CYC2-like protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CYC2-like protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJQ6_LEIDO

TriTrypDb:

LdBPK_303690.1 , LdCL_300042300 , LDHU3_30.4920

Length:

253

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IJQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJQ6

Function

Biological processes
Term	Name	Level	Count
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	6	10
GO:0001932	regulation of protein phosphorylation	7	10
GO:0019220	regulation of phosphate metabolic process	6	10
GO:0019222	regulation of metabolic process	3	10
GO:0031323	regulation of cellular metabolic process	4	10
GO:0031399	regulation of protein modification process	6	10
GO:0042325	regulation of phosphorylation	7	10
GO:0043549	regulation of kinase activity	5	10
GO:0045859	regulation of protein kinase activity	6	10
GO:0050789	regulation of biological process	2	10
GO:0050790	regulation of catalytic activity	3	10
GO:0050794	regulation of cellular process	3	10
GO:0051171	regulation of nitrogen compound metabolic process	4	10
GO:0051174	regulation of phosphorus metabolic process	5	10
GO:0051246	regulation of protein metabolic process	5	10
GO:0051338	regulation of transferase activity	4	10
GO:0051726	regulation of cell cycle	4	10
GO:0060255	regulation of macromolecule metabolic process	4	10
GO:0065007	biological regulation	1	10
GO:0065009	regulation of molecular function	2	10
GO:0071900	regulation of protein serine/threonine kinase activity	7	10
GO:0080090	regulation of primary metabolic process	4	10
GO:1904029	regulation of cyclin-dependent protein kinase activity	5	10

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0019899	enzyme binding	3	10
GO:0019900	kinase binding	4	10
GO:0019901	protein kinase binding	5	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	38	42	PF00656	0.634
CLV_NRD_NRD_1	180	182	PF00675	0.501
CLV_NRD_NRD_1	247	249	PF00675	0.491
CLV_NRD_NRD_1	94	96	PF00675	0.369
CLV_PCSK_KEX2_1	180	182	PF00082	0.501
CLV_PCSK_KEX2_1	69	71	PF00082	0.382
CLV_PCSK_KEX2_1	94	96	PF00082	0.369
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.258
CLV_PCSK_PC7_1	176	182	PF00082	0.467
CLV_PCSK_SKI1_1	110	114	PF00082	0.344
CLV_PCSK_SKI1_1	181	185	PF00082	0.571
CLV_PCSK_SKI1_1	74	78	PF00082	0.397
CLV_PCSK_SKI1_1	95	99	PF00082	0.328
DEG_APCC_DBOX_1	109	117	PF00400	0.344
DEG_SPOP_SBC_1	202	206	PF00917	0.619
DOC_CKS1_1	8	13	PF01111	0.366
DOC_CYCLIN_RxL_1	104	114	PF00134	0.299
DOC_CYCLIN_RxL_1	91	99	PF00134	0.406
DOC_MAPK_gen_1	142	151	PF00069	0.361
DOC_MAPK_HePTP_8	139	151	PF00069	0.428
DOC_MAPK_MEF2A_6	142	151	PF00069	0.356
DOC_PP2B_PxIxI_1	63	69	PF00149	0.428
DOC_PP4_FxxP_1	232	235	PF00568	0.627
DOC_PP4_FxxP_1	240	243	PF00568	0.591
DOC_USP7_MATH_1	235	239	PF00917	0.696
DOC_WW_Pin1_4	204	209	PF00397	0.582
DOC_WW_Pin1_4	7	12	PF00397	0.454
DOC_WW_Pin1_4	79	84	PF00397	0.399
LIG_14-3-3_CanoR_1	110	120	PF00244	0.344
LIG_14-3-3_CanoR_1	150	158	PF00244	0.433
LIG_14-3-3_CanoR_1	176	183	PF00244	0.551
LIG_14-3-3_CanoR_1	195	203	PF00244	0.632
LIG_14-3-3_CanoR_1	248	252	PF00244	0.499
LIG_14-3-3_CanoR_1	34	40	PF00244	0.456
LIG_14-3-3_CanoR_1	70	78	PF00244	0.406
LIG_14-3-3_CterR_2	248	253	PF00244	0.503
LIG_BRCT_BRCA1_1	53	57	PF00533	0.344
LIG_Clathr_ClatBox_1	155	159	PF01394	0.512
LIG_deltaCOP1_diTrp_1	230	240	PF00928	0.632
LIG_FHA_1	112	118	PF00498	0.337
LIG_FHA_1	139	145	PF00498	0.363
LIG_FHA_1	70	76	PF00498	0.468
LIG_FHA_2	138	144	PF00498	0.400
LIG_FHA_2	205	211	PF00498	0.590
LIG_FHA_2	36	42	PF00498	0.624
LIG_LIR_Apic_2	230	235	PF02991	0.532
LIG_LIR_Apic_2	238	243	PF02991	0.537
LIG_LIR_Gen_1	131	139	PF02991	0.396
LIG_LIR_Gen_1	166	175	PF02991	0.459
LIG_LIR_Nem_3	131	136	PF02991	0.372
LIG_LIR_Nem_3	166	170	PF02991	0.389
LIG_LIR_Nem_3	230	236	PF02991	0.620
LIG_PCNA_yPIPBox_3	9	20	PF02747	0.506
LIG_PDZ_Class_2	248	253	PF00595	0.503
LIG_Pex14_2	221	225	PF04695	0.552
LIG_SH2_CRK	167	171	PF00017	0.394
LIG_SH2_CRK	8	12	PF00017	0.374
LIG_SH2_NCK_1	133	137	PF00017	0.344
LIG_SH2_SRC	133	136	PF00017	0.484
LIG_SH2_STAP1	71	75	PF00017	0.400
LIG_SH2_STAT5	23	26	PF00017	0.384
LIG_SH2_STAT5	71	74	PF00017	0.355
LIG_SH2_STAT5	92	95	PF00017	0.358
LIG_SH3_3	41	47	PF00018	0.636
LIG_SUMO_SIM_par_1	15	21	PF11976	0.545
LIG_SUMO_SIM_par_1	168	173	PF11976	0.551
LIG_UBA3_1	182	189	PF00899	0.548
MOD_CK1_1	224	230	PF00069	0.476
MOD_CK1_1	238	244	PF00069	0.462
MOD_CK1_1	33	39	PF00069	0.508
MOD_CK2_1	224	230	PF00069	0.511
MOD_GlcNHglycan	198	201	PF01048	0.630
MOD_GlcNHglycan	20	23	PF01048	0.358
MOD_GlcNHglycan	237	240	PF01048	0.709
MOD_GlcNHglycan	98	101	PF01048	0.361
MOD_N-GLC_2	194	196	PF02516	0.581
MOD_NEK2_1	111	116	PF00069	0.356
MOD_NEK2_1	203	208	PF00069	0.708
MOD_NEK2_1	221	226	PF00069	0.390
MOD_NEK2_1	58	63	PF00069	0.429
MOD_NEK2_1	96	101	PF00069	0.454
MOD_NEK2_2	128	133	PF00069	0.443
MOD_NEK2_2	64	69	PF00069	0.402
MOD_PKA_1	69	75	PF00069	0.484
MOD_PKA_2	175	181	PF00069	0.519
MOD_PKA_2	247	253	PF00069	0.500
MOD_PKA_2	33	39	PF00069	0.441
MOD_PKA_2	69	75	PF00069	0.258
MOD_Plk_1	160	166	PF00069	0.478
MOD_Plk_4	128	134	PF00069	0.348
MOD_Plk_4	74	80	PF00069	0.393
MOD_ProDKin_1	204	210	PF00069	0.585
MOD_ProDKin_1	7	13	PF00069	0.447
MOD_ProDKin_1	79	85	PF00069	0.399
TRG_DiLeu_BaLyEn_6	107	112	PF01217	0.400
TRG_ENDOCYTIC_2	127	130	PF00928	0.330
TRG_ENDOCYTIC_2	133	136	PF00928	0.335
TRG_ENDOCYTIC_2	167	170	PF00928	0.400
TRG_ER_diArg_1	180	182	PF00400	0.501
TRG_ER_diArg_1	93	95	PF00400	0.369
TRG_NES_CRM1_1	154	166	PF08389	0.489
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRS5	Leptomonas seymouri	62%	100%
A0A1X0P2T0	Trypanosomatidae	45%	100%
A0A3R7RLR0	Trypanosoma rangeli	48%	100%
A4HIU9	Leishmania braziliensis	73%	100%
A4I654	Leishmania infantum	99%	100%
C9ZRH4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B1D7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q6S5	Leishmania major	93%	100%