Ethanolamine_phosphotransferase_putative/GeneDB:L mjF.18.0810

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ethanolamine phosphotransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJQ4_LEIDO

TriTrypDb:

LdBPK_180810.1 , LdCL_180013200 , LDHU3_18.1060

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0005783	endoplasmic reticulum	5	1
GO:0016020	membrane	2	11
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	11

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Expansion

Sequence features

A0A3Q8IJQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJQ4

Function

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Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0006644	phospholipid metabolic process	4	11
GO:0006646	phosphatidylethanolamine biosynthetic process	6	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0008610	lipid biosynthetic process	4	11
GO:0008654	phospholipid biosynthetic process	5	11
GO:0009058	biosynthetic process	2	11

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004307	ethanolaminephosphotransferase activity	6	6
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	11
GO:0017169	CDP-alcohol phosphatidyltransferase activity	5	6

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.482
CLV_NRD_NRD_1	137	139	PF00675	0.282
CLV_NRD_NRD_1	253	255	PF00675	0.580
CLV_PCSK_KEX2_1	137	139	PF00082	0.282
CLV_PCSK_KEX2_1	253	255	PF00082	0.580
CLV_PCSK_SKI1_1	196	200	PF00082	0.307
CLV_PCSK_SKI1_1	204	208	PF00082	0.321
DEG_Nend_UBRbox_3	1	3	PF02207	0.635
DEG_SCF_FBW7_1	10	17	PF00400	0.682
DEG_SPOP_SBC_1	338	342	PF00917	0.342

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8V7	Leptomonas seymouri	65%	94%
A0A0S4J4C6	Bodo saltans	39%	100%
A0A1X0P7R6	Trypanosomatidae	47%	98%
A0A3R7N2B7	Trypanosoma rangeli	47%	99%
A4H9J2	Leishmania braziliensis	78%	100%
A4HXV5	Leishmania infantum	100%	100%
C9ZZU8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9ARL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QDW1	Leishmania major	94%	100%

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