UAA transporter family/Triose-phosphate Transporter family, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UAA transporter family, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJU2_LEIDO

TriTrypDb:

LdBPK_181530.1 , LdCL_180020600 , LDHU3_18.1940

Length:

363

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3Q8IJU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJU2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0009987	cellular process	1	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0055085	transmembrane transport	2	10
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0022857	transmembrane transporter activity	2	1
GO:0003824	catalytic activity	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	157	159	PF00675	0.426
CLV_NRD_NRD_1	215	217	PF00675	0.406
CLV_NRD_NRD_1	298	300	PF00675	0.229
CLV_NRD_NRD_1	74	76	PF00675	0.287
CLV_PCSK_KEX2_1	131	133	PF00082	0.223
CLV_PCSK_KEX2_1	157	159	PF00082	0.482
CLV_PCSK_KEX2_1	74	76	PF00082	0.299
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.218
CLV_PCSK_SKI1_1	131	135	PF00082	0.301
CLV_PCSK_SKI1_1	83	87	PF00082	0.324
DOC_CDC14_PxL_1	46	54	PF14671	0.373
DOC_CYCLIN_yCln2_LP_2	245	251	PF00134	0.308
DOC_MAPK_gen_1	74	80	PF00069	0.461
DOC_MAPK_gen_1	81	88	PF00069	0.477
DOC_MAPK_MEF2A_6	114	122	PF00069	0.227
DOC_MAPK_MEF2A_6	81	88	PF00069	0.495
DOC_MAPK_NFAT4_5	81	89	PF00069	0.432
DOC_PP4_FxxP_1	133	136	PF00568	0.499
DOC_PP4_FxxP_1	239	242	PF00568	0.315
DOC_PP4_FxxP_1	47	50	PF00568	0.278
DOC_PP4_FxxP_1	55	58	PF00568	0.385
DOC_SPAK_OSR1_1	75	79	PF12202	0.387
DOC_USP7_MATH_1	172	176	PF00917	0.232
DOC_USP7_MATH_1	218	222	PF00917	0.637
DOC_USP7_MATH_1	351	355	PF00917	0.590
DOC_WW_Pin1_4	173	178	PF00397	0.307
DOC_WW_Pin1_4	26	31	PF00397	0.218
LIG_14-3-3_CanoR_1	114	119	PF00244	0.239
LIG_14-3-3_CanoR_1	132	136	PF00244	0.432
LIG_14-3-3_CanoR_1	250	258	PF00244	0.302
LIG_14-3-3_CanoR_1	299	305	PF00244	0.261
LIG_14-3-3_CanoR_1	315	323	PF00244	0.160
LIG_14-3-3_CanoR_1	75	81	PF00244	0.400
LIG_APCC_ABBA_1	198	203	PF00400	0.259
LIG_BIR_II_1	1	5	PF00653	0.474
LIG_BIR_III_2	224	228	PF00653	0.506
LIG_BRCT_BRCA1_1	235	239	PF00533	0.395
LIG_eIF4E_1	41	47	PF01652	0.319
LIG_FHA_1	168	174	PF00498	0.169
LIG_FHA_1	193	199	PF00498	0.292
LIG_FHA_1	228	234	PF00498	0.505
LIG_FHA_1	270	276	PF00498	0.244
LIG_FHA_1	289	295	PF00498	0.185
LIG_FHA_1	46	52	PF00498	0.380
LIG_HCF-1_HBM_1	203	206	PF13415	0.499
LIG_LIR_Apic_2	236	242	PF02991	0.373
LIG_LIR_Gen_1	253	260	PF02991	0.262
LIG_LIR_Gen_1	321	330	PF02991	0.219
LIG_LIR_Nem_3	253	258	PF02991	0.262
LIG_LIR_Nem_3	32	36	PF02991	0.259
LIG_LIR_Nem_3	333	338	PF02991	0.317
LIG_LIR_Nem_3	79	85	PF02991	0.548
LIG_LYPXL_yS_3	335	338	PF13949	0.241
LIG_Pex14_2	129	133	PF04695	0.432
LIG_Pex14_2	235	239	PF04695	0.376
LIG_REV1ctd_RIR_1	125	135	PF16727	0.243
LIG_SH2_CRK	82	86	PF00017	0.432
LIG_SH2_PTP2	41	44	PF00017	0.241
LIG_SH2_STAT5	281	284	PF00017	0.241
LIG_SH2_STAT5	310	313	PF00017	0.227
LIG_SH2_STAT5	41	44	PF00017	0.247
LIG_SH3_3	333	339	PF00018	0.243
LIG_Sin3_3	139	146	PF02671	0.191
LIG_SUMO_SIM_par_1	147	152	PF11976	0.285
LIG_SUMO_SIM_par_1	290	295	PF11976	0.242
LIG_TRFH_1	244	248	PF08558	0.284
LIG_TYR_ITIM	80	85	PF00017	0.432
LIG_UBA3_1	148	155	PF00899	0.284
LIG_WRC_WIRS_1	301	306	PF05994	0.259
MOD_CK1_1	175	181	PF00069	0.310
MOD_CK1_1	288	294	PF00069	0.397
MOD_CK1_1	29	35	PF00069	0.215
MOD_CK1_1	352	358	PF00069	0.600
MOD_CK2_1	315	321	PF00069	0.218
MOD_Cter_Amidation	129	132	PF01082	0.232
MOD_GlcNHglycan	139	142	PF01048	0.345
MOD_GlcNHglycan	160	163	PF01048	0.496
MOD_GlcNHglycan	287	290	PF01048	0.205
MOD_GlcNHglycan	317	320	PF01048	0.228
MOD_GlcNHglycan	344	348	PF01048	0.436
MOD_GlcNHglycan	350	354	PF01048	0.435
MOD_GlcNHglycan	356	360	PF01048	0.418
MOD_GSK3_1	109	116	PF00069	0.228
MOD_GSK3_1	163	170	PF00069	0.215
MOD_GSK3_1	188	195	PF00069	0.284
MOD_GSK3_1	284	291	PF00069	0.396
MOD_GSK3_1	300	307	PF00069	0.237
MOD_GSK3_1	351	358	PF00069	0.569
MOD_LATS_1	313	319	PF00433	0.218
MOD_NEK2_1	1	6	PF00069	0.495
MOD_NEK2_1	103	108	PF00069	0.230
MOD_NEK2_1	109	114	PF00069	0.295
MOD_NEK2_1	188	193	PF00069	0.237
MOD_NEK2_1	233	238	PF00069	0.268
MOD_NEK2_1	24	29	PF00069	0.278
MOD_NEK2_1	290	295	PF00069	0.245
MOD_NEK2_1	304	309	PF00069	0.201
MOD_NEK2_1	330	335	PF00069	0.376
MOD_NEK2_1	76	81	PF00069	0.441
MOD_NEK2_2	7	12	PF00069	0.319
MOD_PIKK_1	259	265	PF00454	0.256
MOD_PIKK_1	269	275	PF00454	0.213
MOD_PKA_1	131	137	PF00069	0.414
MOD_PKA_1	157	163	PF00069	0.320
MOD_PKA_2	113	119	PF00069	0.239
MOD_PKA_2	131	137	PF00069	0.457
MOD_PKA_2	156	162	PF00069	0.274
MOD_PKA_2	76	82	PF00069	0.430
MOD_Plk_4	114	120	PF00069	0.239
MOD_Plk_4	175	181	PF00069	0.264
MOD_Plk_4	196	202	PF00069	0.377
MOD_Plk_4	29	35	PF00069	0.197
MOD_Plk_4	300	306	PF00069	0.283
MOD_Plk_4	7	13	PF00069	0.319
MOD_ProDKin_1	173	179	PF00069	0.307
MOD_ProDKin_1	26	32	PF00069	0.218
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.278
TRG_ENDOCYTIC_2	314	317	PF00928	0.205
TRG_ENDOCYTIC_2	33	36	PF00928	0.284
TRG_ENDOCYTIC_2	335	338	PF00928	0.227
TRG_ENDOCYTIC_2	41	44	PF00928	0.203
TRG_ENDOCYTIC_2	82	85	PF00928	0.432
TRG_ER_diArg_1	73	75	PF00400	0.423
TRG_ER_diLys_1	360	363	PF00400	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT61	Leptomonas seymouri	59%	96%
A0A0S4JTD4	Bodo saltans	34%	98%
A0A1X0P7E5	Trypanosomatidae	46%	92%
A0A3R7KQ47	Trypanosoma rangeli	53%	100%
A4HY25	Leishmania infantum	100%	100%
D0A561	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ART8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O74750	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
P40004	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q00974	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	27%	100%
Q4QDN5	Leishmania major	89%	100%
Q5R8M3	Pongo abelii	26%	100%
Q7ZW46	Danio rerio	26%	100%
Q869W7	Dictyostelium discoideum	25%	100%
Q8CIA5	Mus musculus	25%	100%
Q95KB4	Macaca fascicularis	25%	100%
Q969S0	Homo sapiens	26%	100%
Q9W429	Drosophila melanogaster	29%	100%
V5B4B4	Trypanosoma cruzi	53%	100%