Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJR0_LEIDO

TriTrypDb:

LdBPK_364430.1 , LdCL_360051400 , LDHU3_36.6000

Length:

611

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IJR0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJR0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.681
CLV_C14_Caspase3-7	310	314	PF00656	0.804
CLV_MEL_PAP_1	576	582	PF00089	0.506
CLV_NRD_NRD_1	108	110	PF00675	0.507
CLV_NRD_NRD_1	16	18	PF00675	0.588
CLV_NRD_NRD_1	221	223	PF00675	0.642
CLV_NRD_NRD_1	288	290	PF00675	0.814
CLV_NRD_NRD_1	35	37	PF00675	0.458
CLV_NRD_NRD_1	384	386	PF00675	0.788
CLV_NRD_NRD_1	448	450	PF00675	0.724
CLV_NRD_NRD_1	505	507	PF00675	0.556
CLV_NRD_NRD_1	546	548	PF00675	0.552
CLV_NRD_NRD_1	94	96	PF00675	0.727
CLV_PCSK_FUR_1	14	18	PF00082	0.652
CLV_PCSK_FUR_1	382	386	PF00082	0.688
CLV_PCSK_KEX2_1	108	110	PF00082	0.507
CLV_PCSK_KEX2_1	154	156	PF00082	0.693
CLV_PCSK_KEX2_1	16	18	PF00082	0.588
CLV_PCSK_KEX2_1	221	223	PF00082	0.642
CLV_PCSK_KEX2_1	288	290	PF00082	0.814
CLV_PCSK_KEX2_1	35	37	PF00082	0.458
CLV_PCSK_KEX2_1	384	386	PF00082	0.788
CLV_PCSK_KEX2_1	409	411	PF00082	0.735
CLV_PCSK_KEX2_1	413	415	PF00082	0.687
CLV_PCSK_KEX2_1	448	450	PF00082	0.727
CLV_PCSK_KEX2_1	505	507	PF00082	0.598
CLV_PCSK_KEX2_1	94	96	PF00082	0.727
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.693
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.735
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.687
CLV_PCSK_PC7_1	217	223	PF00082	0.598
CLV_PCSK_SKI1_1	138	142	PF00082	0.561
CLV_PCSK_SKI1_1	155	159	PF00082	0.625
CLV_PCSK_SKI1_1	406	410	PF00082	0.722
CLV_PCSK_SKI1_1	548	552	PF00082	0.522
CLV_PCSK_SKI1_1	564	568	PF00082	0.379
DEG_APCC_DBOX_1	546	554	PF00400	0.560
DEG_MDM2_SWIB_1	168	176	PF02201	0.580
DEG_Nend_UBRbox_2	1	3	PF02207	0.711
DEG_SCF_FBW7_1	350	357	PF00400	0.646
DEG_SPOP_SBC_1	249	253	PF00917	0.740
DEG_SPOP_SBC_1	258	262	PF00917	0.729
DOC_CKS1_1	351	356	PF01111	0.705
DOC_CYCLIN_RxL_1	545	554	PF00134	0.634
DOC_MAPK_gen_1	108	115	PF00069	0.704
DOC_MAPK_gen_1	323	332	PF00069	0.606
DOC_MAPK_gen_1	382	392	PF00069	0.688
DOC_MAPK_gen_1	547	555	PF00069	0.543
DOC_MAPK_MEF2A_6	547	555	PF00069	0.493
DOC_SPAK_OSR1_1	579	583	PF12202	0.531
DOC_USP7_MATH_1	187	191	PF00917	0.667
DOC_USP7_MATH_1	249	253	PF00917	0.688
DOC_USP7_MATH_1	257	261	PF00917	0.675
DOC_USP7_MATH_1	268	272	PF00917	0.803
DOC_USP7_MATH_1	278	282	PF00917	0.755
DOC_USP7_MATH_1	292	296	PF00917	0.775
DOC_USP7_MATH_1	307	311	PF00917	0.724
DOC_USP7_MATH_1	312	316	PF00917	0.595
DOC_USP7_MATH_1	354	358	PF00917	0.747
DOC_USP7_MATH_1	370	374	PF00917	0.713
DOC_USP7_MATH_1	378	382	PF00917	0.648
DOC_USP7_MATH_1	394	398	PF00917	0.655
DOC_USP7_MATH_1	469	473	PF00917	0.719
DOC_USP7_MATH_1	520	524	PF00917	0.722
DOC_USP7_UBL2_3	409	413	PF12436	0.719
DOC_WW_Pin1_4	126	131	PF00397	0.686
DOC_WW_Pin1_4	177	182	PF00397	0.688
DOC_WW_Pin1_4	189	194	PF00397	0.719
DOC_WW_Pin1_4	202	207	PF00397	0.634
DOC_WW_Pin1_4	251	256	PF00397	0.748
DOC_WW_Pin1_4	274	279	PF00397	0.742
DOC_WW_Pin1_4	305	310	PF00397	0.605
DOC_WW_Pin1_4	325	330	PF00397	0.699
DOC_WW_Pin1_4	338	343	PF00397	0.643
DOC_WW_Pin1_4	350	355	PF00397	0.721
DOC_WW_Pin1_4	357	362	PF00397	0.469
DOC_WW_Pin1_4	364	369	PF00397	0.631
DOC_WW_Pin1_4	50	55	PF00397	0.738
DOC_WW_Pin1_4	516	521	PF00397	0.673
LIG_14-3-3_CanoR_1	173	182	PF00244	0.716
LIG_14-3-3_CanoR_1	250	255	PF00244	0.655
LIG_14-3-3_CanoR_1	356	360	PF00244	0.787
LIG_14-3-3_CanoR_1	384	394	PF00244	0.740
LIG_14-3-3_CanoR_1	448	457	PF00244	0.790
LIG_14-3-3_CanoR_1	94	100	PF00244	0.667
LIG_APCC_ABBAyCdc20_2	548	554	PF00400	0.530
LIG_BIR_III_2	306	310	PF00653	0.588
LIG_Clathr_ClatBox_1	550	554	PF01394	0.524
LIG_CSL_BTD_1	181	184	PF09270	0.578
LIG_deltaCOP1_diTrp_1	71	77	PF00928	0.672
LIG_FHA_1	114	120	PF00498	0.590
LIG_FHA_1	410	416	PF00498	0.713
LIG_FHA_1	441	447	PF00498	0.779
LIG_FHA_1	597	603	PF00498	0.497
LIG_FHA_2	151	157	PF00498	0.692
LIG_FHA_2	22	28	PF00498	0.646
LIG_FHA_2	402	408	PF00498	0.676
LIG_FHA_2	429	435	PF00498	0.714
LIG_FHA_2	496	502	PF00498	0.624
LIG_FHA_2	567	573	PF00498	0.548
LIG_FHA_2	63	69	PF00498	0.731
LIG_LIR_Gen_1	165	176	PF02991	0.428
LIG_LIR_Gen_1	431	440	PF02991	0.551
LIG_LIR_Nem_3	165	171	PF02991	0.423
LIG_LIR_Nem_3	180	185	PF02991	0.615
LIG_LIR_Nem_3	422	428	PF02991	0.681
LIG_Pex14_2	164	168	PF04695	0.530
LIG_PTB_Apo_2	427	434	PF02174	0.678
LIG_PTB_Phospho_1	427	433	PF10480	0.676
LIG_RPA_C_Fungi	379	391	PF08784	0.685
LIG_RPA_C_Fungi	444	456	PF08784	0.588
LIG_SH2_PTP2	552	555	PF00017	0.461
LIG_SH2_SRC	552	555	PF00017	0.461
LIG_SH2_STAT5	114	117	PF00017	0.587
LIG_SH2_STAT5	166	169	PF00017	0.577
LIG_SH2_STAT5	487	490	PF00017	0.573
LIG_SH2_STAT5	552	555	PF00017	0.461
LIG_SH2_STAT5	568	571	PF00017	0.505
LIG_SH3_3	178	184	PF00018	0.768
LIG_SH3_3	190	196	PF00018	0.700
LIG_SH3_3	306	312	PF00018	0.660
LIG_SH3_3	341	347	PF00018	0.673
LIG_SH3_3	348	354	PF00018	0.675
LIG_SH3_3	536	542	PF00018	0.808
LIG_SH3_3	543	549	PF00018	0.620
LIG_SH3_3	552	558	PF00018	0.338
LIG_SH3_CIN85_PxpxPR_1	340	345	PF14604	0.634
LIG_SH3_CIN85_PxpxPR_1	542	547	PF14604	0.675
LIG_TYR_ITIM	550	555	PF00017	0.466
MOD_CDK_SPK_2	126	131	PF00069	0.624
MOD_CDK_SPK_2	189	194	PF00069	0.659
MOD_CDK_SPK_2	357	362	PF00069	0.737
MOD_CDK_SPK_2	516	521	PF00069	0.673
MOD_CDK_SPxK_1	350	356	PF00069	0.644
MOD_CDK_SPxxK_3	338	345	PF00069	0.706
MOD_CK1_1	150	156	PF00069	0.697
MOD_CK1_1	192	198	PF00069	0.705
MOD_CK1_1	240	246	PF00069	0.713
MOD_CK1_1	248	254	PF00069	0.650
MOD_CK1_1	277	283	PF00069	0.818
MOD_CK1_1	328	334	PF00069	0.666
MOD_CK1_1	357	363	PF00069	0.738
MOD_CK1_1	401	407	PF00069	0.709
MOD_CK1_1	439	445	PF00069	0.692
MOD_CK1_1	451	457	PF00069	0.597
MOD_CK1_1	528	534	PF00069	0.756
MOD_CK2_1	21	27	PF00069	0.658
MOD_CK2_1	257	263	PF00069	0.718
MOD_CK2_1	268	274	PF00069	0.589
MOD_CK2_1	281	287	PF00069	0.557
MOD_CK2_1	401	407	PF00069	0.704
MOD_CK2_1	428	434	PF00069	0.702
MOD_CK2_1	495	501	PF00069	0.705
MOD_CMANNOS	74	77	PF00535	0.591
MOD_DYRK1A_RPxSP_1	516	520	PF00069	0.664
MOD_GlcNHglycan	239	242	PF01048	0.740
MOD_GlcNHglycan	244	247	PF01048	0.733
MOD_GlcNHglycan	255	258	PF01048	0.714
MOD_GlcNHglycan	270	273	PF01048	0.748
MOD_GlcNHglycan	274	277	PF01048	0.743
MOD_GlcNHglycan	283	286	PF01048	0.629
MOD_GlcNHglycan	333	337	PF01048	0.707
MOD_GlcNHglycan	36	39	PF01048	0.746
MOD_GlcNHglycan	376	379	PF01048	0.678
MOD_GlcNHglycan	450	453	PF01048	0.590
MOD_GlcNHglycan	483	486	PF01048	0.588
MOD_GlcNHglycan	530	533	PF01048	0.699
MOD_GlcNHglycan	536	539	PF01048	0.653
MOD_GSK3_1	232	239	PF00069	0.755
MOD_GSK3_1	245	252	PF00069	0.574
MOD_GSK3_1	253	260	PF00069	0.685
MOD_GSK3_1	268	275	PF00069	0.777
MOD_GSK3_1	277	284	PF00069	0.643
MOD_GSK3_1	307	314	PF00069	0.736
MOD_GSK3_1	321	328	PF00069	0.665
MOD_GSK3_1	350	357	PF00069	0.721
MOD_GSK3_1	360	367	PF00069	0.590
MOD_GSK3_1	370	377	PF00069	0.713
MOD_GSK3_1	380	387	PF00069	0.459
MOD_GSK3_1	394	401	PF00069	0.621
MOD_GSK3_1	436	443	PF00069	0.760
MOD_GSK3_1	451	458	PF00069	0.806
MOD_GSK3_1	495	502	PF00069	0.628
MOD_GSK3_1	516	523	PF00069	0.742
MOD_NEK2_1	125	130	PF00069	0.596
MOD_NEK2_1	299	304	PF00069	0.720
MOD_NEK2_1	386	391	PF00069	0.668
MOD_NEK2_1	399	404	PF00069	0.656
MOD_NEK2_1	440	445	PF00069	0.791
MOD_NEK2_1	586	591	PF00069	0.581
MOD_PIKK_1	460	466	PF00454	0.668
MOD_PIKK_1	514	520	PF00454	0.692
MOD_PK_1	95	101	PF00069	0.744
MOD_PKA_1	384	390	PF00069	0.747
MOD_PKA_1	409	415	PF00069	0.717
MOD_PKA_1	448	454	PF00069	0.591
MOD_PKA_2	249	255	PF00069	0.735
MOD_PKA_2	287	293	PF00069	0.765
MOD_PKA_2	34	40	PF00069	0.678
MOD_PKA_2	355	361	PF00069	0.733
MOD_PKA_2	384	390	PF00069	0.744
MOD_PKA_2	409	415	PF00069	0.788
MOD_PKA_2	448	454	PF00069	0.618
MOD_PKA_2	455	461	PF00069	0.762
MOD_PKA_2	469	475	PF00069	0.619
MOD_PKA_2	520	526	PF00069	0.790
MOD_PKA_2	578	584	PF00069	0.521
MOD_PKA_2	85	91	PF00069	0.641
MOD_PKB_1	382	390	PF00069	0.687
MOD_Plk_1	155	161	PF00069	0.613
MOD_Plk_1	421	427	PF00069	0.671
MOD_Plk_4	167	173	PF00069	0.576
MOD_Plk_4	428	434	PF00069	0.641
MOD_Plk_4	69	75	PF00069	0.579
MOD_ProDKin_1	126	132	PF00069	0.678
MOD_ProDKin_1	177	183	PF00069	0.695
MOD_ProDKin_1	189	195	PF00069	0.716
MOD_ProDKin_1	202	208	PF00069	0.633
MOD_ProDKin_1	251	257	PF00069	0.751
MOD_ProDKin_1	274	280	PF00069	0.745
MOD_ProDKin_1	305	311	PF00069	0.606
MOD_ProDKin_1	325	331	PF00069	0.699
MOD_ProDKin_1	338	344	PF00069	0.642
MOD_ProDKin_1	350	356	PF00069	0.724
MOD_ProDKin_1	357	363	PF00069	0.466
MOD_ProDKin_1	364	370	PF00069	0.630
MOD_ProDKin_1	50	56	PF00069	0.738
MOD_ProDKin_1	516	522	PF00069	0.678
MOD_SUMO_rev_2	401	411	PF00179	0.723
TRG_DiLeu_BaLyEn_6	546	551	PF01217	0.638
TRG_ENDOCYTIC_2	433	436	PF00928	0.725
TRG_ENDOCYTIC_2	552	555	PF00928	0.461
TRG_ER_diArg_1	108	111	PF00400	0.482
TRG_ER_diArg_1	13	16	PF00400	0.603
TRG_ER_diArg_1	382	385	PF00400	0.727
TRG_ER_diArg_1	504	506	PF00400	0.593
TRG_ER_diArg_1	93	95	PF00400	0.675
TRG_NES_CRM1_1	133	146	PF08389	0.689

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0U0	Leptomonas seymouri	39%	96%
A0A422NT15	Trypanosoma rangeli	25%	95%
A4HPU1	Leishmania braziliensis	68%	99%
A4IE51	Leishmania infantum	100%	100%
E9ATK6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	95%
Q4Q0Z2	Leishmania major	91%	100%