ATP-dependent_zinc_metallopeptidase_putative/Gene DB:LmjF.18.0610/GeneDB:LmjF.19.1590

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent zinc metallopeptidase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJP7_LEIDO

TriTrypDb:

LdBPK_180620.1 , LdCL_180011300 , LDHU3_18.0820

Length:

598

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Annotations by Jardim et al.

Proteases, ATP-dependent zinc metallopeptidase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 33
NetGPI	no	yes: 0, no: 33

Show entries

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0005745	m-AAA complex	4	3
GO:0016020	membrane	2	25
GO:0032991	protein-containing complex	1	3
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098796	membrane protein complex	2	3
GO:0098798	mitochondrial protein-containing complex	2	3

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IJP7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJP7

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	34
GO:0006807	nitrogen compound metabolic process	2	34
GO:0008152	metabolic process	1	34
GO:0009987	cellular process	1	3
GO:0016043	cellular component organization	3	3
GO:0016485	protein processing	5	3
GO:0019538	protein metabolic process	3	34
GO:0022607	cellular component assembly	4	3
GO:0034982	mitochondrial protein processing	6	3
GO:0043170	macromolecule metabolic process	3	34

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Show entries

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	34
GO:0003824	catalytic activity	1	34
GO:0004175	endopeptidase activity	4	34
GO:0004176	ATP-dependent peptidase activity	2	34
GO:0004222	metalloendopeptidase activity	5	34
GO:0005488	binding	1	34
GO:0005524	ATP binding	5	34
GO:0008233	peptidase activity	3	34
GO:0008237	metallopeptidase activity	4	34
GO:0016462	pyrophosphatase activity	5	34

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Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	196	200	PF00656	0.202
CLV_C14_Caspase3-7	2	6	PF00656	0.629
CLV_C14_Caspase3-7	354	358	PF00656	0.239
CLV_NRD_NRD_1	22	24	PF00675	0.414
CLV_NRD_NRD_1	260	262	PF00675	0.402
CLV_NRD_NRD_1	273	275	PF00675	0.462
CLV_NRD_NRD_1	362	364	PF00675	0.535
CLV_NRD_NRD_1	375	377	PF00675	0.401
CLV_NRD_NRD_1	52	54	PF00675	0.523
CLV_PCSK_FUR_1	20	24	PF00082	0.456

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A5	Leptomonas seymouri	51%	100%
A0A0N1HUW7	Leptomonas seymouri	36%	93%
A0A0N1I6C1	Leptomonas seymouri	38%	77%
A0A0N1IMN9	Leptomonas seymouri	52%	85%
A0A0N1PBB9	Leptomonas seymouri	82%	100%
A0A0S4J3N2	Bodo saltans	56%	93%
A0A0S4J9Q2	Bodo saltans	36%	90%
A0A0S4JAH0	Bodo saltans	65%	100%
A0A0S4JGG9	Bodo saltans	49%	89%
A0A0S4KHE9	Bodo saltans	37%	74%

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