Carboxypeptidase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

carboxypeptidase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJY8_LEIDO

TriTrypDb:

LdBPK_366520.1 , LdCL_360072700 , LDHU3_14.0240

Length:

455

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 3
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 2
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 9

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 25
NetGPI	no	yes: 0, no: 25

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IJY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJY8

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	26
GO:0006807	nitrogen compound metabolic process	2	26
GO:0008152	metabolic process	1	26
GO:0019538	protein metabolic process	3	26
GO:0043170	macromolecule metabolic process	3	26
GO:0044238	primary metabolic process	2	26
GO:0071704	organic substance metabolic process	2	26
GO:1901564	organonitrogen compound metabolic process	3	26
GO:0006518	peptide metabolic process	4	1
GO:0043603	amide metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	26
GO:0004180	carboxypeptidase activity	5	26
GO:0004181	metallocarboxypeptidase activity	6	26
GO:0008233	peptidase activity	3	26
GO:0008235	metalloexopeptidase activity	5	26
GO:0008237	metallopeptidase activity	4	26
GO:0008238	exopeptidase activity	4	26
GO:0016787	hydrolase activity	2	26
GO:0140096	catalytic activity, acting on a protein	2	26
GO:0016853	isomerase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.320
CLV_NRD_NRD_1	11	13	PF00675	0.180
CLV_NRD_NRD_1	190	192	PF00675	0.180
CLV_NRD_NRD_1	336	338	PF00675	0.412
CLV_NRD_NRD_1	348	350	PF00675	0.380
CLV_NRD_NRD_1	441	443	PF00675	0.494
CLV_PCSK_KEX2_1	101	103	PF00082	0.412
CLV_PCSK_KEX2_1	441	443	PF00082	0.491
CLV_PCSK_PC7_1	437	443	PF00082	0.401
CLV_PCSK_SKI1_1	18	22	PF00082	0.310
CLV_PCSK_SKI1_1	185	189	PF00082	0.393
CLV_PCSK_SKI1_1	259	263	PF00082	0.373
CLV_PCSK_SKI1_1	280	284	PF00082	0.369
CLV_PCSK_SKI1_1	35	39	PF00082	0.375
CLV_PCSK_SKI1_1	59	63	PF00082	0.398
CLV_PCSK_SKI1_1	65	69	PF00082	0.374
CLV_Separin_Metazoa	84	88	PF03568	0.225
CLV_Separin_Metazoa	98	102	PF03568	0.203
DEG_APCC_DBOX_1	102	110	PF00400	0.180
DEG_APCC_DBOX_1	401	409	PF00400	0.256
DEG_APCC_DBOX_1	78	86	PF00400	0.299
DEG_Nend_UBRbox_3	1	3	PF02207	0.535
DOC_CKS1_1	201	206	PF01111	0.256
DOC_CYCLIN_RxL_1	256	264	PF00134	0.358
DOC_CYCLIN_yCln2_LP_2	433	436	PF00134	0.375
DOC_MAPK_gen_1	15	23	PF00069	0.286
DOC_MAPK_gen_1	390	397	PF00069	0.332
DOC_PP1_RVXF_1	407	414	PF00149	0.161
DOC_PP2B_LxvP_1	433	436	PF13499	0.375
DOC_USP7_MATH_1	145	149	PF00917	0.301
DOC_USP7_UBL2_3	334	338	PF12436	0.161
DOC_WW_Pin1_4	148	153	PF00397	0.438
DOC_WW_Pin1_4	200	205	PF00397	0.256
DOC_WW_Pin1_4	250	255	PF00397	0.443
DOC_WW_Pin1_4	30	35	PF00397	0.142
LIG_14-3-3_CanoR_1	103	113	PF00244	0.363
LIG_14-3-3_CanoR_1	12	18	PF00244	0.277
LIG_14-3-3_CanoR_1	215	224	PF00244	0.400
LIG_14-3-3_CanoR_1	247	251	PF00244	0.451
LIG_14-3-3_CanoR_1	40	45	PF00244	0.470
LIG_14-3-3_CanoR_1	450	455	PF00244	0.653
LIG_14-3-3_CanoR_1	52	58	PF00244	0.390
LIG_Actin_WH2_2	129	146	PF00022	0.298
LIG_Actin_WH2_2	393	411	PF00022	0.161
LIG_BRCT_BRCA1_1	309	313	PF00533	0.291
LIG_Clathr_ClatBox_1	133	137	PF01394	0.256
LIG_CSL_BTD_1	125	128	PF09270	0.357
LIG_deltaCOP1_diTrp_1	220	226	PF00928	0.384
LIG_FHA_1	256	262	PF00498	0.441
LIG_FHA_1	296	302	PF00498	0.454
LIG_FHA_2	127	133	PF00498	0.366
LIG_FHA_2	262	268	PF00498	0.377
LIG_FHA_2	41	47	PF00498	0.351
LIG_GBD_Chelix_1	60	68	PF00786	0.375
LIG_HP1_1	58	62	PF01393	0.212
LIG_LIR_Apic_2	249	254	PF02991	0.250
LIG_LIR_Apic_2	315	319	PF02991	0.332
LIG_LIR_Gen_1	170	181	PF02991	0.204
LIG_LIR_Gen_1	244	251	PF02991	0.167
LIG_LIR_Nem_3	151	156	PF02991	0.442
LIG_LIR_Nem_3	170	176	PF02991	0.167
LIG_LIR_Nem_3	310	316	PF02991	0.309
LIG_LIR_Nem_3	393	397	PF02991	0.305
LIG_NRBOX	16	22	PF00104	0.407
LIG_PDZ_Class_1	450	455	PF00595	0.388
LIG_Pex14_1	413	417	PF04695	0.407
LIG_SH2_CRK	153	157	PF00017	0.256
LIG_SH2_NCK_1	231	235	PF00017	0.256
LIG_SH2_SRC	173	176	PF00017	0.346
LIG_SH2_SRC	231	234	PF00017	0.256
LIG_SH2_STAP1	257	261	PF00017	0.466
LIG_SH2_STAP1	357	361	PF00017	0.366
LIG_SH2_STAT5	245	248	PF00017	0.361
LIG_SH2_STAT5	257	260	PF00017	0.398
LIG_SH2_STAT5	316	319	PF00017	0.378
LIG_SH2_STAT5	424	427	PF00017	0.341
LIG_SH3_3	432	438	PF00018	0.351
LIG_SUMO_SIM_par_1	132	137	PF11976	0.256
LIG_SUMO_SIM_par_1	19	25	PF11976	0.331
LIG_TRAF2_1	129	132	PF00917	0.449
LIG_TRAF2_1	3	6	PF00917	0.279
LIG_WW_3	434	438	PF00397	0.389
MOD_CDK_SPK_2	30	35	PF00069	0.142
MOD_CDK_SPxxK_3	200	207	PF00069	0.256
MOD_CK1_1	148	154	PF00069	0.343
MOD_CK1_1	449	455	PF00069	0.418
MOD_CK2_1	126	132	PF00069	0.360
MOD_CK2_1	194	200	PF00069	0.340
MOD_CK2_1	261	267	PF00069	0.446
MOD_CK2_1	40	46	PF00069	0.393
MOD_GlcNHglycan	147	150	PF01048	0.298
MOD_GlcNHglycan	291	294	PF01048	0.424
MOD_GlcNHglycan	309	312	PF01048	0.237
MOD_GSK3_1	101	108	PF00069	0.304
MOD_GSK3_1	144	151	PF00069	0.256
MOD_GSK3_1	196	203	PF00069	0.256
MOD_GSK3_1	246	253	PF00069	0.413
MOD_GSK3_1	261	268	PF00069	0.436
MOD_GSK3_1	446	453	PF00069	0.411
MOD_LATS_1	11	17	PF00433	0.250
MOD_N-GLC_1	255	260	PF02516	0.380
MOD_NEK2_1	261	266	PF00069	0.348
MOD_NEK2_2	329	334	PF00069	0.283
MOD_NEK2_2	357	362	PF00069	0.161
MOD_PIKK_1	295	301	PF00454	0.391
MOD_PIKK_1	90	96	PF00454	0.477
MOD_PKA_1	101	107	PF00069	0.353
MOD_PKA_2	101	107	PF00069	0.366
MOD_PKA_2	246	252	PF00069	0.311
MOD_PKA_2	449	455	PF00069	0.411
MOD_PKB_1	103	111	PF00069	0.180
MOD_Plk_4	175	181	PF00069	0.322
MOD_Plk_4	246	252	PF00069	0.348
MOD_Plk_4	27	33	PF00069	0.314
MOD_Plk_4	297	303	PF00069	0.283
MOD_ProDKin_1	148	154	PF00069	0.438
MOD_ProDKin_1	200	206	PF00069	0.256
MOD_ProDKin_1	250	256	PF00069	0.443
MOD_ProDKin_1	30	36	PF00069	0.142
MOD_SUMO_for_1	271	274	PF00179	0.251
MOD_SUMO_for_1	70	73	PF00179	0.469
MOD_SUMO_rev_2	170	178	PF00179	0.373
MOD_SUMO_rev_2	5	10	PF00179	0.223
TRG_DiLeu_BaEn_1	297	302	PF01217	0.256
TRG_DiLeu_BaEn_4	5	11	PF01217	0.212
TRG_DiLeu_BaLyEn_6	316	321	PF01217	0.358
TRG_ENDOCYTIC_2	153	156	PF00928	0.323
TRG_ENDOCYTIC_2	173	176	PF00928	0.136
TRG_ENDOCYTIC_2	184	187	PF00928	0.236
TRG_ENDOCYTIC_2	245	248	PF00928	0.450
TRG_ENDOCYTIC_2	394	397	PF00928	0.326
TRG_ENDOCYTIC_2	4	7	PF00928	0.364
TRG_ER_diArg_1	100	103	PF00400	0.411
TRG_NES_CRM1_1	315	328	PF08389	0.437
TRG_Pf-PMV_PEXEL_1	215	220	PF00026	0.307
TRG_Pf-PMV_PEXEL_1	280	285	PF00026	0.282
TRG_Pf-PMV_PEXEL_1	337	341	PF00026	0.423
TRG_Pf-PMV_PEXEL_1	349	353	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	371	375	PF00026	0.316

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMA5	Leptomonas seymouri	43%	100%
A0A0S4IZ28	Bodo saltans	44%	100%
A0A1X0NY67	Trypanosomatidae	48%	90%
A0A1X0P441	Trypanosomatidae	51%	90%
A0A1X0P598	Trypanosomatidae	51%	90%
A0A3Q8IBW2	Leishmania donovani	89%	100%
A0A3Q8IU74	Leishmania donovani	46%	91%
A0A3S7WSA3	Leishmania donovani	49%	90%
A0A422P042	Trypanosoma rangeli	47%	90%
A0A422P4R1	Trypanosoma rangeli	47%	91%
A4H716	Leishmania braziliensis	49%	100%
A4HLW4	Leishmania braziliensis	46%	100%
A4HVE5	Leishmania infantum	49%	100%
A4HVW0	Leishmania infantum	89%	100%
A4I993	Leishmania infantum	46%	100%
A4IC85	Leishmania infantum	98%	100%
D0A656	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	90%
E9AP43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E9B493	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
P42663	Thermus aquaticus	32%	89%
P50848	Bacillus subtilis (strain 168)	30%	91%
Q4Q0D4	Leishmania major	89%	100%
Q4Q3T3	Leishmania major	45%	100%
Q4QFW7	Leishmania major	87%	100%
Q4QGE5	Leishmania major	47%	100%
Q5SLM3	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	31%	89%
Q8U3L0	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	28%	91%
V5DQA0	Trypanosoma cruzi	50%	90%