Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJZ4_LEIDO

TriTrypDb:

LdBPK_361350.1 , LdCL_360018600 , LDHU3_36.1700

Length:

544

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0032797	SMN complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0120114	Sm-like protein family complex	2	1

Expansion

Sequence features

A0A3Q8IJZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJZ4

Function

Biological processes
Term	Name	Level	Count
GO:0000387	spliceosomal snRNP assembly	7	9
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	9
GO:0022607	cellular component assembly	4	9
GO:0022618	ribonucleoprotein complex assembly	6	9
GO:0043933	protein-containing complex organization	4	9
GO:0065003	protein-containing complex assembly	5	9
GO:0071826	ribonucleoprotein complex subunit organization	5	9
GO:0071840	cellular component organization or biogenesis	2	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	225	229	PF00656	0.714
CLV_C14_Caspase3-7	266	270	PF00656	0.528
CLV_C14_Caspase3-7	354	358	PF00656	0.704
CLV_C14_Caspase3-7	369	373	PF00656	0.687
CLV_NRD_NRD_1	169	171	PF00675	0.656
CLV_NRD_NRD_1	237	239	PF00675	0.705
CLV_NRD_NRD_1	290	292	PF00675	0.527
CLV_NRD_NRD_1	500	502	PF00675	0.521
CLV_NRD_NRD_1	516	518	PF00675	0.271
CLV_PCSK_FUR_1	235	239	PF00082	0.523
CLV_PCSK_FUR_1	288	292	PF00082	0.549
CLV_PCSK_KEX2_1	237	239	PF00082	0.654
CLV_PCSK_KEX2_1	288	290	PF00082	0.512
CLV_PCSK_KEX2_1	500	502	PF00082	0.541
CLV_PCSK_KEX2_1	516	518	PF00082	0.271
CLV_PCSK_KEX2_1	80	82	PF00082	0.681
CLV_PCSK_KEX2_1	84	86	PF00082	0.674
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.667
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.658
CLV_PCSK_PC7_1	284	290	PF00082	0.568
CLV_PCSK_SKI1_1	417	421	PF00082	0.456
CLV_PCSK_SKI1_1	490	494	PF00082	0.579
CLV_PCSK_SKI1_1	81	85	PF00082	0.749
CLV_Separin_Metazoa	250	254	PF03568	0.398
DEG_APCC_DBOX_1	416	424	PF00400	0.493
DEG_SCF_FBW7_1	107	114	PF00400	0.642
DEG_SIAH_1	141	149	PF03145	0.774
DEG_SPOP_SBC_1	111	115	PF00917	0.765
DEG_SPOP_SBC_1	328	332	PF00917	0.507
DOC_CYCLIN_yCln2_LP_2	453	459	PF00134	0.546
DOC_MAPK_gen_1	189	199	PF00069	0.503
DOC_MAPK_gen_1	316	326	PF00069	0.482
DOC_MAPK_gen_1	516	523	PF00069	0.327
DOC_PP1_RVXF_1	124	131	PF00149	0.718
DOC_PP2B_LxvP_1	453	456	PF13499	0.545
DOC_PP2B_PxIxI_1	46	52	PF00149	0.593
DOC_PP4_FxxP_1	425	428	PF00568	0.500
DOC_USP7_MATH_1	100	104	PF00917	0.780
DOC_USP7_MATH_1	111	115	PF00917	0.591
DOC_USP7_MATH_1	329	333	PF00917	0.451
DOC_USP7_MATH_1	337	341	PF00917	0.390
DOC_USP7_MATH_1	39	43	PF00917	0.699
DOC_USP7_MATH_1	83	87	PF00917	0.764
DOC_USP7_MATH_2	119	125	PF00917	0.691
DOC_USP7_UBL2_3	80	84	PF12436	0.773
DOC_USP7_UBL2_3	9	13	PF12436	0.636
DOC_WW_Pin1_4	107	112	PF00397	0.634
DOC_WW_Pin1_4	138	143	PF00397	0.679
DOC_WW_Pin1_4	43	48	PF00397	0.759
LIG_14-3-3_CanoR_1	215	222	PF00244	0.665
LIG_14-3-3_CanoR_1	319	326	PF00244	0.578
LIG_14-3-3_CanoR_1	417	423	PF00244	0.523
LIG_14-3-3_CanoR_1	436	441	PF00244	0.552
LIG_14-3-3_CanoR_1	474	480	PF00244	0.450
LIG_Actin_WH2_2	186	203	PF00022	0.522
LIG_APCC_ABBAyCdc20_2	126	132	PF00400	0.673
LIG_BIR_II_1	1	5	PF00653	0.659
LIG_BIR_III_2	503	507	PF00653	0.553
LIG_BIR_III_3	1	5	PF00653	0.592
LIG_BRCT_BRCA1_1	15	19	PF00533	0.668
LIG_BRCT_BRCA1_1	178	182	PF00533	0.596
LIG_BRCT_BRCA1_1	331	335	PF00533	0.483
LIG_FHA_1	123	129	PF00498	0.748
LIG_FHA_1	141	147	PF00498	0.518
LIG_FHA_1	435	441	PF00498	0.538
LIG_FHA_1	44	50	PF00498	0.746
LIG_FHA_1	459	465	PF00498	0.516
LIG_FHA_1	487	493	PF00498	0.599
LIG_FHA_1	523	529	PF00498	0.347
LIG_FHA_1	55	61	PF00498	0.647
LIG_FHA_2	365	371	PF00498	0.744
LIG_FHA_2	385	391	PF00498	0.678
LIG_FHA_2	508	514	PF00498	0.483
LIG_LIR_Gen_1	195	204	PF02991	0.503
LIG_LIR_Gen_1	421	428	PF02991	0.423
LIG_LIR_LC3C_4	57	62	PF02991	0.779
LIG_LIR_Nem_3	195	199	PF02991	0.522
LIG_LIR_Nem_3	239	243	PF02991	0.477
LIG_LIR_Nem_3	421	425	PF02991	0.416
LIG_LIR_Nem_3	539	544	PF02991	0.635
LIG_PCNA_PIPBox_1	416	425	PF02747	0.524
LIG_PCNA_yPIPBox_3	416	424	PF02747	0.525
LIG_Pex14_2	272	276	PF04695	0.513
LIG_PTAP_UEV_1	141	146	PF05743	0.781
LIG_REV1ctd_RIR_1	531	539	PF16727	0.544
LIG_SH2_CRK	283	287	PF00017	0.551
LIG_SH2_CRK	524	528	PF00017	0.433
LIG_SH2_GRB2like	306	309	PF00017	0.591
LIG_SH2_PTP2	196	199	PF00017	0.569
LIG_SH2_STAP1	524	528	PF00017	0.424
LIG_SH2_STAT5	196	199	PF00017	0.499
LIG_SH2_STAT5	306	309	PF00017	0.468
LIG_SH2_STAT5	509	512	PF00017	0.534
LIG_SH2_STAT5	524	527	PF00017	0.393
LIG_SH2_STAT5	7	10	PF00017	0.583
LIG_SH3_1	496	502	PF00018	0.558
LIG_SH3_1	93	99	PF00018	0.601
LIG_SH3_3	136	142	PF00018	0.711
LIG_SH3_3	252	258	PF00018	0.571
LIG_SH3_3	289	295	PF00018	0.539
LIG_SH3_3	403	409	PF00018	0.620
LIG_SH3_3	453	459	PF00018	0.464
LIG_SH3_3	496	502	PF00018	0.558
LIG_SH3_3	93	99	PF00018	0.719
LIG_SUMO_SIM_anti_2	195	201	PF11976	0.560
LIG_SUMO_SIM_anti_2	525	531	PF11976	0.358
LIG_SUMO_SIM_anti_2	55	64	PF11976	0.769
LIG_SUMO_SIM_par_1	518	525	PF11976	0.373
LIG_TRAF2_1	166	169	PF00917	0.642
LIG_TRAF2_1	25	28	PF00917	0.720
LIG_TRAF2_1	388	391	PF00917	0.755
LIG_WRC_WIRS_1	257	262	PF05994	0.403
LIG_WRC_WIRS_1	419	424	PF05994	0.414
LIG_WW_1	506	509	PF00397	0.540
LIG_WW_3	316	320	PF00397	0.407
MOD_CK1_1	214	220	PF00069	0.553
MOD_CK1_1	274	280	PF00069	0.463
MOD_CK1_1	327	333	PF00069	0.428
MOD_CK1_1	356	362	PF00069	0.696
MOD_CK1_1	373	379	PF00069	0.769
MOD_CK1_1	486	492	PF00069	0.584
MOD_CK1_1	53	59	PF00069	0.736
MOD_CK2_1	163	169	PF00069	0.621
MOD_CK2_1	241	247	PF00069	0.541
MOD_CK2_1	364	370	PF00069	0.755
MOD_CK2_1	384	390	PF00069	0.680
MOD_CK2_1	429	435	PF00069	0.637
MOD_Cter_Amidation	10	13	PF01082	0.686
MOD_GlcNHglycan	225	228	PF01048	0.705
MOD_GlcNHglycan	276	279	PF01048	0.489
MOD_GlcNHglycan	326	329	PF01048	0.449
MOD_GlcNHglycan	331	334	PF01048	0.356
MOD_GlcNHglycan	372	375	PF01048	0.680
MOD_GlcNHglycan	402	405	PF01048	0.603
MOD_GlcNHglycan	450	453	PF01048	0.426
MOD_GlcNHglycan	485	488	PF01048	0.582
MOD_GlcNHglycan	57	60	PF01048	0.705
MOD_GlcNHglycan	87	90	PF01048	0.759
MOD_GSK3_1	107	114	PF00069	0.745
MOD_GSK3_1	117	124	PF00069	0.718
MOD_GSK3_1	134	141	PF00069	0.734
MOD_GSK3_1	324	331	PF00069	0.434
MOD_GSK3_1	333	340	PF00069	0.375
MOD_GSK3_1	362	369	PF00069	0.763
MOD_GSK3_1	39	46	PF00069	0.733
MOD_GSK3_1	49	56	PF00069	0.684
MOD_GSK3_1	83	90	PF00069	0.736
MOD_N-GLC_1	107	112	PF02516	0.686
MOD_N-GLC_1	134	139	PF02516	0.707
MOD_N-GLC_1	229	234	PF02516	0.688
MOD_N-GLC_1	53	58	PF02516	0.719
MOD_NEK2_1	134	139	PF00069	0.707
MOD_NEK2_1	211	216	PF00069	0.577
MOD_NEK2_1	251	256	PF00069	0.545
MOD_NEK2_1	324	329	PF00069	0.507
MOD_NEK2_1	335	340	PF00069	0.417
MOD_NEK2_1	468	473	PF00069	0.443
MOD_NEK2_1	492	497	PF00069	0.544
MOD_PIKK_1	214	220	PF00454	0.559
MOD_PK_1	436	442	PF00069	0.509
MOD_PKA_2	214	220	PF00069	0.567
MOD_PKA_2	318	324	PF00069	0.588
MOD_PKA_2	362	368	PF00069	0.766
MOD_PKA_2	435	441	PF00069	0.570
MOD_PKB_1	434	442	PF00069	0.538
MOD_PKB_1	85	93	PF00069	0.779
MOD_Plk_1	183	189	PF00069	0.489
MOD_Plk_1	27	33	PF00069	0.767
MOD_Plk_1	356	362	PF00069	0.665
MOD_Plk_2-3	351	357	PF00069	0.632
MOD_Plk_4	102	108	PF00069	0.697
MOD_Plk_4	176	182	PF00069	0.554
MOD_Plk_4	27	33	PF00069	0.761
MOD_Plk_4	418	424	PF00069	0.397
MOD_Plk_4	522	528	PF00069	0.349
MOD_ProDKin_1	107	113	PF00069	0.636
MOD_ProDKin_1	138	144	PF00069	0.677
MOD_ProDKin_1	43	49	PF00069	0.762
MOD_SUMO_rev_2	166	172	PF00179	0.602
TRG_DiLeu_BaEn_1	247	252	PF01217	0.443
TRG_DiLeu_BaLyEn_6	281	286	PF01217	0.480
TRG_DiLeu_BaLyEn_6	338	343	PF01217	0.495
TRG_ENDOCYTIC_2	196	199	PF00928	0.539
TRG_ENDOCYTIC_2	240	243	PF00928	0.553
TRG_ENDOCYTIC_2	283	286	PF00928	0.551
TRG_ENDOCYTIC_2	509	512	PF00928	0.406
TRG_ENDOCYTIC_2	524	527	PF00928	0.348
TRG_ENDOCYTIC_2	7	10	PF00928	0.672
TRG_ER_diArg_1	235	238	PF00400	0.632
TRG_ER_diArg_1	288	291	PF00400	0.551
TRG_ER_diArg_1	378	381	PF00400	0.778
TRG_ER_diArg_1	499	501	PF00400	0.472
TRG_ER_diArg_1	515	517	PF00400	0.253
TRG_NLS_MonoCore_2	77	82	PF00514	0.701
TRG_NLS_MonoExtN_4	76	83	PF00514	0.656

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC77	Leptomonas seymouri	48%	99%
A0A0S4IYS2	Bodo saltans	27%	100%
A0A1X0P8B5	Trypanosomatidae	32%	100%
A0A3R7RAQ0	Trypanosoma rangeli	30%	100%
A4HNY7	Leishmania braziliensis	77%	100%
A4ICK6	Leishmania infantum	100%	100%
D0A2V6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ASP9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q1U6	Leishmania major	92%	100%