Nucleolar protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleolar protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJS8_LEIDO

TriTrypDb:

LdBPK_310200.1 , LdCL_310007000 , LDHU3_31.0240

Length:

628

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A0A3Q8IJS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJS8

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0022613	ribonucleoprotein complex biogenesis	4	11
GO:0032259	methylation	2	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0042254	ribosome biogenesis	5	11
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043414	macromolecule methylation	3	12
GO:0044085	cellular component biogenesis	3	11
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0071840	cellular component organization or biogenesis	2	11
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000154	rRNA modification	6	1
GO:0000470	maturation of LSU-rRNA	9	1
GO:0006364	rRNA processing	8	1
GO:0016072	rRNA metabolic process	7	1
GO:0031167	rRNA methylation	5	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1
GO:0070475	rRNA base methylation	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0008169	C-methyltransferase activity	5	1
GO:0008173	RNA methyltransferase activity	4	1
GO:0008649	rRNA methyltransferase activity	5	1
GO:0009383	rRNA (cytosine-C5-)-methyltransferase activity	6	1
GO:0016434	rRNA (cytosine) methyltransferase activity	6	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140102	catalytic activity, acting on a rRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.746
CLV_C14_Caspase3-7	163	167	PF00656	0.489
CLV_C14_Caspase3-7	449	453	PF00656	0.470
CLV_NRD_NRD_1	132	134	PF00675	0.521
CLV_NRD_NRD_1	273	275	PF00675	0.252
CLV_NRD_NRD_1	482	484	PF00675	0.253
CLV_NRD_NRD_1	515	517	PF00675	0.231
CLV_NRD_NRD_1	620	622	PF00675	0.737
CLV_NRD_NRD_1	626	628	PF00675	0.727
CLV_PCSK_KEX2_1	131	133	PF00082	0.520
CLV_PCSK_KEX2_1	272	274	PF00082	0.252
CLV_PCSK_KEX2_1	282	284	PF00082	0.252
CLV_PCSK_KEX2_1	481	483	PF00082	0.254
CLV_PCSK_KEX2_1	515	517	PF00082	0.231
CLV_PCSK_KEX2_1	563	565	PF00082	0.672
CLV_PCSK_KEX2_1	579	581	PF00082	0.486
CLV_PCSK_KEX2_1	620	622	PF00082	0.753
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.252
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.252
CLV_PCSK_PC1ET2_1	563	565	PF00082	0.716
CLV_PCSK_PC1ET2_1	579	581	PF00082	0.452
CLV_PCSK_PC1ET2_1	620	622	PF00082	0.746
CLV_PCSK_SKI1_1	132	136	PF00082	0.500
CLV_PCSK_SKI1_1	152	156	PF00082	0.388
CLV_PCSK_SKI1_1	24	28	PF00082	0.676
CLV_PCSK_SKI1_1	4	8	PF00082	0.654
CLV_PCSK_SKI1_1	40	44	PF00082	0.636
CLV_PCSK_SKI1_1	408	412	PF00082	0.256
CLV_PCSK_SKI1_1	425	429	PF00082	0.264
CLV_PCSK_SKI1_1	444	448	PF00082	0.277
CLV_PCSK_SKI1_1	615	619	PF00082	0.806
CLV_Separin_Metazoa	220	224	PF03568	0.468
DEG_APCC_DBOX_1	222	230	PF00400	0.444
DEG_ODPH_VHL_1	332	343	PF01847	0.452
DOC_CYCLIN_RxL_1	438	452	PF00134	0.477
DOC_CYCLIN_yCln2_LP_2	243	249	PF00134	0.477
DOC_MAPK_gen_1	192	201	PF00069	0.409
DOC_MAPK_gen_1	213	221	PF00069	0.437
DOC_MAPK_gen_1	258	266	PF00069	0.464
DOC_MAPK_gen_1	292	300	PF00069	0.452
DOC_MAPK_gen_1	401	411	PF00069	0.452
DOC_MAPK_gen_1	481	487	PF00069	0.477
DOC_MAPK_gen_1	503	513	PF00069	0.538
DOC_MAPK_gen_1	582	591	PF00069	0.718
DOC_MAPK_MEF2A_6	292	300	PF00069	0.452
DOC_PP2B_LxvP_1	243	246	PF13499	0.477
DOC_PP2B_LxvP_1	411	414	PF13499	0.452
DOC_PP2B_LxvP_1	602	605	PF13499	0.751
DOC_PP4_FxxP_1	494	497	PF00568	0.452
DOC_USP7_MATH_1	22	26	PF00917	0.692
DOC_USP7_MATH_1	322	326	PF00917	0.518
DOC_USP7_MATH_1	42	46	PF00917	0.417
DOC_USP7_MATH_1	556	560	PF00917	0.688
DOC_USP7_MATH_1	75	79	PF00917	0.657
DOC_USP7_MATH_2	289	295	PF00917	0.452
DOC_USP7_UBL2_3	24	28	PF12436	0.701
DOC_USP7_UBL2_3	39	43	PF12436	0.544
DOC_USP7_UBL2_3	594	598	PF12436	0.721
DOC_USP7_UBL2_3	618	622	PF12436	0.724
DOC_WW_Pin1_4	154	159	PF00397	0.554
LIG_14-3-3_CanoR_1	265	270	PF00244	0.477
LIG_14-3-3_CanoR_1	373	378	PF00244	0.464
LIG_14-3-3_CanoR_1	438	446	PF00244	0.464
LIG_14-3-3_CanoR_1	564	574	PF00244	0.621
LIG_BRCT_BRCA1_1	509	513	PF00533	0.470
LIG_CaM_IQ_9	571	587	PF13499	0.641
LIG_EH1_1	234	242	PF00400	0.459
LIG_FHA_1	196	202	PF00498	0.444
LIG_FHA_1	261	267	PF00498	0.463
LIG_FHA_1	30	36	PF00498	0.684
LIG_FHA_1	349	355	PF00498	0.452
LIG_FHA_1	359	365	PF00498	0.452
LIG_FHA_1	385	391	PF00498	0.486
LIG_FHA_1	416	422	PF00498	0.529
LIG_FHA_2	185	191	PF00498	0.475
LIG_FHA_2	390	396	PF00498	0.464
LIG_FHA_2	609	615	PF00498	0.738
LIG_LIR_Gen_1	217	226	PF02991	0.384
LIG_LIR_Gen_1	231	240	PF02991	0.366
LIG_LIR_Gen_1	291	301	PF02991	0.452
LIG_LIR_Gen_1	397	406	PF02991	0.538
LIG_LIR_Nem_3	217	221	PF02991	0.409
LIG_LIR_Nem_3	231	235	PF02991	0.380
LIG_LIR_Nem_3	291	296	PF02991	0.452
LIG_LIR_Nem_3	325	329	PF02991	0.330
LIG_LIR_Nem_3	397	402	PF02991	0.489
LIG_MAD2	13	21	PF02301	0.667
LIG_MAD2	339	347	PF02301	0.452
LIG_PCNA_PIPBox_1	237	246	PF02747	0.452
LIG_REV1ctd_RIR_1	525	535	PF16727	0.464
LIG_SH2_NCK_1	71	75	PF00017	0.559
LIG_SH2_SRC	230	233	PF00017	0.427
LIG_SH2_SRC	71	74	PF00017	0.560
LIG_SH2_STAP1	232	236	PF00017	0.424
LIG_SH2_STAP1	399	403	PF00017	0.477
LIG_SH2_STAP1	71	75	PF00017	0.598
LIG_SH2_STAT3	318	321	PF00017	0.452
LIG_SH2_STAT3	353	356	PF00017	0.452
LIG_SH2_STAT5	218	221	PF00017	0.457
LIG_SH2_STAT5	313	316	PF00017	0.445
LIG_SH2_STAT5	353	356	PF00017	0.452
LIG_SH2_STAT5	459	462	PF00017	0.464
LIG_SH2_STAT5	517	520	PF00017	0.513
LIG_SH3_1	620	626	PF00018	0.658
LIG_SH3_2	623	628	PF14604	0.651
LIG_SH3_3	366	372	PF00018	0.477
LIG_SH3_3	620	626	PF00018	0.658
LIG_SUMO_SIM_anti_2	217	225	PF11976	0.446
LIG_SUMO_SIM_par_1	224	231	PF11976	0.439
LIG_TRAF2_1	169	172	PF00917	0.657
LIG_TRAF2_1	187	190	PF00917	0.365
LIG_TRAF2_1	333	336	PF00917	0.464
LIG_TRAF2_1	58	61	PF00917	0.754
LIG_TYR_ITSM	395	402	PF00017	0.503
LIG_UBA3_1	447	455	PF00899	0.494
MOD_CK1_1	426	432	PF00069	0.436
MOD_CK1_1	463	469	PF00069	0.452
MOD_CK1_1	536	542	PF00069	0.553
MOD_CK1_1	557	563	PF00069	0.778
MOD_CK1_1	607	613	PF00069	0.665
MOD_CK2_1	183	189	PF00069	0.503
MOD_CK2_1	394	400	PF00069	0.538
MOD_CK2_1	608	614	PF00069	0.703
MOD_Cter_Amidation	1	4	PF01082	0.516
MOD_Cter_Amidation	618	621	PF01082	0.752
MOD_GlcNHglycan	342	346	PF01048	0.313
MOD_GlcNHglycan	415	418	PF01048	0.283
MOD_GlcNHglycan	44	47	PF01048	0.672
MOD_GlcNHglycan	448	451	PF01048	0.256
MOD_GlcNHglycan	554	557	PF01048	0.718
MOD_GSK3_1	150	157	PF00069	0.606
MOD_GSK3_1	256	263	PF00069	0.538
MOD_GSK3_1	38	45	PF00069	0.686
MOD_GSK3_1	415	422	PF00069	0.454
MOD_GSK3_1	423	430	PF00069	0.449
MOD_GSK3_1	507	514	PF00069	0.513
MOD_GSK3_1	533	540	PF00069	0.500
MOD_GSK3_1	548	555	PF00069	0.617
MOD_GSK3_1	600	607	PF00069	0.677
MOD_N-GLC_1	29	34	PF02516	0.699
MOD_N-GLC_1	76	81	PF02516	0.756
MOD_NEK2_1	182	187	PF00069	0.649
MOD_NEK2_1	236	241	PF00069	0.459
MOD_NEK2_1	256	261	PF00069	0.431
MOD_NEK2_1	341	346	PF00069	0.505
MOD_NEK2_1	358	363	PF00069	0.355
MOD_NEK2_1	384	389	PF00069	0.464
MOD_NEK2_1	446	451	PF00069	0.450
MOD_NEK2_1	511	516	PF00069	0.493
MOD_NEK2_1	535	540	PF00069	0.500
MOD_NEK2_2	22	27	PF00069	0.676
MOD_PIKK_1	437	443	PF00454	0.464
MOD_PK_1	423	429	PF00069	0.452
MOD_PKA_1	533	539	PF00069	0.423
MOD_PKA_1	548	554	PF00069	0.623
MOD_PKA_2	259	265	PF00069	0.452
MOD_PKA_2	437	443	PF00069	0.464
MOD_Plk_1	423	429	PF00069	0.452
MOD_Plk_1	64	70	PF00069	0.731
MOD_Plk_1	76	82	PF00069	0.665
MOD_Plk_4	236	242	PF00069	0.465
MOD_Plk_4	322	328	PF00069	0.444
MOD_Plk_4	349	355	PF00069	0.443
MOD_Plk_4	463	469	PF00069	0.452
MOD_ProDKin_1	154	160	PF00069	0.556
MOD_SUMO_for_1	125	128	PF00179	0.529
MOD_SUMO_for_1	205	208	PF00179	0.472
MOD_SUMO_for_1	58	61	PF00179	0.694
MOD_SUMO_rev_2	119	127	PF00179	0.547
MOD_SUMO_rev_2	544	551	PF00179	0.627
TRG_DiLeu_BaEn_1	217	222	PF01217	0.431
TRG_DiLeu_BaEn_2	230	236	PF01217	0.358
TRG_DiLeu_BaEn_2	247	253	PF01217	0.510
TRG_DiLeu_BaEn_3	470	476	PF01217	0.557
TRG_ENDOCYTIC_2	218	221	PF00928	0.400
TRG_ENDOCYTIC_2	232	235	PF00928	0.361
TRG_ENDOCYTIC_2	399	402	PF00928	0.461
TRG_ER_diArg_1	130	133	PF00400	0.521
TRG_ER_diArg_1	480	483	PF00400	0.449
TRG_ER_diArg_1	515	517	PF00400	0.431
TRG_ER_diArg_1	580	583	PF00400	0.654
TRG_NLS_Bipartite_1	548	566	PF00514	0.697
TRG_NLS_MonoExtC_3	578	584	PF00514	0.706
TRG_NLS_MonoExtN_4	618	624	PF00514	0.748
TRG_Pf-PMV_PEXEL_1	133	137	PF00026	0.580
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	274	278	PF00026	0.252
TRG_Pf-PMV_PEXEL_1	408	412	PF00026	0.252

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P967	Leptomonas seymouri	72%	100%
A0A0S4KG56	Bodo saltans	65%	100%
A0A1X0NJV9	Trypanosomatidae	69%	100%
A0A422N5J0	Trypanosoma rangeli	70%	100%
A4HIZ4	Leishmania braziliensis	80%	99%
A4I6B1	Leishmania infantum	99%	100%
C9ZN38	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9B1G7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q08J23	Homo sapiens	26%	82%
Q1HFZ0	Mus musculus	25%	83%
Q28E61	Xenopus tropicalis	24%	79%
Q4Q6P5	Leishmania major	93%	100%
Q5ZLV4	Gallus gallus	24%	79%
V5BIK5	Trypanosoma cruzi	68%	100%