Universal minicircle sequence binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

universal minicircle sequence binding protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IK17_LEIDO

TriTrypDb:

LdBPK_361680.1 , LdCL_360022400 , LDHU3_36.2190

Length:

175

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3Q8IK17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IK17

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009891	positive regulation of biosynthetic process	5	2
GO:0009893	positive regulation of metabolic process	4	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010557	positive regulation of macromolecule biosynthetic process	6	2
GO:0010604	positive regulation of macromolecule metabolic process	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0010628	positive regulation of gene expression	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031325	positive regulation of cellular metabolic process	5	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0031328	positive regulation of cellular biosynthetic process	6	2
GO:0034248	regulation of amide metabolic process	5	2
GO:0034250	positive regulation of amide metabolic process	6	2
GO:0045727	positive regulation of translation	7	2
GO:0048518	positive regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051173	positive regulation of nitrogen compound metabolic process	5	2
GO:0051246	regulation of protein metabolic process	5	2
GO:0051247	positive regulation of protein metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0080090	regulation of primary metabolic process	4	2
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	2
GO:2000765	regulation of cytoplasmic translation	7	2
GO:2000767	positive regulation of cytoplasmic translation	8	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0005488	binding	1	11
GO:0008270	zinc ion binding	6	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003723	RNA binding	4	2
GO:0003727	single-stranded RNA binding	5	2
GO:0003729	mRNA binding	5	2
GO:0045182	translation regulator activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.344
CLV_NRD_NRD_1	104	106	PF00675	0.285
CLV_NRD_NRD_1	152	154	PF00675	0.277
CLV_NRD_NRD_1	20	22	PF00675	0.344
CLV_PCSK_KEX2_1	20	22	PF00082	0.364
DEG_Nend_UBRbox_4	1	3	PF02207	0.340
DOC_CYCLIN_RxL_1	42	52	PF00134	0.340
DOC_PP4_FxxP_1	16	19	PF00568	0.315
DOC_PP4_FxxP_1	53	56	PF00568	0.350
DOC_USP7_MATH_1	84	88	PF00917	0.326
DOC_WW_Pin1_4	1	6	PF00397	0.357
DOC_WW_Pin1_4	52	57	PF00397	0.350
LIG_14-3-3_CanoR_1	45	50	PF00244	0.636
LIG_BRCT_BRCA1_1	49	53	PF00533	0.347
LIG_FHA_1	114	120	PF00498	0.279
LIG_FHA_1	140	146	PF00498	0.138
LIG_FHA_1	162	168	PF00498	0.167
LIG_FHA_2	24	30	PF00498	0.346
LIG_LIR_Apic_2	15	19	PF02991	0.317
LIG_LIR_Apic_2	50	56	PF02991	0.349
LIG_LIR_Gen_1	34	44	PF02991	0.405
LIG_LIR_Gen_1	4	14	PF02991	0.356
LIG_LIR_Nem_3	34	39	PF02991	0.350
LIG_LIR_Nem_3	4	9	PF02991	0.334
LIG_NRBOX	9	15	PF00104	0.332
LIG_SH3_3	16	22	PF00018	0.335
LIG_UBA3_1	60	68	PF00899	0.138
LIG_WRC_WIRS_1	13	18	PF05994	0.334
MOD_CK1_1	52	58	PF00069	0.388
MOD_CK1_1	62	68	PF00069	0.168
MOD_GlcNHglycan	61	64	PF01048	0.324
MOD_GSK3_1	113	120	PF00069	0.279
MOD_GSK3_1	139	146	PF00069	0.285
MOD_GSK3_1	161	168	PF00069	0.183
MOD_GSK3_1	23	30	PF00069	0.382
MOD_GSK3_1	39	46	PF00069	0.384
MOD_GSK3_1	55	62	PF00069	0.577
MOD_GSK3_1	91	98	PF00069	0.272
MOD_NEK2_1	39	44	PF00069	0.391
MOD_NEK2_1	47	52	PF00069	0.358
MOD_NEK2_1	75	80	PF00069	0.335
MOD_NEK2_1	9	14	PF00069	0.344
MOD_NEK2_2	84	89	PF00069	0.265
MOD_Plk_4	55	61	PF00069	0.348
MOD_Plk_4	9	15	PF00069	0.377
MOD_ProDKin_1	1	7	PF00069	0.351
MOD_ProDKin_1	52	58	PF00069	0.347
MOD_SUMO_rev_2	120	129	PF00179	0.157
MOD_SUMO_rev_2	146	155	PF00179	0.157
MOD_SUMO_rev_2	98	107	PF00179	0.157
TRG_ER_diArg_1	19	21	PF00400	0.389
TRG_ER_FFAT_2	48	58	PF00635	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD50	Leptomonas seymouri	37%	100%
A0A1X0P815	Trypanosomatidae	49%	85%
A0A1X0P8V4	Trypanosomatidae	34%	90%
A0A3R7K9Q9	Trypanosoma rangeli	36%	91%
A0A3S5H821	Leishmania donovani	35%	100%
A0A422MWM4	Trypanosoma rangeli	42%	100%
A4HP24	Leishmania braziliensis	39%	100%
A4IDD4	Leishmania infantum	35%	96%
D0A309	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	82%
D0A311	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AST3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
E9AST5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
O42395	Gallus gallus	35%	100%
P36627	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	98%
P53849	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	41%	100%
P53996	Mus musculus	33%	98%
P62633	Homo sapiens	37%	99%
P62634	Rattus norvegicus	37%	99%
Q3T0Q6	Bos taurus	37%	100%
Q4Q1R1	Leishmania major	41%	100%
Q4Q1R3	Leishmania major	87%	100%
Q5R5R5	Pongo abelii	37%	99%
Q8T8R1	Drosophila melanogaster	35%	100%
Q8WW36	Homo sapiens	30%	100%
V5BJZ6	Trypanosoma cruzi	35%	91%
V5BU64	Trypanosoma cruzi	50%	91%
V5BU71	Trypanosoma cruzi	47%	100%