LeishMANIAdb
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VHS domain containing protein, putative

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
VHS domain containing protein, putative
Gene product:
VHS domain containing protein, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IJX3_LEIDO
TriTrypDb:
LdBPK_365370.1 * , LdCL_360060900 , LDHU3_36.7190
Length:
518

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Promastigote/Amastigote: 419

Expansion

Sequence features

A0A3Q8IJX3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJX3

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 10
GO:0006886 intracellular protein transport 4 10
GO:0007034 vacuolar transport 4 10
GO:0008104 protein localization 4 10
GO:0009987 cellular process 1 10
GO:0015031 protein transport 4 10
GO:0016192 vesicle-mediated transport 4 10
GO:0016197 endosomal transport 4 10
GO:0032509 endosome transport via multivesicular body sorting pathway 5 10
GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway 6 10
GO:0033036 macromolecule localization 2 10
GO:0033365 protein localization to organelle 5 10
GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway 5 10
GO:0045184 establishment of protein localization 3 10
GO:0045324 late endosome to vacuole transport 5 10
GO:0046907 intracellular transport 3 10
GO:0051179 localization 1 10
GO:0051234 establishment of localization 2 10
GO:0051641 cellular localization 2 10
GO:0051649 establishment of localization in cell 3 10
GO:0070727 cellular macromolecule localization 3 10
GO:0071702 organic substance transport 4 10
GO:0071705 nitrogen compound transport 4 10
GO:0071985 multivesicular body sorting pathway 5 10
GO:0072594 establishment of protein localization to organelle 4 10
GO:0072665 protein localization to vacuole 6 10
GO:0072666 establishment of protein localization to vacuole 5 10
Molecular functions
Term Name Level Count
GO:0005488 binding 1 10
GO:0005515 protein binding 2 10
GO:0005543 phospholipid binding 3 10
GO:0008289 lipid binding 2 10
GO:0032182 ubiquitin-like protein binding 3 10
GO:0035091 phosphatidylinositol binding 4 10
GO:0043130 ubiquitin binding 4 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 214 218 PF00656 0.639
CLV_C14_Caspase3-7 291 295 PF00656 0.579
CLV_C14_Caspase3-7 432 436 PF00656 0.704
CLV_C14_Caspase3-7 463 467 PF00656 0.705
CLV_NRD_NRD_1 187 189 PF00675 0.805
CLV_NRD_NRD_1 65 67 PF00675 0.444
CLV_PCSK_FUR_1 185 189 PF00082 0.858
CLV_PCSK_FUR_1 210 214 PF00082 0.784
CLV_PCSK_KEX2_1 187 189 PF00082 0.836
CLV_PCSK_KEX2_1 212 214 PF00082 0.771
CLV_PCSK_KEX2_1 64 66 PF00082 0.444
CLV_PCSK_PC1ET2_1 212 214 PF00082 0.804
CLV_PCSK_PC7_1 61 67 PF00082 0.444
CLV_PCSK_SKI1_1 101 105 PF00082 0.431
CLV_PCSK_SKI1_1 286 290 PF00082 0.624
CLV_PCSK_SKI1_1 75 79 PF00082 0.429
DEG_APCC_DBOX_1 285 293 PF00400 0.596
DEG_SPOP_SBC_1 448 452 PF00917 0.781
DOC_CKS1_1 378 383 PF01111 0.825
DOC_CKS1_1 401 406 PF01111 0.702
DOC_CYCLIN_RxL_1 98 106 PF00134 0.508
DOC_MAPK_gen_1 172 180 PF00069 0.696
DOC_MAPK_gen_1 51 59 PF00069 0.585
DOC_MAPK_MEF2A_6 124 132 PF00069 0.516
DOC_MAPK_MEF2A_6 172 180 PF00069 0.689
DOC_MAPK_MEF2A_6 268 276 PF00069 0.688
DOC_PP2B_LxvP_1 34 37 PF13499 0.501
DOC_PP2B_LxvP_1 409 412 PF13499 0.691
DOC_USP7_MATH_1 123 127 PF00917 0.570
DOC_USP7_MATH_1 316 320 PF00917 0.851
DOC_USP7_MATH_1 364 368 PF00917 0.814
DOC_USP7_MATH_1 402 406 PF00917 0.816
DOC_USP7_MATH_1 410 414 PF00917 0.783
DOC_USP7_MATH_1 449 453 PF00917 0.843
DOC_USP7_MATH_1 455 459 PF00917 0.828
DOC_WW_Pin1_4 312 317 PF00397 0.803
DOC_WW_Pin1_4 371 376 PF00397 0.792
DOC_WW_Pin1_4 377 382 PF00397 0.796
DOC_WW_Pin1_4 400 405 PF00397 0.793
DOC_WW_Pin1_4 416 421 PF00397 0.837
DOC_WW_Pin1_4 426 431 PF00397 0.866
LIG_14-3-3_CanoR_1 228 235 PF00244 0.571
LIG_14-3-3_CanoR_1 290 299 PF00244 0.675
LIG_Actin_WH2_2 275 292 PF00022 0.614
LIG_BH_BH3_1 141 157 PF00452 0.615
LIG_BIR_III_2 313 317 PF00653 0.823
LIG_BIR_III_4 466 470 PF00653 0.701
LIG_BRCT_BRCA1_1 134 138 PF00533 0.484
LIG_BRCT_BRCA1_1 89 93 PF00533 0.585
LIG_FHA_1 129 135 PF00498 0.525
LIG_FHA_1 273 279 PF00498 0.619
LIG_FHA_1 378 384 PF00498 0.825
LIG_FHA_1 496 502 PF00498 0.722
LIG_FHA_1 54 60 PF00498 0.566
LIG_FHA_1 76 82 PF00498 0.442
LIG_FHA_2 149 155 PF00498 0.512
LIG_FHA_2 236 242 PF00498 0.550
LIG_FHA_2 289 295 PF00498 0.618
LIG_GBD_Chelix_1 215 223 PF00786 0.791
LIG_HCF-1_HBM_1 270 273 PF13415 0.631
LIG_IBAR_NPY_1 20 22 PF08397 0.448
LIG_LIR_Gen_1 270 278 PF02991 0.637
LIG_LIR_Gen_1 38 45 PF02991 0.505
LIG_LIR_Gen_1 506 512 PF02991 0.743
LIG_LIR_Nem_3 238 242 PF02991 0.650
LIG_LIR_Nem_3 270 276 PF02991 0.680
LIG_LIR_Nem_3 38 42 PF02991 0.505
LIG_LIR_Nem_3 506 511 PF02991 0.744
LIG_LIR_Nem_3 90 95 PF02991 0.469
LIG_SH2_GRB2like 242 245 PF00017 0.593
LIG_SH2_PTP2 273 276 PF00017 0.684
LIG_SH2_SRC 22 25 PF00017 0.507
LIG_SH2_SRC 39 42 PF00017 0.453
LIG_SH2_STAP1 22 26 PF00017 0.470
LIG_SH2_STAT3 263 266 PF00017 0.694
LIG_SH2_STAT5 147 150 PF00017 0.545
LIG_SH2_STAT5 242 245 PF00017 0.593
LIG_SH2_STAT5 263 266 PF00017 0.653
LIG_SH2_STAT5 273 276 PF00017 0.543
LIG_SH3_3 177 183 PF00018 0.745
LIG_SH3_3 353 359 PF00018 0.752
LIG_SH3_3 375 381 PF00018 0.880
LIG_SH3_3 401 407 PF00018 0.882
LIG_SH3_3 414 420 PF00018 0.709
LIG_SH3_3 470 476 PF00018 0.789
LIG_SH3_3 491 497 PF00018 0.867
LIG_SUMO_SIM_anti_2 54 61 PF11976 0.578
LIG_SUMO_SIM_par_1 274 280 PF11976 0.609
LIG_TRAF2_1 142 145 PF00917 0.680
LIG_TRAF2_1 346 349 PF00917 0.844
LIG_TRAF2_1 413 416 PF00917 0.808
LIG_TRAF2_1 429 432 PF00917 0.874
LIG_TRAF2_2 190 195 PF00917 0.830
LIG_UBA3_1 6 13 PF00899 0.511
LIG_UBA3_1 81 87 PF00899 0.505
LIG_WW_3 357 361 PF00397 0.868
MOD_CDK_SPxxK_3 416 423 PF00069 0.691
MOD_CK1_1 262 268 PF00069 0.693
MOD_CK1_1 342 348 PF00069 0.866
MOD_CK1_1 482 488 PF00069 0.855
MOD_CK1_1 88 94 PF00069 0.547
MOD_CK2_1 2 8 PF00069 0.600
MOD_CK2_1 410 416 PF00069 0.894
MOD_CK2_1 426 432 PF00069 0.857
MOD_CK2_1 483 489 PF00069 0.829
MOD_GlcNHglycan 125 128 PF01048 0.639
MOD_GlcNHglycan 229 232 PF01048 0.599
MOD_GlcNHglycan 296 299 PF01048 0.615
MOD_GlcNHglycan 319 322 PF01048 0.841
MOD_GlcNHglycan 332 335 PF01048 0.793
MOD_GlcNHglycan 341 344 PF01048 0.774
MOD_GlcNHglycan 364 367 PF01048 0.858
MOD_GlcNHglycan 397 400 PF01048 0.813
MOD_GlcNHglycan 485 488 PF01048 0.872
MOD_GSK3_1 128 135 PF00069 0.522
MOD_GSK3_1 223 230 PF00069 0.641
MOD_GSK3_1 272 279 PF00069 0.628
MOD_GSK3_1 288 295 PF00069 0.436
MOD_GSK3_1 312 319 PF00069 0.737
MOD_GSK3_1 326 333 PF00069 0.807
MOD_GSK3_1 334 341 PF00069 0.802
MOD_GSK3_1 426 433 PF00069 0.904
MOD_GSK3_1 443 450 PF00069 0.814
MOD_GSK3_1 479 486 PF00069 0.855
MOD_GSK3_1 495 502 PF00069 0.709
MOD_GSK3_1 81 88 PF00069 0.543
MOD_N-GLC_1 132 137 PF02516 0.483
MOD_N-GLC_1 243 248 PF02516 0.598
MOD_N-GLC_1 339 344 PF02516 0.876
MOD_N-GLC_2 251 253 PF02516 0.687
MOD_NEK2_1 128 133 PF00069 0.493
MOD_NEK2_1 235 240 PF00069 0.582
MOD_NEK2_1 277 282 PF00069 0.616
MOD_NEK2_1 288 293 PF00069 0.552
MOD_NEK2_1 326 331 PF00069 0.859
MOD_NEK2_1 347 352 PF00069 0.810
MOD_NEK2_1 370 375 PF00069 0.795
MOD_NEK2_1 444 449 PF00069 0.864
MOD_NEK2_1 45 50 PF00069 0.439
MOD_NEK2_1 81 86 PF00069 0.541
MOD_PIKK_1 262 268 PF00454 0.645
MOD_PIKK_1 292 298 PF00454 0.570
MOD_PIKK_1 479 485 PF00454 0.829
MOD_PIKK_1 96 102 PF00454 0.449
MOD_PKA_2 227 233 PF00069 0.648
MOD_Plk_1 132 138 PF00069 0.481
MOD_Plk_1 303 309 PF00069 0.692
MOD_Plk_1 53 59 PF00069 0.508
MOD_Plk_2-3 211 217 PF00069 0.643
MOD_Plk_4 132 138 PF00069 0.478
MOD_Plk_4 2 8 PF00069 0.548
MOD_Plk_4 259 265 PF00069 0.645
MOD_Plk_4 272 278 PF00069 0.548
MOD_Plk_4 326 332 PF00069 0.846
MOD_Plk_4 455 461 PF00069 0.811
MOD_Plk_4 81 87 PF00069 0.458
MOD_Plk_4 88 94 PF00069 0.467
MOD_ProDKin_1 312 318 PF00069 0.805
MOD_ProDKin_1 371 377 PF00069 0.788
MOD_ProDKin_1 400 406 PF00069 0.795
MOD_ProDKin_1 416 422 PF00069 0.840
MOD_ProDKin_1 426 432 PF00069 0.867
MOD_SUMO_for_1 176 179 PF00179 0.722
MOD_SUMO_for_1 301 304 PF00179 0.663
TRG_DiLeu_BaEn_1 125 130 PF01217 0.595
TRG_DiLeu_BaEn_2 39 45 PF01217 0.544
TRG_DiLeu_BaEn_4 144 150 PF01217 0.667
TRG_ENDOCYTIC_2 22 25 PF00928 0.515
TRG_ENDOCYTIC_2 273 276 PF00928 0.642
TRG_ENDOCYTIC_2 39 42 PF00928 0.538
TRG_ER_diArg_1 185 188 PF00400 0.774
TRG_ER_diArg_1 63 66 PF00400 0.444
TRG_Pf-PMV_PEXEL_1 43 47 PF00026 0.544
TRG_Pf-PMV_PEXEL_1 65 69 PF00026 0.446

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PB53 Leptomonas seymouri 58% 96%
A0A0S4JSH6 Bodo saltans 34% 100%
A0A3R7M014 Trypanosoma rangeli 41% 100%
A4HQ30 Leishmania braziliensis 65% 99%
A4IDT6 Leishmania infantum 100% 100%
E9ATU8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 98%
Q4Q0P8 Leishmania major 87% 100%
V5BM99 Trypanosoma cruzi 40% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS