Pyridine nucleotide-disulfide oxidoreductase/Thi4 family/FAD dependent oxidoreductase/NAD(P)-binding Rossmann-like domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FAD dependent oxidoreductase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IK10_LEIDO

TriTrypDb:

LdBPK_365910.1 , LdCL_360066500 , LDHU3_36.7820

Length:

717

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IK10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IK10

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016491	oxidoreductase activity	2	11
GO:0000166	nucleotide binding	3	1
GO:0004497	monooxygenase activity	3	1
GO:0005488	binding	1	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0050660	flavin adenine dinucleotide binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	14	18	PF00656	0.623
CLV_C14_Caspase3-7	682	686	PF00656	0.683
CLV_NRD_NRD_1	180	182	PF00675	0.417
CLV_NRD_NRD_1	209	211	PF00675	0.417
CLV_NRD_NRD_1	534	536	PF00675	0.531
CLV_NRD_NRD_1	555	557	PF00675	0.650
CLV_NRD_NRD_1	587	589	PF00675	0.596
CLV_NRD_NRD_1	619	621	PF00675	0.639
CLV_NRD_NRD_1	62	64	PF00675	0.411
CLV_NRD_NRD_1	657	659	PF00675	0.657
CLV_NRD_NRD_1	699	701	PF00675	0.713
CLV_NRD_NRD_1	707	709	PF00675	0.707
CLV_PCSK_KEX2_1	209	211	PF00082	0.417
CLV_PCSK_KEX2_1	534	536	PF00082	0.501
CLV_PCSK_KEX2_1	555	557	PF00082	0.625
CLV_PCSK_KEX2_1	618	620	PF00082	0.637
CLV_PCSK_KEX2_1	62	64	PF00082	0.411
CLV_PCSK_KEX2_1	699	701	PF00082	0.717
CLV_PCSK_KEX2_1	707	709	PF00082	0.703
CLV_PCSK_KEX2_1	715	717	PF00082	0.748
CLV_PCSK_PC1ET2_1	555	557	PF00082	0.636
CLV_PCSK_PC1ET2_1	699	701	PF00082	0.742
CLV_PCSK_PC1ET2_1	715	717	PF00082	0.748
CLV_PCSK_SKI1_1	461	465	PF00082	0.435
CLV_PCSK_SKI1_1	589	593	PF00082	0.637
CLV_PCSK_SKI1_1	710	714	PF00082	0.656
CLV_PCSK_SKI1_1	89	93	PF00082	0.364
CLV_PCSK_SKI1_1	98	102	PF00082	0.298
CLV_Separin_Metazoa	615	619	PF03568	0.595
CLV_Separin_Metazoa	95	99	PF03568	0.378
DEG_APCC_DBOX_1	71	79	PF00400	0.479
DEG_SPOP_SBC_1	317	321	PF00917	0.721
DEG_SPOP_SBC_1	437	441	PF00917	0.536
DOC_CKS1_1	673	678	PF01111	0.710
DOC_CKS1_1	691	696	PF01111	0.691
DOC_CYCLIN_yCln2_LP_2	119	125	PF00134	0.479
DOC_MAPK_DCC_7	72	80	PF00069	0.479
DOC_MAPK_gen_1	209	216	PF00069	0.445
DOC_MAPK_gen_1	429	438	PF00069	0.486
DOC_MAPK_MEF2A_6	72	80	PF00069	0.479
DOC_PP1_RVXF_1	50	56	PF00149	0.408
DOC_PP1_RVXF_1	637	644	PF00149	0.576
DOC_PP2B_LxvP_1	29	32	PF13499	0.571
DOC_PP4_FxxP_1	171	174	PF00568	0.447
DOC_PP4_FxxP_1	73	76	PF00568	0.417
DOC_USP7_MATH_1	13	17	PF00917	0.709
DOC_USP7_MATH_1	266	270	PF00917	0.411
DOC_USP7_MATH_1	316	320	PF00917	0.719
DOC_USP7_MATH_1	328	332	PF00917	0.768
DOC_USP7_MATH_1	376	380	PF00917	0.750
DOC_USP7_MATH_1	381	385	PF00917	0.755
DOC_USP7_MATH_1	415	419	PF00917	0.613
DOC_USP7_MATH_1	437	441	PF00917	0.609
DOC_USP7_MATH_1	695	699	PF00917	0.674
DOC_USP7_MATH_2	23	29	PF00917	0.668
DOC_USP7_UBL2_3	499	503	PF12436	0.396
DOC_USP7_UBL2_3	52	56	PF12436	0.393
DOC_WW_Pin1_4	17	22	PF00397	0.702
DOC_WW_Pin1_4	311	316	PF00397	0.756
DOC_WW_Pin1_4	320	325	PF00397	0.692
DOC_WW_Pin1_4	461	466	PF00397	0.407
DOC_WW_Pin1_4	528	533	PF00397	0.664
DOC_WW_Pin1_4	558	563	PF00397	0.665
DOC_WW_Pin1_4	593	598	PF00397	0.656
DOC_WW_Pin1_4	631	636	PF00397	0.584
DOC_WW_Pin1_4	672	677	PF00397	0.731
DOC_WW_Pin1_4	690	695	PF00397	0.698
LIG_14-3-3_CanoR_1	133	142	PF00244	0.473
LIG_14-3-3_CanoR_1	252	262	PF00244	0.437
LIG_14-3-3_CanoR_1	26	30	PF00244	0.679
LIG_14-3-3_CanoR_1	378	386	PF00244	0.751
LIG_14-3-3_CanoR_1	534	542	PF00244	0.557
LIG_14-3-3_CanoR_1	72	76	PF00244	0.439
LIG_Actin_WH2_2	284	302	PF00022	0.447
LIG_BRCT_BRCA1_1	363	367	PF00533	0.510
LIG_BRCT_BRCA1_1	73	77	PF00533	0.447
LIG_Clathr_ClatBox_1	402	406	PF01394	0.463
LIG_Clathr_ClatBox_1	570	574	PF01394	0.463
LIG_deltaCOP1_diTrp_1	301	307	PF00928	0.437
LIG_deltaCOP1_diTrp_1	636	643	PF00928	0.645
LIG_FHA_1	143	149	PF00498	0.368
LIG_FHA_1	199	205	PF00498	0.383
LIG_FHA_1	22	28	PF00498	0.666
LIG_FHA_1	234	240	PF00498	0.415
LIG_FHA_1	270	276	PF00498	0.361
LIG_FHA_1	344	350	PF00498	0.506
LIG_FHA_1	411	417	PF00498	0.654
LIG_FHA_1	520	526	PF00498	0.615
LIG_FHA_1	92	98	PF00498	0.417
LIG_FHA_2	441	447	PF00498	0.666
LIG_FHA_2	534	540	PF00498	0.494
LIG_FHA_2	559	565	PF00498	0.693
LIG_FHA_2	56	62	PF00498	0.335
LIG_FHA_2	610	616	PF00498	0.655
LIG_FHA_2	680	686	PF00498	0.757
LIG_FHA_2	691	697	PF00498	0.687
LIG_IBAR_NPY_1	576	578	PF08397	0.530
LIG_Integrin_RGD_1	63	65	PF01839	0.479
LIG_LIR_Apic_2	671	676	PF02991	0.700
LIG_LIR_Apic_2	70	76	PF02991	0.361
LIG_LIR_Gen_1	113	124	PF02991	0.354
LIG_LIR_Gen_1	256	266	PF02991	0.411
LIG_LIR_Gen_1	301	311	PF02991	0.437
LIG_LIR_Gen_1	477	486	PF02991	0.447
LIG_LIR_Gen_1	580	591	PF02991	0.611
LIG_LIR_Gen_1	640	647	PF02991	0.621
LIG_LIR_Nem_3	113	119	PF02991	0.373
LIG_LIR_Nem_3	227	231	PF02991	0.383
LIG_LIR_Nem_3	256	262	PF02991	0.381
LIG_LIR_Nem_3	301	307	PF02991	0.437
LIG_LIR_Nem_3	425	430	PF02991	0.461
LIG_LIR_Nem_3	477	481	PF02991	0.461
LIG_LIR_Nem_3	520	526	PF02991	0.636
LIG_LIR_Nem_3	74	80	PF02991	0.447
LIG_LYPXL_yS_3	163	166	PF13949	0.408
LIG_NRBOX	398	404	PF00104	0.484
LIG_PCNA_yPIPBox_3	121	133	PF02747	0.447
LIG_Pex14_2	73	77	PF04695	0.417
LIG_SH2_CRK	259	263	PF00017	0.426
LIG_SH2_GRB2like	144	147	PF00017	0.354
LIG_SH2_STAP1	144	148	PF00017	0.354
LIG_SH2_STAP1	212	216	PF00017	0.496
LIG_SH2_STAP1	259	263	PF00017	0.447
LIG_SH2_STAT3	212	215	PF00017	0.479
LIG_SH2_STAT5	144	147	PF00017	0.354
LIG_SH2_STAT5	228	231	PF00017	0.369
LIG_SH2_STAT5	359	362	PF00017	0.505
LIG_SH2_STAT5	427	430	PF00017	0.465
LIG_SH2_STAT5	459	462	PF00017	0.422
LIG_SH3_1	243	249	PF00018	0.447
LIG_SH3_3	238	244	PF00018	0.458
LIG_SH3_3	289	295	PF00018	0.447
LIG_SH3_3	688	694	PF00018	0.659
LIG_SUMO_SIM_anti_2	24	31	PF11976	0.645
LIG_SUMO_SIM_anti_2	260	265	PF11976	0.354
LIG_SUMO_SIM_anti_2	346	352	PF11976	0.462
LIG_SUMO_SIM_anti_2	566	572	PF11976	0.628
LIG_SUMO_SIM_par_1	191	196	PF11976	0.355
LIG_SUMO_SIM_par_1	401	408	PF11976	0.531
LIG_TRAF2_1	537	540	PF00917	0.538
LIG_UBA3_1	402	410	PF00899	0.589
MOD_CDC14_SPxK_1	531	534	PF00782	0.632
MOD_CDK_SPxK_1	528	534	PF00069	0.655
MOD_CDK_SPxxK_3	528	535	PF00069	0.645
MOD_CK1_1	134	140	PF00069	0.400
MOD_CK1_1	149	155	PF00069	0.150
MOD_CK1_1	16	22	PF00069	0.670
MOD_CK1_1	235	241	PF00069	0.474
MOD_CK1_1	269	275	PF00069	0.440
MOD_CK1_1	286	292	PF00069	0.261
MOD_CK1_1	319	325	PF00069	0.685
MOD_CK1_1	352	358	PF00069	0.443
MOD_CK1_1	363	369	PF00069	0.560
MOD_CK1_1	377	383	PF00069	0.662
MOD_CK1_1	404	410	PF00069	0.524
MOD_CK1_1	439	445	PF00069	0.672
MOD_CK1_1	528	534	PF00069	0.655
MOD_CK1_1	563	569	PF00069	0.684
MOD_CK2_1	134	140	PF00069	0.408
MOD_CK2_1	319	325	PF00069	0.731
MOD_CK2_1	440	446	PF00069	0.655
MOD_CK2_1	533	539	PF00069	0.462
MOD_CK2_1	55	61	PF00069	0.354
MOD_CK2_1	558	564	PF00069	0.748
MOD_CK2_1	609	615	PF00069	0.641
MOD_CK2_1	668	674	PF00069	0.697
MOD_CK2_1	690	696	PF00069	0.746
MOD_DYRK1A_RPxSP_1	461	465	PF00069	0.418
MOD_GlcNHglycan	13	16	PF01048	0.727
MOD_GlcNHglycan	285	288	PF01048	0.408
MOD_GlcNHglycan	295	298	PF01048	0.408
MOD_GlcNHglycan	32	35	PF01048	0.490
MOD_GlcNHglycan	379	382	PF01048	0.755
MOD_GlcNHglycan	564	568	PF01048	0.709
MOD_GSK3_1	11	18	PF00069	0.711
MOD_GSK3_1	142	149	PF00069	0.403
MOD_GSK3_1	21	28	PF00069	0.601
MOD_GSK3_1	235	242	PF00069	0.382
MOD_GSK3_1	267	274	PF00069	0.338
MOD_GSK3_1	316	323	PF00069	0.733
MOD_GSK3_1	357	364	PF00069	0.503
MOD_GSK3_1	377	384	PF00069	0.439
MOD_GSK3_1	401	408	PF00069	0.456
MOD_GSK3_1	432	439	PF00069	0.544
MOD_GSK3_1	524	531	PF00069	0.649
MOD_GSK3_1	556	563	PF00069	0.713
MOD_GSK3_1	668	675	PF00069	0.670
MOD_GSK3_1	83	90	PF00069	0.454
MOD_N-GLC_1	146	151	PF02516	0.378
MOD_N-GLC_1	352	357	PF02516	0.507
MOD_NEK2_1	115	120	PF00069	0.390
MOD_NEK2_1	142	147	PF00069	0.354
MOD_NEK2_1	283	288	PF00069	0.410
MOD_NEK2_1	349	354	PF00069	0.512
MOD_NEK2_1	365	370	PF00069	0.706
MOD_NEK2_1	385	390	PF00069	0.608
MOD_NEK2_1	405	410	PF00069	0.311
MOD_NEK2_1	438	443	PF00069	0.589
MOD_NEK2_1	525	530	PF00069	0.661
MOD_NEK2_1	55	60	PF00069	0.335
MOD_NEK2_1	87	92	PF00069	0.479
MOD_NEK2_2	302	307	PF00069	0.447
MOD_NMyristoyl	1	7	PF02799	0.640
MOD_PIKK_1	391	397	PF00454	0.490
MOD_PIKK_1	410	416	PF00454	0.357
MOD_PIKK_1	668	674	PF00454	0.722
MOD_PKA_1	556	562	PF00069	0.721
MOD_PKA_2	239	245	PF00069	0.354
MOD_PKA_2	25	31	PF00069	0.670
MOD_PKA_2	3	9	PF00069	0.726
MOD_PKA_2	377	383	PF00069	0.749
MOD_PKA_2	533	539	PF00069	0.480
MOD_PKA_2	71	77	PF00069	0.449
MOD_Plk_1	146	152	PF00069	0.378
MOD_Plk_1	352	358	PF00069	0.331
MOD_Plk_1	405	411	PF00069	0.540
MOD_Plk_1	563	569	PF00069	0.684
MOD_Plk_2-3	191	197	PF00069	0.273
MOD_Plk_4	115	121	PF00069	0.415
MOD_Plk_4	151	157	PF00069	0.447
MOD_Plk_4	173	179	PF00069	0.395
MOD_Plk_4	224	230	PF00069	0.378
MOD_Plk_4	25	31	PF00069	0.640
MOD_Plk_4	352	358	PF00069	0.500
MOD_Plk_4	381	387	PF00069	0.711
MOD_Plk_4	423	429	PF00069	0.561
MOD_Plk_4	55	61	PF00069	0.335
MOD_ProDKin_1	17	23	PF00069	0.697
MOD_ProDKin_1	311	317	PF00069	0.759
MOD_ProDKin_1	320	326	PF00069	0.693
MOD_ProDKin_1	461	467	PF00069	0.410
MOD_ProDKin_1	528	534	PF00069	0.655
MOD_ProDKin_1	558	564	PF00069	0.666
MOD_ProDKin_1	593	599	PF00069	0.653
MOD_ProDKin_1	631	637	PF00069	0.586
MOD_ProDKin_1	672	678	PF00069	0.735
MOD_ProDKin_1	690	696	PF00069	0.694
MOD_SUMO_rev_2	674	683	PF00179	0.705
TRG_DiLeu_BaEn_1	25	30	PF01217	0.655
TRG_DiLeu_BaEn_1	540	545	PF01217	0.496
TRG_ENDOCYTIC_2	125	128	PF00928	0.428
TRG_ENDOCYTIC_2	163	166	PF00928	0.408
TRG_ENDOCYTIC_2	259	262	PF00928	0.447
TRG_ENDOCYTIC_2	427	430	PF00928	0.465
TRG_ER_diArg_1	454	457	PF00400	0.579
TRG_ER_diArg_1	617	620	PF00400	0.661
TRG_ER_diArg_1	707	710	PF00400	0.723
TRG_NES_CRM1_1	49	61	PF08389	0.335
TRG_NLS_MonoExtC_3	698	704	PF00514	0.693
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I902	Leptomonas seymouri	60%	97%
A0A0S4IXS1	Bodo saltans	27%	100%
A0A1X0P069	Trypanosomatidae	34%	100%
A4HQ82	Leishmania braziliensis	82%	100%
A4IDY0	Leishmania infantum	100%	100%
D0A430	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AU00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q0J5	Leishmania major	95%	100%
V5DK61	Trypanosoma cruzi	36%	100%