Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJZ7_LEIDO

TriTrypDb:

LdBPK_365720.1 , LdCL_360064600 , LDHU3_36.7600

Length:

668

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IJZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJZ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.643
CLV_NRD_NRD_1	286	288	PF00675	0.735
CLV_NRD_NRD_1	293	295	PF00675	0.532
CLV_PCSK_FUR_1	284	288	PF00082	0.636
CLV_PCSK_KEX2_1	286	288	PF00082	0.735
CLV_PCSK_KEX2_1	293	295	PF00082	0.532
CLV_PCSK_KEX2_1	301	303	PF00082	0.401
CLV_PCSK_KEX2_1	411	413	PF00082	0.628
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.648
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.628
CLV_PCSK_SKI1_1	391	395	PF00082	0.684
DEG_Nend_UBRbox_2	1	3	PF02207	0.818
DEG_SPOP_SBC_1	598	602	PF00917	0.591
DEG_SPOP_SBC_1	661	665	PF00917	0.569
DOC_CKS1_1	562	567	PF01111	0.794
DOC_MAPK_gen_1	298	305	PF00069	0.650
DOC_MAPK_MEF2A_6	166	173	PF00069	0.605
DOC_PP2B_LxvP_1	571	574	PF13499	0.726
DOC_PP2B_LxvP_1	629	632	PF13499	0.826
DOC_PP4_FxxP_1	21	24	PF00568	0.819
DOC_PP4_FxxP_1	237	240	PF00568	0.792
DOC_PP4_FxxP_1	658	661	PF00568	0.711
DOC_USP7_MATH_1	120	124	PF00917	0.826
DOC_USP7_MATH_1	143	147	PF00917	0.747
DOC_USP7_MATH_1	211	215	PF00917	0.491
DOC_USP7_MATH_1	251	255	PF00917	0.657
DOC_USP7_MATH_1	32	36	PF00917	0.658
DOC_USP7_MATH_1	368	372	PF00917	0.637
DOC_USP7_MATH_1	534	538	PF00917	0.778
DOC_USP7_MATH_1	560	564	PF00917	0.754
DOC_USP7_MATH_1	611	615	PF00917	0.672
DOC_WW_Pin1_4	149	154	PF00397	0.674
DOC_WW_Pin1_4	235	240	PF00397	0.676
DOC_WW_Pin1_4	247	252	PF00397	0.583
DOC_WW_Pin1_4	472	477	PF00397	0.787
DOC_WW_Pin1_4	478	483	PF00397	0.747
DOC_WW_Pin1_4	561	566	PF00397	0.793
DOC_WW_Pin1_4	66	71	PF00397	0.798
DOC_WW_Pin1_4	662	667	PF00397	0.677
DOC_WW_Pin1_4	79	84	PF00397	0.586
LIG_14-3-3_CanoR_1	187	191	PF00244	0.627
LIG_14-3-3_CanoR_1	243	252	PF00244	0.630
LIG_14-3-3_CanoR_1	319	325	PF00244	0.645
LIG_Actin_WH2_2	172	189	PF00022	0.609
LIG_BRCT_BRCA1_1	260	264	PF00533	0.670
LIG_BRCT_BRCA1_1	654	658	PF00533	0.709
LIG_Clathr_ClatBox_1	170	174	PF01394	0.439
LIG_Clathr_ClatBox_1	5	9	PF01394	0.725
LIG_FHA_1	187	193	PF00498	0.531
LIG_FHA_1	225	231	PF00498	0.639
LIG_FHA_1	339	345	PF00498	0.579
LIG_FHA_1	35	41	PF00498	0.705
LIG_FHA_1	388	394	PF00498	0.686
LIG_FHA_1	513	519	PF00498	0.727
LIG_FHA_1	533	539	PF00498	0.613
LIG_FHA_2	111	117	PF00498	0.698
LIG_FHA_2	120	126	PF00498	0.596
LIG_FHA_2	146	152	PF00498	0.692
LIG_FHA_2	199	205	PF00498	0.667
LIG_FHA_2	294	300	PF00498	0.646
LIG_FHA_2	362	368	PF00498	0.491
LIG_FHA_2	637	643	PF00498	0.768
LIG_LIR_Apic_2	20	24	PF02991	0.798
LIG_LIR_Apic_2	234	240	PF02991	0.682
LIG_LIR_Apic_2	655	661	PF02991	0.713
LIG_LIR_Gen_1	400	407	PF02991	0.655
LIG_LIR_Gen_1	639	646	PF02991	0.806
LIG_LIR_Gen_1	648	659	PF02991	0.637
LIG_LIR_Nem_3	373	379	PF02991	0.636
LIG_LIR_Nem_3	400	406	PF02991	0.652
LIG_LIR_Nem_3	592	598	PF02991	0.811
LIG_LIR_Nem_3	639	643	PF02991	0.806
LIG_LIR_Nem_3	648	654	PF02991	0.633
LIG_LIR_Nem_3	655	659	PF02991	0.527
LIG_LYPXL_yS_3	545	548	PF13949	0.808
LIG_LYPXL_yS_3	656	659	PF13949	0.800
LIG_MAD2	243	251	PF02301	0.722
LIG_PCNA_yPIPBox_3	307	318	PF02747	0.531
LIG_Pex14_2	173	177	PF04695	0.627
LIG_RPA_C_Fungi	302	314	PF08784	0.628
LIG_SH2_CRK	403	407	PF00017	0.654
LIG_SH2_CRK	651	655	PF00017	0.789
LIG_SH2_NCK_1	403	407	PF00017	0.654
LIG_SH2_NCK_1	497	501	PF00017	0.817
LIG_SH2_STAP1	403	407	PF00017	0.654
LIG_SH2_STAT3	504	507	PF00017	0.818
LIG_SH2_STAT3	58	61	PF00017	0.852
LIG_SH2_STAT5	200	203	PF00017	0.602
LIG_SH2_STAT5	304	307	PF00017	0.649
LIG_SH2_STAT5	343	346	PF00017	0.613
LIG_SH2_STAT5	461	464	PF00017	0.827
LIG_SH2_STAT5	497	500	PF00017	0.707
LIG_SH2_STAT5	504	507	PF00017	0.702
LIG_SH2_STAT5	597	600	PF00017	0.822
LIG_SH3_2	565	570	PF14604	0.704
LIG_SH3_3	101	107	PF00018	0.840
LIG_SH3_3	130	136	PF00018	0.735
LIG_SH3_3	428	434	PF00018	0.761
LIG_SH3_3	500	506	PF00018	0.792
LIG_SH3_3	53	59	PF00018	0.723
LIG_SH3_3	540	546	PF00018	0.818
LIG_SH3_3	559	565	PF00018	0.522
LIG_SH3_3	587	593	PF00018	0.737
LIG_SH3_3	632	638	PF00018	0.775
LIG_SH3_3	651	657	PF00018	0.512
LIG_SUMO_SIM_anti_2	537	542	PF11976	0.745
LIG_SUMO_SIM_par_1	143	148	PF11976	0.604
LIG_SUMO_SIM_par_1	168	174	PF11976	0.600
LIG_SUMO_SIM_par_1	2	9	PF11976	0.724
LIG_SUMO_SIM_par_1	519	525	PF11976	0.768
LIG_TRAF2_1	113	116	PF00917	0.745
LIG_TRFH_1	497	501	PF08558	0.817
LIG_TYR_ITIM	401	406	PF00017	0.646
LIG_TYR_ITIM	543	548	PF00017	0.811
LIG_TYR_ITIM	654	659	PF00017	0.793
MOD_CDC14_SPxK_1	82	85	PF00782	0.836
MOD_CDK_SPxK_1	79	85	PF00069	0.846
MOD_CK1_1	226	232	PF00069	0.682
MOD_CK1_1	456	462	PF00069	0.734
MOD_CK1_1	478	484	PF00069	0.781
MOD_CK1_1	588	594	PF00069	0.607
MOD_CK1_1	662	668	PF00069	0.634
MOD_CK1_1	97	103	PF00069	0.832
MOD_CK2_1	110	116	PF00069	0.751
MOD_CK2_1	145	151	PF00069	0.692
MOD_CK2_1	198	204	PF00069	0.665
MOD_CK2_1	251	257	PF00069	0.718
MOD_CK2_1	636	642	PF00069	0.768
MOD_GlcNHglycan	108	111	PF01048	0.661
MOD_GlcNHglycan	115	120	PF01048	0.528
MOD_GlcNHglycan	122	125	PF01048	0.784
MOD_GlcNHglycan	183	186	PF01048	0.524
MOD_GlcNHglycan	260	263	PF01048	0.716
MOD_GlcNHglycan	276	279	PF01048	0.492
MOD_GlcNHglycan	329	332	PF01048	0.575
MOD_GlcNHglycan	353	356	PF01048	0.607
MOD_GlcNHglycan	413	416	PF01048	0.610
MOD_GlcNHglycan	42	45	PF01048	0.765
MOD_GlcNHglycan	469	472	PF01048	0.804
MOD_GlcNHglycan	587	590	PF01048	0.757
MOD_GlcNHglycan	614	617	PF01048	0.673
MOD_GlcNHglycan	96	99	PF01048	0.746
MOD_GSK3_1	106	113	PF00069	0.672
MOD_GSK3_1	115	122	PF00069	0.621
MOD_GSK3_1	143	150	PF00069	0.645
MOD_GSK3_1	247	254	PF00069	0.803
MOD_GSK3_1	265	272	PF00069	0.443
MOD_GSK3_1	32	39	PF00069	0.811
MOD_GSK3_1	387	394	PF00069	0.692
MOD_GSK3_1	452	459	PF00069	0.741
MOD_GSK3_1	513	520	PF00069	0.801
MOD_GSK3_1	522	529	PF00069	0.728
MOD_GSK3_1	532	539	PF00069	0.556
MOD_GSK3_1	581	588	PF00069	0.693
MOD_GSK3_1	661	668	PF00069	0.695
MOD_LATS_1	409	415	PF00433	0.707
MOD_N-GLC_1	40	45	PF02516	0.820
MOD_N-GLC_1	560	565	PF02516	0.752
MOD_NEK2_1	1	6	PF00069	0.650
MOD_NEK2_1	186	191	PF00069	0.624
MOD_NEK2_1	19	24	PF00069	0.735
MOD_NEK2_1	264	269	PF00069	0.737
MOD_NEK2_1	361	366	PF00069	0.634
MOD_NEK2_1	387	392	PF00069	0.704
MOD_NEK2_1	40	45	PF00069	0.750
MOD_NEK2_1	495	500	PF00069	0.716
MOD_NEK2_2	338	343	PF00069	0.506
MOD_PIKK_1	346	352	PF00454	0.672
MOD_PIKK_1	438	444	PF00454	0.835
MOD_PIKK_1	481	487	PF00454	0.694
MOD_PIKK_1	528	534	PF00454	0.727
MOD_PIKK_1	546	552	PF00454	0.610
MOD_PIKK_1	599	605	PF00454	0.628
MOD_PKA_1	293	299	PF00069	0.645
MOD_PKA_1	411	417	PF00069	0.674
MOD_PKA_2	186	192	PF00069	0.627
MOD_PKA_2	293	299	PF00069	0.645
MOD_PKA_2	411	417	PF00069	0.674
MOD_Plk_1	1	7	PF00069	0.808
MOD_Plk_1	211	217	PF00069	0.633
MOD_Plk_1	32	38	PF00069	0.743
MOD_Plk_4	1	7	PF00069	0.726
MOD_Plk_4	205	211	PF00069	0.602
MOD_Plk_4	212	218	PF00069	0.527
MOD_Plk_4	251	257	PF00069	0.718
MOD_Plk_4	338	344	PF00069	0.527
MOD_Plk_4	361	367	PF00069	0.642
MOD_Plk_4	462	468	PF00069	0.673
MOD_Plk_4	536	542	PF00069	0.827
MOD_Plk_4	619	625	PF00069	0.819
MOD_Plk_4	636	642	PF00069	0.565
MOD_ProDKin_1	149	155	PF00069	0.675
MOD_ProDKin_1	235	241	PF00069	0.677
MOD_ProDKin_1	247	253	PF00069	0.582
MOD_ProDKin_1	472	478	PF00069	0.788
MOD_ProDKin_1	561	567	PF00069	0.795
MOD_ProDKin_1	66	72	PF00069	0.798
MOD_ProDKin_1	662	668	PF00069	0.679
MOD_ProDKin_1	79	85	PF00069	0.586
TRG_DiLeu_BaLyEn_6	433	438	PF01217	0.614
TRG_ENDOCYTIC_2	403	406	PF00928	0.648
TRG_ENDOCYTIC_2	545	548	PF00928	0.808
TRG_ENDOCYTIC_2	595	598	PF00928	0.820
TRG_ENDOCYTIC_2	651	654	PF00928	0.791
TRG_ENDOCYTIC_2	656	659	PF00928	0.718
TRG_ER_diArg_1	284	287	PF00400	0.724
TRG_ER_diArg_1	292	294	PF00400	0.523
TRG_NES_CRM1_1	388	400	PF08389	0.492
TRG_Pf-PMV_PEXEL_1	319	324	PF00026	0.639

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HQ65	Leishmania braziliensis	68%	97%
A4IDW2	Leishmania infantum	98%	100%
E9ATY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	98%
Q4Q0L3	Leishmania major	91%	99%