Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IK12_LEIDO

TriTrypDb:

LdBPK_330880.1 , LdCL_330014900 , LDHU3_33.1410

Length:

709

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IK12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IK12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.538
CLV_NRD_NRD_1	112	114	PF00675	0.705
CLV_NRD_NRD_1	23	25	PF00675	0.672
CLV_NRD_NRD_1	281	283	PF00675	0.600
CLV_NRD_NRD_1	314	316	PF00675	0.506
CLV_NRD_NRD_1	599	601	PF00675	0.654
CLV_NRD_NRD_1	664	666	PF00675	0.555
CLV_NRD_NRD_1	704	706	PF00675	0.627
CLV_NRD_NRD_1	73	75	PF00675	0.619
CLV_PCSK_FUR_1	110	114	PF00082	0.633
CLV_PCSK_FUR_1	278	282	PF00082	0.592
CLV_PCSK_FUR_1	702	706	PF00082	0.636
CLV_PCSK_KEX2_1	112	114	PF00082	0.705
CLV_PCSK_KEX2_1	23	25	PF00082	0.672
CLV_PCSK_KEX2_1	278	280	PF00082	0.614
CLV_PCSK_KEX2_1	281	283	PF00082	0.603
CLV_PCSK_KEX2_1	599	601	PF00082	0.631
CLV_PCSK_KEX2_1	664	666	PF00082	0.558
CLV_PCSK_KEX2_1	704	706	PF00082	0.687
CLV_PCSK_KEX2_1	73	75	PF00082	0.619
CLV_PCSK_SKI1_1	315	319	PF00082	0.462
CLV_PCSK_SKI1_1	392	396	PF00082	0.493
CLV_PCSK_SKI1_1	460	464	PF00082	0.372
CLV_PCSK_SKI1_1	534	538	PF00082	0.641
CLV_PCSK_SKI1_1	600	604	PF00082	0.620
CLV_PCSK_SKI1_1	78	82	PF00082	0.698
CLV_PCSK_SKI1_1	8	12	PF00082	0.673
DEG_Nend_Nbox_1	1	3	PF02207	0.654
DEG_SCF_FBW7_1	552	557	PF00400	0.602
DEG_SPOP_SBC_1	46	50	PF00917	0.585
DOC_AGCK_PIF_2	484	489	PF00069	0.515
DOC_CKS1_1	132	137	PF01111	0.611
DOC_CKS1_1	27	32	PF01111	0.793
DOC_CKS1_1	51	56	PF01111	0.596
DOC_CYCLIN_RxL_1	309	320	PF00134	0.554
DOC_CYCLIN_RxL_1	454	467	PF00134	0.488
DOC_CYCLIN_RxL_1	596	605	PF00134	0.559
DOC_CYCLIN_yCln2_LP_2	76	82	PF00134	0.529
DOC_MAPK_gen_1	236	246	PF00069	0.560
DOC_MAPK_gen_1	492	501	PF00069	0.402
DOC_MAPK_gen_1	680	688	PF00069	0.602
DOC_MAPK_MEF2A_6	495	503	PF00069	0.367
DOC_PP1_RVXF_1	6	12	PF00149	0.613
DOC_PP2B_LxvP_1	297	300	PF13499	0.677
DOC_PP2B_LxvP_1	368	371	PF13499	0.429
DOC_PP2B_LxvP_1	86	89	PF13499	0.687
DOC_PP4_FxxP_1	11	14	PF00568	0.676
DOC_USP7_MATH_1	154	158	PF00917	0.578
DOC_USP7_MATH_1	207	211	PF00917	0.473
DOC_USP7_MATH_1	254	258	PF00917	0.693
DOC_USP7_MATH_1	335	339	PF00917	0.374
DOC_USP7_MATH_1	379	383	PF00917	0.506
DOC_USP7_MATH_1	554	558	PF00917	0.649
DOC_USP7_MATH_1	89	93	PF00917	0.698
DOC_WW_Pin1_4	115	120	PF00397	0.707
DOC_WW_Pin1_4	12	17	PF00397	0.657
DOC_WW_Pin1_4	131	136	PF00397	0.490
DOC_WW_Pin1_4	26	31	PF00397	0.734
DOC_WW_Pin1_4	455	460	PF00397	0.364
DOC_WW_Pin1_4	47	52	PF00397	0.735
DOC_WW_Pin1_4	550	555	PF00397	0.640
DOC_WW_Pin1_4	649	654	PF00397	0.681
LIG_14-3-3_CanoR_1	227	232	PF00244	0.551
LIG_14-3-3_CanoR_1	309	313	PF00244	0.519
LIG_14-3-3_CanoR_1	4	11	PF00244	0.603
LIG_14-3-3_CanoR_1	512	520	PF00244	0.540
LIG_14-3-3_CanoR_1	547	553	PF00244	0.791
LIG_BIR_III_2	650	654	PF00653	0.538
LIG_BRCT_BRCA1_1	138	142	PF00533	0.550
LIG_eIF4E_1	312	318	PF01652	0.575
LIG_eIF4E_1	497	503	PF01652	0.425
LIG_FHA_1	27	33	PF00498	0.554
LIG_FHA_1	437	443	PF00498	0.494
LIG_FHA_1	509	515	PF00498	0.500
LIG_FHA_1	51	57	PF00498	0.648
LIG_FHA_1	553	559	PF00498	0.576
LIG_FHA_2	261	267	PF00498	0.759
LIG_FHA_2	268	274	PF00498	0.538
LIG_FHA_2	289	295	PF00498	0.664
LIG_FHA_2	328	334	PF00498	0.415
LIG_FHA_2	511	517	PF00498	0.651
LIG_FHA_2	551	557	PF00498	0.664
LIG_LIR_Gen_1	201	211	PF02991	0.536
LIG_LIR_Gen_1	500	509	PF02991	0.402
LIG_LIR_Nem_3	131	136	PF02991	0.671
LIG_LIR_Nem_3	139	143	PF02991	0.660
LIG_LIR_Nem_3	201	206	PF02991	0.553
LIG_LIR_Nem_3	210	216	PF02991	0.508
LIG_LIR_Nem_3	414	418	PF02991	0.617
LIG_LIR_Nem_3	500	506	PF02991	0.368
LIG_LYPXL_yS_3	452	455	PF13949	0.530
LIG_NRBOX	340	346	PF00104	0.396
LIG_PCNA_PIPBox_1	387	396	PF02747	0.348
LIG_PTB_Apo_2	211	218	PF02174	0.598
LIG_PTB_Phospho_1	211	217	PF10480	0.600
LIG_REV1ctd_RIR_1	8	13	PF16727	0.481
LIG_RPA_C_Fungi	660	672	PF08784	0.578
LIG_SH2_CRK	213	217	PF00017	0.403
LIG_SH2_CRK	325	329	PF00017	0.466
LIG_SH2_STAP1	364	368	PF00017	0.447
LIG_SH2_STAP1	489	493	PF00017	0.511
LIG_SH2_STAT3	102	105	PF00017	0.719
LIG_SH2_STAT5	102	105	PF00017	0.628
LIG_SH2_STAT5	352	355	PF00017	0.449
LIG_SH2_STAT5	359	362	PF00017	0.404
LIG_SH2_STAT5	430	433	PF00017	0.319
LIG_SH3_1	24	30	PF00018	0.619
LIG_SH3_1	447	453	PF00018	0.549
LIG_SH3_2	18	23	PF14604	0.598
LIG_SH3_3	15	21	PF00018	0.595
LIG_SH3_3	24	30	PF00018	0.606
LIG_SH3_3	302	308	PF00018	0.678
LIG_SH3_3	397	403	PF00018	0.349
LIG_SH3_3	447	453	PF00018	0.419
LIG_SH3_3	462	468	PF00018	0.356
LIG_SH3_3	48	54	PF00018	0.736
LIG_SH3_3	76	82	PF00018	0.620
LIG_TRAF2_1	263	266	PF00917	0.753
LIG_TRAF2_1	270	273	PF00917	0.671
LIG_TRAF2_1	300	303	PF00917	0.681
LIG_TRAF2_1	580	583	PF00917	0.664
LIG_TYR_ITIM	323	328	PF00017	0.461
LIG_WRC_WIRS_1	412	417	PF05994	0.490
MOD_CDK_SPK_2	26	31	PF00069	0.571
MOD_CDK_SPK_2	455	460	PF00069	0.355
MOD_CDK_SPK_2	47	52	PF00069	0.554
MOD_CDK_SPxxK_3	131	138	PF00069	0.577
MOD_CDK_SPxxK_3	649	656	PF00069	0.642
MOD_CK1_1	131	137	PF00069	0.628
MOD_CK1_1	426	432	PF00069	0.490
MOD_CK1_1	50	56	PF00069	0.650
MOD_CK2_1	172	178	PF00069	0.549
MOD_CK2_1	260	266	PF00069	0.660
MOD_CK2_1	267	273	PF00069	0.695
MOD_CK2_1	288	294	PF00069	0.673
MOD_CK2_1	327	333	PF00069	0.422
MOD_CK2_1	510	516	PF00069	0.650
MOD_CK2_1	550	556	PF00069	0.631
MOD_CK2_1	89	95	PF00069	0.658
MOD_GlcNHglycan	174	177	PF01048	0.526
MOD_GlcNHglycan	209	212	PF01048	0.558
MOD_GlcNHglycan	252	255	PF01048	0.681
MOD_GlcNHglycan	256	259	PF01048	0.694
MOD_GlcNHglycan	415	418	PF01048	0.401
MOD_GlcNHglycan	624	627	PF01048	0.698
MOD_GlcNHglycan	659	662	PF01048	0.645
MOD_GSK3_1	115	122	PF00069	0.691
MOD_GSK3_1	124	131	PF00069	0.661
MOD_GSK3_1	250	257	PF00069	0.656
MOD_GSK3_1	422	429	PF00069	0.448
MOD_GSK3_1	46	53	PF00069	0.659
MOD_GSK3_1	508	515	PF00069	0.603
MOD_GSK3_1	548	555	PF00069	0.704
MOD_GSK3_1	613	620	PF00069	0.635
MOD_GSK3_1	96	103	PF00069	0.666
MOD_N-GLC_2	404	406	PF02516	0.353
MOD_NEK2_1	212	217	PF00069	0.585
MOD_NEK2_1	250	255	PF00069	0.611
MOD_NEK2_1	288	293	PF00069	0.678
MOD_NEK2_1	3	8	PF00069	0.569
MOD_NEK2_1	301	306	PF00069	0.669
MOD_NEK2_1	378	383	PF00069	0.531
MOD_NEK2_1	411	416	PF00069	0.485
MOD_NEK2_1	436	441	PF00069	0.360
MOD_NEK2_1	536	541	PF00069	0.639
MOD_NEK2_1	56	61	PF00069	0.528
MOD_NEK2_1	679	684	PF00069	0.572
MOD_PIKK_1	101	107	PF00454	0.562
MOD_PIKK_1	33	39	PF00454	0.614
MOD_PKA_2	154	160	PF00069	0.570
MOD_PKA_2	165	171	PF00069	0.514
MOD_PKA_2	3	9	PF00069	0.609
MOD_PKA_2	308	314	PF00069	0.512
MOD_PKA_2	491	497	PF00069	0.480
MOD_PKB_1	225	233	PF00069	0.524
MOD_PKB_1	611	619	PF00069	0.630
MOD_Plk_1	333	339	PF00069	0.421
MOD_Plk_2-3	267	273	PF00069	0.592
MOD_Plk_2-3	333	339	PF00069	0.424
MOD_Plk_4	128	134	PF00069	0.693
MOD_Plk_4	212	218	PF00069	0.558
MOD_Plk_4	426	432	PF00069	0.406
MOD_Plk_4	437	443	PF00069	0.314
MOD_ProDKin_1	115	121	PF00069	0.711
MOD_ProDKin_1	12	18	PF00069	0.659
MOD_ProDKin_1	131	137	PF00069	0.485
MOD_ProDKin_1	26	32	PF00069	0.735
MOD_ProDKin_1	455	461	PF00069	0.358
MOD_ProDKin_1	47	53	PF00069	0.733
MOD_ProDKin_1	550	556	PF00069	0.640
MOD_ProDKin_1	649	655	PF00069	0.681
MOD_SUMO_rev_2	525	533	PF00179	0.444
TRG_DiLeu_BaEn_1	340	345	PF01217	0.396
TRG_DiLeu_BaLyEn_6	691	696	PF01217	0.695
TRG_ENDOCYTIC_2	143	146	PF00928	0.582
TRG_ENDOCYTIC_2	213	216	PF00928	0.495
TRG_ENDOCYTIC_2	325	328	PF00928	0.396
TRG_ENDOCYTIC_2	391	394	PF00928	0.475
TRG_ENDOCYTIC_2	430	433	PF00928	0.316
TRG_ENDOCYTIC_2	452	455	PF00928	0.530
TRG_ER_diArg_1	109	112	PF00400	0.697
TRG_ER_diArg_1	23	25	PF00400	0.687
TRG_ER_diArg_1	278	281	PF00400	0.575
TRG_ER_diArg_1	563	566	PF00400	0.583
TRG_ER_diArg_1	598	600	PF00400	0.629
TRG_ER_diArg_1	611	614	PF00400	0.689
TRG_ER_diArg_1	664	666	PF00400	0.546
TRG_ER_diArg_1	683	686	PF00400	0.776
TRG_ER_diArg_1	704	706	PF00400	0.713
TRG_ER_diArg_1	73	75	PF00400	0.619
TRG_Pf-PMV_PEXEL_1	315	320	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	512	516	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	541	545	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	600	605	PF00026	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3E3	Leptomonas seymouri	60%	99%
A0A1X0P130	Trypanosomatidae	50%	100%
A0A422P2K6	Trypanosoma rangeli	50%	100%
A4HLD8	Leishmania braziliensis	81%	100%
A4I8U7	Leishmania infantum	100%	100%
D0A4U5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9B3R6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q4A8	Leishmania major	93%	100%
V5AZV9	Trypanosoma cruzi	49%	100%