tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Gcd10p family, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJV9_LEIDO

TriTrypDb:

LdBPK_366030.1 , LdCL_360067700 , LDHU3_36.7960

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0031515	tRNA (m1A) methyltransferase complex	6	12
GO:0032991	protein-containing complex	1	12
GO:0034708	methyltransferase complex	4	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0043527	tRNA methyltransferase complex	5	12
GO:0110165	cellular anatomical entity	1	12
GO:1902494	catalytic complex	2	12
GO:1990234	transferase complex	3	12
GO:0005643	nuclear pore	3	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3Q8IJV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJV9

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006399	tRNA metabolic process	7	12
GO:0006400	tRNA modification	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008033	tRNA processing	8	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0030488	tRNA methylation	5	12
GO:0032259	methylation	2	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043414	macromolecule methylation	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	76	80	PF00656	0.279
CLV_C14_Caspase3-7	82	86	PF00656	0.217
CLV_NRD_NRD_1	107	109	PF00675	0.338
CLV_NRD_NRD_1	296	298	PF00675	0.585
CLV_NRD_NRD_1	59	61	PF00675	0.375
CLV_PCSK_KEX2_1	107	109	PF00082	0.338
CLV_PCSK_KEX2_1	296	298	PF00082	0.502
CLV_PCSK_KEX2_1	389	391	PF00082	0.560
CLV_PCSK_KEX2_1	437	439	PF00082	0.593
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.536
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.593
CLV_PCSK_SKI1_1	136	140	PF00082	0.353
CLV_PCSK_SKI1_1	201	205	PF00082	0.309
CLV_PCSK_SKI1_1	243	247	PF00082	0.479
CLV_PCSK_SKI1_1	28	32	PF00082	0.292
CLV_PCSK_SKI1_1	314	318	PF00082	0.401
DOC_MAPK_gen_1	181	189	PF00069	0.282
DOC_MAPK_gen_1	27	34	PF00069	0.338
DOC_MAPK_MEF2A_6	183	191	PF00069	0.244
DOC_MAPK_MEF2A_6	27	34	PF00069	0.389
DOC_MAPK_MEF2A_6	368	376	PF00069	0.341
DOC_MAPK_MEF2A_6	389	397	PF00069	0.397
DOC_PP2B_LxvP_1	162	165	PF13499	0.451
DOC_PP2B_LxvP_1	245	248	PF13499	0.398
DOC_USP7_MATH_1	321	325	PF00917	0.290
DOC_USP7_UBL2_3	136	140	PF12436	0.243
DOC_USP7_UBL2_3	251	255	PF12436	0.404
DOC_WW_Pin1_4	317	322	PF00397	0.481
DOC_WW_Pin1_4	329	334	PF00397	0.419
DOC_WW_Pin1_4	351	356	PF00397	0.343
DOC_WW_Pin1_4	410	415	PF00397	0.509
LIG_14-3-3_CanoR_1	153	157	PF00244	0.389
LIG_14-3-3_CanoR_1	219	227	PF00244	0.265
LIG_BIR_II_1	1	5	PF00653	0.523
LIG_Clathr_ClatBox_1	148	152	PF01394	0.389
LIG_CtBP_PxDLS_1	357	361	PF00389	0.325
LIG_FAT_LD_1	112	120	PF03623	0.389
LIG_FHA_1	184	190	PF00498	0.311
LIG_FHA_1	206	212	PF00498	0.338
LIG_FHA_1	29	35	PF00498	0.369
LIG_FHA_1	303	309	PF00498	0.521
LIG_FHA_1	41	47	PF00498	0.280
LIG_FHA_2	116	122	PF00498	0.322
LIG_FHA_2	171	177	PF00498	0.320
LIG_FHA_2	455	461	PF00498	0.504
LIG_IRF3_LxIS_1	372	377	PF10401	0.343
LIG_LIR_Gen_1	361	372	PF02991	0.317
LIG_LIR_Nem_3	252	257	PF02991	0.311
LIG_LIR_Nem_3	361	367	PF02991	0.312
LIG_LIR_Nem_3	66	72	PF02991	0.245
LIG_LIR_Nem_3	9	15	PF02991	0.309
LIG_LYPXL_yS_3	69	72	PF13949	0.259
LIG_NRBOX	111	117	PF00104	0.389
LIG_SH2_CRK	145	149	PF00017	0.278
LIG_SH2_CRK	50	54	PF00017	0.389
LIG_SH2_PTP2	12	15	PF00017	0.303
LIG_SH2_STAT5	12	15	PF00017	0.305
LIG_SH2_STAT5	137	140	PF00017	0.276
LIG_SH2_STAT5	403	406	PF00017	0.303
LIG_SH3_1	255	261	PF00018	0.327
LIG_SH3_3	255	261	PF00018	0.496
LIG_SH3_3	349	355	PF00018	0.330
LIG_SH3_3	411	417	PF00018	0.533
LIG_SH3_3	420	426	PF00018	0.539
LIG_SUMO_SIM_anti_2	185	191	PF11976	0.244
LIG_TRAF2_1	173	176	PF00917	0.188
LIG_TRAF2_1	440	443	PF00917	0.643
LIG_UBA3_1	115	122	PF00899	0.338
LIG_UBA3_1	226	232	PF00899	0.253
LIG_UBA3_1	404	409	PF00899	0.311
MOD_CDC14_SPxK_1	332	335	PF00782	0.436
MOD_CDK_SPxK_1	329	335	PF00069	0.449
MOD_CK1_1	125	131	PF00069	0.369
MOD_CK1_1	170	176	PF00069	0.359
MOD_CK1_1	215	221	PF00069	0.309
MOD_CK1_1	429	435	PF00069	0.689
MOD_CK1_1	449	455	PF00069	0.572
MOD_CK2_1	115	121	PF00069	0.298
MOD_CK2_1	170	176	PF00069	0.210
MOD_CK2_1	436	442	PF00069	0.686
MOD_CK2_1	454	460	PF00069	0.703
MOD_CK2_1	96	102	PF00069	0.244
MOD_GlcNHglycan	121	125	PF01048	0.315
MOD_GlcNHglycan	15	18	PF01048	0.353
MOD_GlcNHglycan	273	276	PF01048	0.530
MOD_GlcNHglycan	36	39	PF01048	0.293
MOD_GlcNHglycan	428	431	PF01048	0.685
MOD_GlcNHglycan	438	441	PF01048	0.718
MOD_GlcNHglycan	451	454	PF01048	0.491
MOD_GSK3_1	13	20	PF00069	0.385
MOD_GSK3_1	163	170	PF00069	0.269
MOD_GSK3_1	271	278	PF00069	0.665
MOD_GSK3_1	297	304	PF00069	0.474
MOD_GSK3_1	317	324	PF00069	0.500
MOD_GSK3_1	391	398	PF00069	0.418
MOD_N-GLC_1	171	176	PF02516	0.243
MOD_N-GLC_1	395	400	PF02516	0.432
MOD_NEK2_1	115	120	PF00069	0.270
MOD_NEK2_1	34	39	PF00069	0.259
MOD_NEK2_1	41	46	PF00069	0.259
MOD_NEK2_1	428	433	PF00069	0.553
MOD_PIKK_1	302	308	PF00454	0.397
MOD_PKA_2	152	158	PF00069	0.389
MOD_PKA_2	218	224	PF00069	0.265
MOD_PKA_2	275	281	PF00069	0.576
MOD_PKB_1	181	189	PF00069	0.244
MOD_Plk_1	28	34	PF00069	0.378
MOD_Plk_2-3	152	158	PF00069	0.381
MOD_Plk_2-3	171	177	PF00069	0.381
MOD_Plk_4	115	121	PF00069	0.273
MOD_Plk_4	144	150	PF00069	0.281
MOD_Plk_4	212	218	PF00069	0.389
MOD_Plk_4	321	327	PF00069	0.314
MOD_Plk_4	376	382	PF00069	0.379
MOD_Plk_4	41	47	PF00069	0.338
MOD_ProDKin_1	317	323	PF00069	0.484
MOD_ProDKin_1	329	335	PF00069	0.422
MOD_ProDKin_1	351	357	PF00069	0.347
MOD_ProDKin_1	410	416	PF00069	0.516
MOD_SUMO_for_1	149	152	PF00179	0.338
TRG_DiLeu_BaEn_1	312	317	PF01217	0.380
TRG_DiLeu_BaEn_4	175	181	PF01217	0.188
TRG_ENDOCYTIC_2	12	15	PF00928	0.303
TRG_ENDOCYTIC_2	145	148	PF00928	0.327
TRG_ENDOCYTIC_2	353	356	PF00928	0.383
TRG_ENDOCYTIC_2	50	53	PF00928	0.377
TRG_ENDOCYTIC_2	69	72	PF00928	0.136
TRG_ER_diArg_1	106	108	PF00400	0.338
TRG_ER_diArg_1	180	183	PF00400	0.244
TRG_ER_diArg_1	295	297	PF00400	0.725
TRG_NLS_MonoExtC_3	138	143	PF00514	0.245
TRG_NLS_MonoExtC_3	59	65	PF00514	0.243
TRG_NLS_MonoExtN_4	136	143	PF00514	0.244
TRG_Pf-PMV_PEXEL_1	314	319	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.282

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I267	Leptomonas seymouri	77%	98%
A0A0S4JAT8	Bodo saltans	46%	100%
A0A1X0NLQ1	Trypanosomatidae	55%	99%
A0A422NSE7	Trypanosoma rangeli	52%	99%
A4HQ94	Leishmania braziliensis	82%	100%
A4IDZ2	Leishmania infantum	100%	100%
D0A417	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	97%
E9AU12	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P0CS06	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	26%	83%
P0CS07	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	26%	83%
P41814	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	97%
Q2T9V5	Bos taurus	26%	93%
Q4Q0I3	Leishmania major	93%	100%
Q54UB1	Dictyostelium discoideum	28%	89%
Q5A6Q4	Candida albicans (strain SC5314 / ATCC MYA-2876)	26%	100%
Q6BKK7	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	22%	98%
Q6CF35	Yarrowia lipolytica (strain CLIB 122 / E 150)	23%	95%
Q6CLF6	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	97%
Q6FNP9	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	22%	98%
Q75B32	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	23%	100%
Q8CE96	Mus musculus	27%	93%
Q9HGL4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
Q9UJA5	Homo sapiens	26%	93%
V5B3L2	Trypanosoma cruzi	51%	99%