PSP1 C-terminal conserved region containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PSP1 C-terminal conserved region, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJZ1_LEIDO

TriTrypDb:

LdBPK_355040.1 , LdCL_350055500 , LDHU3_35.6620

Length:

280

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IJZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJZ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	64	68	PF00656	0.573
CLV_NRD_NRD_1	108	110	PF00675	0.460
CLV_NRD_NRD_1	154	156	PF00675	0.347
CLV_NRD_NRD_1	166	168	PF00675	0.279
CLV_NRD_NRD_1	218	220	PF00675	0.340
CLV_NRD_NRD_1	253	255	PF00675	0.598
CLV_NRD_NRD_1	257	259	PF00675	0.583
CLV_PCSK_KEX2_1	154	156	PF00082	0.347
CLV_PCSK_KEX2_1	16	18	PF00082	0.596
CLV_PCSK_KEX2_1	166	168	PF00082	0.318
CLV_PCSK_KEX2_1	218	220	PF00082	0.285
CLV_PCSK_KEX2_1	253	255	PF00082	0.609
CLV_PCSK_KEX2_1	257	259	PF00082	0.593
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.666
CLV_PCSK_PC7_1	253	259	PF00082	0.717
CLV_PCSK_SKI1_1	148	152	PF00082	0.454
CLV_PCSK_SKI1_1	154	158	PF00082	0.328
CLV_PCSK_SKI1_1	16	20	PF00082	0.612
CLV_PCSK_SKI1_1	167	171	PF00082	0.286
CLV_PCSK_SKI1_1	201	205	PF00082	0.320
CLV_PCSK_SKI1_1	222	226	PF00082	0.275
CLV_PCSK_SKI1_1	268	272	PF00082	0.491
CLV_PCSK_SKI1_1	63	67	PF00082	0.483
DOC_CKS1_1	30	35	PF01111	0.654
DOC_CYCLIN_RxL_1	218	226	PF00134	0.400
DOC_CYCLIN_yCln2_LP_2	30	36	PF00134	0.702
DOC_CYCLIN_yCln2_LP_2	87	93	PF00134	0.648
DOC_MAPK_gen_1	201	207	PF00069	0.278
DOC_MAPK_gen_1	209	217	PF00069	0.292
DOC_PP1_RVXF_1	146	152	PF00149	0.489
DOC_PP1_RVXF_1	229	235	PF00149	0.350
DOC_PP2B_LxvP_1	87	90	PF13499	0.692
DOC_USP7_MATH_1	210	214	PF00917	0.291
DOC_USP7_MATH_1	272	276	PF00917	0.455
DOC_USP7_MATH_1	52	56	PF00917	0.633
DOC_USP7_MATH_1	61	65	PF00917	0.627
DOC_USP7_MATH_1	69	73	PF00917	0.667
DOC_USP7_MATH_1	77	81	PF00917	0.593
DOC_USP7_MATH_1	83	87	PF00917	0.548
DOC_USP7_UBL2_3	106	110	PF12436	0.354
DOC_USP7_UBL2_3	15	19	PF12436	0.644
DOC_WW_Pin1_4	140	145	PF00397	0.550
DOC_WW_Pin1_4	29	34	PF00397	0.616
DOC_WW_Pin1_4	45	50	PF00397	0.631
DOC_WW_Pin1_4	57	62	PF00397	0.563
LIG_14-3-3_CanoR_1	166	170	PF00244	0.373
LIG_14-3-3_CanoR_1	179	188	PF00244	0.304
LIG_14-3-3_CanoR_1	209	215	PF00244	0.314
LIG_14-3-3_CanoR_1	219	225	PF00244	0.262
LIG_Actin_WH2_2	237	255	PF00022	0.425
LIG_BRCT_BRCA1_1	210	214	PF00533	0.358
LIG_FHA_1	140	146	PF00498	0.510
LIG_FHA_1	202	208	PF00498	0.271
LIG_FHA_1	247	253	PF00498	0.677
LIG_FHA_2	155	161	PF00498	0.271
LIG_FHA_2	166	172	PF00498	0.273
LIG_FHA_2	187	193	PF00498	0.461
LIG_LIR_Gen_1	211	220	PF02991	0.331
LIG_LIR_Gen_1	99	107	PF02991	0.460
LIG_LIR_Nem_3	211	217	PF02991	0.310
LIG_LIR_Nem_3	223	228	PF02991	0.304
LIG_LIR_Nem_3	99	105	PF02991	0.390
LIG_PALB2_WD40_1	229	237	PF16756	0.345
LIG_PCNA_yPIPBox_3	110	124	PF02747	0.280
LIG_PCNA_yPIPBox_3	218	228	PF02747	0.377
LIG_Pex14_2	112	116	PF04695	0.326
LIG_SH2_STAP1	26	30	PF00017	0.559
LIG_SH2_STAT5	236	239	PF00017	0.322
LIG_SH3_3	182	188	PF00018	0.285
LIG_SH3_3	245	251	PF00018	0.653
LIG_SH3_3	30	36	PF00018	0.535
LIG_SH3_3	46	52	PF00018	0.741
LIG_SUMO_SIM_par_1	122	127	PF11976	0.518
LIG_SUMO_SIM_par_1	203	208	PF11976	0.395
LIG_UBA3_1	195	202	PF00899	0.347
MOD_CDC14_SPxK_1	60	63	PF00782	0.650
MOD_CDK_SPK_2	45	50	PF00069	0.652
MOD_CDK_SPxK_1	57	63	PF00069	0.660
MOD_CK1_1	180	186	PF00069	0.215
MOD_CK1_1	208	214	PF00069	0.354
MOD_CK1_1	29	35	PF00069	0.597
MOD_CK1_1	3	9	PF00069	0.589
MOD_CK1_1	48	54	PF00069	0.628
MOD_CK1_1	55	61	PF00069	0.608
MOD_CK2_1	165	171	PF00069	0.345
MOD_CK2_1	186	192	PF00069	0.468
MOD_CK2_1	258	264	PF00069	0.685
MOD_CK2_1	32	38	PF00069	0.450
MOD_Cter_Amidation	107	110	PF01082	0.474
MOD_Cter_Amidation	199	202	PF01082	0.299
MOD_GlcNHglycan	71	74	PF01048	0.571
MOD_GSK3_1	154	161	PF00069	0.398
MOD_GSK3_1	201	208	PF00069	0.259
MOD_GSK3_1	242	249	PF00069	0.512
MOD_GSK3_1	270	277	PF00069	0.484
MOD_GSK3_1	3	10	PF00069	0.554
MOD_GSK3_1	48	55	PF00069	0.616
MOD_GSK3_1	57	64	PF00069	0.571
MOD_NEK2_1	2	7	PF00069	0.628
MOD_NEK2_1	220	225	PF00069	0.356
MOD_NEK2_1	9	14	PF00069	0.652
MOD_NEK2_2	174	179	PF00069	0.359
MOD_PIKK_1	159	165	PF00454	0.362
MOD_PIKK_1	180	186	PF00454	0.217
MOD_PIKK_1	4	10	PF00454	0.469
MOD_PKA_1	154	160	PF00069	0.400
MOD_PKA_1	201	207	PF00069	0.321
MOD_PKA_1	257	263	PF00069	0.597
MOD_PKA_2	154	160	PF00069	0.400
MOD_PKA_2	165	171	PF00069	0.400
MOD_PKA_2	208	214	PF00069	0.327
MOD_PKA_2	257	263	PF00069	0.574
MOD_Plk_4	26	32	PF00069	0.571
MOD_ProDKin_1	140	146	PF00069	0.550
MOD_ProDKin_1	29	35	PF00069	0.611
MOD_ProDKin_1	45	51	PF00069	0.630
MOD_ProDKin_1	57	63	PF00069	0.563
MOD_SUMO_rev_2	193	203	PF00179	0.333
MOD_SUMO_rev_2	261	271	PF00179	0.473
TRG_DiLeu_BaEn_2	146	152	PF01217	0.381
TRG_ER_diArg_1	153	155	PF00400	0.349
TRG_ER_diArg_1	217	219	PF00400	0.317
TRG_ER_diArg_1	228	231	PF00400	0.274
TRG_ER_diArg_1	252	254	PF00400	0.635
TRG_NLS_MonoExtC_3	14	19	PF00514	0.462
TRG_NLS_MonoExtN_4	15	20	PF00514	0.461
TRG_Pf-PMV_PEXEL_1	179	184	PF00026	0.335
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.647

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYT9	Leptomonas seymouri	25%	73%
A0A0N1I362	Leptomonas seymouri	26%	69%
A0A0N1PC14	Leptomonas seymouri	65%	97%
A0A0S4J5L8	Bodo saltans	33%	95%
A0A0S4JEW1	Bodo saltans	27%	80%
A0A1X0NLP9	Trypanosomatidae	28%	100%
A0A1X0P536	Trypanosomatidae	43%	100%
A0A3Q8IC14	Leishmania donovani	25%	100%
A0A3Q8ILM8	Leishmania donovani	29%	100%
A0A3R7NIU7	Trypanosoma rangeli	41%	100%
A4HMC6	Leishmania braziliensis	24%	68%
A4HNG2	Leishmania braziliensis	82%	100%
A4HUB9	Leishmania infantum	25%	100%
A4IC69	Leishmania infantum	99%	100%
A4ICE2	Leishmania infantum	29%	100%
C9ZYF4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
D0A3S8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AFX3	Leishmania major	95%	100%
E9B726	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BJK0	Trypanosoma cruzi	27%	77%