Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJU1_LEIDO

TriTrypDb:

LdBPK_330080.1 , LdCL_330005700 , LDHU3_33.0090

Length:

175

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IJU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJU1

PDB structure(s): 7aih_At , 7am2_At , 7ane_At

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.565
CLV_NRD_NRD_1	112	114	PF00675	0.453
CLV_NRD_NRD_1	132	134	PF00675	0.311
CLV_NRD_NRD_1	2	4	PF00675	0.564
CLV_NRD_NRD_1	60	62	PF00675	0.500
CLV_NRD_NRD_1	86	88	PF00675	0.485
CLV_PCSK_KEX2_1	112	114	PF00082	0.453
CLV_PCSK_KEX2_1	131	133	PF00082	0.440
CLV_PCSK_KEX2_1	16	18	PF00082	0.441
CLV_PCSK_KEX2_1	2	4	PF00082	0.565
CLV_PCSK_KEX2_1	60	62	PF00082	0.500
CLV_PCSK_KEX2_1	86	88	PF00082	0.503
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.512
CLV_PCSK_PC7_1	128	134	PF00082	0.588
CLV_PCSK_PC7_1	82	88	PF00082	0.494
CLV_PCSK_SKI1_1	60	64	PF00082	0.583
CLV_PCSK_SKI1_1	77	81	PF00082	0.352
DEG_Nend_UBRbox_1	1	4	PF02207	0.565
DEG_SPOP_SBC_1	95	99	PF00917	0.472
DOC_MAPK_gen_1	2	8	PF00069	0.553
DOC_USP7_MATH_1	123	127	PF00917	0.591
DOC_USP7_MATH_1	62	66	PF00917	0.539
DOC_WW_Pin1_4	166	171	PF00397	0.542
LIG_14-3-3_CanoR_1	2	7	PF00244	0.551
LIG_14-3-3_CanoR_1	39	43	PF00244	0.455
LIG_14-3-3_CanoR_1	54	58	PF00244	0.574
LIG_14-3-3_CanoR_1	61	67	PF00244	0.512
LIG_14-3-3_CterR_2	173	175	PF00244	0.491
LIG_BRCT_BRCA1_1	4	8	PF00533	0.467
LIG_FHA_1	158	164	PF00498	0.529
LIG_LIR_Gen_1	158	167	PF02991	0.592
LIG_LIR_Nem_3	158	162	PF02991	0.568
LIG_LIR_Nem_3	5	11	PF02991	0.605
LIG_SH2_CRK	159	163	PF00017	0.594
LIG_SH2_STAP1	159	163	PF00017	0.501
LIG_SH2_STAT5	159	162	PF00017	0.578
LIG_SH2_STAT5	35	38	PF00017	0.446
LIG_SH3_3	143	149	PF00018	0.468
LIG_SH3_3	164	170	PF00018	0.498
MOD_CDK_SPxxK_3	166	173	PF00069	0.528
MOD_CK1_1	169	175	PF00069	0.585
MOD_CK1_1	37	43	PF00069	0.578
MOD_GlcNHglycan	36	39	PF01048	0.484
MOD_GlcNHglycan	74	77	PF01048	0.468
MOD_GSK3_1	151	158	PF00069	0.559
MOD_GSK3_1	34	41	PF00069	0.458
MOD_NEK2_1	1	6	PF00069	0.504
MOD_NEK2_1	155	160	PF00069	0.536
MOD_NEK2_1	72	77	PF00069	0.455
MOD_NEK2_1	96	101	PF00069	0.461
MOD_NEK2_2	38	43	PF00069	0.457
MOD_NEK2_2	9	14	PF00069	0.465
MOD_PIKK_1	123	129	PF00454	0.638
MOD_PIKK_1	157	163	PF00454	0.613
MOD_PIKK_1	60	66	PF00454	0.494
MOD_PKA_1	16	22	PF00069	0.420
MOD_PKA_1	2	8	PF00069	0.566
MOD_PKA_1	60	66	PF00069	0.494
MOD_PKA_2	1	7	PF00069	0.582
MOD_PKA_2	16	22	PF00069	0.374
MOD_PKA_2	38	44	PF00069	0.451
MOD_PKA_2	53	59	PF00069	0.452
MOD_PKA_2	60	66	PF00069	0.506
MOD_ProDKin_1	166	172	PF00069	0.543
TRG_ENDOCYTIC_2	159	162	PF00928	0.604
TRG_ENDOCYTIC_2	45	48	PF00928	0.416
TRG_ER_diArg_1	1	3	PF00400	0.541
TRG_ER_diArg_1	111	113	PF00400	0.451
TRG_ER_diArg_1	131	133	PF00400	0.316

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I402	Leptomonas seymouri	82%	100%
A0A0S4JQA3	Bodo saltans	58%	98%
A0A1X0P2R8	Trypanosomatidae	66%	98%
A0A422NYD9	Trypanosoma rangeli	70%	92%
A4HL44	Leishmania braziliensis	91%	100%
C9ZPU8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	92%
E9AHM6	Leishmania infantum	99%	100%
E9B3I5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q4L5	Leishmania major	94%	100%
V5DB04	Trypanosoma cruzi	72%	80%