Valine--tRNA ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Valine--tRNA ligase

Gene product:

valyl-tRNA synthetase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJP4_LEIDO

TriTrypDb:

LdBPK_303170.1 , LdCL_300037300 , LDHU3_30.4230

Length:

967

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0005829	cytosol	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

A0A3Q8IJP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJP4

Function

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Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006399	tRNA metabolic process	7	12
GO:0006418	tRNA aminoacylation for protein translation	6	12
GO:0006438	valyl-tRNA aminoacylation	7	12
GO:0006520	amino acid metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0002161	aminoacyl-tRNA editing activity	5	12
GO:0003824	catalytic activity	1	12
GO:0004812	aminoacyl-tRNA ligase activity	4	12
GO:0004832	valine-tRNA ligase activity	5	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016874	ligase activity	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	689	693	PF00656	0.503
CLV_NRD_NRD_1	134	136	PF00675	0.294
CLV_NRD_NRD_1	209	211	PF00675	0.314
CLV_NRD_NRD_1	336	338	PF00675	0.254
CLV_NRD_NRD_1	386	388	PF00675	0.261
CLV_NRD_NRD_1	96	98	PF00675	0.320
CLV_PCSK_KEX2_1	116	118	PF00082	0.122
CLV_PCSK_KEX2_1	134	136	PF00082	0.299
CLV_PCSK_KEX2_1	306	308	PF00082	0.339
CLV_PCSK_KEX2_1	336	338	PF00082	0.265

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKP0	Leptomonas seymouri	85%	99%
A0A0S4JI29	Bodo saltans	70%	99%
A0A1X0P1G2	Trypanosomatidae	75%	99%
A0A422P0P6	Trypanosoma rangeli	74%	99%
A0B7C2	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	26%	100%
A0B7P3	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	25%	92%
A0KG39	Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)	24%	100%
A0KZZ1	Shewanella sp. (strain ANA-3)	25%	100%
A0M5I5	Gramella forsetii (strain KT0803)	33%	100%
A1A774	Escherichia coli O1:K1 / APEC	25%	100%

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