ATP-dependent_zinc_metallopeptidase_putative/Gene DB:LmjF.18.0610/GeneDB:LmjF.19.1590

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent zinc metallopeptidase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJP7_LEIDO

TriTrypDb:

LdBPK_180620.1 , LdCL_180011300 , LDHU3_18.0820

Length:

598

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Annotations by Jardim et al.

Proteases, ATP-dependent zinc metallopeptidase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 33
NetGPI	no	yes: 0, no: 33

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	25
GO:0110165	cellular anatomical entity	1	26
GO:0005739	mitochondrion	5	1
GO:0005745	m-AAA complex	4	3
GO:0032991	protein-containing complex	1	3
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098796	membrane protein complex	2	3
GO:0098798	mitochondrial protein-containing complex	2	3
GO:0098800	inner mitochondrial membrane protein complex	3	3
GO:1902494	catalytic complex	2	3
GO:1905368	peptidase complex	3	3

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IJP7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJP7

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	34
GO:0006807	nitrogen compound metabolic process	2	34
GO:0008152	metabolic process	1	34
GO:0019538	protein metabolic process	3	34
GO:0043170	macromolecule metabolic process	3	34
GO:0044238	primary metabolic process	2	34
GO:0071704	organic substance metabolic process	2	34
GO:1901564	organonitrogen compound metabolic process	3	34
GO:0009987	cellular process	1	3
GO:0016043	cellular component organization	3	3
GO:0016485	protein processing	5	3
GO:0022607	cellular component assembly	4	3
GO:0034982	mitochondrial protein processing	6	3
GO:0043933	protein-containing complex organization	4	3
GO:0051604	protein maturation	4	3
GO:0065003	protein-containing complex assembly	5	3
GO:0071840	cellular component organization or biogenesis	2	3

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	34
GO:0003824	catalytic activity	1	34
GO:0004175	endopeptidase activity	4	34
GO:0004176	ATP-dependent peptidase activity	2	34
GO:0004222	metalloendopeptidase activity	5	34
GO:0005488	binding	1	34
GO:0005524	ATP binding	5	34
GO:0008233	peptidase activity	3	34
GO:0008237	metallopeptidase activity	4	34
GO:0016462	pyrophosphatase activity	5	34
GO:0016787	hydrolase activity	2	34
GO:0016817	hydrolase activity, acting on acid anhydrides	3	34
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	34
GO:0016887	ATP hydrolysis activity	7	34
GO:0017076	purine nucleotide binding	4	34
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	34
GO:0030554	adenyl nucleotide binding	5	34
GO:0032553	ribonucleotide binding	3	34
GO:0032555	purine ribonucleotide binding	4	34
GO:0032559	adenyl ribonucleotide binding	5	34
GO:0035639	purine ribonucleoside triphosphate binding	4	34
GO:0036094	small molecule binding	2	34
GO:0043167	ion binding	2	34
GO:0043168	anion binding	3	34
GO:0097159	organic cyclic compound binding	2	34
GO:0097367	carbohydrate derivative binding	2	34
GO:0140096	catalytic activity, acting on a protein	2	34
GO:0140657	ATP-dependent activity	1	34
GO:1901265	nucleoside phosphate binding	3	34
GO:1901363	heterocyclic compound binding	2	34

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	196	200	PF00656	0.202
CLV_C14_Caspase3-7	2	6	PF00656	0.629
CLV_C14_Caspase3-7	354	358	PF00656	0.239
CLV_NRD_NRD_1	22	24	PF00675	0.414
CLV_NRD_NRD_1	260	262	PF00675	0.402
CLV_NRD_NRD_1	273	275	PF00675	0.462
CLV_NRD_NRD_1	362	364	PF00675	0.535
CLV_NRD_NRD_1	375	377	PF00675	0.401
CLV_NRD_NRD_1	52	54	PF00675	0.523
CLV_PCSK_FUR_1	20	24	PF00082	0.456
CLV_PCSK_KEX2_1	176	178	PF00082	0.402
CLV_PCSK_KEX2_1	22	24	PF00082	0.393
CLV_PCSK_KEX2_1	273	275	PF00082	0.501
CLV_PCSK_KEX2_1	375	377	PF00082	0.408
CLV_PCSK_KEX2_1	52	54	PF00082	0.522
CLV_PCSK_KEX2_1	524	526	PF00082	0.419
CLV_PCSK_KEX2_1	84	86	PF00082	0.558
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.400
CLV_PCSK_PC1ET2_1	524	526	PF00082	0.428
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.558
CLV_PCSK_SKI1_1	143	147	PF00082	0.406
CLV_PCSK_SKI1_1	179	183	PF00082	0.402
CLV_PCSK_SKI1_1	22	26	PF00082	0.445
CLV_PCSK_SKI1_1	251	255	PF00082	0.402
CLV_PCSK_SKI1_1	274	278	PF00082	0.487
CLV_PCSK_SKI1_1	31	35	PF00082	0.189
CLV_PCSK_SKI1_1	396	400	PF00082	0.401
CLV_PCSK_SKI1_1	466	470	PF00082	0.449
CLV_PCSK_SKI1_1	491	495	PF00082	0.478
CLV_PCSK_SKI1_1	535	539	PF00082	0.421
DEG_APCC_DBOX_1	30	38	PF00400	0.340
DEG_SCF_FBW7_1	319	324	PF00400	0.277
DEG_SCF_FBW7_2	556	562	PF00400	0.402
DOC_CDC14_PxL_1	346	354	PF14671	0.355
DOC_CKS1_1	556	561	PF01111	0.383
DOC_CKS1_1	589	594	PF01111	0.315
DOC_CYCLIN_RxL_1	176	184	PF00134	0.214
DOC_CYCLIN_RxL_1	271	278	PF00134	0.347
DOC_CYCLIN_RxL_1	529	542	PF00134	0.260
DOC_CYCLIN_yCln2_LP_2	40	46	PF00134	0.340
DOC_MAPK_gen_1	255	265	PF00069	0.202
DOC_MAPK_gen_1	524	534	PF00069	0.203
DOC_MAPK_gen_1	83	91	PF00069	0.305
DOC_MAPK_gen_1	92	102	PF00069	0.269
DOC_MAPK_HePTP_8	522	534	PF00069	0.157
DOC_MAPK_MEF2A_6	186	194	PF00069	0.201
DOC_MAPK_MEF2A_6	258	267	PF00069	0.202
DOC_MAPK_MEF2A_6	31	40	PF00069	0.269
DOC_MAPK_MEF2A_6	525	534	PF00069	0.157
DOC_PP2B_LxvP_1	40	43	PF13499	0.340
DOC_USP7_MATH_1	200	204	PF00917	0.217
DOC_USP7_MATH_1	336	340	PF00917	0.246
DOC_USP7_MATH_1	514	518	PF00917	0.300
DOC_USP7_MATH_1	554	558	PF00917	0.374
DOC_USP7_MATH_1	59	63	PF00917	0.465
DOC_USP7_MATH_1	590	594	PF00917	0.317
DOC_USP7_MATH_1	65	69	PF00917	0.383
DOC_USP7_MATH_1	71	75	PF00917	0.403
DOC_WW_Pin1_4	317	322	PF00397	0.283
DOC_WW_Pin1_4	400	405	PF00397	0.221
DOC_WW_Pin1_4	5	10	PF00397	0.617
DOC_WW_Pin1_4	55	60	PF00397	0.441
DOC_WW_Pin1_4	555	560	PF00397	0.311
DOC_WW_Pin1_4	588	593	PF00397	0.461
LIG_14-3-3_CanoR_1	22	30	PF00244	0.580
LIG_14-3-3_CanoR_1	459	465	PF00244	0.209
LIG_14-3-3_CanoR_1	52	57	PF00244	0.392
LIG_14-3-3_CanoR_1	95	103	PF00244	0.321
LIG_Actin_WH2_2	242	257	PF00022	0.198
LIG_Actin_WH2_2	383	401	PF00022	0.215
LIG_BIR_II_1	1	5	PF00653	0.628
LIG_BIR_III_4	199	203	PF00653	0.202
LIG_EH_1	69	73	PF12763	0.395
LIG_FHA_1	318	324	PF00498	0.280
LIG_FHA_1	475	481	PF00498	0.252
LIG_FHA_1	543	549	PF00498	0.228
LIG_FHA_1	556	562	PF00498	0.252
LIG_FHA_1	577	583	PF00498	0.461
LIG_FHA_1	589	595	PF00498	0.271
LIG_FHA_2	230	236	PF00498	0.226
LIG_FHA_2	291	297	PF00498	0.358
LIG_FHA_2	516	522	PF00498	0.224
LIG_FHA_2	558	564	PF00498	0.370
LIG_HP1_1	236	240	PF01393	0.157
LIG_Integrin_isoDGR_2	290	292	PF01839	0.611
LIG_IRF3_LxIS_1	394	401	PF10401	0.245
LIG_LIR_Apic_2	26	32	PF02991	0.428
LIG_LIR_Apic_2	387	392	PF02991	0.198
LIG_LIR_Gen_1	165	170	PF02991	0.206
LIG_LIR_Gen_1	427	436	PF02991	0.228
LIG_LIR_Gen_1	492	500	PF02991	0.277
LIG_LIR_Gen_1	572	582	PF02991	0.448
LIG_LIR_Gen_1	94	103	PF02991	0.280
LIG_LIR_Nem_3	165	169	PF02991	0.206
LIG_LIR_Nem_3	275	280	PF02991	0.260
LIG_LIR_Nem_3	417	422	PF02991	0.227
LIG_LIR_Nem_3	492	496	PF02991	0.239
LIG_LIR_Nem_3	572	578	PF02991	0.431
LIG_LIR_Nem_3	94	99	PF02991	0.272
LIG_MAD2	396	404	PF02301	0.292
LIG_MYND_1	32	36	PF01753	0.378
LIG_MYND_1	321	325	PF01753	0.318
LIG_Pex14_2	44	48	PF04695	0.310
LIG_SH2_GRB2like	280	283	PF00017	0.284
LIG_SH2_NCK_1	486	490	PF00017	0.292
LIG_SH2_NCK_1	575	579	PF00017	0.302
LIG_SH2_SRC	575	578	PF00017	0.296
LIG_SH2_STAP1	411	415	PF00017	0.213
LIG_SH2_STAT5	112	115	PF00017	0.258
LIG_SH2_STAT5	280	283	PF00017	0.272
LIG_SH2_STAT5	411	414	PF00017	0.207
LIG_SH2_STAT5	486	489	PF00017	0.292
LIG_SH3_3	344	350	PF00018	0.340
LIG_SH3_3	553	559	PF00018	0.284
LIG_SH3_3	586	592	PF00018	0.482
LIG_SH3_3	97	103	PF00018	0.358
LIG_SH3_4	344	351	PF00018	0.363
LIG_SUMO_SIM_anti_2	165	171	PF11976	0.216
LIG_SUMO_SIM_anti_2	235	241	PF11976	0.208
LIG_SUMO_SIM_anti_2	517	524	PF11976	0.279
LIG_SUMO_SIM_par_1	567	572	PF11976	0.251
LIG_TRAF2_1	213	216	PF00917	0.213
LIG_TRAF2_1	24	27	PF00917	0.653
LIG_TRAF2_1	440	443	PF00917	0.203
LIG_UBA3_1	75	84	PF00899	0.479
LIG_WRC_WIRS_1	493	498	PF05994	0.340
MOD_CDK_SPK_2	400	405	PF00069	0.300
MOD_CK1_1	211	217	PF00069	0.272
MOD_CK1_1	324	330	PF00069	0.376
MOD_CK1_1	370	376	PF00069	0.260
MOD_CK1_1	474	480	PF00069	0.336
MOD_CK1_1	55	61	PF00069	0.550
MOD_CK1_1	557	563	PF00069	0.500
MOD_CK2_1	210	216	PF00069	0.267
MOD_CK2_1	290	296	PF00069	0.471
MOD_CK2_1	571	577	PF00069	0.583
MOD_CK2_1	71	77	PF00069	0.511
MOD_Cter_Amidation	361	364	PF01082	0.417
MOD_DYRK1A_RPxSP_1	555	559	PF00069	0.413
MOD_GlcNHglycan	172	175	PF01048	0.271
MOD_GlcNHglycan	232	235	PF01048	0.313
MOD_GlcNHglycan	269	273	PF01048	0.407
MOD_GlcNHglycan	338	341	PF01048	0.357
MOD_GlcNHglycan	371	375	PF01048	0.296
MOD_GlcNHglycan	448	452	PF01048	0.256
MOD_GlcNHglycan	61	64	PF01048	0.617
MOD_GlcNHglycan	65	68	PF01048	0.595
MOD_GSK3_1	1	8	PF00069	0.572
MOD_GSK3_1	317	324	PF00069	0.353
MOD_GSK3_1	370	377	PF00069	0.256
MOD_GSK3_1	474	481	PF00069	0.276
MOD_GSK3_1	55	62	PF00069	0.579
MOD_N-GLC_1	216	221	PF02516	0.255
MOD_N-GLC_1	424	429	PF02516	0.253
MOD_NEK2_1	240	245	PF00069	0.261
MOD_NEK2_1	303	308	PF00069	0.532
MOD_NEK2_1	356	361	PF00069	0.409
MOD_NEK2_1	398	403	PF00069	0.279
MOD_NEK2_1	409	414	PF00069	0.255
MOD_NEK2_1	471	476	PF00069	0.274
MOD_PIKK_1	409	415	PF00454	0.252
MOD_PIKK_1	484	490	PF00454	0.213
MOD_PKA_1	22	28	PF00069	0.501
MOD_PKA_1	52	58	PF00069	0.487
MOD_PKA_2	22	28	PF00069	0.488
MOD_PKA_2	367	373	PF00069	0.273
MOD_PKA_2	374	380	PF00069	0.265
MOD_PKA_2	458	464	PF00069	0.252
MOD_PKA_2	52	58	PF00069	0.504
MOD_PKA_2	554	560	PF00069	0.384
MOD_PKA_2	94	100	PF00069	0.367
MOD_PKB_1	20	28	PF00069	0.548
MOD_Plk_1	216	222	PF00069	0.252
MOD_Plk_1	303	309	PF00069	0.458
MOD_Plk_1	356	362	PF00069	0.344
MOD_Plk_1	424	430	PF00069	0.253
MOD_Plk_1	491	497	PF00069	0.378
MOD_Plk_4	141	147	PF00069	0.257
MOD_Plk_4	327	333	PF00069	0.315
MOD_Plk_4	356	362	PF00069	0.376
MOD_Plk_4	424	430	PF00069	0.200
MOD_Plk_4	71	77	PF00069	0.501
MOD_ProDKin_1	317	323	PF00069	0.360
MOD_ProDKin_1	400	406	PF00069	0.279
MOD_ProDKin_1	5	11	PF00069	0.549
MOD_ProDKin_1	55	61	PF00069	0.593
MOD_ProDKin_1	555	561	PF00069	0.407
MOD_ProDKin_1	588	594	PF00069	0.613
MOD_SUMO_for_1	105	108	PF00179	0.412
MOD_SUMO_rev_2	256	264	PF00179	0.252
MOD_SUMO_rev_2	98	107	PF00179	0.371
TRG_DiLeu_BaEn_1	507	512	PF01217	0.257
TRG_ENDOCYTIC_2	112	115	PF00928	0.330
TRG_ENDOCYTIC_2	575	578	PF00928	0.384
TRG_ER_diArg_1	20	23	PF00400	0.464
TRG_ER_diArg_1	51	53	PF00400	0.418
TRG_NLS_MonoExtN_4	81	87	PF00514	0.469
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.405
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.247
TRG_Pf-PMV_PEXEL_1	218	222	PF00026	0.280
TRG_Pf-PMV_PEXEL_1	274	278	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	535	539	PF00026	0.315
TRG_Pf-PMV_PEXEL_1	546	550	PF00026	0.120

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A5	Leptomonas seymouri	51%	100%
A0A0N1HUW7	Leptomonas seymouri	36%	93%
A0A0N1I6C1	Leptomonas seymouri	38%	77%
A0A0N1IMN9	Leptomonas seymouri	52%	85%
A0A0N1PBB9	Leptomonas seymouri	82%	100%
A0A0S4J3N2	Bodo saltans	56%	93%
A0A0S4J9Q2	Bodo saltans	36%	90%
A0A0S4JAH0	Bodo saltans	65%	100%
A0A0S4JGG9	Bodo saltans	49%	89%
A0A0S4KHE9	Bodo saltans	37%	74%
A0A1X0NKD8	Trypanosomatidae	37%	91%
A0A1X0NW32	Trypanosomatidae	48%	87%
A0A1X0P749	Trypanosomatidae	72%	100%
A0A1X0P7E6	Trypanosomatidae	53%	100%
A0A1X0P9F5	Trypanosomatidae	37%	83%
A0A3Q8IFG3	Leishmania donovani	48%	100%
A0A3Q8IHD0	Leishmania donovani	38%	100%
A0A3R7KKD0	Trypanosoma rangeli	50%	100%
A0A3R7L0P7	Trypanosoma rangeli	50%	87%
A0A3R7REN1	Trypanosoma rangeli	37%	91%
A0A3S5H547	Leishmania donovani	33%	100%
A0A3S5H775	Leishmania donovani	51%	100%
A0A3S5H828	Leishmania donovani	34%	100%
A0A422N673	Trypanosoma rangeli	37%	84%
A0A422NJ44	Trypanosoma rangeli	71%	100%
A0L4S0	Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1)	37%	89%
A0LN68	Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)	39%	92%
A0LR74	Acidothermus cellulolyticus (strain ATCC 43068 / DSM 8971 / 11B)	39%	90%
A0PXM8	Clostridium novyi (strain NT)	39%	88%
A1AT11	Pelobacter propionicus (strain DSM 2379 / NBRC 103807 / OttBd1)	38%	96%
A1TZE0	Marinobacter nauticus (strain ATCC 700491 / DSM 11845 / VT8)	34%	94%
A1URA3	Bartonella bacilliformis (strain ATCC 35685 / NCTC 12138 / KC583)	36%	78%
A2SHH9	Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1)	40%	97%
A2ZVG7	Oryza sativa subsp. japonica	36%	76%
A4H3L6	Leishmania braziliensis	34%	100%
A4H9H1	Leishmania braziliensis	93%	100%
A4HAA8	Leishmania braziliensis	50%	100%
A4HAL9	Leishmania braziliensis	38%	76%
A4HKD8	Leishmania braziliensis	51%	100%
A4HPD5	Leishmania braziliensis	37%	100%
A4HXT7	Leishmania infantum	100%	100%
A4HYI8	Leishmania infantum	51%	100%
A4I809	Leishmania infantum	48%	100%
A4I9Q6	Leishmania infantum	38%	100%
A4ICH8	Leishmania infantum	34%	100%
A5U8T5	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)	38%	79%
A5W382	Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)	37%	97%
A6LD25	Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)	39%	87%
A6TSZ1	Alkaliphilus metalliredigens (strain QYMF)	36%	100%
A6TWP7	Alkaliphilus metalliredigens (strain QYMF)	37%	87%
A8F7F7	Pseudothermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / NBRC 107922 / TMO)	40%	96%
A8MPR5	Arabidopsis thaliana	31%	68%
A8ZNZ4	Acaryochloris marina (strain MBIC 11017)	36%	91%
A9BFL9	Petrotoga mobilis (strain DSM 10674 / SJ95)	36%	92%
A9BHD3	Petrotoga mobilis (strain DSM 10674 / SJ95)	35%	95%
A9BJK3	Petrotoga mobilis (strain DSM 10674 / SJ95)	37%	93%
A9EXK6	Sorangium cellulosum (strain So ce56)	37%	92%
A9FDV9	Sorangium cellulosum (strain So ce56)	39%	99%
A9GAW6	Sorangium cellulosum (strain So ce56)	41%	99%
A9GRC9	Sorangium cellulosum (strain So ce56)	37%	97%
A9KIG5	Lachnoclostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg)	33%	100%
A9NE17	Acholeplasma laidlawii (strain PG-8A)	38%	93%
B0K5A3	Thermoanaerobacter sp. (strain X514)	37%	98%
B0K657	Thermoanaerobacter sp. (strain X514)	37%	100%
B1AI94	Ureaplasma parvum serovar 3 (strain ATCC 27815 / 27 / NCTC 11736)	39%	83%
B1GZK7	Endomicrobium trichonymphae	36%	95%
B1ZMG6	Opitutus terrae (strain DSM 11246 / JCM 15787 / PB90-1)	36%	97%
B2A3Q4	Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)	35%	86%
B2JVU2	Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815)	40%	93%
B2UE66	Ralstonia pickettii (strain 12J)	38%	84%
B2UMY1	Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013 / CIP 107961 / Muc)	38%	74%
B2XTF7	Heterosigma akashiwo (strain NIES-293 / 8280G21-1)	34%	90%
B3DV46	Methylacidiphilum infernorum (isolate V4)	37%	94%
B3DY14	Methylacidiphilum infernorum (isolate V4)	41%	93%
B3PNH3	Metamycoplasma arthritidis (strain 158L3-1)	38%	80%
B3QZS3	Phytoplasma mali (strain AT)	36%	87%
B4SCV5	Pelodictyon phaeoclathratiforme (strain DSM 5477 / BU-1)	38%	90%
B4U7U4	Hydrogenobaculum sp. (strain Y04AAS1)	37%	94%
B7J0N5	Borreliella burgdorferi (strain ZS7)	36%	94%
B7T1V0	Vaucheria litorea	35%	93%
B8D065	Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)	37%	95%
B8G4Q6	Chloroflexus aggregans (strain MD-66 / DSM 9485)	36%	91%
B8H444	Caulobacter vibrioides (strain NA1000 / CB15N)	36%	96%
B8I4B9	Ruminiclostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)	36%	97%
B8J992	Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)	37%	85%
B9KXV3	Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)	38%	92%
B9L3S8	Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)	40%	86%
B9MPK5	Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320)	37%	97%
C0ZPK5	Rhodococcus erythropolis (strain PR4 / NBRC 100887)	36%	70%
C1F8X6	Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / BCRC 80197 / JCM 7670 / NBRC 15755 / NCIMB 13165 / 161)	39%	94%
C5CES8	Kosmotoga olearia (strain ATCC BAA-1733 / DSM 21960 / TBF 19.5.1)	36%	93%
C5J6A7	Mesomycoplasma conjunctivae (strain ATCC 25834 / NCTC 10147 / HRC/581)	35%	79%
C6V4R9	Neorickettsia risticii (strain Illinois)	39%	94%
C6VKW6	Lactiplantibacillus plantarum (strain JDM1)	39%	80%
C7M0M0	Acidimicrobium ferrooxidans (strain DSM 10331 / JCM 15462 / NBRC 103882 / ICP)	36%	91%
C7MC16	Brachybacterium faecium (strain ATCC 43885 / DSM 4810 / JCM 11609 / LMG 19847 / NBRC 14762 / NCIMB 9860 / 6-10)	38%	85%
C7N1I1	Slackia heliotrinireducens (strain ATCC 29202 / DSM 20476 / NCTC 11029 / RHS 1)	40%	76%
C7N914	Leptotrichia buccalis (strain ATCC 14201 / DSM 1135 / JCM 12969 / NCTC 10249 / C-1013-b)	40%	78%
C8W731	Lancefieldella parvula (strain ATCC 33793 / DSM 20469 / CCUG 32760 / JCM 10300 / KCTC 3663 / VPI 0546 / 1246)	35%	93%
C8WEG0	Zymomonas mobilis subsp. mobilis (strain NCIMB 11163 / B70)	39%	90%
C9ZMX6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	83%
C9ZZX3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
D0A0W3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
D0A3J7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	91%
D0AA32	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	88%
D0LWB8	Haliangium ochraceum (strain DSM 14365 / JCM 11303 / SMP-2)	40%	88%
D0MGU8	Rhodothermus marinus (strain ATCC 43812 / DSM 4252 / R-10)	40%	86%
D1AXT4	Streptobacillus moniliformis (strain ATCC 14647 / DSM 12112 / NCTC 10651 / 9901)	39%	88%
D1BLD0	Veillonella parvula (strain ATCC 10790 / DSM 2008 / CCUG 5123 / JCM 12972 / NCTC 11810 / Te3)	38%	93%
D1C1U7	Sphaerobacter thermophilus (strain DSM 20745 / S 6022)	37%	92%
D1C2C6	Sphaerobacter thermophilus (strain DSM 20745 / S 6022)	43%	92%
D1C4U5	Sphaerobacter thermophilus (strain DSM 20745 / S 6022)	39%	100%
D1C8C0	Sphaerobacter thermophilus (strain DSM 20745 / S 6022)	39%	91%
D1CDT8	Thermobaculum terrenum (strain ATCC BAA-798 / YNP1)	39%	93%
D2NQQ7	Rothia mucilaginosa (strain DY-18)	40%	79%
D2QZ34	Pirellula staleyi (strain ATCC 27377 / DSM 6068 / ICPB 4128)	40%	85%
D3EZK2	Conexibacter woesei (strain DSM 14684 / CIP 108061 / JCM 11494 / NBRC 100937 / ID131577)	37%	80%
D3F124	Conexibacter woesei (strain DSM 14684 / CIP 108061 / JCM 11494 / NBRC 100937 / ID131577)	38%	92%
D3FFN2	Mycoplasma gallisepticum (strain R(high / passage 156))	38%	78%
D4HA34	Cutibacterium acnes (strain SK137)	39%	83%
D5D8E3	Sulcia muelleri (strain DMIN)	38%	97%
D5H7Z5	Salinibacter ruber (strain M8)	42%	87%
D5HA94	Salinibacter ruber (strain M8)	34%	88%
E9ACJ9	Leishmania major	33%	100%
E9AG43	Leishmania infantum	33%	100%
E9AJT7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9ARJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9ASB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9AT49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B2S6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9B4S8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
F3YDF1	Drosophila melanogaster	37%	81%
F4KF14	Arabidopsis thaliana	30%	70%
O19922	Cyanidium caldarium	34%	97%
O32617	Helicobacter felis (strain ATCC 49179 / NCTC 12436 / CS1)	37%	94%
O59824	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	84%
O67077	Aquifex aeolicus (strain VF5)	38%	94%
O69076	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	37%	92%
O78516	Guillardia theta	35%	95%
O80860	Arabidopsis thaliana	37%	86%
O80983	Arabidopsis thaliana	39%	83%
O82150	Nicotiana tabacum	37%	84%
O83746	Treponema pallidum (strain Nichols)	39%	98%
O88967	Mus musculus	38%	84%
P0A4V9	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	38%	79%
P0AAI3	Escherichia coli (strain K12)	35%	93%
P0AAI4	Shigella flexneri	35%	93%
P32795	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	80%
P37476	Bacillus subtilis (strain 168)	38%	94%
P39925	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	79%
P40341	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	72%
P46469	Lactococcus lactis subsp. lactis (strain IL1403)	38%	86%
P47695	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	36%	85%
P49825	Trieres chinensis	35%	93%
P51327	Porphyra purpurea	35%	95%
P54813	Caenorhabditis elegans	41%	83%
P57462	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	35%	98%
P59652	Streptococcus pneumoniae (strain ATCC BAA-255 / R6)	37%	92%
P63343	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	35%	93%
P63344	Salmonella typhi	35%	93%
P71377	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	35%	94%
P71408	Helicobacter pylori (strain ATCC 700392 / 26695)	38%	95%
P72991	Synechocystis sp. (strain PCC 6803 / Kazusa)	38%	97%
P73179	Synechocystis sp. (strain PCC 6803 / Kazusa)	37%	90%
P73437	Synechocystis sp. (strain PCC 6803 / Kazusa)	37%	95%
P75120	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	36%	84%
P94304	Alkalihalophilus pseudofirmus (strain ATCC BAA-2126 / JCM 17055 / OF4)	38%	88%
P9WQN2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	38%	79%
P9WQN3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	38%	79%
Q03Z46	Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / DSM 20343 / BCRC 11652 / CCM 1803 / JCM 6124 / NCDO 523 / NBRC 100496 / NCIMB 8023 / NCTC 12954 / NRRL B-1118 / 37Y)	39%	85%
Q04Q03	Leptospira borgpetersenii serovar Hardjo-bovis (strain JB197)	36%	92%
Q0DHL4	Oryza sativa subsp. japonica	40%	73%
Q0TTK8	Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)	38%	83%
Q10ZF7	Trichodesmium erythraeum (strain IMS101)	35%	90%
Q1AV13	Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129 / PRD-1)	39%	92%
Q1D491	Myxococcus xanthus (strain DK1622)	37%	94%
Q1LLA9	Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)	36%	92%
Q1PDW5	Arabidopsis thaliana	37%	87%
Q1RGP0	Rickettsia bellii (strain RML369-C)	37%	94%
Q1XDF9	Neopyropia yezoensis	34%	95%
Q2JNP0	Synechococcus sp. (strain JA-2-3B'a(2-13))	38%	94%
Q2KJI7	Bos taurus	40%	74%
Q2LUQ1	Syntrophus aciditrophicus (strain SB)	39%	81%
Q2NIN5	Aster yellows witches'-broom phytoplasma (strain AYWB)	39%	88%
Q2SF13	Hahella chejuensis (strain KCTC 2396)	34%	97%
Q39102	Arabidopsis thaliana	38%	84%
Q39444	Capsicum annuum	38%	90%
Q3A579	Syntrophotalea carbinolica (strain DSM 2380 / NBRC 103641 / GraBd1)	38%	93%
Q3B6R3	Chlorobium luteolum (strain DSM 273 / BCRC 81028 / 2530)	40%	85%
Q3JEE4	Nitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / JCM 30415 / NCIMB 11848 / C-107)	38%	94%
Q3JMH0	Burkholderia pseudomallei (strain 1710b)	39%	90%
Q3ULF4	Mus musculus	41%	77%
Q4A5F0	Mycoplasmopsis synoviae (strain 53)	36%	90%
Q4L3G8	Staphylococcus haemolyticus (strain JCSC1435)	37%	82%
Q4Q1E9	Leishmania major	34%	100%
Q4Q399	Leishmania major	38%	100%
Q4Q5D1	Leishmania major	48%	100%
Q4QD50	Leishmania major	51%	100%
Q4QDY0	Leishmania major	99%	100%
Q4UN68	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	38%	94%
Q55700	Synechocystis sp. (strain PCC 6803 / Kazusa)	36%	95%
Q5SI82	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	38%	96%
Q5Z974	Oryza sativa subsp. japonica	38%	87%
Q60AK1	Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)	37%	94%
Q655S1	Oryza sativa subsp. japonica	37%	88%
Q67JH0	Symbiobacterium thermophilum (strain T / IAM 14863)	41%	96%
Q67LC0	Symbiobacterium thermophilum (strain T / IAM 14863)	38%	100%
Q67T82	Symbiobacterium thermophilum (strain T / IAM 14863)	40%	100%
Q67WJ2	Oryza sativa subsp. japonica	37%	87%
Q68XR9	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	38%	94%
Q6F0E5	Mesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1)	38%	92%
Q6H6R9	Oryza sativa subsp. japonica	40%	73%
Q6KHA4	Mycoplasma mobile (strain ATCC 43663 / 163K / NCTC 11711)	38%	85%
Q6LUJ8	Photobacterium profundum (strain SS9)	37%	86%
Q6M2F0	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	38%	70%
Q6MJV1	Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100)	40%	97%
Q6MLS7	Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100)	34%	93%
Q7TT47	Rattus norvegicus	41%	77%
Q7URM7	Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)	35%	82%
Q7UUZ7	Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)	37%	89%
Q83FV7	Tropheryma whipplei (strain Twist)	36%	90%
Q83XX3	Oenococcus oeni	38%	84%
Q84WU8	Arabidopsis thaliana	42%	74%
Q88Z31	Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)	39%	80%
Q89AF2	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	35%	98%
Q8EUA6	Malacoplasma penetrans (strain HF-2)	38%	73%
Q8JZQ2	Mus musculus	40%	75%
Q8K9G8	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	34%	98%
Q8LQJ8	Oryza sativa subsp. japonica	39%	84%
Q8LQJ9	Oryza sativa subsp. japonica	39%	84%
Q8S2A7	Oryza sativa subsp. japonica	42%	75%
Q8VZI8	Arabidopsis thaliana	42%	74%
Q8W585	Arabidopsis thaliana	37%	87%
Q8X9L0	Escherichia coli O157:H7	35%	93%
Q8YMZ8	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	38%	91%
Q920A7	Mus musculus	40%	76%
Q925S8	Rattus norvegicus	36%	84%
Q92JJ9	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	38%	94%
Q96TA2	Homo sapiens	38%	77%
Q98PE4	Mycoplasmopsis pulmonis (strain UAB CTIP)	38%	82%
Q9BAE0	Medicago sativa	37%	85%
Q9CD58	Mycobacterium leprae (strain TN)	38%	76%
Q9FGM0	Arabidopsis thaliana	38%	74%
Q9FH02	Arabidopsis thaliana	37%	85%
Q9FIM2	Arabidopsis thaliana	40%	74%
Q9HGM3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	77%
Q9MUP8	Mesostigma viride	25%	67%
Q9N3T5	Caenorhabditis elegans	39%	76%
Q9SD67	Arabidopsis thaliana	40%	75%
Q9TJ83	Cyanidioschyzon merolae (strain NIES-3377 / 10D)	35%	99%
Q9UQ90	Homo sapiens	41%	75%
Q9WZ49	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	37%	98%
Q9Y4W6	Homo sapiens	40%	75%
Q9ZEA2	Rickettsia prowazekii (strain Madrid E)	38%	94%
Q9ZM66	Helicobacter pylori (strain J99 / ATCC 700824)	38%	95%
V5B092	Trypanosoma cruzi	37%	91%
V5B4C8	Trypanosoma cruzi	49%	100%
V5BEV9	Trypanosoma cruzi	37%	84%
V5BP04	Trypanosoma cruzi	49%	87%
V5DN25	Trypanosoma cruzi	71%	100%