Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJP5_LEIDO

TriTrypDb:

LdBPK_323790.1 , LdCL_320043900 , LDHU3_32.4790

Length:

437

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IJP5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJP5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.586
CLV_NRD_NRD_1	134	136	PF00675	0.619
CLV_NRD_NRD_1	67	69	PF00675	0.625
CLV_PCSK_KEX2_1	134	136	PF00082	0.619
CLV_PCSK_KEX2_1	67	69	PF00082	0.621
CLV_PCSK_SKI1_1	250	254	PF00082	0.604
CLV_PCSK_SKI1_1	62	66	PF00082	0.592
DOC_CDC14_PxL_1	1	9	PF14671	0.551
DOC_CYCLIN_yCln2_LP_2	422	428	PF00134	0.741
DOC_MAPK_gen_1	336	344	PF00069	0.520
DOC_PP2B_LxvP_1	225	228	PF13499	0.839
DOC_PP2B_LxvP_1	422	425	PF13499	0.731
DOC_USP7_MATH_1	116	120	PF00917	0.535
DOC_USP7_MATH_1	122	126	PF00917	0.691
DOC_USP7_MATH_1	130	134	PF00917	0.823
DOC_USP7_MATH_1	175	179	PF00917	0.688
DOC_USP7_MATH_1	183	187	PF00917	0.596
DOC_USP7_MATH_1	197	201	PF00917	0.746
DOC_USP7_MATH_1	220	224	PF00917	0.779
DOC_USP7_MATH_1	232	236	PF00917	0.737
DOC_USP7_MATH_1	239	243	PF00917	0.742
DOC_USP7_MATH_1	252	256	PF00917	0.584
DOC_USP7_MATH_1	289	293	PF00917	0.652
DOC_USP7_MATH_1	376	380	PF00917	0.704
DOC_USP7_MATH_1	408	412	PF00917	0.695
DOC_USP7_MATH_1	426	430	PF00917	0.577
DOC_USP7_MATH_1	56	60	PF00917	0.560
DOC_USP7_MATH_1	97	101	PF00917	0.571
DOC_USP7_MATH_2	211	217	PF00917	0.794
DOC_WW_Pin1_4	135	140	PF00397	0.719
DOC_WW_Pin1_4	243	248	PF00397	0.836
DOC_WW_Pin1_4	34	39	PF00397	0.520
DOC_WW_Pin1_4	86	91	PF00397	0.580
LIG_14-3-3_CanoR_1	134	140	PF00244	0.630
LIG_14-3-3_CanoR_1	149	159	PF00244	0.634
LIG_14-3-3_CanoR_1	336	344	PF00244	0.520
LIG_14-3-3_CanoR_1	350	359	PF00244	0.300
LIG_14-3-3_CanoR_1	398	402	PF00244	0.651
LIG_14-3-3_CanoR_1	98	104	PF00244	0.704
LIG_Actin_WH2_2	373	389	PF00022	0.656
LIG_APCC_ABBA_1	47	52	PF00400	0.544
LIG_CaM_IQ_9	357	372	PF13499	0.571
LIG_CSL_BTD_1	329	332	PF09270	0.556
LIG_EH1_1	259	267	PF00400	0.652
LIG_FHA_1	1	7	PF00498	0.552
LIG_FHA_1	118	124	PF00498	0.594
LIG_FHA_1	25	31	PF00498	0.553
LIG_FHA_1	87	93	PF00498	0.638
LIG_FHA_2	407	413	PF00498	0.672
LIG_GBD_Chelix_1	414	422	PF00786	0.704
LIG_LIR_Gen_1	146	155	PF02991	0.459
LIG_LIR_Gen_1	29	38	PF02991	0.559
LIG_LIR_Nem_3	146	150	PF02991	0.523
LIG_LIR_Nem_3	160	165	PF02991	0.619
LIG_LIR_Nem_3	29	34	PF02991	0.566
LIG_LIR_Nem_3	327	333	PF02991	0.550
LIG_LYPXL_yS_3	109	112	PF13949	0.529
LIG_NRBOX	72	78	PF00104	0.584
LIG_PCNA_yPIPBox_3	67	77	PF02747	0.553
LIG_Pex14_1	330	334	PF04695	0.545
LIG_SH2_CRK	31	35	PF00017	0.571
LIG_SH2_CRK	334	338	PF00017	0.513
LIG_SH2_GRB2like	343	346	PF00017	0.560
LIG_SH2_PTP2	158	161	PF00017	0.631
LIG_SH2_SRC	158	161	PF00017	0.675
LIG_SH2_STAP1	165	169	PF00017	0.718
LIG_SH2_STAT3	358	361	PF00017	0.544
LIG_SH2_STAT5	158	161	PF00017	0.650
LIG_SH2_STAT5	169	172	PF00017	0.538
LIG_SH2_STAT5	31	34	PF00017	0.575
LIG_SH2_STAT5	343	346	PF00017	0.625
LIG_SH2_STAT5	358	361	PF00017	0.643
LIG_SH3_3	326	332	PF00018	0.651
LIG_TRAF2_1	211	214	PF00917	0.801
LIG_TRAF2_1	284	287	PF00917	0.619
LIG_WRC_WIRS_1	30	35	PF05994	0.569
MOD_CDK_SPxxK_3	243	250	PF00069	0.615
MOD_CK1_1	133	139	PF00069	0.840
MOD_CK1_1	216	222	PF00069	0.733
MOD_CK1_1	223	229	PF00069	0.745
MOD_CK1_1	24	30	PF00069	0.628
MOD_CK1_1	353	359	PF00069	0.532
MOD_CK1_1	36	42	PF00069	0.465
MOD_CK1_1	399	405	PF00069	0.681
MOD_CK2_1	160	166	PF00069	0.608
MOD_CK2_1	193	199	PF00069	0.802
MOD_CK2_1	281	287	PF00069	0.741
MOD_CK2_1	36	42	PF00069	0.529
MOD_DYRK1A_RPxSP_1	135	139	PF00069	0.757
MOD_GlcNHglycan	124	127	PF01048	0.737
MOD_GlcNHglycan	130	133	PF01048	0.703
MOD_GlcNHglycan	135	138	PF01048	0.667
MOD_GlcNHglycan	162	165	PF01048	0.600
MOD_GlcNHglycan	177	180	PF01048	0.661
MOD_GlcNHglycan	185	188	PF01048	0.713
MOD_GlcNHglycan	195	198	PF01048	0.668
MOD_GlcNHglycan	199	203	PF01048	0.732
MOD_GlcNHglycan	218	221	PF01048	0.537
MOD_GlcNHglycan	222	225	PF01048	0.725
MOD_GlcNHglycan	239	242	PF01048	0.740
MOD_GlcNHglycan	254	257	PF01048	0.605
MOD_GlcNHglycan	283	286	PF01048	0.611
MOD_GlcNHglycan	352	355	PF01048	0.526
MOD_GlcNHglycan	38	41	PF01048	0.495
MOD_GlcNHglycan	418	421	PF01048	0.690
MOD_GlcNHglycan	59	62	PF01048	0.579
MOD_GSK3_1	193	200	PF00069	0.764
MOD_GSK3_1	216	223	PF00069	0.738
MOD_GSK3_1	239	246	PF00069	0.745
MOD_GSK3_1	277	284	PF00069	0.663
MOD_GSK3_1	29	36	PF00069	0.564
MOD_GSK3_1	332	339	PF00069	0.562
MOD_GSK3_1	346	353	PF00069	0.503
MOD_LATS_1	8	14	PF00433	0.535
MOD_N-GLC_1	15	20	PF02516	0.565
MOD_N-GLC_1	193	198	PF02516	0.794
MOD_NEK2_1	23	28	PF00069	0.552
MOD_NEK2_1	33	38	PF00069	0.507
MOD_NEK2_1	337	342	PF00069	0.516
MOD_NEK2_1	50	55	PF00069	0.549
MOD_NEK2_1	76	81	PF00069	0.570
MOD_NEK2_1	9	14	PF00069	0.559
MOD_PIKK_1	311	317	PF00454	0.581
MOD_PIKK_1	426	432	PF00454	0.761
MOD_PKA_2	133	139	PF00069	0.619
MOD_PKA_2	150	156	PF00069	0.622
MOD_PKA_2	205	211	PF00069	0.784
MOD_PKA_2	281	287	PF00069	0.654
MOD_PKA_2	364	370	PF00069	0.581
MOD_PKA_2	397	403	PF00069	0.649
MOD_PKA_2	97	103	PF00069	0.577
MOD_Plk_1	15	21	PF00069	0.566
MOD_Plk_1	213	219	PF00069	0.764
MOD_Plk_1	220	226	PF00069	0.717
MOD_Plk_4	26	32	PF00069	0.556
MOD_Plk_4	353	359	PF00069	0.632
MOD_ProDKin_1	135	141	PF00069	0.716
MOD_ProDKin_1	243	249	PF00069	0.832
MOD_ProDKin_1	34	40	PF00069	0.518
MOD_ProDKin_1	86	92	PF00069	0.579
MOD_SUMO_rev_2	293	302	PF00179	0.679
MOD_SUMO_rev_2	340	349	PF00179	0.621
TRG_ENDOCYTIC_2	109	112	PF00928	0.595
TRG_ENDOCYTIC_2	31	34	PF00928	0.575
TRG_ENDOCYTIC_2	334	337	PF00928	0.509
TRG_ER_diArg_1	148	151	PF00400	0.681
TRG_ER_diArg_1	389	392	PF00400	0.713
TRG_ER_diArg_1	66	68	PF00400	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK58	Leptomonas seymouri	48%	98%
A4HL02	Leishmania braziliensis	69%	100%
E9AHM4	Leishmania infantum	99%	100%
E9B3E3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q4Q9	Leishmania major	90%	100%