F-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IK34_LEIDO

TriTrypDb:

LdBPK_331280.1 , LdCL_330019000 , LDHU3_33.1930

Length:

803

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IK34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IK34

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	376	380	PF00656	0.566
CLV_MEL_PAP_1	346	352	PF00089	0.696
CLV_NRD_NRD_1	124	126	PF00675	0.623
CLV_NRD_NRD_1	177	179	PF00675	0.795
CLV_NRD_NRD_1	196	198	PF00675	0.420
CLV_NRD_NRD_1	534	536	PF00675	0.716
CLV_NRD_NRD_1	796	798	PF00675	0.730
CLV_PCSK_FUR_1	794	798	PF00082	0.747
CLV_PCSK_KEX2_1	124	126	PF00082	0.593
CLV_PCSK_KEX2_1	196	198	PF00082	0.619
CLV_PCSK_KEX2_1	534	536	PF00082	0.716
CLV_PCSK_KEX2_1	794	796	PF00082	0.721
CLV_PCSK_SKI1_1	529	533	PF00082	0.670
CLV_PCSK_SKI1_1	718	722	PF00082	0.518
DEG_ODPH_VHL_1	721	733	PF01847	0.548
DEG_SPOP_SBC_1	317	321	PF00917	0.765
DOC_CDC14_PxL_1	719	727	PF14671	0.540
DOC_CKS1_1	341	346	PF01111	0.803
DOC_CKS1_1	694	699	PF01111	0.700
DOC_MAPK_gen_1	529	538	PF00069	0.692
DOC_PP2B_LxvP_1	290	293	PF13499	0.678
DOC_PP2B_LxvP_1	614	617	PF13499	0.671
DOC_PP2B_LxvP_1	83	86	PF13499	0.570
DOC_PP4_FxxP_1	720	723	PF00568	0.531
DOC_USP7_MATH_1	108	112	PF00917	0.597
DOC_USP7_MATH_1	266	270	PF00917	0.730
DOC_USP7_MATH_1	281	285	PF00917	0.611
DOC_USP7_MATH_1	291	295	PF00917	0.686
DOC_USP7_MATH_1	339	343	PF00917	0.767
DOC_USP7_MATH_1	387	391	PF00917	0.698
DOC_USP7_MATH_1	435	439	PF00917	0.692
DOC_USP7_MATH_1	458	462	PF00917	0.786
DOC_USP7_MATH_1	480	484	PF00917	0.731
DOC_USP7_MATH_1	556	560	PF00917	0.805
DOC_USP7_MATH_1	684	688	PF00917	0.742
DOC_WW_Pin1_4	12	17	PF00397	0.699
DOC_WW_Pin1_4	149	154	PF00397	0.733
DOC_WW_Pin1_4	237	242	PF00397	0.767
DOC_WW_Pin1_4	253	258	PF00397	0.547
DOC_WW_Pin1_4	272	277	PF00397	0.497
DOC_WW_Pin1_4	292	297	PF00397	0.604
DOC_WW_Pin1_4	304	309	PF00397	0.748
DOC_WW_Pin1_4	310	315	PF00397	0.720
DOC_WW_Pin1_4	329	334	PF00397	0.802
DOC_WW_Pin1_4	340	345	PF00397	0.700
DOC_WW_Pin1_4	36	41	PF00397	0.704
DOC_WW_Pin1_4	439	444	PF00397	0.809
DOC_WW_Pin1_4	576	581	PF00397	0.844
DOC_WW_Pin1_4	650	655	PF00397	0.830
DOC_WW_Pin1_4	672	677	PF00397	0.649
DOC_WW_Pin1_4	693	698	PF00397	0.787
DOC_WW_Pin1_4	704	709	PF00397	0.760
DOC_WW_Pin1_4	756	761	PF00397	0.675
LIG_14-3-3_CanoR_1	124	130	PF00244	0.695
LIG_14-3-3_CanoR_1	156	164	PF00244	0.687
LIG_14-3-3_CanoR_1	396	403	PF00244	0.662
LIG_14-3-3_CanoR_1	425	429	PF00244	0.656
LIG_14-3-3_CanoR_1	437	443	PF00244	0.656
LIG_14-3-3_CanoR_1	510	518	PF00244	0.656
LIG_14-3-3_CanoR_1	637	645	PF00244	0.714
LIG_14-3-3_CanoR_1	7	16	PF00244	0.694
LIG_AP2alpha_2	245	247	PF02296	0.706
LIG_BIR_II_1	1	5	PF00653	0.679
LIG_BRCT_BRCA1_1	274	278	PF00533	0.693
LIG_Clathr_ClatBox_1	733	737	PF01394	0.496
LIG_Clathr_ClatBox_1	742	746	PF01394	0.546
LIG_deltaCOP1_diTrp_1	120	130	PF00928	0.594
LIG_deltaCOP1_diTrp_1	175	181	PF00928	0.667
LIG_deltaCOP1_diTrp_1	206	209	PF00928	0.642
LIG_FHA_1	143	149	PF00498	0.682
LIG_FHA_1	222	228	PF00498	0.698
LIG_FHA_1	341	347	PF00498	0.803
LIG_FHA_1	39	45	PF00498	0.745
LIG_FHA_1	454	460	PF00498	0.786
LIG_FHA_1	479	485	PF00498	0.526
LIG_FHA_1	705	711	PF00498	0.679
LIG_FHA_2	511	517	PF00498	0.626
LIG_FHA_2	600	606	PF00498	0.592
LIG_FHA_2	641	647	PF00498	0.789
LIG_FHA_2	651	657	PF00498	0.663
LIG_FHA_2	779	785	PF00498	0.590
LIG_GBD_Chelix_1	403	411	PF00786	0.640
LIG_LIR_Apic_2	717	723	PF02991	0.523
LIG_LIR_Apic_2	756	760	PF02991	0.674
LIG_LIR_Gen_1	128	137	PF02991	0.696
LIG_LIR_Gen_1	187	193	PF02991	0.609
LIG_LIR_Gen_1	206	215	PF02991	0.645
LIG_LIR_Gen_1	30	38	PF02991	0.720
LIG_LIR_Gen_1	621	631	PF02991	0.581
LIG_LIR_Gen_1	783	792	PF02991	0.684
LIG_LIR_Gen_1	98	105	PF02991	0.608
LIG_LIR_Nem_3	111	116	PF02991	0.600
LIG_LIR_Nem_3	187	192	PF02991	0.593
LIG_LIR_Nem_3	206	212	PF02991	0.451
LIG_LIR_Nem_3	30	34	PF02991	0.726
LIG_LIR_Nem_3	621	626	PF02991	0.563
LIG_LIR_Nem_3	66	71	PF02991	0.579
LIG_LIR_Nem_3	783	788	PF02991	0.619
LIG_LIR_Nem_3	98	102	PF02991	0.597
LIG_MYND_1	344	348	PF01753	0.721
LIG_MYND_1	708	712	PF01753	0.758
LIG_Pex14_1	181	185	PF04695	0.649
LIG_Pex14_2	249	253	PF04695	0.680
LIG_Pex14_2	715	719	PF04695	0.551
LIG_REV1ctd_RIR_1	190	201	PF16727	0.614
LIG_REV1ctd_RIR_1	713	722	PF16727	0.554
LIG_SH2_CRK	635	639	PF00017	0.719
LIG_SH2_CRK	785	789	PF00017	0.682
LIG_SH2_PTP2	787	790	PF00017	0.697
LIG_SH2_SRC	629	632	PF00017	0.698
LIG_SH2_STAP1	189	193	PF00017	0.608
LIG_SH2_STAP1	388	392	PF00017	0.496
LIG_SH2_STAT3	75	78	PF00017	0.721
LIG_SH2_STAT3	775	778	PF00017	0.679
LIG_SH2_STAT5	129	132	PF00017	0.604
LIG_SH2_STAT5	199	202	PF00017	0.572
LIG_SH2_STAT5	422	425	PF00017	0.595
LIG_SH2_STAT5	780	783	PF00017	0.652
LIG_SH2_STAT5	787	790	PF00017	0.697
LIG_SH2_STAT5	81	84	PF00017	0.509
LIG_SH2_STAT5	96	99	PF00017	0.504
LIG_SH3_2	789	794	PF14604	0.706
LIG_SH3_3	144	150	PF00018	0.681
LIG_SH3_3	290	296	PF00018	0.698
LIG_SH3_3	302	308	PF00018	0.719
LIG_SH3_3	338	344	PF00018	0.711
LIG_SH3_3	347	353	PF00018	0.699
LIG_SH3_3	578	584	PF00018	0.738
LIG_SH3_3	691	697	PF00018	0.833
LIG_SH3_3	786	792	PF00018	0.697
LIG_SUMO_SIM_anti_2	487	494	PF11976	0.592
LIG_SUMO_SIM_par_1	223	229	PF11976	0.697
LIG_SUMO_SIM_par_1	487	494	PF11976	0.592
LIG_SUMO_SIM_par_1	597	603	PF11976	0.596
LIG_SUMO_SIM_par_1	732	737	PF11976	0.489
LIG_SUMO_SIM_par_1	740	746	PF11976	0.564
LIG_TRFH_1	719	723	PF08558	0.527
LIG_TYR_ITIM	504	509	PF00017	0.729
LIG_TYR_ITIM	633	638	PF00017	0.705
LIG_TYR_ITIM	97	102	PF00017	0.537
MOD_CDK_SPK_2	650	655	PF00069	0.830
MOD_CDK_SPxxK_3	149	156	PF00069	0.578
MOD_CDK_SPxxK_3	672	679	PF00069	0.615
MOD_CDK_SPxxK_3	704	711	PF00069	0.770
MOD_CK1_1	15	21	PF00069	0.698
MOD_CK1_1	152	158	PF00069	0.763
MOD_CK1_1	184	190	PF00069	0.578
MOD_CK1_1	240	246	PF00069	0.683
MOD_CK1_1	295	301	PF00069	0.756
MOD_CK1_1	32	38	PF00069	0.534
MOD_CK1_1	321	327	PF00069	0.833
MOD_CK1_1	328	334	PF00069	0.735
MOD_CK1_1	39	45	PF00069	0.677
MOD_CK1_1	399	405	PF00069	0.781
MOD_CK1_1	412	418	PF00069	0.485
MOD_CK1_1	436	442	PF00069	0.714
MOD_CK1_1	6	12	PF00069	0.691
MOD_CK1_1	640	646	PF00069	0.588
MOD_CK1_1	668	674	PF00069	0.690
MOD_CK1_1	675	681	PF00069	0.668
MOD_CK1_1	687	693	PF00069	0.835
MOD_CK2_1	15	21	PF00069	0.660
MOD_CK2_1	184	190	PF00069	0.604
MOD_CK2_1	200	206	PF00069	0.622
MOD_CK2_1	281	287	PF00069	0.706
MOD_CK2_1	424	430	PF00069	0.667
MOD_CK2_1	510	516	PF00069	0.624
MOD_CK2_1	599	605	PF00069	0.600
MOD_CK2_1	650	656	PF00069	0.759
MOD_CK2_1	778	784	PF00069	0.623
MOD_GlcNHglycan	17	20	PF01048	0.736
MOD_GlcNHglycan	186	189	PF01048	0.641
MOD_GlcNHglycan	249	252	PF01048	0.719
MOD_GlcNHglycan	253	256	PF01048	0.731
MOD_GlcNHglycan	270	273	PF01048	0.659
MOD_GlcNHglycan	320	323	PF01048	0.733
MOD_GlcNHglycan	407	410	PF01048	0.747
MOD_GlcNHglycan	411	414	PF01048	0.697
MOD_GlcNHglycan	44	47	PF01048	0.687
MOD_GlcNHglycan	460	463	PF01048	0.736
MOD_GlcNHglycan	529	532	PF01048	0.660
MOD_GlcNHglycan	558	561	PF01048	0.818
MOD_GlcNHglycan	56	59	PF01048	0.623
MOD_GlcNHglycan	563	566	PF01048	0.739
MOD_GlcNHglycan	572	575	PF01048	0.634
MOD_GlcNHglycan	686	689	PF01048	0.769
MOD_GlcNHglycan	800	803	PF01048	0.766
MOD_GSK3_1	15	22	PF00069	0.697
MOD_GSK3_1	152	159	PF00069	0.684
MOD_GSK3_1	217	224	PF00069	0.687
MOD_GSK3_1	233	240	PF00069	0.697
MOD_GSK3_1	247	254	PF00069	0.745
MOD_GSK3_1	266	273	PF00069	0.562
MOD_GSK3_1	291	298	PF00069	0.749
MOD_GSK3_1	3	10	PF00069	0.684
MOD_GSK3_1	30	37	PF00069	0.798
MOD_GSK3_1	317	324	PF00069	0.822
MOD_GSK3_1	325	332	PF00069	0.735
MOD_GSK3_1	38	45	PF00069	0.686
MOD_GSK3_1	399	406	PF00069	0.701
MOD_GSK3_1	424	431	PF00069	0.654
MOD_GSK3_1	433	440	PF00069	0.678
MOD_GSK3_1	480	487	PF00069	0.630
MOD_GSK3_1	494	501	PF00069	0.592
MOD_GSK3_1	566	573	PF00069	0.781
MOD_GSK3_1	668	675	PF00069	0.797
MOD_GSK3_1	679	686	PF00069	0.644
MOD_GSK3_1	702	709	PF00069	0.595
MOD_LATS_1	316	322	PF00433	0.844
MOD_LATS_1	508	514	PF00433	0.648
MOD_N-GLC_1	324	329	PF02516	0.729
MOD_N-GLC_1	498	503	PF02516	0.644
MOD_N-GLC_1	510	515	PF02516	0.501
MOD_NEK2_1	142	147	PF00069	0.678
MOD_NEK2_1	247	252	PF00069	0.745
MOD_NEK2_1	299	304	PF00069	0.713
MOD_NEK2_1	403	408	PF00069	0.654
MOD_NEK2_1	424	429	PF00069	0.589
MOD_NEK2_1	524	529	PF00069	0.637
MOD_NEK2_1	570	575	PF00069	0.830
MOD_NEK2_1	638	643	PF00069	0.540
MOD_NEK2_1	8	13	PF00069	0.688
MOD_PIKK_1	299	305	PF00454	0.747
MOD_PIKK_1	428	434	PF00454	0.598
MOD_PIKK_1	460	466	PF00454	0.842
MOD_PIKK_1	679	685	PF00454	0.755
MOD_PK_1	665	671	PF00069	0.670
MOD_PKA_1	796	802	PF00069	0.750
MOD_PKA_2	155	161	PF00069	0.727
MOD_PKA_2	317	323	PF00069	0.836
MOD_PKA_2	424	430	PF00069	0.661
MOD_PKA_2	436	442	PF00069	0.649
MOD_PKA_2	522	528	PF00069	0.649
MOD_PKA_2	6	12	PF00069	0.691
MOD_PKA_2	678	684	PF00069	0.791
MOD_PKA_2	796	802	PF00069	0.828
MOD_PKB_1	794	802	PF00069	0.749
MOD_Plk_1	29	35	PF00069	0.726
MOD_Plk_1	665	671	PF00069	0.690
MOD_Plk_4	118	124	PF00069	0.535
MOD_Plk_4	125	131	PF00069	0.537
MOD_Plk_4	181	187	PF00069	0.534
MOD_Plk_4	39	45	PF00069	0.683
MOD_Plk_4	609	615	PF00069	0.681
MOD_Plk_4	665	671	PF00069	0.782
MOD_Plk_4	95	101	PF00069	0.673
MOD_ProDKin_1	12	18	PF00069	0.699
MOD_ProDKin_1	149	155	PF00069	0.731
MOD_ProDKin_1	237	243	PF00069	0.765
MOD_ProDKin_1	253	259	PF00069	0.547
MOD_ProDKin_1	272	278	PF00069	0.500
MOD_ProDKin_1	292	298	PF00069	0.605
MOD_ProDKin_1	304	310	PF00069	0.752
MOD_ProDKin_1	329	335	PF00069	0.828
MOD_ProDKin_1	340	346	PF00069	0.803
MOD_ProDKin_1	36	42	PF00069	0.704
MOD_ProDKin_1	439	445	PF00069	0.808
MOD_ProDKin_1	576	582	PF00069	0.844
MOD_ProDKin_1	650	656	PF00069	0.829
MOD_ProDKin_1	672	678	PF00069	0.652
MOD_ProDKin_1	693	699	PF00069	0.786
MOD_ProDKin_1	704	710	PF00069	0.756
MOD_ProDKin_1	756	762	PF00069	0.674
MOD_SUMO_rev_2	211	220	PF00179	0.640
TRG_DiLeu_BaEn_2	515	521	PF01217	0.618
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.802
TRG_DiLeu_BaLyEn_6	757	762	PF01217	0.673
TRG_DiLeu_LyEn_5	357	362	PF01217	0.635
TRG_ENDOCYTIC_2	131	134	PF00928	0.704
TRG_ENDOCYTIC_2	189	192	PF00928	0.590
TRG_ENDOCYTIC_2	506	509	PF00928	0.698
TRG_ENDOCYTIC_2	635	638	PF00928	0.716
TRG_ENDOCYTIC_2	785	788	PF00928	0.679
TRG_ENDOCYTIC_2	99	102	PF00928	0.536
TRG_ER_diArg_1	123	125	PF00400	0.616
TRG_ER_diArg_1	196	198	PF00400	0.619
TRG_ER_diArg_1	362	365	PF00400	0.735
TRG_ER_diArg_1	534	536	PF00400	0.716
TRG_ER_diArg_1	794	797	PF00400	0.727
TRG_NES_CRM1_1	418	430	PF08389	0.588
TRG_Pf-PMV_PEXEL_1	618	622	PF00026	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWH7	Leptomonas seymouri	49%	97%
A4HLH7	Leishmania braziliensis	75%	97%
A4I8Y7	Leishmania infantum	100%	100%
E9B3V6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q468	Leishmania major	91%	98%