Nucleoside_diphosphate_kinase_putative/GeneDB:Lmj F.35.3870

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleoside diphosphate kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJQ8_LEIDO

TriTrypDb:

LdBPK_353910.1 , LdCL_350044200 , LDHU3_35.5080

Length:

337

Annotations

Annotations by Jardim et al.

Pyrimidine metabolism, nucleoside diphosphate kinase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

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Expansion

Sequence features

A0A3Q8IJQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJQ8

Function

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Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0044237	cellular metabolic process	2	12

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004550	nucleoside diphosphate kinase activity	5	8
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016776	phosphotransferase activity, phosphate group as acceptor	4	8
GO:0019205	nucleobase-containing compound kinase activity	5	8

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	236	240	PF00656	0.453
CLV_NRD_NRD_1	83	85	PF00675	0.439
CLV_PCSK_KEX2_1	43	45	PF00082	0.397
CLV_PCSK_KEX2_1	48	50	PF00082	0.368
CLV_PCSK_KEX2_1	85	87	PF00082	0.486
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.397
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.368
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.572
CLV_PCSK_PC7_1	44	50	PF00082	0.390
CLV_PCSK_SKI1_1	43	47	PF00082	0.379

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJQ8	Leptomonas seymouri	28%	98%
A0A0N1PC23	Leptomonas seymouri	73%	100%
A0A0S4IXH2	Bodo saltans	55%	100%
A0A1X0P5C0	Trypanosomatidae	58%	100%
A0A1X0PAT4	Trypanosomatidae	27%	96%
A0A3R7M6K1	Trypanosoma rangeli	27%	97%
A0A3R7N390	Trypanosoma rangeli	60%	100%
A0A3S7X855	Leishmania donovani	28%	98%
A4HB17	Leishmania braziliensis	29%	100%
A4HN58	Leishmania braziliensis	91%	100%

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