Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJS4_LEIDO

TriTrypDb:

LdBPK_365540.1 , LdCL_360062700 , LDHU3_36.7370

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IJS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJS4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.416
CLV_NRD_NRD_1	181	183	PF00675	0.418
CLV_NRD_NRD_1	209	211	PF00675	0.406
CLV_NRD_NRD_1	327	329	PF00675	0.511
CLV_NRD_NRD_1	339	341	PF00675	0.455
CLV_PCSK_KEX2_1	11	13	PF00082	0.534
CLV_PCSK_KEX2_1	181	183	PF00082	0.418
CLV_PCSK_KEX2_1	209	211	PF00082	0.406
CLV_PCSK_KEX2_1	327	329	PF00082	0.531
CLV_PCSK_KEX2_1	339	341	PF00082	0.462
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.586
CLV_PCSK_SKI1_1	107	111	PF00082	0.470
CLV_PCSK_SKI1_1	12	16	PF00082	0.533
CLV_PCSK_SKI1_1	182	186	PF00082	0.418
CLV_PCSK_SKI1_1	272	276	PF00082	0.453
CLV_PCSK_SKI1_1	294	298	PF00082	0.471
CLV_PCSK_SKI1_1	322	326	PF00082	0.406
CLV_PCSK_SKI1_1	44	48	PF00082	0.531
CLV_Separin_Metazoa	269	273	PF03568	0.428
CLV_Separin_Metazoa	94	98	PF03568	0.434
DEG_Nend_Nbox_1	1	3	PF02207	0.588
DOC_ANK_TNKS_1	133	140	PF00023	0.559
DOC_CKS1_1	127	132	PF01111	0.421
DOC_MAPK_gen_1	209	216	PF00069	0.389
DOC_MAPK_gen_1	23	32	PF00069	0.483
DOC_MAPK_gen_1	73	81	PF00069	0.446
DOC_MAPK_MEF2A_6	120	128	PF00069	0.477
DOC_PP4_FxxP_1	24	27	PF00568	0.500
DOC_USP7_MATH_1	280	284	PF00917	0.572
DOC_USP7_MATH_1	55	59	PF00917	0.608
DOC_USP7_MATH_1	7	11	PF00917	0.638
DOC_USP7_UBL2_3	11	15	PF12436	0.495
DOC_WW_Pin1_4	126	131	PF00397	0.448
DOC_WW_Pin1_4	163	168	PF00397	0.425
LIG_14-3-3_CanoR_1	181	185	PF00244	0.442
LIG_14-3-3_CanoR_1	209	215	PF00244	0.367
LIG_14-3-3_CanoR_1	66	74	PF00244	0.537
LIG_14-3-3_CanoR_1	97	103	PF00244	0.505
LIG_Actin_WH2_2	83	99	PF00022	0.450
LIG_BRCT_BRCA1_1	98	102	PF00533	0.456
LIG_EH1_1	237	245	PF00400	0.402
LIG_EVH1_2	124	128	PF00568	0.482
LIG_FHA_1	82	88	PF00498	0.451
LIG_FHA_2	169	175	PF00498	0.465
LIG_GBD_Chelix_1	176	184	PF00786	0.409
LIG_LIR_Gen_1	196	205	PF02991	0.393
LIG_LIR_Nem_3	196	200	PF02991	0.399
LIG_LIR_Nem_3	58	63	PF02991	0.464
LIG_PCNA_yPIPBox_3	199	212	PF02747	0.398
LIG_Pex14_1	311	315	PF04695	0.425
LIG_RPA_C_Fungi	205	217	PF08784	0.348
LIG_SH2_CRK	112	116	PF00017	0.523
LIG_SH2_NCK_1	121	125	PF00017	0.472
LIG_SH2_STAT3	62	65	PF00017	0.439
LIG_SH2_STAT3	85	88	PF00017	0.430
LIG_SH2_STAT5	158	161	PF00017	0.545
LIG_SH2_STAT5	215	218	PF00017	0.361
LIG_SH2_STAT5	295	298	PF00017	0.469
LIG_SH2_STAT5	315	318	PF00017	0.240
LIG_SH2_STAT5	62	65	PF00017	0.418
LIG_SH3_1	121	127	PF00018	0.460
LIG_SH3_1	140	146	PF00018	0.582
LIG_SH3_1	249	255	PF00018	0.428
LIG_SH3_3	121	127	PF00018	0.460
LIG_SH3_3	140	146	PF00018	0.459
LIG_SH3_3	249	255	PF00018	0.428
LIG_TRAF2_1	318	321	PF00917	0.550
LIG_TYR_ITIM	110	115	PF00017	0.579
LIG_WW_1	366	369	PF00397	0.652
MOD_CK1_1	10	16	PF00069	0.587
MOD_CK1_1	168	174	PF00069	0.439
MOD_CK1_1	208	214	PF00069	0.392
MOD_CK1_1	283	289	PF00069	0.548
MOD_CK1_1	355	361	PF00069	0.668
MOD_CK1_1	69	75	PF00069	0.435
MOD_CK2_1	102	108	PF00069	0.469
MOD_CK2_1	284	290	PF00069	0.468
MOD_CK2_1	315	321	PF00069	0.528
MOD_GlcNHglycan	167	170	PF01048	0.434
MOD_GlcNHglycan	353	357	PF01048	0.680
MOD_GSK3_1	280	287	PF00069	0.509
MOD_GSK3_1	98	105	PF00069	0.599
MOD_N-GLC_1	163	168	PF02516	0.440
MOD_N-GLC_1	284	289	PF02516	0.581
MOD_N-GLC_1	55	60	PF02516	0.601
MOD_N-GLC_1	81	86	PF02516	0.456
MOD_NEK2_1	1	6	PF00069	0.599
MOD_NEK2_1	180	185	PF00069	0.423
MOD_NEK2_1	32	37	PF00069	0.537
MOD_NEK2_1	67	72	PF00069	0.505
MOD_NEK2_1	81	86	PF00069	0.390
MOD_NEK2_1	96	101	PF00069	0.420
MOD_PK_1	210	216	PF00069	0.355
MOD_PK_1	25	31	PF00069	0.543
MOD_PKA_2	180	186	PF00069	0.427
MOD_PKA_2	208	214	PF00069	0.381
MOD_PKA_2	347	353	PF00069	0.642
MOD_PKA_2	96	102	PF00069	0.476
MOD_PKB_1	23	31	PF00069	0.539
MOD_Plk_1	284	290	PF00069	0.580
MOD_Plk_1	39	45	PF00069	0.549
MOD_Plk_1	55	61	PF00069	0.576
MOD_Plk_1	81	87	PF00069	0.454
MOD_Plk_4	210	216	PF00069	0.538
MOD_Plk_4	25	31	PF00069	0.526
MOD_ProDKin_1	126	132	PF00069	0.439
MOD_ProDKin_1	163	169	PF00069	0.418
MOD_SUMO_for_1	119	122	PF00179	0.524
MOD_SUMO_rev_2	318	324	PF00179	0.543
TRG_DiLeu_BaLyEn_6	239	244	PF01217	0.435
TRG_ENDOCYTIC_2	112	115	PF00928	0.577
TRG_ENDOCYTIC_2	60	63	PF00928	0.436
TRG_ER_diArg_1	159	162	PF00400	0.547
TRG_ER_diArg_1	180	182	PF00400	0.409
TRG_ER_diArg_1	20	23	PF00400	0.521
TRG_ER_diArg_1	248	251	PF00400	0.517
TRG_ER_diArg_1	291	294	PF00400	0.525
TRG_ER_diArg_1	327	330	PF00400	0.603
TRG_ER_diArg_1	339	341	PF00400	0.513
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	268	273	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	331	335	PF00026	0.608

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2J5	Leptomonas seymouri	84%	100%
A0A0S4KDW2	Bodo saltans	53%	100%
A0A1X0P3G7	Trypanosomatidae	67%	100%
A0A3R7KL34	Trypanosoma rangeli	65%	100%
A4HQ45	Leishmania braziliensis	92%	100%
A4IC81	Leishmania infantum	99%	100%
D0A8R9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9ATW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q0N1	Leishmania major	97%	100%
V5BMB9	Trypanosoma cruzi	65%	100%