Cytochrome P450

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Cytochrome P450

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJN4_LEIDO

TriTrypDb:

LdBPK_302950.1 , LdCL_300035100 , LDHU3_30.3910

Length:

191

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3Q8IJN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJN4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.533
CLV_NRD_NRD_1	166	168	PF00675	0.682
CLV_PCSK_KEX2_1	166	168	PF00082	0.682
CLV_PCSK_SKI1_1	101	105	PF00082	0.707
CLV_PCSK_SKI1_1	87	91	PF00082	0.664
DEG_APCC_DBOX_1	9	17	PF00400	0.447
DOC_CYCLIN_yCln2_LP_2	77	83	PF00134	0.456
DOC_MAPK_gen_1	166	177	PF00069	0.477
DOC_PP4_FxxP_1	177	180	PF00568	0.446
DOC_PP4_FxxP_1	187	190	PF00568	0.476
DOC_WW_Pin1_4	176	181	PF00397	0.481
DOC_WW_Pin1_4	95	100	PF00397	0.496
LIG_14-3-3_CanoR_1	10	14	PF00244	0.471
LIG_14-3-3_CanoR_1	166	174	PF00244	0.455
LIG_FHA_1	104	110	PF00498	0.477
LIG_FHA_1	69	75	PF00498	0.493
LIG_FHA_1	76	82	PF00498	0.426
LIG_LIR_Apic_2	184	190	PF02991	0.506
LIG_LIR_Nem_3	159	165	PF02991	0.451
LIG_LIR_Nem_3	26	32	PF02991	0.630
LIG_MYND_1	137	141	PF01753	0.521
LIG_Pex14_2	187	191	PF04695	0.529
LIG_SH2_STAT3	32	35	PF00017	0.483
LIG_SH2_STAT5	27	30	PF00017	0.601
LIG_SH2_STAT5	32	35	PF00017	0.505
LIG_WRC_WIRS_1	104	109	PF05994	0.498
LIG_WRC_WIRS_1	69	74	PF05994	0.484
MOD_CDK_SPxK_1	95	101	PF00069	0.497
MOD_CK1_1	4	10	PF00069	0.577
MOD_CK1_1	67	73	PF00069	0.513
MOD_CK2_1	148	154	PF00069	0.478
MOD_GlcNHglycan	150	153	PF01048	0.649
MOD_GlcNHglycan	18	21	PF01048	0.447
MOD_GlcNHglycan	3	6	PF01048	0.502
MOD_GlcNHglycan	51	54	PF01048	0.661
MOD_GSK3_1	64	71	PF00069	0.504
MOD_NEK2_1	129	134	PF00069	0.494
MOD_NEK2_1	23	28	PF00069	0.402
MOD_PIKK_1	64	70	PF00454	0.482
MOD_PKA_1	166	172	PF00069	0.450
MOD_PKA_2	165	171	PF00069	0.476
MOD_PKA_2	9	15	PF00069	0.385
MOD_Plk_1	183	189	PF00069	0.452
MOD_Plk_1	56	62	PF00069	0.484
MOD_Plk_4	23	29	PF00069	0.402
MOD_Plk_4	4	10	PF00069	0.537
MOD_ProDKin_1	176	182	PF00069	0.480
MOD_ProDKin_1	95	101	PF00069	0.497
TRG_ER_diArg_1	165	167	PF00400	0.477
TRG_NES_CRM1_1	64	75	PF08389	0.447
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.696

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCB6	Leptomonas seymouri	61%	100%
A0A0S4ITI4	Bodo saltans	32%	83%
A0A1X0P1H2	Trypanosomatidae	35%	97%
A0A3R7M429	Trypanosoma rangeli	38%	100%
A4HIM7	Leishmania braziliensis	83%	100%
A4I5X2	Leishmania infantum	99%	100%
C9ZR96	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B166	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q6Z9	Leishmania major	95%	100%