SEC7 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJW1_LEIDO

TriTrypDb:

LdBPK_365230.1 , LdCL_360059500 , LDHU3_36.7010

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 6
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3Q8IJW1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJW1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	169	171	PF00675	0.709
CLV_NRD_NRD_1	172	174	PF00675	0.693
CLV_NRD_NRD_1	208	210	PF00675	0.550
CLV_NRD_NRD_1	291	293	PF00675	0.701
CLV_NRD_NRD_1	346	348	PF00675	0.722
CLV_PCSK_FUR_1	344	348	PF00082	0.630
CLV_PCSK_KEX2_1	169	171	PF00082	0.697
CLV_PCSK_KEX2_1	208	210	PF00082	0.550
CLV_PCSK_KEX2_1	291	293	PF00082	0.701
CLV_PCSK_KEX2_1	344	346	PF00082	0.620
CLV_PCSK_PC7_1	341	347	PF00082	0.624
CLV_PCSK_SKI1_1	123	127	PF00082	0.486
CLV_PCSK_SKI1_1	209	213	PF00082	0.628
CLV_PCSK_SKI1_1	249	253	PF00082	0.504
DEG_MDM2_SWIB_1	135	142	PF02201	0.495
DEG_SPOP_SBC_1	301	305	PF00917	0.615
DOC_CDC14_PxL_1	20	28	PF14671	0.437
DOC_CKS1_1	45	50	PF01111	0.539
DOC_CYCLIN_yCln2_LP_2	21	27	PF00134	0.474
DOC_MAPK_FxFP_2	218	221	PF00069	0.385
DOC_MAPK_gen_1	113	121	PF00069	0.422
DOC_MAPK_gen_1	208	214	PF00069	0.488
DOC_MAPK_gen_1	341	351	PF00069	0.614
DOC_MAPK_JIP1_4	247	253	PF00069	0.517
DOC_MAPK_MEF2A_6	12	21	PF00069	0.433
DOC_MAPK_MEF2A_6	243	252	PF00069	0.428
DOC_PP1_RVXF_1	116	122	PF00149	0.418
DOC_PP1_RVXF_1	201	207	PF00149	0.380
DOC_PP2B_LxvP_1	21	24	PF13499	0.430
DOC_PP4_FxxP_1	218	221	PF00568	0.385
DOC_SPAK_OSR1_1	239	243	PF12202	0.422
DOC_USP7_MATH_1	290	294	PF00917	0.528
DOC_USP7_MATH_1	322	326	PF00917	0.696
DOC_USP7_MATH_1	33	37	PF00917	0.519
DOC_WW_Pin1_4	44	49	PF00397	0.558
DOC_WW_Pin1_4	80	85	PF00397	0.647
LIG_14-3-3_CanoR_1	226	230	PF00244	0.473
LIG_14-3-3_CanoR_1	280	289	PF00244	0.722
LIG_APCC_ABBA_1	212	217	PF00400	0.414
LIG_BIR_II_1	1	5	PF00653	0.574
LIG_BIR_III_4	88	92	PF00653	0.497
LIG_EH_1	73	77	PF12763	0.567
LIG_FHA_1	14	20	PF00498	0.542
LIG_FHA_1	153	159	PF00498	0.477
LIG_FHA_1	186	192	PF00498	0.562
LIG_FHA_1	258	264	PF00498	0.514
LIG_FHA_2	45	51	PF00498	0.499
LIG_LIR_Apic_2	217	221	PF02991	0.394
LIG_LIR_Gen_1	40	48	PF02991	0.548
LIG_LIR_LC3C_4	260	263	PF02991	0.453
LIG_LIR_Nem_3	228	233	PF02991	0.440
LIG_LIR_Nem_3	40	46	PF02991	0.543
LIG_PCNA_PIPBox_1	234	243	PF02747	0.465
LIG_PCNA_yPIPBox_3	232	241	PF02747	0.460
LIG_PDZ_Class_2	347	352	PF00595	0.568
LIG_Pex14_2	135	139	PF04695	0.495
LIG_SH2_SRC	184	187	PF00017	0.550
LIG_SH2_STAT5	146	149	PF00017	0.456
LIG_SH2_STAT5	157	160	PF00017	0.351
LIG_SH2_STAT5	241	244	PF00017	0.468
LIG_SH2_STAT5	41	44	PF00017	0.459
LIG_SH3_3	180	186	PF00018	0.672
LIG_SH3_3	275	281	PF00018	0.533
LIG_SUMO_SIM_anti_2	13	19	PF11976	0.559
LIG_SUMO_SIM_anti_2	210	215	PF11976	0.424
LIG_SUMO_SIM_anti_2	63	69	PF11976	0.451
LIG_SUMO_SIM_par_1	16	22	PF11976	0.616
LIG_SUMO_SIM_par_1	23	28	PF11976	0.503
LIG_SUMO_SIM_par_1	259	265	PF11976	0.499
LIG_TRAF2_1	37	40	PF00917	0.462
LIG_TRAF2_1	83	86	PF00917	0.456
LIG_ULM_U2AF65_1	344	349	PF00076	0.629
MOD_CK1_1	187	193	PF00069	0.559
MOD_CK1_1	199	205	PF00069	0.505
MOD_CK1_1	302	308	PF00069	0.638
MOD_CK1_1	44	50	PF00069	0.490
MOD_CK2_1	138	144	PF00069	0.450
MOD_CK2_1	80	86	PF00069	0.443
MOD_Cter_Amidation	167	170	PF01082	0.558
MOD_Cter_Amidation	342	345	PF01082	0.580
MOD_GlcNHglycan	285	288	PF01048	0.744
MOD_GlcNHglycan	292	295	PF01048	0.641
MOD_GlcNHglycan	307	310	PF01048	0.569
MOD_GlcNHglycan	311	314	PF01048	0.551
MOD_GlcNHglycan	317	321	PF01048	0.625
MOD_GlcNHglycan	324	327	PF01048	0.620
MOD_GlcNHglycan	328	331	PF01048	0.609
MOD_GlcNHglycan	34	38	PF01048	0.435
MOD_GSK3_1	158	165	PF00069	0.476
MOD_GSK3_1	281	288	PF00069	0.717
MOD_GSK3_1	297	304	PF00069	0.539
MOD_GSK3_1	305	312	PF00069	0.627
MOD_GSK3_1	322	329	PF00069	0.664
MOD_GSK3_1	6	13	PF00069	0.566
MOD_N-GLC_1	10	15	PF02516	0.519
MOD_N-GLC_2	56	58	PF02516	0.387
MOD_NEK2_1	19	24	PF00069	0.373
MOD_NEK2_1	27	32	PF00069	0.468
MOD_NEK2_1	283	288	PF00069	0.717
MOD_NEK2_1	4	9	PF00069	0.566
MOD_NEK2_2	225	230	PF00069	0.460
MOD_PIKK_1	158	164	PF00454	0.489
MOD_PKA_2	225	231	PF00069	0.527
MOD_PKA_2	257	263	PF00069	0.506
MOD_PKA_2	290	296	PF00069	0.664
MOD_PKA_2	4	10	PF00069	0.626
MOD_Plk_1	10	16	PF00069	0.516
MOD_Plk_1	162	168	PF00069	0.585
MOD_Plk_1	27	33	PF00069	0.408
MOD_Plk_4	106	112	PF00069	0.530
MOD_Plk_4	13	19	PF00069	0.510
MOD_Plk_4	153	159	PF00069	0.459
MOD_Plk_4	196	202	PF00069	0.472
MOD_Plk_4	225	231	PF00069	0.494
MOD_Plk_4	257	263	PF00069	0.458
MOD_ProDKin_1	44	50	PF00069	0.554
MOD_ProDKin_1	80	86	PF00069	0.651
TRG_DiLeu_BaEn_1	196	201	PF01217	0.436
TRG_DiLeu_BaEn_1	63	68	PF01217	0.376
TRG_DiLeu_BaLyEn_6	21	26	PF01217	0.437
TRG_DiLeu_BaLyEn_6	246	251	PF01217	0.489
TRG_ER_diArg_1	207	209	PF00400	0.526
TRG_ER_diArg_1	344	347	PF00400	0.676
TRG_NES_CRM1_1	265	276	PF08389	0.506
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVC1	Leptomonas seymouri	54%	100%
A0A1X0P309	Trypanosomatidae	28%	100%
A0A3R7KTI3	Trypanosoma rangeli	26%	100%
A4HQ17	Leishmania braziliensis	74%	100%
A4IDS3	Leishmania infantum	99%	100%
E9ATT4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q0R2	Leishmania major	90%	100%
V5D4Y6	Trypanosoma cruzi	25%	100%