	0.527
TRG_NLS_MonoExtC_3	89	95	PF00514	0.492
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.608
TRG_Pf-PMV_PEXEL_1	18	23	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEB0	Leptomonas seymouri	65%	100%
A0A1X0NMA0	Trypanosomatidae	34%	100%
A0A3R7KFM9	Trypanosoma rangeli	37%	100%
A4HQB1	Leishmania braziliensis	76%	100%
A4IE06	Leishmania infantum	100%	100%
D0A3Z4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AU28	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q0G7	Leishmania major	93%	100%
V5BNM8	Trypanosoma cruzi	37%	100%