Enolase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Enolase, putative

Gene product:

enolase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJR5_LEIDO

TriTrypDb:

LdBPK_323910.1 , LdCL_320045100 , LDHU3_32.5040

Length:

608

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0000015	phosphopyruvate hydratase complex	3	4
GO:0032991	protein-containing complex	1	4
GO:1902494	catalytic complex	2	4

Expansion

Sequence features

A0A3Q8IJR5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJR5

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	4
GO:0006082	organic acid metabolic process	3	4
GO:0006090	pyruvate metabolic process	7	4
GO:0006091	generation of precursor metabolites and energy	3	4
GO:0006096	glycolytic process	5	4
GO:0006139	nucleobase-containing compound metabolic process	3	4
GO:0006163	purine nucleotide metabolic process	5	4
GO:0006165	obsolete nucleoside diphosphate phosphorylation	6	4
GO:0006725	cellular aromatic compound metabolic process	3	4
GO:0006753	nucleoside phosphate metabolic process	4	4
GO:0006757	obsolete ATP generation from ADP	4	4
GO:0006793	phosphorus metabolic process	3	4
GO:0006796	phosphate-containing compound metabolic process	4	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0009056	catabolic process	2	4
GO:0009117	nucleotide metabolic process	5	4
GO:0009132	nucleoside diphosphate metabolic process	5	4
GO:0009135	purine nucleoside diphosphate metabolic process	6	4
GO:0009141	nucleoside triphosphate metabolic process	5	4
GO:0009144	purine nucleoside triphosphate metabolic process	6	4
GO:0009150	purine ribonucleotide metabolic process	6	4
GO:0009179	purine ribonucleoside diphosphate metabolic process	7	4
GO:0009185	ribonucleoside diphosphate metabolic process	6	4
GO:0009199	ribonucleoside triphosphate metabolic process	6	4
GO:0009205	purine ribonucleoside triphosphate metabolic process	7	4
GO:0009259	ribonucleotide metabolic process	5	4
GO:0009987	cellular process	1	4
GO:0016052	carbohydrate catabolic process	4	4
GO:0016310	phosphorylation	5	4
GO:0019637	organophosphate metabolic process	3	4
GO:0019693	ribose phosphate metabolic process	4	4
GO:0019752	carboxylic acid metabolic process	5	4
GO:0032787	monocarboxylic acid metabolic process	6	4
GO:0034641	cellular nitrogen compound metabolic process	3	4
GO:0043436	oxoacid metabolic process	4	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044281	small molecule metabolic process	2	4
GO:0046031	ADP metabolic process	7	4
GO:0046034	ATP metabolic process	7	4
GO:0046483	heterocycle metabolic process	3	4
GO:0046939	obsolete nucleotide phosphorylation	6	4
GO:0055086	nucleobase-containing small molecule metabolic process	3	4
GO:0071704	organic substance metabolic process	2	4
GO:0072521	purine-containing compound metabolic process	4	4
GO:1901135	carbohydrate derivative metabolic process	3	4
GO:1901360	organic cyclic compound metabolic process	3	4
GO:1901564	organonitrogen compound metabolic process	3	4
GO:1901575	organic substance catabolic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004634	phosphopyruvate hydratase activity	5	9
GO:0016829	lyase activity	2	9
GO:0016835	carbon-oxygen lyase activity	3	9
GO:0016836	hydro-lyase activity	4	9
GO:0000287	magnesium ion binding	5	4
GO:0005488	binding	1	4
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	84	88	PF00656	0.399
CLV_NRD_NRD_1	195	197	PF00675	0.581
CLV_NRD_NRD_1	501	503	PF00675	0.561
CLV_NRD_NRD_1	590	592	PF00675	0.586
CLV_NRD_NRD_1	606	608	PF00675	0.656
CLV_PCSK_KEX2_1	195	197	PF00082	0.625
CLV_PCSK_KEX2_1	501	503	PF00082	0.561
CLV_PCSK_KEX2_1	590	592	PF00082	0.570
CLV_PCSK_KEX2_1	606	608	PF00082	0.675
CLV_PCSK_PC1ET2_1	606	608	PF00082	0.730
CLV_PCSK_SKI1_1	332	336	PF00082	0.568
CLV_PCSK_SKI1_1	36	40	PF00082	0.618
CLV_PCSK_SKI1_1	502	506	PF00082	0.532
DEG_SIAH_1	581	589	PF03145	0.585
DEG_SPOP_SBC_1	151	155	PF00917	0.476
DEG_SPOP_SBC_1	308	312	PF00917	0.646
DOC_CYCLIN_RxL_1	128	139	PF00134	0.527
DOC_MAPK_DCC_7	229	238	PF00069	0.514
DOC_MAPK_gen_1	430	437	PF00069	0.531
DOC_MAPK_gen_1	501	508	PF00069	0.582
DOC_MAPK_MEF2A_6	229	238	PF00069	0.514
DOC_MAPK_MEF2A_6	257	265	PF00069	0.504
DOC_MAPK_MEF2A_6	501	508	PF00069	0.582
DOC_PP2B_LxvP_1	464	467	PF13499	0.616
DOC_USP7_MATH_1	100	104	PF00917	0.631
DOC_USP7_MATH_1	127	131	PF00917	0.550
DOC_USP7_MATH_1	244	248	PF00917	0.686
DOC_USP7_MATH_1	26	30	PF00917	0.503
DOC_USP7_MATH_1	308	312	PF00917	0.562
DOC_USP7_MATH_1	455	459	PF00917	0.564
DOC_USP7_MATH_1	546	550	PF00917	0.522
DOC_USP7_MATH_1	566	570	PF00917	0.317
DOC_USP7_MATH_1	79	83	PF00917	0.506
DOC_USP7_UBL2_3	404	408	PF12436	0.516
DOC_USP7_UBL2_3	592	596	PF12436	0.578
DOC_USP7_UBL2_3	598	602	PF12436	0.606
DOC_WW_Pin1_4	152	157	PF00397	0.557
DOC_WW_Pin1_4	267	272	PF00397	0.443
LIG_14-3-3_CanoR_1	117	121	PF00244	0.505
LIG_14-3-3_CanoR_1	149	157	PF00244	0.525
LIG_14-3-3_CanoR_1	229	234	PF00244	0.478
LIG_14-3-3_CanoR_1	25	35	PF00244	0.614
LIG_14-3-3_CanoR_1	257	265	PF00244	0.415
LIG_14-3-3_CanoR_1	302	308	PF00244	0.546
LIG_14-3-3_CanoR_1	356	363	PF00244	0.597
LIG_14-3-3_CanoR_1	381	387	PF00244	0.455
LIG_14-3-3_CanoR_1	501	507	PF00244	0.505
LIG_APCC_ABBAyCdc20_2	316	322	PF00400	0.377
LIG_BIR_II_1	1	5	PF00653	0.678
LIG_BIR_III_4	112	116	PF00653	0.584
LIG_BIR_III_4	274	278	PF00653	0.668
LIG_BRCT_BRCA1_1	39	43	PF00533	0.532
LIG_BRCT_BRCA1_1	87	91	PF00533	0.504
LIG_CaM_NSCaTE_8	144	151	PF13499	0.521
LIG_EH1_1	185	193	PF00400	0.324
LIG_eIF4E_1	231	237	PF01652	0.481
LIG_EVH1_1	578	582	PF00568	0.562
LIG_FHA_1	152	158	PF00498	0.517
LIG_FHA_1	237	243	PF00498	0.465
LIG_FHA_1	326	332	PF00498	0.481
LIG_FHA_1	333	339	PF00498	0.469
LIG_FHA_1	357	363	PF00498	0.642
LIG_FHA_1	503	509	PF00498	0.450
LIG_FHA_1	553	559	PF00498	0.565
LIG_FHA_1	581	587	PF00498	0.595
LIG_FHA_1	68	74	PF00498	0.437
LIG_FHA_2	109	115	PF00498	0.692
LIG_FHA_2	483	489	PF00498	0.422
LIG_FHA_2	494	500	PF00498	0.530
LIG_FHA_2	82	88	PF00498	0.539
LIG_LIR_Gen_1	224	233	PF02991	0.424
LIG_LIR_Gen_1	259	268	PF02991	0.509
LIG_LIR_Gen_1	531	540	PF02991	0.446
LIG_LIR_Nem_3	224	228	PF02991	0.507
LIG_LIR_Nem_3	259	265	PF02991	0.485
LIG_LIR_Nem_3	37	42	PF02991	0.572
LIG_LIR_Nem_3	4	10	PF02991	0.498
LIG_LIR_Nem_3	470	476	PF02991	0.608
LIG_LIR_Nem_3	531	535	PF02991	0.483
LIG_LIR_Nem_3	577	581	PF02991	0.668
LIG_MLH1_MIPbox_1	39	43	PF16413	0.532
LIG_Pex14_2	39	43	PF04695	0.577
LIG_REV1ctd_RIR_1	36	45	PF16727	0.617
LIG_SH2_CRK	118	122	PF00017	0.589
LIG_SH2_CRK	225	229	PF00017	0.644
LIG_SH2_CRK	231	235	PF00017	0.457
LIG_SH2_NCK_1	118	122	PF00017	0.593
LIG_SH2_NCK_1	231	235	PF00017	0.407
LIG_SH2_PTP2	262	265	PF00017	0.483
LIG_SH2_PTP2	532	535	PF00017	0.431
LIG_SH2_STAP1	10	14	PF00017	0.598
LIG_SH2_STAT5	187	190	PF00017	0.394
LIG_SH2_STAT5	225	228	PF00017	0.500
LIG_SH2_STAT5	262	265	PF00017	0.483
LIG_SH2_STAT5	402	405	PF00017	0.460
LIG_SH2_STAT5	42	45	PF00017	0.490
LIG_SH2_STAT5	532	535	PF00017	0.435
LIG_SH3_1	576	582	PF00018	0.593
LIG_SH3_3	474	480	PF00018	0.489
LIG_SH3_3	576	582	PF00018	0.520
LIG_SUMO_SIM_par_1	504	510	PF11976	0.566
LIG_UBA3_1	170	178	PF00899	0.476
LIG_WRC_WIRS_1	237	242	PF05994	0.507
LIG_WW_2	579	582	PF00397	0.635
MOD_CK1_1	215	221	PF00069	0.758
MOD_CK1_1	224	230	PF00069	0.536
MOD_CK1_1	3	9	PF00069	0.605
MOD_CK1_1	306	312	PF00069	0.597
MOD_CK1_1	541	547	PF00069	0.445
MOD_CK1_1	82	88	PF00069	0.495
MOD_CK2_1	108	114	PF00069	0.704
MOD_GlcNHglycan	145	148	PF01048	0.535
MOD_GlcNHglycan	16	19	PF01048	0.470
MOD_GlcNHglycan	161	164	PF01048	0.389
MOD_GlcNHglycan	196	199	PF01048	0.654
MOD_GlcNHglycan	214	217	PF01048	0.754
MOD_GlcNHglycan	28	31	PF01048	0.530
MOD_GlcNHglycan	284	287	PF01048	0.601
MOD_GlcNHglycan	376	379	PF01048	0.608
MOD_GlcNHglycan	452	455	PF01048	0.633
MOD_GlcNHglycan	457	460	PF01048	0.672
MOD_GlcNHglycan	535	538	PF01048	0.536
MOD_GlcNHglycan	540	543	PF01048	0.459
MOD_GlcNHglycan	568	571	PF01048	0.589
MOD_GlcNHglycan	61	64	PF01048	0.563
MOD_GSK3_1	100	107	PF00069	0.728
MOD_GSK3_1	116	123	PF00069	0.595
MOD_GSK3_1	14	21	PF00069	0.464
MOD_GSK3_1	166	173	PF00069	0.405
MOD_GSK3_1	212	219	PF00069	0.647
MOD_GSK3_1	26	33	PF00069	0.471
MOD_GSK3_1	303	310	PF00069	0.552
MOD_GSK3_1	332	339	PF00069	0.571
MOD_GSK3_1	351	358	PF00069	0.541
MOD_GSK3_1	437	444	PF00069	0.483
MOD_GSK3_1	455	462	PF00069	0.787
MOD_GSK3_1	493	500	PF00069	0.557
MOD_GSK3_1	546	553	PF00069	0.518
MOD_GSK3_1	598	605	PF00069	0.539
MOD_GSK3_1	81	88	PF00069	0.405
MOD_N-GLC_1	325	330	PF02516	0.445
MOD_N-GLC_1	374	379	PF02516	0.516
MOD_NEK2_1	1	6	PF00069	0.662
MOD_NEK2_1	14	19	PF00069	0.603
MOD_NEK2_1	207	212	PF00069	0.550
MOD_NEK2_1	236	241	PF00069	0.405
MOD_NEK2_1	303	308	PF00069	0.590
MOD_NEK2_1	355	360	PF00069	0.601
MOD_NEK2_1	418	423	PF00069	0.518
MOD_NEK2_1	437	442	PF00069	0.517
MOD_NEK2_1	460	465	PF00069	0.630
MOD_NEK2_1	507	512	PF00069	0.563
MOD_NEK2_2	48	53	PF00069	0.531
MOD_PIKK_1	207	213	PF00454	0.527
MOD_PIKK_1	357	363	PF00454	0.424
MOD_PK_1	229	235	PF00069	0.466
MOD_PKA_2	116	122	PF00069	0.498
MOD_PKA_2	194	200	PF00069	0.618
MOD_PKA_2	256	262	PF00069	0.534
MOD_PKA_2	355	361	PF00069	0.631
MOD_PKA_2	450	456	PF00069	0.686
MOD_PKA_2	566	572	PF00069	0.579
MOD_Plk_1	556	562	PF00069	0.590
MOD_Plk_1	79	85	PF00069	0.487
MOD_Plk_2-3	108	114	PF00069	0.627
MOD_Plk_2-3	482	488	PF00069	0.496
MOD_Plk_2-3	87	93	PF00069	0.648
MOD_Plk_4	116	122	PF00069	0.507
MOD_Plk_4	166	172	PF00069	0.377
MOD_Plk_4	236	242	PF00069	0.482
MOD_Plk_4	382	388	PF00069	0.460
MOD_Plk_4	437	443	PF00069	0.540
MOD_Plk_4	502	508	PF00069	0.537
MOD_Plk_4	528	534	PF00069	0.491
MOD_ProDKin_1	152	158	PF00069	0.560
MOD_ProDKin_1	267	273	PF00069	0.450
MOD_SUMO_rev_2	29	38	PF00179	0.613
TRG_ENDOCYTIC_2	118	121	PF00928	0.592
TRG_ENDOCYTIC_2	225	228	PF00928	0.500
TRG_ENDOCYTIC_2	262	265	PF00928	0.444
TRG_ENDOCYTIC_2	384	387	PF00928	0.403
TRG_ENDOCYTIC_2	532	535	PF00928	0.482
TRG_ER_diArg_1	289	292	PF00400	0.491
TRG_ER_diArg_1	430	433	PF00400	0.435
TRG_ER_diArg_1	589	591	PF00400	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4A1	Leptomonas seymouri	39%	94%
A0A0S4IQJ6	Bodo saltans	24%	100%
A0A1X0NS02	Trypanosomatidae	26%	100%
A4HL13	Leishmania braziliensis	73%	100%
A4I8J4	Leishmania infantum	100%	100%
D0AAM4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9B3F4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q4P6	Leishmania major	88%	100%
V5DME2	Trypanosoma cruzi	28%	100%