Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IK06_LEIDO

TriTrypDb:

LdBPK_361520.1 , LdCL_360020700 , LDHU3_36.1950

Length:

654

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IK06

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IK06

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.698
CLV_C14_Caspase3-7	344	348	PF00656	0.725
CLV_C14_Caspase3-7	491	495	PF00656	0.595
CLV_MEL_PAP_1	563	569	PF00089	0.698
CLV_NRD_NRD_1	101	103	PF00675	0.589
CLV_NRD_NRD_1	248	250	PF00675	0.664
CLV_NRD_NRD_1	326	328	PF00675	0.809
CLV_NRD_NRD_1	424	426	PF00675	0.715
CLV_NRD_NRD_1	481	483	PF00675	0.716
CLV_NRD_NRD_1	512	514	PF00675	0.768
CLV_NRD_NRD_1	52	54	PF00675	0.818
CLV_NRD_NRD_1	628	630	PF00675	0.607
CLV_NRD_NRD_1	646	648	PF00675	0.526
CLV_PCSK_FUR_1	99	103	PF00082	0.725
CLV_PCSK_KEX2_1	101	103	PF00082	0.589
CLV_PCSK_KEX2_1	248	250	PF00082	0.663
CLV_PCSK_KEX2_1	326	328	PF00082	0.753
CLV_PCSK_KEX2_1	424	426	PF00082	0.820
CLV_PCSK_KEX2_1	481	483	PF00082	0.716
CLV_PCSK_KEX2_1	512	514	PF00082	0.768
CLV_PCSK_KEX2_1	52	54	PF00082	0.816
CLV_PCSK_KEX2_1	628	630	PF00082	0.611
CLV_PCSK_KEX2_1	645	647	PF00082	0.540
CLV_PCSK_PC7_1	48	54	PF00082	0.627
CLV_PCSK_PC7_1	641	647	PF00082	0.692
CLV_PCSK_SKI1_1	210	214	PF00082	0.718
CLV_PCSK_SKI1_1	326	330	PF00082	0.810
CLV_PCSK_SKI1_1	456	460	PF00082	0.664
CLV_PCSK_SKI1_1	512	516	PF00082	0.653
DEG_APCC_DBOX_1	391	399	PF00400	0.699
DEG_COP1_1	303	314	PF00400	0.562
DEG_COP1_1	480	489	PF00400	0.586
DEG_SCF_FBW7_2	457	464	PF00400	0.722
DEG_SPOP_SBC_1	251	255	PF00917	0.838
DEG_SPOP_SBC_1	408	412	PF00917	0.793
DEG_SPOP_SBC_1	517	521	PF00917	0.726
DEG_SPOP_SBC_1	78	82	PF00917	0.733
DOC_CDC14_PxL_1	362	370	PF14671	0.613
DOC_CKS1_1	458	463	PF01111	0.718
DOC_CYCLIN_RxL_1	323	333	PF00134	0.810
DOC_MAPK_RevD_3	87	102	PF00069	0.693
DOC_PP1_RVXF_1	58	65	PF00149	0.803
DOC_PP2B_LxvP_1	368	371	PF13499	0.600
DOC_PP4_FxxP_1	150	153	PF00568	0.682
DOC_PP4_FxxP_1	29	32	PF00568	0.832
DOC_PP4_FxxP_1	484	487	PF00568	0.671
DOC_PP4_FxxP_1	64	67	PF00568	0.794
DOC_USP7_MATH_1	112	116	PF00917	0.507
DOC_USP7_MATH_1	167	171	PF00917	0.805
DOC_USP7_MATH_1	173	177	PF00917	0.761
DOC_USP7_MATH_1	212	216	PF00917	0.746
DOC_USP7_MATH_1	223	227	PF00917	0.688
DOC_USP7_MATH_1	300	304	PF00917	0.692
DOC_USP7_MATH_1	33	37	PF00917	0.754
DOC_USP7_MATH_1	371	375	PF00917	0.720
DOC_USP7_MATH_1	408	412	PF00917	0.757
DOC_USP7_MATH_1	416	420	PF00917	0.747
DOC_USP7_MATH_1	462	466	PF00917	0.655
DOC_USP7_MATH_1	571	575	PF00917	0.779
DOC_USP7_MATH_1	578	582	PF00917	0.619
DOC_USP7_MATH_1	97	101	PF00917	0.647
DOC_WW_Pin1_4	162	167	PF00397	0.718
DOC_WW_Pin1_4	216	221	PF00397	0.727
DOC_WW_Pin1_4	262	267	PF00397	0.740
DOC_WW_Pin1_4	277	282	PF00397	0.760
DOC_WW_Pin1_4	337	342	PF00397	0.823
DOC_WW_Pin1_4	350	355	PF00397	0.755
DOC_WW_Pin1_4	360	365	PF00397	0.636
DOC_WW_Pin1_4	386	391	PF00397	0.841
DOC_WW_Pin1_4	436	441	PF00397	0.612
DOC_WW_Pin1_4	457	462	PF00397	0.775
DOC_WW_Pin1_4	465	470	PF00397	0.746
DOC_WW_Pin1_4	492	497	PF00397	0.650
DOC_WW_Pin1_4	550	555	PF00397	0.636
DOC_WW_Pin1_4	567	572	PF00397	0.650
LIG_14-3-3_CanoR_1	161	166	PF00244	0.667
LIG_14-3-3_CanoR_1	210	220	PF00244	0.690
LIG_14-3-3_CanoR_1	243	251	PF00244	0.798
LIG_14-3-3_CanoR_1	433	440	PF00244	0.735
LIG_14-3-3_CanoR_1	456	461	PF00244	0.681
LIG_14-3-3_CanoR_1	566	571	PF00244	0.787
LIG_14-3-3_CanoR_1	573	583	PF00244	0.705
LIG_14-3-3_CanoR_1	628	637	PF00244	0.456
LIG_BRCT_BRCA1_1	271	275	PF00533	0.667
LIG_BRCT_BRCA1_1	541	545	PF00533	0.719
LIG_deltaCOP1_diTrp_1	474	484	PF00928	0.660
LIG_EVH1_1	150	154	PF00568	0.684
LIG_FHA_1	252	258	PF00498	0.834
LIG_FHA_1	443	449	PF00498	0.683
LIG_FHA_1	562	568	PF00498	0.754
LIG_FHA_1	587	593	PF00498	0.701
LIG_FHA_2	200	206	PF00498	0.664
LIG_FHA_2	342	348	PF00498	0.762
LIG_FHA_2	350	356	PF00498	0.560
LIG_FHA_2	513	519	PF00498	0.678
LIG_FHA_2	617	623	PF00498	0.622
LIG_Integrin_RGD_1	48	50	PF01839	0.637
LIG_LIR_Apic_2	149	153	PF02991	0.682
LIG_LIR_Apic_2	27	32	PF02991	0.671
LIG_LIR_Apic_2	335	341	PF02991	0.817
LIG_LIR_Apic_2	483	487	PF02991	0.670
LIG_LIR_Gen_1	585	593	PF02991	0.603
LIG_LIR_Nem_3	313	319	PF02991	0.687
LIG_LIR_Nem_3	585	591	PF02991	0.705
LIG_LIR_Nem_3	598	603	PF02991	0.621
LIG_MYND_1	366	370	PF01753	0.606
LIG_PDZ_Class_1	649	654	PF00595	0.798
LIG_RPA_C_Fungi	96	108	PF08784	0.651
LIG_SH2_CRK	316	320	PF00017	0.686
LIG_SH2_CRK	588	592	PF00017	0.534
LIG_SH2_PTP2	338	341	PF00017	0.787
LIG_SH2_STAP1	588	592	PF00017	0.569
LIG_SH2_STAT5	338	341	PF00017	0.787
LIG_SH2_STAT5	588	591	PF00017	0.540
LIG_SH3_2	156	161	PF14604	0.623
LIG_SH3_3	119	125	PF00018	0.639
LIG_SH3_3	135	141	PF00018	0.665
LIG_SH3_3	145	151	PF00018	0.593
LIG_SH3_3	153	159	PF00018	0.734
LIG_SH3_3	444	450	PF00018	0.720
LIG_SUMO_SIM_par_1	126	132	PF11976	0.734
LIG_SUMO_SIM_par_1	87	92	PF11976	0.744
LIG_TRAF2_1	610	613	PF00917	0.541
LIG_TRAF2_2	45	50	PF00917	0.778
LIG_TYR_ITIM	314	319	PF00017	0.697
LIG_WRC_WIRS_1	401	406	PF05994	0.609
LIG_WW_3	460	464	PF00397	0.726
MOD_CDC14_SPxK_1	553	556	PF00782	0.581
MOD_CDC14_SPxK_1	570	573	PF00782	0.531
MOD_CDK_SPxK_1	386	392	PF00069	0.757
MOD_CDK_SPxK_1	457	463	PF00069	0.716
MOD_CDK_SPxK_1	550	556	PF00069	0.579
MOD_CDK_SPxK_1	567	573	PF00069	0.528
MOD_CK1_1	115	121	PF00069	0.729
MOD_CK1_1	224	230	PF00069	0.772
MOD_CK1_1	252	258	PF00069	0.842
MOD_CK1_1	280	286	PF00069	0.840
MOD_CK1_1	384	390	PF00069	0.738
MOD_CK1_1	410	416	PF00069	0.672
MOD_CK1_1	439	445	PF00069	0.713
MOD_CK1_1	465	471	PF00069	0.653
MOD_CK1_1	477	483	PF00069	0.759
MOD_CK1_1	488	494	PF00069	0.668
MOD_CK1_1	495	501	PF00069	0.576
MOD_CK1_1	516	522	PF00069	0.830
MOD_CK1_1	540	546	PF00069	0.806
MOD_CK1_1	55	61	PF00069	0.734
MOD_CK1_1	569	575	PF00069	0.775
MOD_CK1_1	581	587	PF00069	0.546
MOD_CK1_1	635	641	PF00069	0.592
MOD_CK2_1	212	218	PF00069	0.706
MOD_CK2_1	304	310	PF00069	0.760
MOD_CK2_1	349	355	PF00069	0.859
MOD_CK2_1	385	391	PF00069	0.833
MOD_CK2_1	394	400	PF00069	0.695
MOD_CK2_1	512	518	PF00069	0.699
MOD_CK2_1	530	536	PF00069	0.515
MOD_CK2_1	607	613	PF00069	0.757
MOD_CK2_1	616	622	PF00069	0.602
MOD_CK2_1	68	74	PF00069	0.633
MOD_DYRK1A_RPxSP_1	216	220	PF00069	0.637
MOD_GlcNHglycan	117	120	PF01048	0.733
MOD_GlcNHglycan	14	18	PF01048	0.663
MOD_GlcNHglycan	169	172	PF01048	0.699
MOD_GlcNHglycan	175	178	PF01048	0.710
MOD_GlcNHglycan	226	229	PF01048	0.825
MOD_GlcNHglycan	254	257	PF01048	0.831
MOD_GlcNHglycan	306	309	PF01048	0.721
MOD_GlcNHglycan	35	38	PF01048	0.702
MOD_GlcNHglycan	373	376	PF01048	0.640
MOD_GlcNHglycan	515	518	PF01048	0.804
MOD_GlcNHglycan	526	529	PF01048	0.636
MOD_GlcNHglycan	533	536	PF01048	0.520
MOD_GlcNHglycan	54	57	PF01048	0.530
MOD_GlcNHglycan	542	545	PF01048	0.583
MOD_GlcNHglycan	576	579	PF01048	0.765
MOD_GlcNHglycan	584	587	PF01048	0.673
MOD_GlcNHglycan	612	616	PF01048	0.710
MOD_GlcNHglycan	82	85	PF01048	0.698
MOD_GSK3_1	157	164	PF00069	0.831
MOD_GSK3_1	206	213	PF00069	0.733
MOD_GSK3_1	252	259	PF00069	0.841
MOD_GSK3_1	269	276	PF00069	0.750
MOD_GSK3_1	300	307	PF00069	0.660
MOD_GSK3_1	333	340	PF00069	0.794
MOD_GSK3_1	381	388	PF00069	0.826
MOD_GSK3_1	39	46	PF00069	0.760
MOD_GSK3_1	400	407	PF00069	0.526
MOD_GSK3_1	410	417	PF00069	0.673
MOD_GSK3_1	428	435	PF00069	0.574
MOD_GSK3_1	436	443	PF00069	0.724
MOD_GSK3_1	470	477	PF00069	0.701
MOD_GSK3_1	488	495	PF00069	0.670
MOD_GSK3_1	498	505	PF00069	0.720
MOD_GSK3_1	512	519	PF00069	0.600
MOD_GSK3_1	520	527	PF00069	0.668
MOD_GSK3_1	536	543	PF00069	0.648
MOD_GSK3_1	561	568	PF00069	0.704
MOD_GSK3_1	574	581	PF00069	0.597
MOD_GSK3_1	582	589	PF00069	0.616
MOD_GSK3_1	591	598	PF00069	0.552
MOD_GSK3_1	604	611	PF00069	0.551
MOD_GSK3_1	628	635	PF00069	0.581
MOD_N-GLC_1	319	324	PF02516	0.698
MOD_N-GLC_1	330	335	PF02516	0.657
MOD_N-GLC_1	385	390	PF02516	0.615
MOD_NEK2_1	143	148	PF00069	0.689
MOD_NEK2_1	432	437	PF00069	0.740
MOD_NEK2_1	530	535	PF00069	0.690
MOD_NEK2_1	582	587	PF00069	0.605
MOD_NEK2_1	591	596	PF00069	0.586
MOD_NEK2_1	6	11	PF00069	0.638
MOD_PIKK_1	243	249	PF00454	0.723
MOD_PIKK_1	319	325	PF00454	0.751
MOD_PIKK_1	43	49	PF00454	0.796
MOD_PIKK_1	498	504	PF00454	0.731
MOD_PKA_1	512	518	PF00069	0.730
MOD_PKA_1	52	58	PF00069	0.807
MOD_PKA_1	628	634	PF00069	0.597
MOD_PKA_2	160	166	PF00069	0.692
MOD_PKA_2	206	212	PF00069	0.635
MOD_PKA_2	349	355	PF00069	0.764
MOD_PKA_2	432	438	PF00069	0.709
MOD_PKA_2	462	468	PF00069	0.717
MOD_PKA_2	512	518	PF00069	0.756
MOD_PKA_2	52	58	PF00069	0.679
MOD_PKA_2	530	536	PF00069	0.558
MOD_PKA_2	565	571	PF00069	0.762
MOD_PKA_2	578	584	PF00069	0.654
MOD_PKA_2	616	622	PF00069	0.673
MOD_PKA_2	628	634	PF00069	0.548
MOD_PKB_1	392	400	PF00069	0.610
MOD_PKB_1	529	537	PF00069	0.707
MOD_Plk_1	198	204	PF00069	0.642
MOD_Plk_1	474	480	PF00069	0.786
MOD_Plk_1	506	512	PF00069	0.728
MOD_Plk_1	537	543	PF00069	0.830
MOD_Plk_1	604	610	PF00069	0.645
MOD_Plk_1	7	13	PF00069	0.742
MOD_Plk_2-3	199	205	PF00069	0.646
MOD_Plk_2-3	616	622	PF00069	0.725
MOD_Plk_4	112	118	PF00069	0.558
MOD_Plk_4	333	339	PF00069	0.657
MOD_Plk_4	394	400	PF00069	0.670
MOD_Plk_4	578	584	PF00069	0.677
MOD_ProDKin_1	162	168	PF00069	0.720
MOD_ProDKin_1	216	222	PF00069	0.730
MOD_ProDKin_1	262	268	PF00069	0.737
MOD_ProDKin_1	277	283	PF00069	0.757
MOD_ProDKin_1	337	343	PF00069	0.824
MOD_ProDKin_1	350	356	PF00069	0.755
MOD_ProDKin_1	360	366	PF00069	0.634
MOD_ProDKin_1	386	392	PF00069	0.841
MOD_ProDKin_1	436	442	PF00069	0.611
MOD_ProDKin_1	457	463	PF00069	0.779
MOD_ProDKin_1	465	471	PF00069	0.742
MOD_ProDKin_1	492	498	PF00069	0.651
MOD_ProDKin_1	550	556	PF00069	0.638
MOD_ProDKin_1	567	573	PF00069	0.650
MOD_SUMO_for_1	294	297	PF00179	0.647
MOD_SUMO_for_1	633	636	PF00179	0.683
MOD_SUMO_rev_2	468	477	PF00179	0.691
TRG_DiLeu_BaEn_2	399	405	PF01217	0.612
TRG_DiLeu_BaLyEn_6	453	458	PF01217	0.713
TRG_ENDOCYTIC_2	316	319	PF00928	0.660
TRG_ENDOCYTIC_2	588	591	PF00928	0.713
TRG_ENDOCYTIC_2	600	603	PF00928	0.637
TRG_ER_diArg_1	248	250	PF00400	0.663
TRG_ER_diArg_1	326	328	PF00400	0.809
TRG_ER_diArg_1	392	395	PF00400	0.618
TRG_ER_diArg_1	423	425	PF00400	0.710
TRG_ER_diArg_1	51	53	PF00400	0.741
TRG_ER_diArg_1	511	513	PF00400	0.753
TRG_ER_diArg_1	555	558	PF00400	0.633
TRG_ER_diArg_1	628	630	PF00400	0.637
TRG_ER_diArg_1	639	642	PF00400	0.573
TRG_ER_diArg_1	645	647	PF00400	0.513
TRG_ER_diArg_1	98	101	PF00400	0.721
TRG_Pf-PMV_PEXEL_1	101	106	PF00026	0.723

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HP06	Leishmania braziliensis	49%	100%
A4HP26	Leishmania braziliensis	48%	100%
A4IDB5	Leishmania infantum	98%	100%
E9ASR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q1T0	Leishmania major	83%	100%