PHM7_ext domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJX6_LEIDO

TriTrypDb:

LdBPK_354900.1 , LdCL_350054000 , LDHU3_35.6430

Length:

256

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A0A3Q8IJX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJX6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	254	256	PF00675	0.725
CLV_PCSK_SKI1_1	83	87	PF00082	0.526
DEG_APCC_DBOX_1	82	90	PF00400	0.648
DEG_Nend_Nbox_1	1	3	PF02207	0.504
DOC_CKS1_1	7	12	PF01111	0.480
DOC_CYCLIN_yCln2_LP_2	43	49	PF00134	0.434
DOC_CYCLIN_yCln2_LP_2	85	91	PF00134	0.654
DOC_PP2B_LxvP_1	85	88	PF13499	0.648
DOC_PP4_FxxP_1	221	224	PF00568	0.462
DOC_PP4_FxxP_1	228	231	PF00568	0.470
DOC_USP7_UBL2_3	133	137	PF12436	0.541
DOC_WW_Pin1_4	1	6	PF00397	0.508
DOC_WW_Pin1_4	238	243	PF00397	0.539
DOC_WW_Pin1_4	90	95	PF00397	0.530
LIG_14-3-3_CanoR_1	247	251	PF00244	0.495
LIG_BRCT_BRCA1_1	16	20	PF00533	0.469
LIG_BRCT_BRCA1_1	240	244	PF00533	0.505
LIG_BRCT_BRCA1_1	92	96	PF00533	0.456
LIG_EH_1	225	229	PF12763	0.481
LIG_FHA_1	189	195	PF00498	0.483
LIG_FHA_1	234	240	PF00498	0.491
LIG_FHA_1	72	78	PF00498	0.363
LIG_FHA_2	144	150	PF00498	0.488
LIG_FHA_2	176	182	PF00498	0.560
LIG_FHA_2	247	253	PF00498	0.498
LIG_LIR_Apic_2	219	224	PF02991	0.475
LIG_LIR_Gen_1	73	82	PF02991	0.356
LIG_LIR_Gen_1	93	104	PF02991	0.332
LIG_LIR_Nem_3	17	23	PF02991	0.441
LIG_LIR_Nem_3	178	183	PF02991	0.560
LIG_LIR_Nem_3	73	79	PF02991	0.431
LIG_LIR_Nem_3	93	99	PF02991	0.332
LIG_NRBOX	81	87	PF00104	0.645
LIG_Pex14_1	72	76	PF04695	0.349
LIG_Pex14_2	101	105	PF04695	0.375
LIG_PTB_Apo_2	215	222	PF02174	0.496
LIG_SH2_CRK	2	6	PF00017	0.491
LIG_SH2_NCK_1	2	6	PF00017	0.455
LIG_SH2_STAP1	113	117	PF00017	0.475
LIG_SH2_STAP1	167	171	PF00017	0.455
LIG_SH2_STAT3	159	162	PF00017	0.438
LIG_SH2_STAT3	54	57	PF00017	0.349
LIG_SH2_STAT5	113	116	PF00017	0.539
LIG_SH2_STAT5	159	162	PF00017	0.461
LIG_SH2_STAT5	167	170	PF00017	0.354
LIG_SH2_STAT5	54	57	PF00017	0.383
LIG_SH3_1	2	8	PF00018	0.453
LIG_SH3_3	2	8	PF00018	0.461
LIG_SH3_3	221	227	PF00018	0.469
LIG_SH3_3	43	49	PF00018	0.457
LIG_SH3_3	85	91	PF00018	0.654
LIG_SUMO_SIM_par_1	24	31	PF11976	0.434
LIG_TRAF2_1	139	142	PF00917	0.545
LIG_TRAF2_1	249	252	PF00917	0.511
MOD_CK1_1	132	138	PF00069	0.539
MOD_CK1_1	143	149	PF00069	0.487
MOD_CK1_1	166	172	PF00069	0.362
MOD_CK1_1	28	34	PF00069	0.423
MOD_CK2_1	136	142	PF00069	0.543
MOD_CK2_1	143	149	PF00069	0.501
MOD_CK2_1	175	181	PF00069	0.474
MOD_CK2_1	246	252	PF00069	0.507
MOD_DYRK1A_RPxSP_1	90	94	PF00069	0.530
MOD_GlcNHglycan	134	137	PF01048	0.732
MOD_GlcNHglycan	30	33	PF01048	0.647
MOD_GSK3_1	132	139	PF00069	0.539
MOD_GSK3_1	188	195	PF00069	0.485
MOD_GSK3_1	21	28	PF00069	0.425
MOD_GSK3_1	233	240	PF00069	0.519
MOD_LATS_1	12	18	PF00433	0.432
MOD_NEK2_1	129	134	PF00069	0.533
MOD_NEK2_1	163	168	PF00069	0.340
MOD_NEK2_1	186	191	PF00069	0.506
MOD_NEK2_1	30	35	PF00069	0.453
MOD_NEK2_1	61	66	PF00069	0.476
MOD_NEK2_1	71	76	PF00069	0.318
MOD_PIKK_1	21	27	PF00454	0.431
MOD_PK_1	140	146	PF00069	0.523
MOD_PKA_2	246	252	PF00069	0.496
MOD_Plk_1	140	146	PF00069	0.523
MOD_Plk_2-3	246	252	PF00069	0.496
MOD_Plk_4	25	31	PF00069	0.415
MOD_Plk_4	61	67	PF00069	0.476
MOD_Plk_4	71	77	PF00069	0.318
MOD_ProDKin_1	1	7	PF00069	0.506
MOD_ProDKin_1	238	244	PF00069	0.540
MOD_ProDKin_1	90	96	PF00069	0.530
MOD_SUMO_rev_2	143	152	PF00179	0.538
TRG_ENDOCYTIC_2	183	186	PF00928	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4IC20	Leishmania infantum	99%	100%
E9AFV9	Leishmania major	91%	100%
E9B712	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	73%