Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJU5_LEIDO

TriTrypDb:

LdBPK_365850.1 , LdCL_360065900 , LDHU3_36.7750

Length:

565

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IJU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJU5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.602
CLV_C14_Caspase3-7	238	242	PF00656	0.436
CLV_C14_Caspase3-7	401	405	PF00656	0.530
CLV_NRD_NRD_1	142	144	PF00675	0.463
CLV_NRD_NRD_1	229	231	PF00675	0.395
CLV_NRD_NRD_1	28	30	PF00675	0.569
CLV_NRD_NRD_1	318	320	PF00675	0.483
CLV_NRD_NRD_1	375	377	PF00675	0.471
CLV_NRD_NRD_1	447	449	PF00675	0.459
CLV_NRD_NRD_1	67	69	PF00675	0.695
CLV_PCSK_FUR_1	316	320	PF00082	0.481
CLV_PCSK_KEX2_1	142	144	PF00082	0.463
CLV_PCSK_KEX2_1	229	231	PF00082	0.453
CLV_PCSK_KEX2_1	27	29	PF00082	0.589
CLV_PCSK_KEX2_1	318	320	PF00082	0.483
CLV_PCSK_KEX2_1	375	377	PF00082	0.471
CLV_PCSK_KEX2_1	447	449	PF00082	0.459
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.602
CLV_PCSK_PC7_1	23	29	PF00082	0.604
CLV_PCSK_SKI1_1	143	147	PF00082	0.417
CLV_PCSK_SKI1_1	150	154	PF00082	0.452
CLV_PCSK_SKI1_1	230	234	PF00082	0.444
CLV_PCSK_SKI1_1	269	273	PF00082	0.655
CLV_PCSK_SKI1_1	319	323	PF00082	0.432
CLV_PCSK_SKI1_1	378	382	PF00082	0.472
CLV_PCSK_SKI1_1	503	507	PF00082	0.340
CLV_PCSK_SKI1_1	531	535	PF00082	0.498
DEG_APCC_DBOX_1	142	150	PF00400	0.447
DEG_APCC_DBOX_1	228	236	PF00400	0.394
DEG_Nend_Nbox_1	1	3	PF02207	0.629
DEG_SPOP_SBC_1	523	527	PF00917	0.443
DOC_CKS1_1	9	14	PF01111	0.634
DOC_CYCLIN_RxL_1	227	237	PF00134	0.457
DOC_CYCLIN_yCln2_LP_2	152	155	PF00134	0.496
DOC_CYCLIN_yCln2_LP_2	283	289	PF00134	0.412
DOC_CYCLIN_yCln2_LP_2	427	433	PF00134	0.433
DOC_MAPK_gen_1	170	178	PF00069	0.620
DOC_MAPK_gen_1	447	454	PF00069	0.355
DOC_MAPK_gen_1	503	513	PF00069	0.368
DOC_PP2B_LxvP_1	152	155	PF13499	0.532
DOC_PP2B_LxvP_1	283	286	PF13499	0.395
DOC_SPAK_OSR1_1	172	176	PF12202	0.595
DOC_USP7_MATH_1	157	161	PF00917	0.650
DOC_USP7_MATH_1	177	181	PF00917	0.572
DOC_USP7_MATH_1	385	389	PF00917	0.411
DOC_USP7_MATH_1	542	546	PF00917	0.618
DOC_USP7_UBL2_3	65	69	PF12436	0.657
DOC_WW_Pin1_4	126	131	PF00397	0.526
DOC_WW_Pin1_4	179	184	PF00397	0.614
DOC_WW_Pin1_4	2	7	PF00397	0.615
DOC_WW_Pin1_4	248	253	PF00397	0.589
DOC_WW_Pin1_4	278	283	PF00397	0.479
DOC_WW_Pin1_4	387	392	PF00397	0.588
DOC_WW_Pin1_4	476	481	PF00397	0.612
DOC_WW_Pin1_4	67	72	PF00397	0.679
DOC_WW_Pin1_4	75	80	PF00397	0.610
DOC_WW_Pin1_4	8	13	PF00397	0.585
DOC_WW_Pin1_4	92	97	PF00397	0.760
LIG_14-3-3_CanoR_1	16	25	PF00244	0.497
LIG_14-3-3_CanoR_1	191	198	PF00244	0.604
LIG_14-3-3_CanoR_1	327	332	PF00244	0.391
LIG_14-3-3_CanoR_1	360	364	PF00244	0.479
LIG_14-3-3_CanoR_1	375	381	PF00244	0.488
LIG_Actin_WH2_2	490	505	PF00022	0.424
LIG_BIR_III_2	34	38	PF00653	0.584
LIG_BRCT_BRCA1_1	518	522	PF00533	0.405
LIG_CSL_BTD_1	9	12	PF09270	0.623
LIG_EH1_1	328	336	PF00400	0.415
LIG_eIF4E_1	329	335	PF01652	0.431
LIG_FHA_1	249	255	PF00498	0.527
LIG_FHA_1	350	356	PF00498	0.472
LIG_FHA_1	405	411	PF00498	0.554
LIG_FHA_1	466	472	PF00498	0.601
LIG_FHA_1	48	54	PF00498	0.637
LIG_FHA_1	553	559	PF00498	0.501
LIG_FHA_2	236	242	PF00498	0.430
LIG_FHA_2	256	262	PF00498	0.541
LIG_FHA_2	399	405	PF00498	0.663
LIG_NRBOX	333	339	PF00104	0.385
LIG_Pex14_1	10	14	PF04695	0.615
LIG_RPA_C_Fungi	24	36	PF08784	0.593
LIG_SH2_CRK	323	327	PF00017	0.441
LIG_SH2_NCK_1	210	214	PF00017	0.432
LIG_SH2_NCK_1	329	333	PF00017	0.369
LIG_SH2_NCK_1	551	555	PF00017	0.508
LIG_SH2_SRC	551	554	PF00017	0.573
LIG_SH2_STAT5	14	17	PF00017	0.624
LIG_SH2_STAT5	24	27	PF00017	0.604
LIG_SH2_STAT5	290	293	PF00017	0.423
LIG_SH3_2	183	188	PF14604	0.607
LIG_SH3_2	63	68	PF14604	0.633
LIG_SH3_3	142	148	PF00018	0.493
LIG_SH3_3	180	186	PF00018	0.595
LIG_SH3_3	58	64	PF00018	0.636
LIG_SH3_3	73	79	PF00018	0.562
LIG_SH3_4	65	72	PF00018	0.603
LIG_SUMO_SIM_par_1	299	308	PF11976	0.401
LIG_SUMO_SIM_par_1	456	462	PF11976	0.377
LIG_TRAF2_1	416	419	PF00917	0.446
LIG_TYR_ITIM	321	326	PF00017	0.423
LIG_WW_3	185	189	PF00397	0.647
MOD_CDK_SPK_2	8	13	PF00069	0.633
MOD_CDK_SPxK_1	2	8	PF00069	0.583
MOD_CK1_1	124	130	PF00069	0.572
MOD_CK1_1	250	256	PF00069	0.657
MOD_CK1_1	362	368	PF00069	0.378
MOD_CK1_1	77	83	PF00069	0.649
MOD_CK2_1	67	73	PF00069	0.714
MOD_Cter_Amidation	25	28	PF01082	0.613
MOD_Cter_Amidation	316	319	PF01082	0.528
MOD_DYRK1A_RPxSP_1	387	391	PF00069	0.533
MOD_GlcNHglycan	138	142	PF01048	0.455
MOD_GlcNHglycan	159	162	PF01048	0.575
MOD_GlcNHglycan	163	166	PF01048	0.658
MOD_GlcNHglycan	179	182	PF01048	0.497
MOD_GlcNHglycan	19	22	PF01048	0.657
MOD_GlcNHglycan	211	214	PF01048	0.458
MOD_GlcNHglycan	278	281	PF01048	0.560
MOD_GlcNHglycan	392	395	PF01048	0.701
MOD_GlcNHglycan	528	531	PF01048	0.458
MOD_GlcNHglycan	562	565	PF01048	0.674
MOD_GlcNHglycan	90	93	PF01048	0.710
MOD_GSK3_1	117	124	PF00069	0.510
MOD_GSK3_1	157	164	PF00069	0.777
MOD_GSK3_1	246	253	PF00069	0.636
MOD_GSK3_1	272	279	PF00069	0.635
MOD_GSK3_1	349	356	PF00069	0.552
MOD_GSK3_1	359	366	PF00069	0.381
MOD_GSK3_1	436	443	PF00069	0.495
MOD_GSK3_1	522	529	PF00069	0.382
MOD_GSK3_1	88	95	PF00069	0.670
MOD_LATS_1	374	380	PF00433	0.418
MOD_NEK2_1	101	106	PF00069	0.560
MOD_NEK2_1	209	214	PF00069	0.417
MOD_NEK2_1	235	240	PF00069	0.522
MOD_NEK2_1	288	293	PF00069	0.343
MOD_NEK2_1	321	326	PF00069	0.544
MOD_NEK2_1	353	358	PF00069	0.477
MOD_NEK2_1	359	364	PF00069	0.467
MOD_NEK2_1	438	443	PF00069	0.432
MOD_NEK2_1	495	500	PF00069	0.528
MOD_NEK2_1	522	527	PF00069	0.423
MOD_PIKK_1	121	127	PF00454	0.549
MOD_PIKK_1	321	327	PF00454	0.450
MOD_PK_1	327	333	PF00069	0.389
MOD_PKA_2	190	196	PF00069	0.727
MOD_PKA_2	359	365	PF00069	0.476
MOD_Plk_1	116	122	PF00069	0.400
MOD_Plk_1	418	424	PF00069	0.393
MOD_Plk_4	359	365	PF00069	0.448
MOD_ProDKin_1	126	132	PF00069	0.520
MOD_ProDKin_1	179	185	PF00069	0.613
MOD_ProDKin_1	2	8	PF00069	0.616
MOD_ProDKin_1	248	254	PF00069	0.591
MOD_ProDKin_1	278	284	PF00069	0.468
MOD_ProDKin_1	387	393	PF00069	0.594
MOD_ProDKin_1	476	482	PF00069	0.610
MOD_ProDKin_1	67	73	PF00069	0.680
MOD_ProDKin_1	75	81	PF00069	0.612
MOD_ProDKin_1	92	98	PF00069	0.758
TRG_DiLeu_BaEn_1	216	221	PF01217	0.456
TRG_DiLeu_BaEn_2	427	433	PF01217	0.373
TRG_DiLeu_BaEn_2	488	494	PF01217	0.469
TRG_DiLeu_BaEn_4	418	424	PF01217	0.441
TRG_ENDOCYTIC_2	323	326	PF00928	0.466
TRG_ENDOCYTIC_2	551	554	PF00928	0.548
TRG_ER_diArg_1	170	173	PF00400	0.538
TRG_ER_diArg_1	228	230	PF00400	0.384
TRG_ER_diArg_1	28	31	PF00400	0.589
TRG_ER_diArg_1	316	319	PF00400	0.503
TRG_ER_diArg_1	375	378	PF00400	0.474
TRG_NLS_MonoExtC_3	26	31	PF00514	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMS8	Leptomonas seymouri	45%	95%
A0A1X0P1C1	Trypanosomatidae	28%	100%
A4HQ76	Leishmania braziliensis	73%	98%
A4IDX4	Leishmania infantum	99%	100%
E9ATZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q0K1	Leishmania major	90%	100%