Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IJY0_LEIDO

TriTrypDb:

LdBPK_361150.1 , LdCL_360016600 , LDHU3_36.1490

Length:

153

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 2
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IJY0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJY0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	143	145	PF00675	0.641
CLV_PCSK_KEX2_1	143	145	PF00082	0.641
CLV_PCSK_SKI1_1	135	139	PF00082	0.373
CLV_PCSK_SKI1_1	46	50	PF00082	0.455
DOC_PP2B_LxvP_1	139	142	PF13499	0.475
DOC_USP7_MATH_1	126	130	PF00917	0.371
DOC_USP7_UBL2_3	99	103	PF12436	0.459
DOC_WW_Pin1_4	128	133	PF00397	0.396
LIG_14-3-3_CanoR_1	117	125	PF00244	0.448
LIG_BIR_II_1	1	5	PF00653	0.397
LIG_EH1_1	7	15	PF00400	0.502
LIG_eIF4E_1	89	95	PF01652	0.398
LIG_FHA_1	106	112	PF00498	0.354
LIG_FHA_1	136	142	PF00498	0.380
LIG_FHA_1	5	11	PF00498	0.530
LIG_FHA_1	59	65	PF00498	0.389
LIG_FHA_1	89	95	PF00498	0.529
LIG_LIR_Apic_2	91	96	PF02991	0.374
LIG_LIR_Gen_1	35	44	PF02991	0.466
LIG_LIR_Gen_1	7	15	PF02991	0.471
LIG_LIR_Nem_3	131	137	PF02991	0.446
LIG_LIR_Nem_3	35	41	PF02991	0.459
LIG_LIR_Nem_3	7	11	PF02991	0.486
LIG_Pex14_2	34	38	PF04695	0.456
LIG_Pex14_2	4	8	PF04695	0.492
LIG_SH2_CRK	134	138	PF00017	0.401
LIG_SH2_CRK	89	93	PF00017	0.417
LIG_SH2_NCK_1	89	93	PF00017	0.373
LIG_SH2_SRC	93	96	PF00017	0.306
LIG_SH2_STAP1	89	93	PF00017	0.373
LIG_SH2_STAT5	93	96	PF00017	0.353
LIG_WRC_WIRS_1	1	6	PF05994	0.507
LIG_WW_3	26	30	PF00397	0.527
MOD_CDK_SPxxK_3	128	135	PF00069	0.402
MOD_CMANNOS	79	82	PF00535	0.381
MOD_GlcNHglycan	128	131	PF01048	0.384
MOD_GSK3_1	33	40	PF00069	0.411
MOD_GSK3_1	48	55	PF00069	0.463
MOD_NEK2_1	19	24	PF00069	0.557
MOD_NEK2_1	4	9	PF00069	0.593
MOD_NEK2_1	78	83	PF00069	0.481
MOD_NEK2_2	88	93	PF00069	0.375
MOD_PIKK_1	106	112	PF00454	0.379
MOD_PIKK_1	39	45	PF00454	0.341
MOD_PK_1	37	43	PF00069	0.401
MOD_PKA_2	116	122	PF00069	0.451
MOD_Plk_4	88	94	PF00069	0.560
MOD_ProDKin_1	128	134	PF00069	0.395
MOD_SUMO_rev_2	70	78	PF00179	0.431
TRG_ENDOCYTIC_2	134	137	PF00928	0.379
TRG_ENDOCYTIC_2	89	92	PF00928	0.409
TRG_ER_diArg_1	142	144	PF00400	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R1	Leptomonas seymouri	47%	100%
A0A1X0P821	Trypanosomatidae	33%	100%
A4HNW9	Leishmania braziliensis	67%	100%
A4ICM5	Leishmania infantum	100%	100%
E9ASM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q1W7	Leishmania major	94%	100%