Mkiaa0324_protein-like_protein/GeneDB:LmjF.36.582 0

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mkiaa0324 protein-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IK24_LEIDO

TriTrypDb:

LdBPK_366070.1 , LdCL_360068100 , LDHU3_36.8000

Length:

500

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IK24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IK24

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.571
CLV_NRD_NRD_1	132	134	PF00675	0.376
CLV_NRD_NRD_1	175	177	PF00675	0.440
CLV_NRD_NRD_1	183	185	PF00675	0.476
CLV_NRD_NRD_1	193	195	PF00675	0.480
CLV_NRD_NRD_1	199	201	PF00675	0.482
CLV_NRD_NRD_1	211	213	PF00675	0.549
CLV_NRD_NRD_1	217	219	PF00675	0.535
CLV_NRD_NRD_1	248	250	PF00675	0.543
CLV_NRD_NRD_1	294	296	PF00675	0.657
CLV_NRD_NRD_1	302	304	PF00675	0.570
CLV_NRD_NRD_1	324	326	PF00675	0.675
CLV_NRD_NRD_1	33	35	PF00675	0.417
CLV_NRD_NRD_1	331	333	PF00675	0.503
CLV_NRD_NRD_1	376	378	PF00675	0.487
CLV_NRD_NRD_1	404	406	PF00675	0.569
CLV_NRD_NRD_1	67	69	PF00675	0.514
CLV_NRD_NRD_1	84	86	PF00675	0.475
CLV_PCSK_FUR_1	194	198	PF00082	0.563
CLV_PCSK_FUR_1	243	247	PF00082	0.454
CLV_PCSK_KEX2_1	103	105	PF00082	0.591
CLV_PCSK_KEX2_1	12	14	PF00082	0.396
CLV_PCSK_KEX2_1	132	134	PF00082	0.376
CLV_PCSK_KEX2_1	144	146	PF00082	0.511
CLV_PCSK_KEX2_1	163	165	PF00082	0.308
CLV_PCSK_KEX2_1	177	179	PF00082	0.454
CLV_PCSK_KEX2_1	192	194	PF00082	0.518
CLV_PCSK_KEX2_1	196	198	PF00082	0.445
CLV_PCSK_KEX2_1	228	230	PF00082	0.535
CLV_PCSK_KEX2_1	245	247	PF00082	0.471
CLV_PCSK_KEX2_1	248	250	PF00082	0.495
CLV_PCSK_KEX2_1	258	260	PF00082	0.500
CLV_PCSK_KEX2_1	274	276	PF00082	0.476
CLV_PCSK_KEX2_1	301	303	PF00082	0.583
CLV_PCSK_KEX2_1	323	325	PF00082	0.552
CLV_PCSK_KEX2_1	330	332	PF00082	0.511
CLV_PCSK_KEX2_1	376	378	PF00082	0.487
CLV_PCSK_KEX2_1	406	408	PF00082	0.537
CLV_PCSK_KEX2_1	484	486	PF00082	0.488
CLV_PCSK_KEX2_1	67	69	PF00082	0.475
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.527
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.356
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.579
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.308
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.454
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.499
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.543
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.440
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.496
CLV_PCSK_PC1ET2_1	274	276	PF00082	0.593
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.583
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.557
CLV_PCSK_PC1ET2_1	406	408	PF00082	0.537
CLV_PCSK_PC1ET2_1	484	486	PF00082	0.481
CLV_PCSK_PC7_1	140	146	PF00082	0.360
CLV_PCSK_PC7_1	192	198	PF00082	0.465
CLV_PCSK_PC7_1	254	260	PF00082	0.519
CLV_PCSK_SKI1_1	118	122	PF00082	0.502
CLV_PCSK_SKI1_1	144	148	PF00082	0.423
CLV_PCSK_SKI1_1	201	205	PF00082	0.713
CLV_PCSK_SKI1_1	213	217	PF00082	0.558
CLV_PCSK_SKI1_1	295	299	PF00082	0.536
CLV_PCSK_SKI1_1	359	363	PF00082	0.374
CLV_PCSK_SKI1_1	435	439	PF00082	0.382
CLV_PCSK_SKI1_1	485	489	PF00082	0.392
CLV_PCSK_SKI1_1	71	75	PF00082	0.376
CLV_PCSK_SKI1_1	79	83	PF00082	0.456
CLV_Separin_Metazoa	129	133	PF03568	0.356
DEG_APCC_DBOX_1	139	147	PF00400	0.362
DEG_Nend_Nbox_1	1	3	PF02207	0.424
DOC_CYCLIN_yClb5_NLxxxL_5	140	147	PF00134	0.354
DOC_MAPK_gen_1	103	109	PF00069	0.476
DOC_MAPK_gen_1	144	151	PF00069	0.580
DOC_MAPK_gen_1	163	171	PF00069	0.315
DOC_MAPK_gen_1	258	265	PF00069	0.489
DOC_MAPK_gen_1	330	339	PF00069	0.425
DOC_MAPK_MEF2A_6	163	171	PF00069	0.365
DOC_MAPK_MEF2A_6	258	267	PF00069	0.490
DOC_MAPK_MEF2A_6	330	339	PF00069	0.425
DOC_MAPK_RevD_3	261	275	PF00069	0.489
DOC_PP2B_LxvP_1	159	162	PF13499	0.400
DOC_PP4_FxxP_1	54	57	PF00568	0.341
DOC_USP7_MATH_1	15	19	PF00917	0.309
DOC_USP7_MATH_1	203	207	PF00917	0.569
DOC_USP7_MATH_1	208	212	PF00917	0.538
DOC_USP7_MATH_1	233	237	PF00917	0.485
DOC_USP7_MATH_1	273	277	PF00917	0.526
DOC_USP7_MATH_1	297	301	PF00917	0.597
DOC_USP7_MATH_1	424	428	PF00917	0.543
DOC_USP7_MATH_1	8	12	PF00917	0.407
DOC_USP7_MATH_1	89	93	PF00917	0.516
DOC_USP7_UBL2_3	185	189	PF12436	0.458
DOC_USP7_UBL2_3	484	488	PF12436	0.400
DOC_USP7_UBL2_3	71	75	PF12436	0.392
DOC_USP7_UBL2_3	82	86	PF12436	0.478
DOC_WW_Pin1_4	118	123	PF00397	0.424
DOC_WW_Pin1_4	22	27	PF00397	0.315
DOC_WW_Pin1_4	317	322	PF00397	0.516
DOC_WW_Pin1_4	411	416	PF00397	0.639
LIG_14-3-3_CanoR_1	155	160	PF00244	0.422
LIG_14-3-3_CanoR_1	212	220	PF00244	0.605
LIG_14-3-3_CanoR_1	234	244	PF00244	0.475
LIG_14-3-3_CanoR_1	259	264	PF00244	0.495
LIG_14-3-3_CanoR_1	28	36	PF00244	0.474
LIG_14-3-3_CanoR_1	303	312	PF00244	0.543
LIG_14-3-3_CanoR_1	477	481	PF00244	0.502
LIG_14-3-3_CanoR_1	53	57	PF00244	0.348
LIG_14-3-3_CanoR_1	98	102	PF00244	0.454
LIG_BRCT_BRCA1_1	444	448	PF00533	0.352
LIG_EH_1	445	449	PF12763	0.340
LIG_FHA_1	197	203	PF00498	0.480
LIG_FHA_1	344	350	PF00498	0.374
LIG_FHA_1	356	362	PF00498	0.375
LIG_FHA_1	36	42	PF00498	0.339
LIG_FHA_1	366	372	PF00498	0.359
LIG_FHA_1	380	386	PF00498	0.348
LIG_FHA_1	72	78	PF00498	0.382
LIG_IBAR_NPY_1	334	336	PF08397	0.387
LIG_LIR_Gen_1	121	131	PF02991	0.354
LIG_LIR_Gen_1	451	459	PF02991	0.331
LIG_LIR_Nem_3	121	126	PF02991	0.368
LIG_LIR_Nem_3	18	23	PF02991	0.405
LIG_LIR_Nem_3	451	455	PF02991	0.311
LIG_SH2_CRK	20	24	PF00017	0.319
LIG_SH2_CRK	452	456	PF00017	0.324
LIG_SH2_STAP1	452	456	PF00017	0.324
LIG_SH2_STAT5	336	339	PF00017	0.363
LIG_SH3_1	254	260	PF00018	0.519
LIG_SH3_3	20	26	PF00018	0.356
LIG_SH3_3	254	260	PF00018	0.519
LIG_SH3_3	309	315	PF00018	0.527
LIG_SH3_3	347	353	PF00018	0.415
LIG_SH3_3	392	398	PF00018	0.459
LIG_SH3_3	418	424	PF00018	0.650
LIG_SH3_4	82	89	PF00018	0.484
LIG_WRC_WIRS_1	16	21	PF05994	0.328
LIG_WW_1	440	443	PF00397	0.348
MOD_CDC14_SPxK_1	25	28	PF00782	0.345
MOD_CDK_SPxK_1	22	28	PF00069	0.325
MOD_CDK_SPxK_1	317	323	PF00069	0.518
MOD_CDK_SPxxK_3	317	324	PF00069	0.513
MOD_CK1_1	211	217	PF00069	0.647
MOD_Cter_Amidation	115	118	PF01082	0.466
MOD_GlcNHglycan	205	208	PF01048	0.556
MOD_GlcNHglycan	237	240	PF01048	0.468
MOD_GlcNHglycan	275	278	PF01048	0.522
MOD_GlcNHglycan	326	329	PF01048	0.498
MOD_GlcNHglycan	402	405	PF01048	0.538
MOD_GlcNHglycan	485	488	PF01048	0.459
MOD_GlcNHglycan	54	57	PF01048	0.350
MOD_GSK3_1	131	138	PF00069	0.434
MOD_GSK3_1	180	187	PF00069	0.464
MOD_GSK3_1	188	195	PF00069	0.467
MOD_GSK3_1	203	210	PF00069	0.489
MOD_GSK3_1	297	304	PF00069	0.538
MOD_GSK3_1	363	370	PF00069	0.355
MOD_GSK3_1	386	393	PF00069	0.411
MOD_GSK3_1	411	418	PF00069	0.537
MOD_GSK3_1	424	431	PF00069	0.486
MOD_NEK2_1	131	136	PF00069	0.379
MOD_NEK2_1	2	7	PF00069	0.415
MOD_NEK2_1	343	348	PF00069	0.360
MOD_NEK2_1	448	453	PF00069	0.308
MOD_NEK2_1	77	82	PF00069	0.435
MOD_NEK2_2	15	20	PF00069	0.325
MOD_PK_1	157	163	PF00069	0.400
MOD_PK_1	259	265	PF00069	0.494
MOD_PK_1	305	311	PF00069	0.529
MOD_PKA_1	184	190	PF00069	0.468
MOD_PKA_1	192	198	PF00069	0.487
MOD_PKA_1	295	301	PF00069	0.529
MOD_PKA_1	305	311	PF00069	0.516
MOD_PKA_1	324	330	PF00069	0.516
MOD_PKA_2	131	137	PF00069	0.380
MOD_PKA_2	192	198	PF00069	0.585
MOD_PKA_2	211	217	PF00069	0.536
MOD_PKA_2	220	226	PF00069	0.530
MOD_PKA_2	233	239	PF00069	0.481
MOD_PKA_2	27	33	PF00069	0.433
MOD_PKA_2	301	307	PF00069	0.543
MOD_PKA_2	324	330	PF00069	0.703
MOD_PKA_2	343	349	PF00069	0.342
MOD_PKA_2	379	385	PF00069	0.355
MOD_PKA_2	400	406	PF00069	0.530
MOD_PKA_2	476	482	PF00069	0.422
MOD_PKA_2	52	58	PF00069	0.372
MOD_PKA_2	97	103	PF00069	0.484
MOD_PKB_1	155	163	PF00069	0.403
MOD_PKB_1	303	311	PF00069	0.523
MOD_Plk_4	15	21	PF00069	0.331
MOD_ProDKin_1	118	124	PF00069	0.416
MOD_ProDKin_1	22	28	PF00069	0.325
MOD_ProDKin_1	317	323	PF00069	0.518
MOD_ProDKin_1	411	417	PF00069	0.640
MOD_SUMO_rev_2	479	486	PF00179	0.429
TRG_DiLeu_BaEn_4	386	392	PF01217	0.377
TRG_DiLeu_BaLyEn_6	167	172	PF01217	0.362
TRG_DiLeu_BaLyEn_6	454	459	PF01217	0.335
TRG_ENDOCYTIC_2	20	23	PF00928	0.314
TRG_ENDOCYTIC_2	24	27	PF00928	0.352
TRG_ENDOCYTIC_2	336	339	PF00928	0.363
TRG_ENDOCYTIC_2	340	343	PF00928	0.355
TRG_ENDOCYTIC_2	452	455	PF00928	0.317
TRG_ER_diArg_1	131	133	PF00400	0.373
TRG_ER_diArg_1	192	194	PF00400	0.479
TRG_ER_diArg_1	246	249	PF00400	0.525
TRG_ER_diArg_1	302	305	PF00400	0.594
TRG_ER_diArg_1	315	318	PF00400	0.528
TRG_ER_diArg_1	330	332	PF00400	0.552
TRG_ER_diArg_1	376	378	PF00400	0.487
TRG_ER_diArg_1	66	68	PF00400	0.347
TRG_NLS_Bipartite_1	163	181	PF00514	0.385
TRG_NLS_Bipartite_1	200	222	PF00514	0.527
TRG_NLS_Bipartite_1	228	249	PF00514	0.486
TRG_NLS_Bipartite_1	305	327	PF00514	0.534
TRG_NLS_Bipartite_1	67	89	PF00514	0.407
TRG_NLS_MonoCore_2	217	222	PF00514	0.532
TRG_NLS_MonoExtC_3	244	249	PF00514	0.463
TRG_NLS_MonoExtC_3	300	305	PF00514	0.563
TRG_NLS_MonoExtN_4	102	107	PF00514	0.511
TRG_NLS_MonoExtN_4	174	181	PF00514	0.432
TRG_NLS_MonoExtN_4	216	222	PF00514	0.529
TRG_NLS_MonoExtN_4	243	249	PF00514	0.464
TRG_NLS_MonoExtN_4	321	327	PF00514	0.498
TRG_NLS_MonoExtN_4	82	89	PF00514	0.484
TRG_Pf-PMV_PEXEL_1	170	175	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3V1	Leptomonas seymouri	41%	100%
A4HQ98	Leishmania braziliensis	63%	100%
A4IDZ5	Leishmania infantum	100%	100%
E9AU16	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q0H9	Leishmania major	88%	100%