Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJS5_LEIDO

TriTrypDb:

LdBPK_360380.1 , LdCL_360008600 , LDHU3_36.0500

Length:

503

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IJS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJS5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.726
CLV_NRD_NRD_1	248	250	PF00675	0.697
CLV_NRD_NRD_1	251	253	PF00675	0.687
CLV_NRD_NRD_1	290	292	PF00675	0.611
CLV_NRD_NRD_1	304	306	PF00675	0.374
CLV_NRD_NRD_1	308	310	PF00675	0.345
CLV_NRD_NRD_1	360	362	PF00675	0.664
CLV_NRD_NRD_1	411	413	PF00675	0.496
CLV_NRD_NRD_1	429	431	PF00675	0.528
CLV_NRD_NRD_1	47	49	PF00675	0.814
CLV_NRD_NRD_1	486	488	PF00675	0.592
CLV_PCSK_FUR_1	249	253	PF00082	0.631
CLV_PCSK_FUR_1	427	431	PF00082	0.720
CLV_PCSK_FUR_1	45	49	PF00082	0.808
CLV_PCSK_KEX2_1	248	250	PF00082	0.697
CLV_PCSK_KEX2_1	251	253	PF00082	0.687
CLV_PCSK_KEX2_1	290	292	PF00082	0.610
CLV_PCSK_KEX2_1	308	310	PF00082	0.351
CLV_PCSK_KEX2_1	360	362	PF00082	0.664
CLV_PCSK_KEX2_1	411	413	PF00082	0.496
CLV_PCSK_KEX2_1	429	431	PF00082	0.528
CLV_PCSK_KEX2_1	47	49	PF00082	0.814
CLV_PCSK_SKI1_1	170	174	PF00082	0.809
CLV_PCSK_SKI1_1	192	196	PF00082	0.590
CLV_PCSK_SKI1_1	214	218	PF00082	0.659
CLV_PCSK_SKI1_1	239	243	PF00082	0.629
CLV_PCSK_SKI1_1	342	346	PF00082	0.653
CLV_PCSK_SKI1_1	59	63	PF00082	0.683
DEG_Nend_UBRbox_3	1	3	PF02207	0.843
DEG_SCF_FBW7_1	442	447	PF00400	0.586
DOC_CKS1_1	199	204	PF01111	0.566
DOC_CYCLIN_RxL_1	167	178	PF00134	0.748
DOC_MAPK_gen_1	293	302	PF00069	0.534
DOC_PP1_RVXF_1	212	218	PF00149	0.660
DOC_PP1_RVXF_1	242	248	PF00149	0.554
DOC_PP2B_LxvP_1	216	219	PF13499	0.657
DOC_PP2B_LxvP_1	264	267	PF13499	0.684
DOC_PP2B_LxvP_1	51	54	PF13499	0.819
DOC_PP4_FxxP_1	62	65	PF00568	0.652
DOC_USP7_MATH_1	110	114	PF00917	0.782
DOC_USP7_MATH_1	368	372	PF00917	0.778
DOC_USP7_MATH_1	376	380	PF00917	0.619
DOC_USP7_MATH_1	82	86	PF00917	0.692
DOC_WW_Pin1_4	154	159	PF00397	0.712
DOC_WW_Pin1_4	195	200	PF00397	0.681
DOC_WW_Pin1_4	332	337	PF00397	0.668
DOC_WW_Pin1_4	440	445	PF00397	0.541
LIG_14-3-3_CanoR_1	104	109	PF00244	0.734
LIG_14-3-3_CanoR_1	255	263	PF00244	0.630
LIG_14-3-3_CanoR_1	411	419	PF00244	0.623
LIG_14-3-3_CanoR_1	47	52	PF00244	0.673
LIG_14-3-3_CanoR_1	5	13	PF00244	0.814
LIG_14-3-3_CanoR_1	88	93	PF00244	0.613
LIG_Actin_WH2_2	256	274	PF00022	0.610
LIG_Actin_WH2_2	395	413	PF00022	0.489
LIG_BRCT_BRCA1_1	403	407	PF00533	0.593
LIG_CaM_IQ_9	282	297	PF13499	0.643
LIG_Clathr_ClatBox_1	397	401	PF01394	0.592
LIG_eIF4E_1	210	216	PF01652	0.669
LIG_FHA_1	176	182	PF00498	0.649
LIG_FHA_1	232	238	PF00498	0.685
LIG_FHA_1	360	366	PF00498	0.740
LIG_FHA_1	401	407	PF00498	0.586
LIG_FHA_1	445	451	PF00498	0.650
LIG_FHA_1	474	480	PF00498	0.488
LIG_FHA_2	129	135	PF00498	0.741
LIG_FHA_2	319	325	PF00498	0.514
LIG_LIR_Gen_1	257	267	PF02991	0.617
LIG_LIR_Gen_1	313	320	PF02991	0.616
LIG_LIR_Gen_1	386	394	PF02991	0.512
LIG_LIR_Gen_1	404	415	PF02991	0.513
LIG_LIR_Gen_1	466	473	PF02991	0.588
LIG_LIR_Nem_3	257	263	PF02991	0.623
LIG_LIR_Nem_3	301	307	PF02991	0.594
LIG_LIR_Nem_3	313	319	PF02991	0.418
LIG_LIR_Nem_3	386	390	PF02991	0.530
LIG_LIR_Nem_3	404	410	PF02991	0.492
LIG_LIR_Nem_3	466	472	PF02991	0.593
LIG_MAD2	115	123	PF02301	0.677
LIG_Pex14_2	217	221	PF04695	0.658
LIG_PTB_Apo_2	472	479	PF02174	0.572
LIG_PTB_Phospho_1	472	478	PF10480	0.566
LIG_SH2_CRK	210	214	PF00017	0.568
LIG_SH2_CRK	304	308	PF00017	0.588
LIG_SH2_CRK	469	473	PF00017	0.489
LIG_SH2_NCK_1	373	377	PF00017	0.557
LIG_SH2_STAP1	373	377	PF00017	0.744
LIG_SH2_STAP1	385	389	PF00017	0.500
LIG_SH2_STAP1	469	473	PF00017	0.489
LIG_SH2_STAT5	478	481	PF00017	0.539
LIG_SH2_STAT5	60	63	PF00017	0.735
LIG_SH3_1	162	168	PF00018	0.720
LIG_SH3_2	165	170	PF14604	0.764
LIG_SH3_3	15	21	PF00018	0.797
LIG_SH3_3	155	161	PF00018	0.747
LIG_SH3_3	162	168	PF00018	0.714
LIG_SH3_3	196	202	PF00018	0.570
LIG_SH3_3	330	336	PF00018	0.695
LIG_SH3_3	65	71	PF00018	0.630
LIG_TYR_ITIM	302	307	PF00017	0.590
LIG_UBA3_1	216	222	PF00899	0.655
LIG_UBA3_1	263	270	PF00899	0.474
LIG_WRC_WIRS_1	384	389	PF05994	0.458
MOD_CDK_SPK_2	154	159	PF00069	0.758
MOD_CDK_SPK_2	198	203	PF00069	0.670
MOD_CDK_SPxxK_3	332	339	PF00069	0.665
MOD_CK1_1	149	155	PF00069	0.827
MOD_CK1_1	188	194	PF00069	0.783
MOD_CK1_1	198	204	PF00069	0.616
MOD_CK1_1	8	14	PF00069	0.622
MOD_CK1_1	96	102	PF00069	0.735
MOD_CK2_1	318	324	PF00069	0.511
MOD_CK2_1	363	369	PF00069	0.551
MOD_CK2_1	432	438	PF00069	0.622
MOD_DYRK1A_RPxSP_1	332	336	PF00069	0.673
MOD_GlcNHglycan	108	111	PF01048	0.747
MOD_GlcNHglycan	112	115	PF01048	0.797
MOD_GlcNHglycan	187	190	PF01048	0.656
MOD_GlcNHglycan	192	195	PF01048	0.660
MOD_GlcNHglycan	23	26	PF01048	0.581
MOD_GlcNHglycan	366	369	PF01048	0.702
MOD_GlcNHglycan	403	406	PF01048	0.587
MOD_GlcNHglycan	412	415	PF01048	0.492
MOD_GlcNHglycan	7	10	PF01048	0.786
MOD_GSK3_1	106	113	PF00069	0.739
MOD_GSK3_1	147	154	PF00069	0.745
MOD_GSK3_1	188	195	PF00069	0.631
MOD_GSK3_1	250	257	PF00069	0.621
MOD_GSK3_1	3	10	PF00069	0.781
MOD_GSK3_1	359	366	PF00069	0.647
MOD_GSK3_1	440	447	PF00069	0.573
MOD_GSK3_1	473	480	PF00069	0.575
MOD_GSK3_1	60	67	PF00069	0.812
MOD_GSK3_1	80	87	PF00069	0.480
MOD_GSK3_1	88	95	PF00069	0.601
MOD_LATS_1	86	92	PF00433	0.640
MOD_N-GLC_1	473	478	PF02516	0.568
MOD_N-GLC_2	475	477	PF02516	0.563
MOD_NEK2_1	148	153	PF00069	0.706
MOD_NEK2_1	185	190	PF00069	0.656
MOD_NEK2_1	400	405	PF00069	0.592
MOD_NEK2_1	410	415	PF00069	0.475
MOD_NEK2_1	423	428	PF00069	0.503
MOD_NEK2_1	449	454	PF00069	0.685
MOD_NEK2_1	473	478	PF00069	0.568
MOD_PIKK_1	135	141	PF00454	0.644
MOD_PIKK_1	318	324	PF00454	0.561
MOD_PK_1	354	360	PF00069	0.640
MOD_PKA_1	47	53	PF00069	0.751
MOD_PKA_2	231	237	PF00069	0.485
MOD_PKA_2	250	256	PF00069	0.670
MOD_PKA_2	359	365	PF00069	0.699
MOD_PKA_2	410	416	PF00069	0.612
MOD_PKA_2	47	53	PF00069	0.659
MOD_PKB_1	104	112	PF00069	0.794
MOD_PKB_1	352	360	PF00069	0.636
MOD_PKB_1	45	53	PF00069	0.827
MOD_Plk_1	135	141	PF00069	0.698
MOD_Plk_1	368	374	PF00069	0.695
MOD_Plk_1	473	479	PF00069	0.574
MOD_Plk_2-3	369	375	PF00069	0.615
MOD_Plk_4	256	262	PF00069	0.702
MOD_Plk_4	393	399	PF00069	0.599
MOD_Plk_4	432	438	PF00069	0.542
MOD_Plk_4	464	470	PF00069	0.568
MOD_Plk_4	478	484	PF00069	0.389
MOD_Plk_4	96	102	PF00069	0.816
MOD_ProDKin_1	154	160	PF00069	0.711
MOD_ProDKin_1	195	201	PF00069	0.722
MOD_ProDKin_1	332	338	PF00069	0.666
MOD_ProDKin_1	440	446	PF00069	0.544
MOD_SUMO_rev_2	182	188	PF00179	0.636
MOD_SUMO_rev_2	481	489	PF00179	0.575
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.666
TRG_ENDOCYTIC_2	210	213	PF00928	0.673
TRG_ENDOCYTIC_2	304	307	PF00928	0.588
TRG_ENDOCYTIC_2	469	472	PF00928	0.570
TRG_ER_diArg_1	247	249	PF00400	0.719
TRG_ER_diArg_1	289	291	PF00400	0.647
TRG_ER_diArg_1	293	296	PF00400	0.566
TRG_ER_diArg_1	307	309	PF00400	0.306
TRG_ER_diArg_1	352	355	PF00400	0.663
TRG_ER_diArg_1	410	412	PF00400	0.623
TRG_ER_diArg_1	427	430	PF00400	0.461
TRG_ER_diArg_1	45	48	PF00400	0.654
TRG_ER_diArg_1	450	453	PF00400	0.693
TRG_ER_diArg_1	493	496	PF00400	0.617
TRG_NLS_Bipartite_1	290	309	PF00514	0.573
TRG_NLS_MonoExtC_3	304	309	PF00514	0.598
TRG_Pf-PMV_PEXEL_1	170	175	PF00026	0.741
TRG_Pf-PMV_PEXEL_1	462	466	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HNP3	Leishmania braziliensis	62%	100%
A4ICV2	Leishmania infantum	99%	100%
E9ASF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q243	Leishmania major	90%	100%