U3 snoRNA-associated protein UTP11, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U3 snoRNA-associated protein UTP11, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IK07_LEIDO

TriTrypDb:

LdBPK_190670.1 , LdCL_190011700 , LDHU3_19.0750

Length:

361

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	11
GO:0030684	preribosome	3	11
GO:0032040	small-subunit processome	4	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11

Expansion

Sequence features

A0A3Q8IK07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IK07

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	227	231	PF00656	0.426
CLV_NRD_NRD_1	100	102	PF00675	0.297
CLV_NRD_NRD_1	113	115	PF00675	0.334
CLV_NRD_NRD_1	19	21	PF00675	0.334
CLV_NRD_NRD_1	213	215	PF00675	0.320
CLV_NRD_NRD_1	217	219	PF00675	0.326
CLV_NRD_NRD_1	225	227	PF00675	0.329
CLV_NRD_NRD_1	298	300	PF00675	0.296
CLV_NRD_NRD_1	333	335	PF00675	0.354
CLV_NRD_NRD_1	347	349	PF00675	0.494
CLV_NRD_NRD_1	358	360	PF00675	0.559
CLV_NRD_NRD_1	50	52	PF00675	0.280
CLV_NRD_NRD_1	56	58	PF00675	0.291
CLV_NRD_NRD_1	89	91	PF00675	0.296
CLV_NRD_NRD_1	92	94	PF00675	0.297
CLV_PCSK_FUR_1	90	94	PF00082	0.382
CLV_PCSK_KEX2_1	113	115	PF00082	0.369
CLV_PCSK_KEX2_1	19	21	PF00082	0.277
CLV_PCSK_KEX2_1	213	215	PF00082	0.317
CLV_PCSK_KEX2_1	217	219	PF00082	0.329
CLV_PCSK_KEX2_1	225	227	PF00082	0.335
CLV_PCSK_KEX2_1	262	264	PF00082	0.462
CLV_PCSK_KEX2_1	298	300	PF00082	0.296
CLV_PCSK_KEX2_1	331	333	PF00082	0.301
CLV_PCSK_KEX2_1	341	343	PF00082	0.314
CLV_PCSK_KEX2_1	347	349	PF00082	0.529
CLV_PCSK_KEX2_1	358	360	PF00082	0.533
CLV_PCSK_KEX2_1	50	52	PF00082	0.285
CLV_PCSK_KEX2_1	56	58	PF00082	0.299
CLV_PCSK_KEX2_1	62	64	PF00082	0.328
CLV_PCSK_KEX2_1	91	93	PF00082	0.298
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.277
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.356
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.461
CLV_PCSK_PC1ET2_1	331	333	PF00082	0.267
CLV_PCSK_PC1ET2_1	341	343	PF00082	0.297
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.305
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.245
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.282
CLV_PCSK_PC7_1	88	94	PF00082	0.329
CLV_PCSK_SKI1_1	16	20	PF00082	0.521
CLV_PCSK_SKI1_1	236	240	PF00082	0.305
CLV_PCSK_SKI1_1	247	251	PF00082	0.304
CLV_PCSK_SKI1_1	51	55	PF00082	0.282
CLV_Separin_Metazoa	175	179	PF03568	0.329
DEG_APCC_DBOX_1	31	39	PF00400	0.277
DEG_SPOP_SBC_1	141	145	PF00917	0.407
DOC_MAPK_gen_1	113	121	PF00069	0.364
DOC_MAPK_gen_1	47	55	PF00069	0.327
DOC_MAPK_gen_1	88	96	PF00069	0.455
DOC_PP1_RVXF_1	148	155	PF00149	0.277
DOC_PP1_RVXF_1	291	298	PF00149	0.407
DOC_USP7_MATH_1	141	145	PF00917	0.296
DOC_USP7_MATH_1	267	271	PF00917	0.319
DOC_USP7_MATH_1	9	13	PF00917	0.678
DOC_USP7_UBL2_3	103	107	PF12436	0.277
DOC_USP7_UBL2_3	246	250	PF12436	0.407
DOC_USP7_UBL2_3	331	335	PF12436	0.407
DOC_USP7_UBL2_3	50	54	PF12436	0.334
DOC_WW_Pin1_4	170	175	PF00397	0.283
DOC_WW_Pin1_4	229	234	PF00397	0.326
DOC_WW_Pin1_4	272	277	PF00397	0.300
LIG_14-3-3_CanoR_1	322	327	PF00244	0.297
LIG_BIR_III_2	171	175	PF00653	0.239
LIG_BIR_III_2	230	234	PF00653	0.344
LIG_DLG_GKlike_1	322	329	PF00625	0.277
LIG_eIF4E_1	252	258	PF01652	0.321
LIG_FHA_1	129	135	PF00498	0.381
LIG_FHA_1	253	259	PF00498	0.385
LIG_FHA_1	290	296	PF00498	0.407
LIG_FHA_1	76	82	PF00498	0.313
LIG_FHA_2	20	26	PF00498	0.321
LIG_FHA_2	273	279	PF00498	0.240
LIG_Integrin_isoDGR_2	86	88	PF01839	0.271
LIG_LIR_Nem_3	158	164	PF02991	0.277
LIG_MAD2	188	196	PF02301	0.241
LIG_NRP_CendR_1	358	361	PF00754	0.543
LIG_PCNA_yPIPBox_3	288	299	PF02747	0.407
LIG_SH2_STAT5	118	121	PF00017	0.262
LIG_TRAF2_1	157	160	PF00917	0.374
LIG_WRC_WIRS_1	161	166	PF05994	0.329
MOD_CDK_SPxxK_3	229	236	PF00069	0.271
MOD_CK1_1	272	278	PF00069	0.201
MOD_CK2_1	154	160	PF00069	0.431
MOD_CK2_1	19	25	PF00069	0.321
MOD_GlcNHglycan	11	14	PF01048	0.668
MOD_GlcNHglycan	201	204	PF01048	0.356
MOD_GlcNHglycan	208	211	PF01048	0.344
MOD_GlcNHglycan	226	229	PF01048	0.221
MOD_GlcNHglycan	326	329	PF01048	0.412
MOD_GSK3_1	24	31	PF00069	0.322
MOD_GSK3_1	265	272	PF00069	0.399
MOD_GSK3_1	320	327	PF00069	0.407
MOD_LATS_1	17	23	PF00433	0.321
MOD_NEK2_1	142	147	PF00069	0.407
MOD_NEK2_1	190	195	PF00069	0.256
MOD_NEK2_1	224	229	PF00069	0.410
MOD_NEK2_1	24	29	PF00069	0.311
MOD_PIKK_1	24	30	PF00454	0.277
MOD_PIKK_1	334	340	PF00454	0.387
MOD_PKA_1	19	25	PF00069	0.321
MOD_PKA_1	334	340	PF00069	0.366
MOD_PKA_1	347	353	PF00069	0.436
MOD_PKA_2	128	134	PF00069	0.407
MOD_PKA_2	19	25	PF00069	0.342
MOD_PKA_2	224	230	PF00069	0.312
MOD_PKA_2	347	353	PF00069	0.498
MOD_PKB_1	332	340	PF00069	0.169
MOD_Plk_1	190	196	PF00069	0.382
MOD_Plk_1	289	295	PF00069	0.428
MOD_Plk_4	190	196	PF00069	0.290
MOD_ProDKin_1	170	176	PF00069	0.283
MOD_ProDKin_1	229	235	PF00069	0.326
MOD_ProDKin_1	272	278	PF00069	0.300
MOD_SUMO_for_1	245	248	PF00179	0.316
MOD_SUMO_for_1	261	264	PF00179	0.296
TRG_DiLeu_BaEn_1	290	295	PF01217	0.407
TRG_DiLeu_LyEn_5	290	295	PF01217	0.407
TRG_ENDOCYTIC_2	118	121	PF00928	0.432
TRG_ER_diArg_1	183	186	PF00400	0.423
TRG_ER_diArg_1	224	226	PF00400	0.350
TRG_ER_diArg_1	297	299	PF00400	0.333
TRG_ER_diArg_1	358	361	PF00400	0.556
TRG_ER_diArg_1	55	57	PF00400	0.362
TRG_ER_diArg_1	89	92	PF00400	0.358
TRG_ER_diArg_1	93	96	PF00400	0.365
TRG_NLS_MonoCore_2	48	53	PF00514	0.356
TRG_NLS_MonoCore_2	89	94	PF00514	0.256
TRG_NLS_MonoExtC_3	330	335	PF00514	0.169
TRG_NLS_MonoExtC_3	49	54	PF00514	0.327
TRG_NLS_MonoExtC_3	90	95	PF00514	0.256
TRG_NLS_MonoExtN_4	16	23	PF00514	0.641
TRG_NLS_MonoExtN_4	47	54	PF00514	0.301
TRG_NLS_MonoExtN_4	88	95	PF00514	0.314
TRG_Pf-PMV_PEXEL_1	56	60	PF00026	0.407

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Z1	Leptomonas seymouri	81%	99%
A0A0S4INY9	Bodo saltans	38%	100%
A0A1X0P6A7	Trypanosomatidae	60%	100%
A0A3R7NS36	Trypanosoma rangeli	56%	100%
A4HA25	Leishmania braziliensis	88%	100%
D0A0L7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AS19	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q9U178	Leishmania major	97%	100%
V5BX19	Trypanosoma cruzi	56%	100%