LeishMANIAdb
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CRAL/TRIO, N-terminal domain/CRAL/TRIO domain containing protein, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
CRAL/TRIO, N-terminal domain/CRAL/TRIO domain containing protein, putative
Gene product:
CRAL/TRIO, N-terminal domain/CRAL/TRIO domain containing protein, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IJP6_LEIDO
TriTrypDb:
LdBPK_353610.1 , LdCL_350041100 , LDHU3_35.4730
Length:
372

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3Q8IJP6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJP6

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 1
GO:0005319 lipid transporter activity 2 1
GO:0005548 phospholipid transporter activity 3 1
GO:0008526 phosphatidylinositol transfer activity 5 1
GO:0120013 lipid transfer activity 3 1
GO:0120014 phospholipid transfer activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 343 347 PF00656 0.649
CLV_NRD_NRD_1 178 180 PF00675 0.391
CLV_NRD_NRD_1 328 330 PF00675 0.673
CLV_NRD_NRD_1 363 365 PF00675 0.762
CLV_NRD_NRD_1 83 85 PF00675 0.630
CLV_PCSK_KEX2_1 356 358 PF00082 0.634
CLV_PCSK_KEX2_1 363 365 PF00082 0.591
CLV_PCSK_KEX2_1 83 85 PF00082 0.630
CLV_PCSK_PC1ET2_1 356 358 PF00082 0.634
CLV_PCSK_PC1ET2_1 83 85 PF00082 0.477
CLV_PCSK_SKI1_1 256 260 PF00082 0.452
CLV_PCSK_SKI1_1 334 338 PF00082 0.768
CLV_PCSK_SKI1_1 345 349 PF00082 0.698
DEG_MDM2_SWIB_1 251 259 PF02201 0.391
DOC_CKS1_1 14 19 PF01111 0.572
DOC_CKS1_1 309 314 PF01111 0.563
DOC_MAPK_FxFP_2 38 41 PF00069 0.461
DOC_MAPK_MEF2A_6 220 227 PF00069 0.472
DOC_PP1_RVXF_1 164 171 PF00149 0.372
DOC_PP1_RVXF_1 267 273 PF00149 0.373
DOC_PP2B_LxvP_1 257 260 PF13499 0.498
DOC_PP2B_LxvP_1 31 34 PF13499 0.524
DOC_PP4_FxxP_1 38 41 PF00568 0.454
DOC_PP4_FxxP_1 47 50 PF00568 0.406
DOC_USP7_MATH_1 15 19 PF00917 0.804
DOC_USP7_MATH_1 277 281 PF00917 0.559
DOC_USP7_MATH_2 2 8 PF00917 0.693
DOC_USP7_UBL2_3 330 334 PF12436 0.729
DOC_USP7_UBL2_3 337 341 PF12436 0.701
DOC_USP7_UBL2_3 344 348 PF12436 0.665
DOC_USP7_UBL2_3 355 359 PF12436 0.733
DOC_WW_Pin1_4 13 18 PF00397 0.701
DOC_WW_Pin1_4 178 183 PF00397 0.401
DOC_WW_Pin1_4 308 313 PF00397 0.555
LIG_CSL_BTD_1 314 317 PF09270 0.569
LIG_deltaCOP1_diTrp_1 202 210 PF00928 0.372
LIG_EVH1_2 247 251 PF00568 0.416
LIG_FHA_1 309 315 PF00498 0.538
LIG_FHA_2 135 141 PF00498 0.565
LIG_FHA_2 14 20 PF00498 0.761
LIG_FHA_2 206 212 PF00498 0.388
LIG_FHA_2 266 272 PF00498 0.440
LIG_LIR_Apic_2 304 309 PF02991 0.670
LIG_LIR_Apic_2 36 41 PF02991 0.450
LIG_LIR_Apic_2 45 50 PF02991 0.443
LIG_LIR_Gen_1 105 115 PF02991 0.340
LIG_LIR_Gen_1 122 131 PF02991 0.356
LIG_LIR_Gen_1 189 198 PF02991 0.387
LIG_LIR_Gen_1 202 210 PF02991 0.344
LIG_LIR_Gen_1 211 221 PF02991 0.347
LIG_LIR_Nem_3 105 110 PF02991 0.371
LIG_LIR_Nem_3 122 127 PF02991 0.356
LIG_LIR_Nem_3 189 193 PF02991 0.393
LIG_LIR_Nem_3 202 207 PF02991 0.346
LIG_LIR_Nem_3 208 213 PF02991 0.295
LIG_LIR_Nem_3 252 258 PF02991 0.450
LIG_LIR_Nem_3 283 288 PF02991 0.454
LIG_MYND_1 286 290 PF01753 0.576
LIG_Pex14_2 251 255 PF04695 0.356
LIG_Pex14_2 285 289 PF04695 0.432
LIG_SH2_CRK 306 310 PF00017 0.692
LIG_SH2_NCK_1 306 310 PF00017 0.692
LIG_SH2_SRC 112 115 PF00017 0.338
LIG_SH2_STAT5 112 115 PF00017 0.372
LIG_SH2_STAT5 296 299 PF00017 0.443
LIG_SH2_STAT5 51 54 PF00017 0.507
LIG_SH3_1 306 312 PF00018 0.686
LIG_SH3_3 11 17 PF00018 0.595
LIG_SH3_3 306 312 PF00018 0.563
LIG_TRAF2_1 55 58 PF00917 0.458
LIG_UBA3_1 250 256 PF00899 0.463
LIG_WRC_WIRS_1 187 192 PF05994 0.429
MOD_CDC14_SPxK_1 181 184 PF00782 0.367
MOD_CDK_SPxK_1 178 184 PF00069 0.367
MOD_CK1_1 7 13 PF00069 0.827
MOD_CK2_1 122 128 PF00069 0.539
MOD_CK2_1 134 140 PF00069 0.477
MOD_CK2_1 205 211 PF00069 0.388
MOD_CK2_1 265 271 PF00069 0.498
MOD_CK2_1 277 283 PF00069 0.620
MOD_CK2_1 51 57 PF00069 0.454
MOD_GlcNHglycan 9 12 PF01048 0.827
MOD_GSK3_1 134 141 PF00069 0.540
MOD_GSK3_1 205 212 PF00069 0.356
MOD_GSK3_1 277 284 PF00069 0.647
MOD_GSK3_1 291 298 PF00069 0.455
MOD_N-GLC_1 5 10 PF02516 0.599
MOD_NEK2_1 127 132 PF00069 0.426
MOD_NEK2_1 169 174 PF00069 0.507
MOD_NEK2_1 186 191 PF00069 0.223
MOD_PIKK_1 291 297 PF00454 0.463
MOD_Plk_1 127 133 PF00069 0.409
MOD_Plk_1 5 11 PF00069 0.720
MOD_Plk_2-3 122 128 PF00069 0.391
MOD_ProDKin_1 13 19 PF00069 0.698
MOD_ProDKin_1 178 184 PF00069 0.401
MOD_ProDKin_1 308 314 PF00069 0.542
MOD_SUMO_rev_2 100 104 PF00179 0.383
MOD_SUMO_rev_2 172 182 PF00179 0.498
MOD_SUMO_rev_2 214 222 PF00179 0.498
MOD_SUMO_rev_2 338 347 PF00179 0.680
MOD_SUMO_rev_2 87 92 PF00179 0.557
TRG_ENDOCYTIC_2 213 216 PF00928 0.416
TRG_ER_diArg_1 363 366 PF00400 0.624
TRG_Pf-PMV_PEXEL_1 229 233 PF00026 0.498
TRG_Pf-PMV_PEXEL_1 84 88 PF00026 0.559

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHG0 Leptomonas seymouri 74% 97%
A0A0S4IKI1 Bodo saltans 47% 100%
A0A1X0P588 Trypanosomatidae 53% 100%
A0A3R7L5B2 Trypanosoma rangeli 55% 100%
A4HN25 Leishmania braziliensis 77% 100%
A4IBP3 Leishmania infantum 100% 100%
C9ZYY3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 53% 100%
E9AFI0 Leishmania major 96% 100%
E9B6N5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
Q55CU8 Dictyostelium discoideum 22% 100%
V5BCV8 Trypanosoma cruzi 55% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS