RING-variant domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RING-variant domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJR8_LEIDO

TriTrypDb:

LdBPK_310040.1 , LdCL_310005200 , LDHU3_31.0050

Length:

1052

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Show entries

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Previous1Next

Expansion

Sequence features

A0A3Q8IJR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJR8

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0000209	protein polyubiquitination	8	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1

Previous1 2Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7

Previous1 2Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	400	404	PF00656	0.395
CLV_NRD_NRD_1	292	294	PF00675	0.619
CLV_NRD_NRD_1	343	345	PF00675	0.424
CLV_NRD_NRD_1	401	403	PF00675	0.632
CLV_NRD_NRD_1	619	621	PF00675	0.410
CLV_NRD_NRD_1	700	702	PF00675	0.436
CLV_NRD_NRD_1	731	733	PF00675	0.434
CLV_NRD_NRD_1	781	783	PF00675	0.374
CLV_NRD_NRD_1	87	89	PF00675	0.415
CLV_PCSK_FUR_1	341	345	PF00082	0.436

Previous1 2 3 4 5…35Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFJ7	Leptomonas seymouri	38%	97%
A4HIW7	Leishmania braziliensis	74%	100%
A4I697	Leishmania infantum	99%	100%
E9B1F1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q6R1	Leishmania major	91%	100%

Previous1Next