Complex 1 protein (LYR family)/Complex1 LYR-like, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Complex 1 protein (LYR family), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJR9_LEIDO

TriTrypDb:

LdBPK_181210.1 , LdCL_180017300 , LDHU3_18.1530

Length:

270

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A0A3Q8IJR9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJR9

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	4
GO:0016043	cellular component organization	3	4
GO:0022607	cellular component assembly	4	4
GO:0033108	mitochondrial respiratory chain complex assembly	6	4
GO:0034552	respiratory chain complex II assembly	6	4
GO:0034553	mitochondrial respiratory chain complex II assembly	7	4
GO:0043933	protein-containing complex organization	4	4
GO:0065003	protein-containing complex assembly	5	4
GO:0071840	cellular component organization or biogenesis	2	4

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	158	160	PF00675	0.621
CLV_NRD_NRD_1	190	192	PF00675	0.580
CLV_NRD_NRD_1	218	220	PF00675	0.446
CLV_NRD_NRD_1	236	238	PF00675	0.334
CLV_NRD_NRD_1	251	253	PF00675	0.334
CLV_NRD_NRD_1	46	48	PF00675	0.672
CLV_NRD_NRD_1	56	58	PF00675	0.562
CLV_PCSK_FUR_1	12	16	PF00082	0.728
CLV_PCSK_FUR_1	54	58	PF00082	0.585
CLV_PCSK_KEX2_1	14	16	PF00082	0.612
CLV_PCSK_KEX2_1	157	159	PF00082	0.617
CLV_PCSK_KEX2_1	190	192	PF00082	0.580
CLV_PCSK_KEX2_1	218	220	PF00082	0.446
CLV_PCSK_KEX2_1	251	253	PF00082	0.334
CLV_PCSK_KEX2_1	46	48	PF00082	0.672
CLV_PCSK_KEX2_1	56	58	PF00082	0.562
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.723
CLV_PCSK_PC1ET2_1	251	253	PF00082	0.334
CLV_PCSK_SKI1_1	203	207	PF00082	0.334
CLV_PCSK_SKI1_1	238	242	PF00082	0.481
DEG_APCC_DBOX_1	202	210	PF00400	0.334
DEG_Nend_UBRbox_1	1	4	PF02207	0.560
DEG_SCF_FBW7_1	178	184	PF00400	0.640
DEG_SPOP_SBC_1	130	134	PF00917	0.670
DEG_SPOP_SBC_1	67	71	PF00917	0.605
DOC_CKS1_1	178	183	PF01111	0.606
DOC_MAPK_gen_1	32	40	PF00069	0.614
DOC_PP1_RVXF_1	240	246	PF00149	0.334
DOC_PP2B_LxvP_1	65	68	PF13499	0.683
DOC_USP7_MATH_1	117	121	PF00917	0.709
DOC_USP7_MATH_1	126	130	PF00917	0.762
DOC_USP7_MATH_1	137	141	PF00917	0.528
DOC_USP7_MATH_1	183	187	PF00917	0.613
DOC_USP7_MATH_1	189	193	PF00917	0.473
DOC_USP7_MATH_1	52	56	PF00917	0.582
DOC_USP7_MATH_1	68	72	PF00917	0.610
DOC_USP7_UBL2_3	14	18	PF12436	0.719
DOC_USP7_UBL2_3	238	242	PF12436	0.334
DOC_WW_Pin1_4	120	125	PF00397	0.605
DOC_WW_Pin1_4	133	138	PF00397	0.469
DOC_WW_Pin1_4	177	182	PF00397	0.682
DOC_WW_Pin1_4	185	190	PF00397	0.541
LIG_14-3-3_CanoR_1	128	137	PF00244	0.633
LIG_14-3-3_CanoR_1	218	222	PF00244	0.366
LIG_Actin_WH2_2	194	209	PF00022	0.346
LIG_APCC_ABBAyCdc20_2	47	53	PF00400	0.653
LIG_FHA_1	6	12	PF00498	0.541
LIG_FHA_1	73	79	PF00498	0.588
LIG_FHA_2	104	110	PF00498	0.620
LIG_FHA_2	143	149	PF00498	0.607
LIG_FHA_2	239	245	PF00498	0.283
LIG_GBD_Chelix_1	87	95	PF00786	0.665
LIG_PCNA_yPIPBox_3	190	202	PF02747	0.451
LIG_Pex14_1	245	249	PF04695	0.334
LIG_RPA_C_Fungi	214	226	PF08784	0.449
LIG_SH2_STAT3	224	227	PF00017	0.437
LIG_SH2_STAT3	229	232	PF00017	0.395
LIG_SH2_STAT3	39	42	PF00017	0.539
LIG_SH2_STAT5	150	153	PF00017	0.488
LIG_SH2_STAT5	224	227	PF00017	0.353
LIG_SH2_STAT5	39	42	PF00017	0.571
LIG_SH3_3	175	181	PF00018	0.539
LIG_SH3_3	35	41	PF00018	0.580
LIG_TRAF2_1	145	148	PF00917	0.634
MOD_CDC14_SPxK_1	188	191	PF00782	0.640
MOD_CDK_SPK_2	185	190	PF00069	0.673
MOD_CDK_SPxK_1	185	191	PF00069	0.663
MOD_CK1_1	120	126	PF00069	0.757
MOD_CK1_1	129	135	PF00069	0.613
MOD_CK1_1	261	267	PF00069	0.520
MOD_CK1_1	69	75	PF00069	0.771
MOD_CK1_1	86	92	PF00069	0.537
MOD_CK2_1	142	148	PF00069	0.672
MOD_CK2_1	238	244	PF00069	0.353
MOD_Cter_Amidation	249	252	PF01082	0.317
MOD_GlcNHglycan	139	142	PF01048	0.646
MOD_GlcNHglycan	170	173	PF01048	0.646
MOD_GlcNHglycan	185	188	PF01048	0.585
MOD_GlcNHglycan	191	194	PF01048	0.505
MOD_GlcNHglycan	221	224	PF01048	0.449
MOD_GSK3_1	126	133	PF00069	0.585
MOD_GSK3_1	142	149	PF00069	0.676
MOD_GSK3_1	173	180	PF00069	0.628
MOD_GSK3_1	181	188	PF00069	0.749
MOD_GSK3_1	197	204	PF00069	0.292
MOD_GSK3_1	68	75	PF00069	0.582
MOD_GSK3_1	82	89	PF00069	0.632
MOD_N-GLC_1	238	243	PF02516	0.482
MOD_NEK2_1	5	10	PF00069	0.595
MOD_PIKK_1	58	64	PF00454	0.648
MOD_PKA_2	189	195	PF00069	0.552
MOD_PKA_2	217	223	PF00069	0.366
MOD_Plk_1	146	152	PF00069	0.689
MOD_Plk_1	207	213	PF00069	0.412
MOD_Plk_4	146	152	PF00069	0.522
MOD_Plk_4	197	203	PF00069	0.334
MOD_ProDKin_1	120	126	PF00069	0.605
MOD_ProDKin_1	133	139	PF00069	0.471
MOD_ProDKin_1	177	183	PF00069	0.683
MOD_ProDKin_1	185	191	PF00069	0.532
TRG_ENDOCYTIC_2	202	205	PF00928	0.334
TRG_ER_diArg_1	156	159	PF00400	0.614
TRG_ER_diArg_1	189	191	PF00400	0.606
TRG_ER_diArg_1	45	47	PF00400	0.667
TRG_ER_diArg_1	54	57	PF00400	0.575
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.334

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8U5	Leptomonas seymouri	49%	98%
A4H9N0	Leishmania braziliensis	67%	100%
A4HXZ4	Leishmania infantum	99%	100%
E9ARQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QDS2	Leishmania major	89%	100%